LOCUS       NM_010135              12337 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus ENAH actin regulator (Enah), transcript variant 1,
            mRNA.
ACCESSION   NM_010135
VERSION     NM_010135.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12337)
  AUTHORS   Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y,
            Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla
            E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS and Entenberg
            D.
  TITLE     Primary tumor associated macrophages activate programs of invasion
            and dormancy in disseminating tumor cells
  JOURNAL   Nat Commun 13 (1), 626 (2022)
   PUBMED   35110548
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12337)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12337)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12337)
  AUTHORS   Carpinelli MR, de Vries ME, Auden A, Butt T, Deng Z, Partridge DD,
            Miles LB, Georgy SR, Haigh JJ, Darido C, Brabletz S, Brabletz T,
            Stemmler MP, Dworkin S and Jane SM.
  TITLE     Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues
            mid-gestation viability and secondary palate closure
  JOURNAL   Dis Model Mech 13 (3) (2020)
   PUBMED   32005677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12337)
  AUTHORS   Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart
            N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller
            JA, Krantz ID, Carstens RP and Epstein DJ.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   6  (bases 1 to 12337)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (bases 1 to 12337)
  AUTHORS   Bedford MT, Chan DC and Leder P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   8  (bases 1 to 12337)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   9  (bases 1 to 12337)
  AUTHORS   Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (bases 1 to 12337)
  AUTHORS   Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M and Kumar S.
  TITLE     Identification of a developmentally regulated gene in the mouse
            central nervous system which encodes a novel proline rich protein
  JOURNAL   Biochim Biophys Acta 1132 (3), 240-248 (1992)
   PUBMED   1420303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122204.3 and AC165229.7.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_010135.4.
            
            On Dec 20, 2013 this sequence version replaced NM_010135.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72523.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AC122204.3         45770-46220
            452-617             AC122204.3         103831-103996
            618-795             AC122204.3         109179-109356
            796-852             AC165229.7         210295-210351       c
            853-937             AC165229.7         205313-205397       c
            938-1218            AC165229.7         198195-198475       c
            1219-2061           AC165229.7         196293-197135       c
            2062-2366           AC165229.7         193960-194264       c
            2367-2512           AC165229.7         193073-193218       c
