LOCUS       NM_010133               2523 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus engrailed 1 (En1), transcript variant 1, mRNA.
ACCESSION   NM_010133 XM_974086
VERSION     NM_010133.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2523)
  AUTHORS   Inskeep,K.A., Crase,B., Dayarathna,T. and Stottmann,R.W.
  TITLE     SMPD4-mediated sphingolipid metabolism regulates brain and primary
            cilia development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470011
REFERENCE   2  (bases 1 to 2523)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2523)
  AUTHORS   Yoshioka,N., Kurose,M., Sano,H., Tran,D.M., Chiken,S., Tainaka,K.,
            Yamamura,K., Kobayashi,K., Nambu,A. and Takebayashi,H.
  TITLE     Sensory-motor circuit is a therapeutic target for dystonia
            musculorum mice, a model of hereditary sensory and autonomic
            neuropathy 6
  JOURNAL   Sci Adv 10 (30), eadj9335 (2024)
   PUBMED   39058787
REFERENCE   4  (bases 1 to 2523)
  AUTHORS   Mora,S., Stuckert,A., von Huth Friis,R., Pietersz,K., Noes-Holt,G.,
            Montanana-Rosell,R., Wang,H., Sorensen,A.T., Selvan,R.,
            Verhaagen,J. and Allodi,I.
  TITLE     Stabilization of V1 interneuron-motor neuron connectivity
            ameliorates motor phenotype in a mouse model of ALS
  JOURNAL   Nat Commun 15 (1), 4867 (2024)
   PUBMED   38849367
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2523)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2523)
  AUTHORS   Shimamura,K. and Takeichi,M.
  TITLE     Local and transient expression of E-cadherin involved in mouse
            embryonic brain morphogenesis
  JOURNAL   Development 116 (4), 1011-1019 (1992)
   PUBMED   1295725
REFERENCE   7  (bases 1 to 2523)
  AUTHORS   Higgins,M., Hill,R.E. and West,J.D.
  TITLE     Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic
  JOURNAL   Genet Res 60 (1), 53-60 (1992)
   PUBMED   1360439
REFERENCE   8  (bases 1 to 2523)
  AUTHORS   Sato,H., Sakai,Y., Koiwai,O. and Watanabe,T.
  TITLE     Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene
            (Gnt-1) to chromosome 1 by restriction fragment length variations
  JOURNAL   Biochem Genet 30 (7-8), 347-352 (1992)
   PUBMED   1359870
REFERENCE   9  (bases 1 to 2523)
  AUTHORS   Kim,J.M., Brannan,C.I., Copeland,N.G., Jenkins,N.A., Khan,T.A. and
            Moore,K.W.
  TITLE     Structure of the mouse IL-10 gene and chromosomal localization of
            the mouse and human genes
  JOURNAL   J Immunol 148 (11), 3618-3623 (1992)
   PUBMED   1350294
REFERENCE   10 (bases 1 to 2523)
  AUTHORS   Logan,C., Hanks,M.C., Noble-Topham,S., Nallainathan,D.,
            Provart,N.J. and Joyner,A.L.
  TITLE     Cloning and sequence comparison of the mouse, human, and chicken
            engrailed genes reveal potential functional domains and regulatory
            regions
  JOURNAL   Dev Genet 13 (5), 345-358 (1992)
   PUBMED   1363401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133286.15.
