LOCUS       NM_172280               4031 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus EMSY, BRCA2-interacting transcriptional repressor
            (Emsy), transcript variant 4, mRNA.
ACCESSION   NM_172280 XM_897335 XM_897367 XM_897404 XM_897412 XM_897423
            XM_897432 XM_897454 XM_897463 XM_897475 XM_919189 XM_919240
            XM_919255 XM_919276 XM_919295 XM_919307 XM_974468 XM_974623
            XM_988525
VERSION     NM_172280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4031)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4031)
  AUTHORS   Marzio,A., Kurz,E., Sahni,J.M., Di Feo,G., Puccini,J., Jiang,S.,
            Hirsch,C.A., Arbini,A.A., Wu,W.L., Pass,H.I., Bar-Sagi,D.,
            Papagiannakopoulos,T. and Pagano,M.
  TITLE     EMSY inhibits homologous recombination repair and the interferon
            response, promoting lung cancer immune evasion
  JOURNAL   Cell 185 (1), 169-183 (2022)
   PUBMED   34963055
  REMARK    GeneRIF: EMSY inhibits homologous recombination repair and the
            interferon response, promoting lung cancer immune evasion.
REFERENCE   3  (bases 1 to 4031)
  AUTHORS   Ezell,S.A., Polytarchou,C., Hatziapostolou,M., Guo,A., Sanidas,I.,
            Bihani,T., Comb,M.J., Sourvinos,G. and Tsichlis,P.N.
  TITLE     The protein kinase Akt1 regulates the interferon response through
            phosphorylation of the transcriptional repressor EMSY
  JOURNAL   Proc Natl Acad Sci U S A 109 (10), E613-E621 (2012)
   PUBMED   22315412
  REMARK    GeneRIF: Akt1 regulates the interferon response through
            phosphorylation of the transcriptional repressor EMSY
REFERENCE   4  (bases 1 to 4031)
  AUTHORS   Vosseller,K., Trinidad,J.C., Chalkley,R.J., Specht,C.G.,
            Thalhammer,A., Lynn,A.J., Snedecor,J.O., Guan,S.,
            Medzihradszky,K.F., Maltby,D.A., Schoepfer,R. and Burlingame,A.L.
  TITLE     O-linked N-acetylglucosamine proteomics of postsynaptic density
            preparations using lectin weak affinity chromatography and mass
            spectrometry
  JOURNAL   Mol Cell Proteomics 5 (5), 923-934 (2006)
   PUBMED   16452088
REFERENCE   5  (bases 1 to 4031)
  AUTHORS   Ekblad,C.M., Chavali,G.B., Basu,B.P., Freund,S.M., Veprintsev,D.,
            Hughes-Davies,L., Kouzarides,T., Doherty,A.J. and Itzhaki,L.S.
  TITLE     Binding of EMSY to HP1beta: implications for recruitment of HP1beta
            and BS69
  JOURNAL   EMBO Rep 6 (7), 675-680 (2005)
   PUBMED   15947784
REFERENCE   6  (bases 1 to 4031)
  AUTHORS   Hughes-Davies,L., Huntsman,D., Ruas,M., Fuks,F., Bye,J., Chin,S.F.,
            Milner,J., Brown,L.A., Hsu,F., Gilks,B., Nielsen,T., Schulzer,M.,
            Chia,S., Ragaz,J., Cahn,A., Linger,L., Ozdag,H., Cattaneo,E.,
            Jordanova,E.S., Schuuring,E., Yu,D.S., Venkitaraman,A., Ponder,B.,
            Doherty,A., Aparicio,S., Bentley,D., Theillet,C., Ponting,C.P.,
            Caldas,C. and Kouzarides,T.