            2513-2570           AC165229.7         192893-192950       c
            2571-2619           AC165229.7         191834-191882       c
            2620-2686           AC165229.7         187942-188008       c
            2687-2765           AC165229.7         182933-183011       c
            2766-2823           AC165229.7         181022-181079       c
            2824-12337          AC165229.7         171019-180532       c
FEATURES             Location/Qualifiers
     source          1..12337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     gene            1..12337
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /note="ENAH actin regulator"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
     exon            1..451
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..2861
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein enabled homolog; NPC derived proline rich protein
                     1"
                     /codon_start=1
                     /product="protein enabled homolog isoform 1"
                     /protein_id="NP_034265.2"
                     /db_xref="CCDS:CCDS35811.1"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
                     /translation="MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNN
                     TFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFAS
                     AMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELE
                     IQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERL
                     ERERLERLERERQERERERLEQLEREQVEWERERRMSNAAPSSDSSLSSAPLPEYSSC
                     QPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPPLRHAATRFATSLGSAFH
                     PVLPHYATVPRPLNKNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPP
                     GKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPP
                     PPPPPPPPLPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAAAPASAE
                     TPLNPELGDSSASEPGLQAASQPAESPTPQGLVLGPPAPPPPPPLPSGPAYASALPPP
                     PGPPPPPPLPSTGPPPPPPPPPPLPNQAPPPPPPPPAPPLPASGIFSGSTSEDNRPLT
                     GLAAAIAGAKLRKVSRVEDGSFPGGGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEM
                     SALLARRRRIAEKGSTIETEQKEDRNEDAEPITAKAPSTSTPEPTRKPWERTNTMNGS
                     KSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQEL
                     SKSNTA"
     exon            452..617
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            618..795
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            796..852
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            853..937
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1218
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..2061
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2366
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2512
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2570
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2619
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2686
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2765