            
            On Dec 21, 2021 this sequence version replaced NM_010133.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140408.1, L12703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1405              AC133286.15        107996-109400       c
            1406-2523           AC133286.15        103927-105044       c
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.74 cM"
     gene            1..2523
                     /gene="En1"
                     /gene_synonym="En-1; engrailed-1; Mo-en.1"
                     /note="engrailed 1"
                     /db_xref="GeneID:13798"
                     /db_xref="MGI:MGI:95389"
     exon            1..1405
                     /gene="En1"
                     /gene_synonym="En-1; engrailed-1; Mo-en.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..2523
                     /gene="En1"
                     /gene_synonym="En-1; engrailed-1; Mo-en.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2499..2504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="En1"
                     /gene_synonym="En-1; engrailed-1; Mo-en.1"
                     /note="hexamer: AATAAA"
     polyA_site      2523
                     /gene="En1"
                     /gene_synonym="En-1; engrailed-1; Mo-en.1"
                     /note="major polyA site"
ORIGIN      
        1 gggcacagct gagcgtgaca ctggggaagt caaacccctc tactgcctag gaagatggct
       61 agactttaaa gattattttt ttccctttaa ggaaaaagtc tcggagcttt aaaaaaaatt
      121 cctttttctc tttttttttc tcccctcttt tttttttttt ctgagccgtg gcttatcccc
      181 ccattaagac caatcactga aatcttgttg ctgaaagaaa aaaaagaaag aaagaaaaag
      241 aaaagaaaat aatagccaag tgtcttcact gtatctggat gtctacaaat tagagagagg
      301 gagagagcga gatttgctcc accagagcgg gcgagagcca ggccagacgc tcgcctttct
      361 tttttccgcc tgcatccgcc ctgtgccttc gctgaggctt cgctttgcct tcttcctctc
      421 cgcgcacccc cacgggcccg ctggcaaagt ggggtgggga gcgaggcgcg gggggcgggg
      481 gccggcgccg cggccagggc tgccgggcgg ccgagcatgg aagaacagca gccggagcct
      541 aaaagtcagc gcgactcggg cctcggcgcg gtggcagcgg cggccccgag cggcctcagt
      601 ctgagtctga gcccaggagc cagcggcagc agcggcagcg atggagacag cgtgccggtg
      661 tccccgcagc cagcgccccc gtcgcctcct gcggcaccct gtctgccgcc cctggcccat
      721 cacccgcacc tccccccgca tcccccgccc ccgccgccgc cgccgccgcc gccaccgcag
      781 catctcgcgg cgcctgctca ccagccgcag cccgcggccc agctgcaccg caccaccaac
      841 tttttcatcg ataacatcct aaggcccgat ttcggttgca aaaaggaaca gcccctgcct
      901 cagctcctgg tggcttcggc tgcagccgga ggaggcgcag cagcaggagg aggaagccgc
      961 gtggagcgtg accgaggcca gactggtgca ggtagagacc ccgttcactc tctgggcaca
     1021 cgagcttcgg gggctgcctc gctcttgtgt gctccagatg cgaactgtgg cccacccgac
     1081 ggctcccagc ccgccaccgc tgtcagcgcc ggcgcatcca aagccgggaa cccggctgct
     1141 gcggcggccg cggccgcagc agcggctgca gcggcagtgg cggcagcggc ggcagcagcc
     1201 tcgaagccct cggacagtgg cggtggtagt ggaggcaacg cggggagtcc cggggcgcag
     1261 ggcgccaagt tcccggaaca caaccctgcg atcctactca tgggttcggc taacggtggg
     1321 ccggtggtca agactgactc acagcaaccc ctagtgtggc ccgcctgggt ctactgcaca
     1381 cgctattcgg accgtccgtc ctctggtcca cgcaccagga agctaaagaa gaaaaagaac
     1441 gagaaggaag acaagcggcc gcggacggcg ttcacggccg agcagctgca gagactcaag
     1501 gcggagttcc aggcaaaccg ctatatcacg gagcagcggc gacagaccct cgcccaggag
     1561 ctcagcctga atgagtccca gatcaagatc tggttccaaa acaagcgtgc caagatcaag
     1621 aaagccaccg gcatcaagaa cggcctggcg ctgcacctca tggcccaggg actgtacaac
     1681 cactctacca ccacggttca ggacaaagac gagagcgagt agctgtggcc agctccgggg
     1741 cccgcggtcc aacggcgccc gtgccacctc caggctcctc ggggctgccg cttcaccagc
     1801 cccacgcaga gacgatcgct atggagggag gcatcaatca gggcgacaga gaaagcgagc
     1861 aagagaaagc aatcctccga gtggacattc acataggaac aaaacggttt ttgaaacggg
     1921 agtaagactc ggacaggtgc tatgggggaa aaataaacat ctattctcta actcactgta
     1981 taagatgaaa ctgcgaattc cttaaagctc tatctagcca aactgctttc gaccgtgtat
     2041 atatttaatt tcaggtaagg aaaacaaata tgtgtagcga tctctatttg ctggacattt
     2101 ttattaatct catttattat tgttataatt attataatta ttataattat ttttcccctc
     2161 ctccctacct tgctgcaccc ccccccccca gcccagtttc gttttcgttg ctcttttcct
     2221 ttgaatgttt ttgcttctct gggtacctcc tgcaccccca acgctggccc tggtttctct
     2281 gggacttttc tttgtgtgag tgtgagtgtg tttccttgtg tgtctgcccc tcgcctcttc
     2341 tctacccacc caggattctt ctattggtct tgtctatccc tcccgtaaat ccccttcctt
     2401 ttctggagac tccttgagaa atacaacccc acagactgcg agactgaacc gccgctacaa
     2461 gccaaagatt ttattatgtt cagaaacctg tagtctgaaa taaaatgttc actgtgttca
     2521 tga
//