  TITLE     EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
  JOURNAL   Cell 115 (5), 523-535 (2003)
   PUBMED   14651845
REFERENCE   7  (bases 1 to 4031)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089304.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XM_897463.2, XM_897432.2, XM_897475.2, XM_897454.2, XM_897404.2,
            XM_897367.2, XM_897423.2, XM_897412.2, XM_897335.2, XM_919295.2,
            XM_919240.2, XM_919307.2, XM_919276.2, XM_974623.1, XM_919255.2,
            XM_974468.1, XM_919189.2, XM_988525.1, NM_172280.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089304.1, SRR9219380.7494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.86 cM"
     gene            1..4031
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /note="EMSY, BRCA2-interacting transcriptional repressor"
                     /db_xref="GeneID:233545"
                     /db_xref="MGI:MGI:1924203"
     exon            1..96
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            97..205
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3930
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /note="isoform 4 is encoded by transcript variant 4;
                     protein EMSY; BRCA2-interacting transcriptional repressor
                     EMSY"
                     /codon_start=1
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform 4"
                     /protein_id="NP_758484.2"
                     /db_xref="CCDS:CCDS40028.1"
                     /db_xref="GeneID:233545"
                     /db_xref="MGI:MGI:1924203"
                     /translation="MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKE
                     KKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNS
                     SSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAVQHNASLPVPAETASKDGVSCSD
                     EDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPP
                     HMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVI
                     ASTTQKPPVVITASQASLVTSSSNGNSSSTSSPISSTVAVTTVVSSTPSVVMSTVAQG
                     VSTSAIKVASTRLPSPKSLVSGPTQILAQFPKQHQQSPKQQLQQVQQQTQQPVAQPSS
                     VSQQQQPQQSALPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIM
                     VVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSLGRVATTPGAATYVKTTSGSIITVVP
                     KSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTT
                     LLNAGGEKTLQTVPAGAKPAIITATRPITKMIVTQPKGIGSAVQPAAKIIPTKIVYGQ
                     QGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVADASNSSAQEGKEEPQGYTD
                     SSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTI
                     KALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAE
                     YITTVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALS
                     SHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSTKQQKLSQPQLEQTQL
                     QVKTLQCFQTKQKQTIHLQADQLQHKLTQMPQLSIRHQKLNPLQQEQAQPKPDAQHTQ
                     HTVVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMAL
                     PSSEKQPASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQ
                     ASEKTAVSDILQMSLMEAQIDTNVEHMVVDPPKKALATNVLTGEAGALPSTHVVVAGM
                     TKCRESCSSPSAVGPPLTTRKIEAAGVPTTGQFMRIQNVGQKKAEESPTEIIIQAIPQ
                     YAIPCHSSSNVVVEPSGLLELNNFTSQQLDDDETAMEQDIDSSTEDGTEPSPSQSAVE
                     RS"
     exon            206..305
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            306..380
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            381..422
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            423..598
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..858
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1135
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1390
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1540
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1711
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1848
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2022
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2221
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2386
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2542
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2694
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..3255
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3735
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..4026
                     /gene="Emsy"
                     /gene_synonym="2210018M11Rik; 2310016L09Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcccctt ctgaggcacc gcaaacaaac ctaattcctg gtgtccccta gtcttggcgg
       61 aggagccttt tagatgagcc ccgaaaggcc gggcagggag gacaagctct ttggggctac
      121 cagacagaag cagcaatgcc tgttgtgtgg ccaacccttt tggatctcag cagggatgaa