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2823
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..12337
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagcccg gctctcctcc cgcggctgca gcagctgccg gttcctcacg gcctcggcgg
       61 cggcggtgac ggcggcgcgc tcggagcggc ctctggagcg gcgggcgggc ggacggacgg
      121 acggacggac gggcgcgcgg ccccggcggc tcccgtctga agcggcggac gaggctcggc
      181 ggggaggagg cggcgacgca ggcggaggag gcggcggccg ccggggaccc gctcggcgcc
      241 tcggccccgt gccccgtccc cagcccgtgg tcgctcgcgc tcggcgggcc ggcgcctcgc
      301 ctctgcgcgc ggagatggtg tagcccggcc gccggagccg gagccgcctc tgctcgcgcg
      361 tccccgcggc gtccgcctcc ccgcctgaga agagaccctc cgctcggcgg ctcccgcgcc
      421 ggggaagcct cggcgccgcc ggcaccatga gtgaacagag tatctgtcag gcaagagctg
      481 ctgtgatggt ctatgatgat gccaataaga agtgggtgcc agctggtggc tcaactgggt
      541 tcagcagagt acatatatat caccatacag gcaacaacac attcagagtt gtgggcagaa
      601 agattcaaga ccatcaggtt gtgataaact gtgccattcc taaagggctg aagtacaatc
      661 aagctacaca gactttccac caatggaggg atgctagaca ggtgtatggt ctcaactttg
      721 gcagcaaaga ggatgccaat gtcttcgcaa gtgccatgat gcatgcctta gaagtgttaa
      781 attcacagga agcagcccag agcaaggtta ctgctacgca ggacagcact aatttgcgat
      841 gtattttctg tgggccaaca ttgcctagac aaaattcaca gctacctgct caagttcaaa
      901 atggcccatc ccaagaagag ctggaaatcc agagaaggca actgcaagaa cagcagcgac
      961 agaaggaact ggagagggaa agaatggaga gggaaaggtt ggagagagaa cgactagaac
     1021 gagagaggct agagagggag cgcctggaac aagagcagct ggagcggcag cggcaggaaa
     1081 gggagcacgt ggagcggctg gagagggaga ggctggagcg cctggagcga gagaggcagg
     1141 agcgggagcg agagcgcctg gagcagctgg agcgggagca agtggagtgg gagcgagagc
     1201 gcagaatgtc caatgctgct ccatcttcag acagctccct gtctagtgct ccacttcctg
     1261 agtattccag ttgccagccg ccttcggcac ctcctccatc atatgctaaa gtcatctcag
     1321 ctccggtgtc agacgccact cctgattacg ctgtagtgac tgctttgcca cctacttcca
     1381 caccccctac accaccactg agacacgcag cgacacgttt tgcaacatct ctaggttcag
     1441 ccttccaccc tgttcttccc cattacgcta cagttcctcg tcctctcaac aaaaactctc
     1501 gaccttcttc tcctgtgaac acaccctctt ctcagcctcc agctgcgaag tcctgtgcct
     1561 ggcctacttc caatttctcg cccctccctc catctcctcc aataatgatt agcagccccc
     1621 ctggcaaagc tactggccca cggcctgtcc ttcccgtttg tgtctcctct cctgtgcccc
     1681 aaatgcctcc gtcaccaaca gcacccaatg ggtcgctaga ctctgtaaca tacccagtgt
     1741 ctccaccgcc tacctcaggg ccagcagcgc cacctccgcc gccaccgcca ccgccaccgc
     1801 cgccgccacc accaccgccg ctgccaccgc cgccgctgcc tcccctcgcc tcactctcac
     1861 actgtggatc acaggcttct cctcctccag gcacccctct tgcctcaact ccctcatcca
     1921 agcccagtgt tctcccttct ccctctgcag ctgcccctgc ctctgcggag acccctctaa
     1981 atcctgagct gggagactcc tctgcttccg agccaggctt gcaggcagcc tctcagccgg
     2041 ccgagtcgcc aaccccacag ggccttgtct tgggaccacc tgcacctccg ccaccacccc
     2101 ctctcccatc aggccctgcc tacgcctcag cacttcctcc tcccccagga ccccctccac
     2161 cacctccact gccatccact ggtcctcctc ctccaccccc tccaccaccc cctcttccta
     2221 atcaagctcc tccccctcct cccccacctc ctgcccctcc cctccccgca tctggaattt
     2281 tctctggatc cacgtcagaa gacaatcgcc ctttaactgg acttgcagct gcaattgcgg
     2341 gagcaaaact taggaaagtg tcccgggtgg aggatggctc tttcccaggt ggagggaata
