LOCUS       NM_010132               2598 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus empty spiracles homeobox 2 (Emx2), mRNA.
ACCESSION   NM_010132
VERSION     NM_010132.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Young,C.A., Burt,E. and Munnamalai,V.
  TITLE     A cochlear progenitor pool influences patterning of the mammalian
            sensory epithelium via MYBL2
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39254648
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Goodrich,E.J. and Deans,M.R.
  TITLE     Emx2 lineage tracing reveals antecedent patterns of planar polarity
            in the mouse inner ear
  JOURNAL   Development 151 (10) (2024)
   PUBMED   38682291
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Moreno,J.A., Dudchenko,O., Feigin,C.Y., Mereby,S.A., Chen,Z.,
            Ramos,R., Almet,A.A., Sen,H., Brack,B.J., Johnson,M.R., Li,S.,
            Wang,W., Gaska,J.M., Ploss,A., Weisz,D., Omer,A.D., Yao,W.,
            Colaric,Z., Kaur,P., Leger,J.S., Nie,Q., Mena,A., Flanagan,J.P.,
            Keller,G., Sanger,T., Ostrow,B., Plikus,M.V., Kvon,E.Z., Aiden,E.L.
            and Mallarino,R.
  TITLE     Emx2 underlies the development and evolution of marsupial gliding
            membranes
  JOURNAL   Nature 629 (8010), 127-135 (2024)
   PUBMED   38658750
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Acampora,D., Mazan,S., Lallemand,Y., Avantaggiato,V., Maury,M.,
            Simeone,A. and Brulet,P.
  TITLE     Forebrain and midbrain regions are deleted in Otx2-/- mutants due
            to a defective anterior neuroectoderm specification during
            gastrulation
  JOURNAL   Development 121 (10), 3279-3290 (1995)
   PUBMED   7588062
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Xuan,S., Baptista,C.A., Balas,G., Tao,W., Soares,V.C. and Lai,E.
  TITLE     Winged helix transcription factor BF-1 is essential for the
            development of the cerebral hemispheres
  JOURNAL   Neuron 14 (6), 1141-1152 (1995)
   PUBMED   7605629
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Simeone,A., Avantaggiato,V., Moroni,M.C., Mavilio,F., Arra,C.,
            Cotelli,F., Nigro,V. and Acampora,D.
  TITLE     Retinoic acid induces stage-specific antero-posterior
            transformation of rostral central nervous system
  JOURNAL   Mech Dev 51 (1), 83-98 (1995)
   PUBMED   7669695
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Simeone,A., Acampora,D., Gulisano,M., Stornaiuolo,A. and
            Boncinelli,E.
  TITLE     Nested expression domains of four homeobox genes in developing
            rostral brain
  JOURNAL   Nature 358 (6388), 687-690 (1992)
   PUBMED   1353865
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Simeone,A., Gulisano,M., Acampora,D., Stornaiuolo,A., Rambaldi,M.
            and Boncinelli,E.
  TITLE     Two vertebrate homeobox genes related to the Drosophila empty
            spiracles gene are expressed in the embryonic cerebral cortex
  JOURNAL   EMBO J 11 (7), 2541-2550 (1992)
   PUBMED   1352754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098733.2.
            
            On Dec 27, 2006 this sequence version replaced NM_010132.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY117415.1, AK132093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               AC098733.2         111918-112852
            936-1120            AC098733.2         114890-115074
            1121-2598           AC098733.2         117108-118585
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.28 cM"
     gene            1..2598
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /note="empty spiracles homeobox 2"
                     /db_xref="GeneID:13797"
                     /db_xref="MGI:MGI:95388"
     exon            1..935
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..1288
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /note="empty spiracles-like protein 2; empty spiracles
                     homolog 2"
                     /codon_start=1
                     /product="homeobox protein EMX2"
                     /protein_id="NP_034262.2"