      181 tgcaaacgga ttcttcgaaa attggaactg gaggcatatg ctggagttat cagtgcactt
      241 cgggcacaag gggacctcac caaggaaaag aaagatcttc ttggagagct ctcaaaagtc
      301 cttagcatct caacagagcg ccaccgtgct gaagttcgga gagcagtaaa cgatgaacgg
      361 ttaacaacaa ttgcacataa aatgaattta tccttatatt tgggtgaaag accaagttac
      421 agtatgtctg gacctaatag ttcttcagag tggtccatcg aaggacgtag attggtacct
      481 ctgatgccca ggctggttcc ccagactgcc ttcactgtaa cagcgaatgc tgtggccaat
      541 gcagctgtcc agcacaatgc gtcccttcct gtgcctgcag agacagcaag caaagacggc
      601 gttagctgct cagatgaaga tgaaaaaccc agaaaacgca ggcgaacaaa ctcctctagc
      661 tcctcccctg ttgtcctcaa ggaagttcca aaggctgttg ttccggtctc aaagacgatc
      721 actgtgcctg tgagtggaag tcccaagatg agcaacatta tgcagagcat tgccaactcc
      781 ttaccacccc atatgtcacc tgtgaaaata acgtttacca aaccatcaac acagacaaca
      841 aacacaacaa cacagaaggt tattatagtg accacatcac caagttcaac ctttgtgccc
      901 aacattctct ccaaatctca taactatgca gcagtcacta agcttgtacc aacatcagtc
      961 attgcctcca cgactcagaa gccacctgtt gttataactg cgtcccaggc ctctctggtc
     1021 accagtagca gcaatggcaa cagcagttct acgtcatcac ctatttctag tacagttgca
     1081 gtaacaacgg tggtatcttc cacaccgtcc gtggtcatgt caacagtagc acaaggtgta
     1141 tccacatcag caatcaaagt ggcatcgaca agacttcctt cccccaaaag cttagtgagt
     1201 ggccctaccc agattcttgc acagtttcct aaacagcatc agcagtctcc taagcagcag
     1261 ttacagcaag tacaacaaca gacacagcag ccagtggccc agccttcttc agtgtctcag
     1321 cagcagcagc ctcagcagtc agcattgccg cctggtatca aacctaccat ccagatcaaa
     1381 caggagtcag gtgttaaaat catcacacag caggttcaac caagtaaaat cttacccaaa
     1441 ccagtgactg caactctacc caccagtagc aattccccaa ttatggtggt tagcagtaat
     1501 ggtgcaatta tgacaactaa actggtaacc actcctaccg gtactcaggc aacctatacc
     1561 cggccaacag tgagcccatc cttaggtcgt gtggctacaa cccctggagc tgcaacctat
     1621 gtgaaaacta ccagtggcag catcatcact gtagtaccca aatcattagc taccttggga
     1681 ggcaagataa ttagcagtaa tattgtttct ggaacgacta ccaaaatcac tacaatccca
     1741 atgacttcca agcccaatgt gattgttgta caaaagacta caggaaaagg aacgaccatt
     1801 caaggcctcc ctggcaaaaa cgttgtcaca accttgctaa atgctggagg agaaaagact
     1861 cttcagacag tgccagctgg agccaagcca gctataatta ctgctacaag acccatcacc
     1921 aaaatgattg taacacagcc caaaggaata ggttccgcag tacagccagc agctaaaatc
     1981 attccaacaa aaattgtgta tggacaacaa gggaaaacac aggttctaat taaacccaaa
     2041 ccagtgacat ttcaagctac agttgtcagt gaacaaacaa ggcagctggt aacagaaaca
     2101 ttacagcaag catccagggt agcagatgcc agtaattcat ctgctcagga aggaaaagag
     2161 gagccacagg gttacacaga cagtagttct tcttccacag agtcctccca gagttctcaa
     2221 gattcccagc ctgtagttca tgtaattgct tcccggcgtc aggattggtc agaacatgag
     2281 attgcaatgg agactagccc caccataata tatcaggatg tatccagtga atcacaatca
     2341 gccacttcaa caatcaaagc tctgttagaa ctccaacaga caacagtaaa ggaaaaattg
     2401 gaatctaaac caagacaacc cactattgac ttgagtcaaa tggcagtacc tattcagatg
     2461 acccaggaaa agagacattc tcctgagagt ccatccattg ctgtggtaga gtcagaacta
     2521 gttgctgaat acatcaccac ggtcagccat cgctcccagc cccaacagcc ttcccagccc
     2581 cagcggaccc tgcttcaaca tgtggctcag tcacagactg cgacgcagac ttcggtggta
     2641 gtaaagtcca tcccagcgtc ttcccctgga gcaatcaccc acatcatgca gcaggcatta
     2701 agcagtcaca ccgcttttac gaaacacagt gaggaacttg gaactgagga gggtgaggtt
     2761 gaagagatgg acacattgga tcctcagaca ggtctgtttt accgctctgc cctgacacaa
     2821 tcgcagtcaa ccaaacagca gaaacttagc cagccccagc tggaacagac tcagctgcaa
     2881 gtgaaaactc tgcagtgctt ccagaccaaa cagaagcaga ccatccacct gcaggcagac
     2941 caactccagc acaaactcac acagatgccc cagctctcta tcaggcatca gaaactgaat
     3001 cctctccagc aggaacaagc acagcccaag ccagatgcac agcacacaca gcatactgtg
     3061 gtggccaaag acaggcagct tcctacctta atggcacagc ccccgcaaac tgtagtacag
     3121 gtgcttgccg tgaaaaccac acagcagctt cctaaactgc agcaagctcc gaaccaacca
     3181 aaaatctacg tgcaacccca aactcctcag agccagatgg cactcccctc ttcagagaaa
     3241 cagcctgcaa gccaggtgga gcagccaatt ataactcaag gatcctctgt tacaaagata
     3301 acatttgagg ggcgccagcc tcccacagtt acaaagataa ctggtggcag ttctgttcct
     3361 aagctgacat caccagttac aagcatatct cccattcagg cctctgagaa gacagcagtg
     3421 tcagacattt tgcaaatgtc tttgatggaa gctcagattg atacaaatgt agaacatatg
     3481 gtagtggatc ccccaaagaa ggctctagcc accaatgtgc tcactggtga ggcaggagct
     3541 ctaccctcca cccatgtggt ggtggcaggg atgacgaaat gtagagagtc ctgttcaagt
     3601 ccatctgctg ttggccctcc cctaacgacc agaaaaatcg aagcagcagg agtgcctacg
     3661 acaggccagt tcatgcgtat tcagaatgta ggccaaaaga aagctgaaga gagcccaaca
     3721 gaaattatca tccaggccat tccccagtat gctattcctt gtcactccag ctccaatgtg
     3781 gtggtggagc ccagtgggct tctagagttg aacaacttca ccagtcagca gctagatgac
     3841 gacgagacag ccatggagca ggacatagac agcagcacgg aggacgggac tgagcccagc
     3901 ccctctcaga gcgctgtaga acggtcctag tgtgcagacg ccggagtgca ctttagagcc
     3961 tgcgtggtta ccaaatgtcc agggaaactt aaaatttgtt atagtaaaaa agaaaaaaaa
     4021 aaaaaaaaaa a
//