     2401 ctgggagtgt gagcttggcc tcatccaaag cagacgctgg gcgtgggaat ggacctcttc
     2461 ctctaggggg tagtggctta atggaagaaa tgagtgccct gctggccagg aggagaagaa
     2521 ttgctgagaa gggatcaaca atagaaacag aacaaaagga agacagaaat gaagatgcag
     2581 agcctataac tgctaaggcc ccatcaacaa gtacacctga accaaccaga aaaccttggg
     2641 aaagaacaaa cacaatgaac ggcagtaagt cacctgtcat ctccagaccc aaatccacac
     2701 cttcatcaca gccaagtgcc aatggagtcc agacagaagg ccttgactat gacaggctga
     2761 agcaggacat tttagatgag atgagaaaag agctggcaaa gctgaaggag gagcttattg
     2821 acgcaatcag gcaggagctg agcaagtcga acactgcata aagaagcaaa ctacggaggg
     2881 gcaggacttg aatctggaga aaacaaaaat tcctacaaac aactcttaac ccccaaactt
     2941 ttaagctgta agaagaaaat ggatacacag tcaggaggga agccgtcaac ctctgaaagc
     3001 ctcagacagt gactctggcg atcagctgtc ccctcagtgt gctgctttat tctgtctgac
     3061 ctttaccaca ggatggagaa tgatattgga gttcccttag cagtactaaa cccgtcaggc
     3121 aagatcaccg tgcattgaaa tattttcatg tctagatgag tctgcacgtt ttccataatc
     3181 cattgctaaa ataaagacga gaaaggcttc agagattttt ttccagaggg cgctgatgaa
     3241 gaatttgatt tagtaagttc tgctgttgcg ttgtaaatgt ttctctcagg tttgtcttcc
     3301 tatcatattt gatattccgt gaacactaag atcataaagg atggaacaaa cggagttgta
     3361 tgtgctttca gagggtggtg tttaatacga aaggtcccaa aatgtttagt cccacttgag
     3421 gaattttaga atgataggaa gtctctcggg ttagccttca tgcaattttg tagtttaaaa
     3481 cataaagtcc gtccagaaat taaagattta gatgccttcc taaattgtta caatgcttta
     3541 ccaaatctat gacttctaca taaccaacag tggtcaaatg gaaaacattc tattatagat
     3601 ttactgtagg ttttcaacct tttttagaca tatgcatgtg gacattttta taatgtaatt
     3661 acaatcacca caaagttagc ttttttaatt acagacaata atgcatgtca cactaatatg
     3721 tagtggcctt ttcagggcct agtcccaggg aaaatatttt gtagaatata gggaagtggg
     3781 aggaagggaa ggaataactt tttatttaaa gttaatttct gcactatctt ttttttctca
     3841 attatctgca tgaattataa tgaaaaatat tttgtgactt taatcagtaa acatgttaac
     3901 aaaaccaagt acttaatctt ttacatcatg tcttcagcta tttgtatttt aaccagcaat
     3961 ttcaacggtc tgaaacatga ttctgagcgt aacatgtgag tccgtctcac tgtggaactc
     4021 acgagtttga tcactgaatt tggcagttat tttcacgcgg cccccacagt gctgcagtgc
     4081 ttgggttcac gctcctgact ctgcggctgc tccttgacct ttgctgtgct aaaatacaag
     4141 aaatatcaat aatggcagca accagggtca cataagtcac taggtaaggg agaccaatga
     4201 ggagttctgc agctttcttt taatagaact aaagtgaggc ttaagtggta gggagtgtct
     4261 gctgttacac cctgagtgtg tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg cgcgcgcgca
     4321 cacacacaca cacgcacaca ggtgagagag agagagaaag tgatcgagct taagagtgtg
     4381 tgatagatat tatgttccac ccctttataa ttggcaagat taaaataagg gagaaaattt
     4441 tatatgttgt aatgttagct ttttggaaaa tctaggaaat caaaaattct ccaggctgtc
     4501 catcatgatt tatgcttgag ttattaatgt gccatatttg ctttggaatc tttggctatc
     4561 aaaacttttg ctaaaaaaat agtagataca atccactttg atttgctttc tagatttcct
     4621 atgtctcagc tgtaaagcaa agcttgatga gagtagtttt ctaaaccctg cagtttgcag
     4681 ctaaccccac tgcagagccg tgtgaatgag gggttttgtt aagagtgttt gtttctgtag
     4741 aaacttcatc tttagattaa agtgtgaggg atgagcggtc ataagtcaat tctgtggctt
     4801 tctctaccca tcagtcgtcg tctcgcagga atagtaaagg cattaaggat gcggcaagca