                     /db_xref="CCDS:CCDS29937.1"
                     /db_xref="GeneID:13797"
                     /db_xref="MGI:MGI:95388"
                     /translation="MFQPAPKRCFTIESLVAKDSPLPASRSEDPIRPAALSYANSSPI
                     NPFLNGFHSAAAAAAAGRGVYSNPDLVFAEAVSHPPNPAVPVHPVPPPHALAAHPLPS
                     SHSPHPLFASQQRDPSTFYPWLIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRT
                     AFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLEEE
                     GSDSQQKKKGTHHINRWRIATKQASPEEIDVTSDD"
     exon            936..1120
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..2598
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /note="hexamer: AATAAA"
     polyA_site      2593
                     /gene="Emx2"
                     /gene_synonym="Pdo"
                     /note="major polyA site"
ORIGIN      
        1 aggcttcgga ggaagctgtt tatgtgatcc ccgcactaat taggctcatg aactaacaaa
       61 tcgtttgcac tactagtgaa gaagcgaaca cttccatgga ttgtccttgg acttagggcg
      121 ccctgcccgc cttttgcaaa ggagagaaaa cttttttttt gcctccccga aaaccccctc
      181 cctgcctcta actccaatct cccccccccc cacgccacct cgctcaaaaa aatattaccc
      241 caatccacgc ctgcaaattc ttctggaagg attttccccc ctctctccag gttgggcgcg
      301 tttggtgcaa gattctcggg atcttcggct ttgcctctcc tccccctccc cctcctttcc
      361 tttttccttt cctttcttcc ttccttcctt tccttacccc cacccccacc ccaaacaaac
      421 gagtccccca ttctcctcgg tcctcgccgc gggcagcggg cggcggaggc agcgcgccgc
      481 ggtcgccggg agcagggagc ccagcgcgcc cgctcctcgg cgcagcatgt ttcagccggc
      541 gcccaagcgc tgcttcacca tcgagtcgct ggtggccaag gacagtcccc tgcctgcctc
      601 gcgctccgag gatcccatcc gtcccgcggc actcagctac gccaattcca gtcccataaa
      661 tccgttcctc aacggcttcc actcggccgc cgccgccgcc gccgccggca ggggcgtcta
      721 ctccaacccg gacttggtgt tcgccgaggc ggtctcgcac ccgcccaacc ccgccgtgcc
      781 ggtgcacccg gtgccgccgc cgcacgccct ggccgcccac cccctgccct cctcgcattc
      841 gccacacccc ctcttcgcct cgcagcagcg ggacccgtcc accttctacc cctggctcat
      901 ccaccgctac cgatatctgg gtcatcgctt ccaagggaac gacacaagtc ccgagagttt
      961 ccttttgcac aacgctctgg ccagaaagcc aaagcggatt cgaaccgcct tctcgccgtc
     1021 ccagctttta aggctagagc acgcttttga gaagaaccat tacgtggtgg gagcggaaag
     1081 gaagcagctg gctcacagtc tcagtcttac ggaaactcag gtaaaagtat ggtttcagaa
     1141 ccggagaacg aaattcaaaa ggcaaaagct agaggaagaa ggctcagatt ctcaacagaa
     1201 gaaaaaaggg acacaccaca ttaaccggtg gagaattgct accaagcagg cgagtccgga
     1261 ggaaatagat gtgacctcag acgattaaaa gtccaaaccc aatcctacaa aaatggacag
     1321 cacagagcaa gaaagacagg gagaggaggg gaagaaaaac cctacaaaac aaaaacaaac
     1381 tgcacacaca tccaccgaga aagggagaga gggaatcaga gcagtgacgc tcgcagcaga
     1441 ctttggacag cgagggcact ggaccgggaa ccggcgccgg gccgggcacc gcttacagga
     1501 cagcagagga cggaggcccg atcatcaaca tgcaaccctc gtctaaagag gcagctgagt
     1561 gagtgagaga gacagagact gggagggaga gagaggaatg agagagagag agagagagaa
     1621 tgaatgatcc ttgtgaggca aaggcacatt ctgacaaggg gagctgtcag tcaaatgcca
     1681 aaccagggaa acaagatgat tggcgggtat tccgcttatc gaagtccatt tagaaatgat
     1741 aatgattttt ttttttggaa aaaaaaaggc acaggacttt taattttgca cttcacagtg
     1801 tttccccctc atctttaatt agaaataaca tacaaaattc catgtctagc cccatcctac
     1861 acctgtttca aaacttgaat tgcatgtagc agttgtcggg cgaatggtgt ctaaaaactg
     1921 aattgtaatt ttattcctct tttaaagaca ggttctgtgt atttttattt tttatttttt
     1981 ttctgagaaa tgttcagtct gtaaaaacac ttttttgata ccttctattg tcaaagtgat
     2041 tgtgaaagct aaacgaagta ggctcggaga tagtggtcct ctgacagaga aatgagggag
     2101 caggactggg atggagggcg ggggagggtg cccctgagaa gaatcaggac tcatgctagg
     2161 ggtaaaaaca acccacgata aaagacccaa attaattcta tttcttggat atttcctttc
     2221 ctaacattct gatactttaa atcaccaagt caacttttcc ttttagtggt tggagagatt
     2281 gactgcatcc agccactcat cataatggcc attcagaact tttaagtctg tctattgcaa
     2341 aagtggaagg aaggactgta tttaatgggg tgatggtggc gtggccaagg acatgggagt
     2401 tttcaagcac tgagtttctc ttccaagacc atagacttac taaagagggt tacaaatgct
     2461 tccttagtgt cttctatacc agattgtaaa tatttttgtg ttttgtgtta atttgttaga
     2521 attctaacac actatatact tccaagaagt atgtcaatgt caatattttg tcaataaaga
     2581 tttatcaata tgccctca
//