     4861 tgtacgctgt tctaaaagaa gtatgcatct catttactgt tgaacgtttg attacgcaac
     4921 tactttgatt gtgtacgtgt gtacatccct tacagatctg atcaaaaatc gcttttcatt
     4981 ttgttgctaa tgttaaatag tctgtagtac gtagagtact gggtctagat ggtccaaagt
     5041 gagacaaaaa tgctgaagtc aaatgctaag tcctaaacaa agctggttta tgcactaaac
     5101 gttttgtgcc ttggtctaat atttaacaca atgtctgtaa aaatgacaaa aaaagaaaaa
     5161 aaaagaaccg acattggctc atgctgtatc tgtatcctcc atgatagtac gtcctcccac
     5221 atgactaaat gtgctcctac ctggatgctt cactgtcacc caggacagtc gtgtcgtcgc
     5281 tagagatttc agtgactaca atcgcaagct aaagcttgag ttgttttccc aaaactgttc
     5341 cttggaacca tattgtgacg gtgggtcctt gcttctgtgt gttgactgtc ttcagctgag
     5401 tccagtttag ggatcgtctg tgatgacagg aaggctctgc tctcctcaac actgtgatct
     5461 gacctgcgac aactctacaa tacactctga atggctagca cgtccatagc aaacaatctg
     5521 aatgtacaaa ccttagcgtg gtgctgaaat ctcttgagaa tagtaaccgt gatctcaaag
     5581 tctgttcaaa acgtgtcaat cagaactgaa gatgaaccgc tgatgaatgt ccggtcctca
     5641 tgccgcaggc gtgtttcctg tctaggtttt cagttctctg ctgttaccac catagctgtt
     5701 ccagttaact ctcctacaca ctaacttcat ttgtgcgatt gaaataaaat tgcagtatgt
     5761 gcatgtttct tgtttgtgac acttagatgg tcttctgcaa tgatgtgtta attccaaacc
     5821 aagtgatact gggtgtgaaa tcagcacctt aggaagccca gggtttcact gtttacagtt
     5881 taaacatcat gtcactgttc tttaaagatt tcatccacgt ctggcgtagt ggaaaacacg
     5941 aagggaatat gtaatgatct ttctaccttt tgttttgcag taagcgctgt gtgcctcttc
     6001 tgtcttacat gctcccagca cagcttgtag tcaatgtggt gaaaagtgtt ttactccatt
     6061 cttttgtcct ataacacagt catatatata tttcacttca tttacacggt tcattttttt
     6121 tctttatgta atttgcatat taaaggatat tgccaagtaa ttaactttaa atgtagcagt
     6181 ctgtaccctc tacagtgatc tctttatgtt ggctttttat atatacttat atatatgtct
     6241 cagcaccttt atctattaca aagttccatt ttccaaactt gtaatttcct cattagaagt
     6301 acaactctgt ctgtgtgtgt gtgtgtgtgt gtgtgtctgt gtgtctgtgt gtgtgtgtgt
     6361 gtgtgtgtgt ctgtgtctgt gtgtctctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     6421 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ctttccccct ttatcagacc tcggcatctc
     6481 tcccaagctc ctccgtcctc tttgtgcttc ctgttcctgg cattaatttg catttgcaac
     6541 caccttgtgt tgctcactgt tgtgaagaca gccagctgat ttttcttttg gttccaactt
     6601 acactcctgc tttatctaca aattaaagtc acttaaattc gaaaatgaat taagtagcaa
     6661 gtcctaagct tttccatttg cttagctaaa attactgtct cttaactttt gcccatcttt
     6721 gcagtgaggc tgtgaagaat tcatgtttgt acgattcagg gcttgccagg cagggctgca
     6781 ggaactgttt gatttcttgt cgccatgaga attacttaag ccctttacca cggtctttaa
     6841 tcctatgggc gtatctgtaa tccagcatcc tggagacaga aacaggagga ttgtggatct
     6901 gatgtcaggc tgggatgcat agagaaaccg tgtctaaaac aaatcagtaa aatcctatgg
     6961 gtcgtaagca taaaaacgcg gagcataaag gaactcaaga tgaacataaa aagcagagtg
     7021 taggggggtg tctgtccctt tatcacacta gaaagcccac ttccaaaggc agaatagttt
     7081 tcacttccag actcaacctg ttctggtgac ggcatttttg tttttaatac aattggtatc
     7141 tgatcatctc cccagagctc tgtgactctt tggtgagagg catttactgt tttataagtt
     7201 cagttccttt tttttttttt ttttaatcaa aacttgttgt attttaaaga atctgactaa
     7261 acagttattc tggtcagtac ttcatgtgaa gatcctggag aacatgtacg tacaggaatc
     7321 gctttcagtt aagcatacgc ctgtttgaga aactaaaatc gtcaatctct caagagaagc
     7381 catttattta tgccaaatat tcttggggtt gagggcgggg atatgatata gtctttctat
     7441 tcccaacatc aaaataggct ctgcactaaa tcttgttccc ttatgtttac cttggtggct
     7501 ttttgaagta ccaagcttct ttctaaagcc tctttgtggg tgaatgtgag aatgagcatg
     7561 tagaaaccag tgttcaacct tggcacccac ctgctttgag acagggtcac aaattcagct
     7621 agacctgctg gcagtgagcc tcaggagatc ctgtctgctg cttgctgctg ggttgcctag
     7681 cttgtaccac cacgcccagc tgctctgttt tacatggatt ctggaatctt aactgatgac
     7741 cttgtgcttg caagggaggc agacactctt ccaattcagc tagctttcta gccctgcccc
     7801 cccccttttt tttttcttta tatcttaatg ctggaacaat gaaagattca aaatttaaac
     7861 attaagattg attagttgat tagaaaagaa agtaaaatgg tacagtaaaa ttaccattta
     7921 cagacagggg ccttctatcg gtacaatatt aatgaatacc tcacataagg aagatggggc
     7981 tttaggataa atttgaaaat tgttgaagta tgaactatgt taatttgtaa agcaaccgtc
     8041 actgaagggt agaaagtgac ttggttactg tgacttgatg ttaaaaagaa ttttctacaa
     8101 tcattggttc tatttgttga aattgtaaag atagggattg tgtgaggagg agagggtttg
     8161 ggaaagggcg tttcccttcg gttatagatg ctctgttgta gaactccctg agcacctgta
     8221 ggtttccagt gcttgctcat taacatagag aataactgaa aactgaagct ttggttaagt
     8281 gcttgaacca gagatcagtc accacaccct acctagtttg aagcttactg ggtattccaa
     8341 taaagagctt ttagaagttt ttggtgtgga accccaggat tcctggataa aggaggccca
     8401 gataagagcg gagagggagg agtacttgac tctcttgagt taggaaactc aagagcatgg
     8461 tgaactcatc actaaatcca gccttttcta aacaaaaatt aaacagagtt aaaagaattt
     8521 cacattctaa taaaagttag aaatgtccat gcacttcatt gaagagctat ttgtaagtga
     8581 cagtctccat ttagcccgta aatatgtctc agctgccccc ttctgagtcc agaaagatgt
     8641 ccttagcagt agaaacagac tccttcaaaa gaaaattaca tgtctaatac aggcagtgag
     8701 tgatgttgcc gatagatagg gtgttagccg gcgctgggtg tcgcaaagga aataaaaccc
     8761 cagggaaaga agtgtgcatc gagtctggct ctgggattca tccctgttgt ggtgggaata
     8821 cacagtgtgt atgaggtccc tagtattgaa aaaatcaaaa tgcagcttta atcatgaagt
     8881 aagtaacaca ggaacctttt tcaagtttga tacctaagga aaaaaaaatg tttgaaattc
     8941 aatattctct agtcaattct gtctacccag ccttcctata aagttttggt ttgtttttgt
     9001 tttgttgttt ttaagatttt aaacttcttt tagtagagac atagaagatt gtcattccat
     9061 ggccaagttt cacctaggtg agttttggca tttgatattc taacttctgg aatttctctg
     9121 agtattttga tcctcagttc tgaggtctgt ctgtttgggg gtggggcggt tgtctttaaa
     9181 ccacaagccc tacatgatgc caaagccacc aggcctctct tgtgtatcag gagtagaact
     9241 aagttggctt agccctttgg ggaccaacct tgttgcgtag tgtgtggtac cagctttgcg
     9301 ctttgcctgg gaaaactgta tctcagaaag gtaattagga aggtctcaat atttaggtgg
     9361 tggtggtagg gacaggttaa agtctagata caatttctgt tgaccacaag ggcagggagc
     9421 agtttcagga gtttgtctac ttactctgga caccttgctt catttgctga cagtgaactt
     9481 gggcatctgt ggttcctgtg agacatctca gatgtgtatc ttgtctctgt gctcctgttt
     9541 aactgtggat gtgagccctg aggcacccag ccgttgactt gggactctgc cagattacat
     9601 gtgtgtaagg tcccttctac ttctgggatg tagtttgagt ttcttcattc acatgtcctc
     9661 aagctgtgat cagtctgtta tttcacccaa gaaaacagaa ttcttctgta tgcatatggg
     9721 tgttttacct ccatgtatat atctgtgcac cacacatgtg cctgctgcct ttggaggtca
     9781 aagaagggca tcagatcccc tggaactgga gttctagaca gtagtgagct accctttgga
     9841 tgctggagct tctgaaaata cacacaaagt gctgttaatg gctgagccat ttctccagcc
     9901 cccttctctc tgaccttaaa gagtagcttt tgaatgttta gaattactag atcgtgtttg
     9961 gtgaaatctt tatatcctat ttatgagtga agtaagagca aatggccatt ctgagaccag
    10021 gcagtggcca ttgttagtcc cagctacgtc agctgtgtgc tttgctgaag cactggggca
    10081 gcttggtggc ttcaggacaa gcatgtgcca tcagaaaggc cagtgttctc tgaggttctt
    10141 ctcttcttcc gtggtaggaa gcctccccat gtactcatgc ctcgagctgt ttctaagcta
    10201 gctgactgct gcactgctgt gagcagtatc ttaaccctcc tctttgccag gggagaatgc
    10261 acctcagctg tgttactgtg taccgtgtca ctagcaactt gaaaaggtga caatacgagt
    10321 ctgtctctag cctttttatt atacaaagtc cattcattcc tagcttcttg tttttaaact
    10381 ccgactttac tgcaattaat tgacagtccc ctctgatact gtttaagtgt tgtgatctct
    10441 cgtttgcttt gtttgtttgt ttgtttgttt aaggcagggt ttctctatgt agccctggct
    10501 gtcctcgaac tcttcttgta gaccagaata gcctggaact gagagatcca ccctcctctg
    10561 actcctgagc actgggactg aaggtgtgag ccactgcctc cacctgcccc actgcttgct
    10621 ttttcagata agtgactaga agataagtct gggcatcttg tcttcctagt gtattttact
    10681 ctgattcttt cctggtttat gtattgagat tcatttctca tagacagaac ttgcttttta
    10741 ttgtgtgtag atttggaggg aaggatcaag ttattcccgt aaatgtaagc aagctatctt
    10801 gaggcatctg tagttgatac aaaatatttt tataatatat taacaggcat ggggtacttt
    10861 tgaggcagcc tctgtaatct gtagccaccc acttaatctc cagggtcccc cattggaaga
    10921 taaaaggcca ctgtatctgt agtttatcta gaacagagct tcaggattcc agctggaaag
    10981 acttgagggc ctaacccctg agagaggtcc agcccctctg cctgatgcag gcctcctgct
    11041 gccttcatgc tttctggagg gcctctggca gtcagaatga gtaggtcagt gtgtggcttg
    11101 aaagctgttt ctaacattga ttttgtttgt ttttcttttg ttagggtttt ttttttccct
    11161 gttttgtttg tttttaagag attttggttg gttttggttt tggtggggtt ttggttcgtt
    11221 tgttttttga caggttagga agtcagtgat gacccttact gtttcaagaa gcagattaaa
    11281 ttcttaaata cattttcctt ctcagacctc aacttgataa accaaaaaac atacactagg
    11341 atagcacagt gtgtgggatt ggaaggggca gtctcagaga tgagctggag cactggagcc
    11401 ctcggcgcag gacacgctga actttcagtc tcgtgtcctc gtcctttgct gtagatacta
    11461 gcaatgtgct cttccgtcct ttaaacacgc ccacagctgg actccttggt aaagggtggt
    11521 gaagatttgc agcctgccaa ctgggacttt tataccctag agtcgggagt ggactgaagt
    11581 cagactttag gagttaagta gatgctcctc cggaatggag agttgtgttg taaatcattt
    11641 gccagctgga actttgtgta ccatatctcg gtgaatctta gggattatag gccttgctaa
    11701 agttcaggag aaaggaaact ggccacagct tactgtaagg ttttgctcaa ttgactgaaa
    11761 ttatttgaaa gtctgtctag aacacgattt catcaagtaa caccttcgtc caagctcggc
    11821 ccacgtttga ggaaggggaa gcgagggggc gagagggaag gcgggatggg tggctgagga
    11881 tcaggtagcg ctggagcttg gcaccaaagt ttctcatgat tgcatatgga ggaccacttg
    11941 tgatccaccc tcggaagact cgccagaaag tagcagttcc tgctacacac tacagtgcct
    12001 tccaacgacg ttctgtgtga actgcatgca gtttcgtgta actccagagt gtaacatgta
    12061 tgtgcatgat ctgtccagaa tgtgcagagc tgggattcaa cagaaagggc tgcgccctgc
    12121 tgctgctggg tcagcaggct gctggggtcg gacttgtgac ttaggcttgc agccttggat
    12181 cctggggttt gcactgatat ggttctgtca tccaatcaga tctgtctccc ttttagctcc
    12241 tttcctactt tgcagctttg ctgattttaa ctgcttcatt cttctgcttc ttggtatctt
    12301 tcttttgaaa taaaaagaca caatacctaa ttcaaaa
//
