LOCUS       NM_007929               3440 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus epithelial membrane protein 2 (Emp2), mRNA.
ACCESSION   NM_007929
VERSION     NM_007929.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3440)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 3440)
  AUTHORS   Gao,H., Cao,M., Deng,K., Yang,Y., Song,J., Ni,M., Xie,C., Fan,W.,
            Ou,C., Huang,D., Lin,L., Liu,L., Li,Y., Sun,H., Cheng,X., Wu,J.,
            Xia,C., Deng,X., Mou,L. and Chen,P.
  TITLE     The Lineage Differentiation and Dynamic Heterogeneity of Thymic
            Epithelial Cells During Thymus Organogenesis
  JOURNAL   Front Immunol 13, 805451 (2022)
   PUBMED   35273595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3440)
  AUTHORS   Chu,A., Kok,S.Y., Tsui,J., Lin,M.C., Aguirre,B. and Wadehra,M.
  TITLE     Epithelial membrane protein 2 (Emp2) modulates innate immune cell
            population recruitment at the maternal-fetal interface
  JOURNAL   J Reprod Immunol 145, 103309 (2021)
   PUBMED   33774530
  REMARK    GeneRIF: Epithelial membrane protein 2 (Emp2) modulates innate
            immune cell population recruitment at the maternal-fetal interface.
REFERENCE   4  (bases 1 to 3440)
  AUTHORS   Li,C., Smith,S.M., Peinado,N., Gao,F., Li,W., Lee,M.K., Zhou,B.,
            Bellusci,S., Pryhuber,G.S., Ho,H.H., Borok,Z. and Minoo,P.
  TITLE     WNT5a-ROR Signaling Is Essential for Alveologenesis
  JOURNAL   Cells 9 (2), 384 (2020)
   PUBMED   32046118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3440)
  AUTHORS   Sun,M., Wadehra,M., Casero,D., Lin,M.C., Aguirre,B., Parikh,S.,
            Matynia,A., Gordon,L. and Chu,A.
  TITLE     Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced
            Pathological Neovascularization in Murine Oxygen-Induced
            Retinopathy
  JOURNAL   Invest Ophthalmol Vis Sci 61 (2), 3 (2020)
   PUBMED   32031575
REFERENCE   6  (bases 1 to 3440)
  AUTHORS   Wadehra,M., Su,H., Gordon,L.K., Goodglick,L. and Braun,J.
  TITLE     The tetraspan protein EMP2 increases surface expression of class I
            major histocompatibility complex proteins and susceptibility to
            CTL-mediated cell death
  JOURNAL   Clin Immunol 107 (2), 129-136 (2003)
   PUBMED   12763482
  REMARK    GeneRIF: The tetraspan protein EMP2 increases surface expression of
            class I major histocompatibility complex proteins and
            susceptibility to CTL-mediated cell death.
REFERENCE   7  (bases 1 to 3440)
  AUTHORS   Wadehra,M., Sulur,G.G., Braun,J., Gordon,L.K. and Goodglick,L.
  TITLE     Epithelial membrane protein-2 is expressed in discrete anatomical
            regions of the eye
  JOURNAL   Exp Mol Pathol 74 (2), 106-112 (2003)
   PUBMED   12710941
  REMARK    GeneRIF: This protein is expressed in discrete anatomical regions
            of the eye.
REFERENCE   8  (bases 1 to 3440)
  AUTHORS   Wadehra,M., Iyer,R., Goodglick,L. and Braun,J.
  TITLE     The tetraspan protein epithelial membrane protein-2 interacts with
            beta1 integrins and regulates adhesion
  JOURNAL   J Biol Chem 277 (43), 41094-41100 (2002)
   PUBMED   12189152
  REMARK    GeneRIF: addressed the normal function of EMP2 by testing the
            prediction that it influences integrin-related cell functions
REFERENCE   9  (bases 1 to 3440)
  AUTHORS   Ben-Porath,I., Kozak,C.A. and Benvenisty,N.
  TITLE     Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3),
            genes encoding membrane proteins related to Pmp22
  JOURNAL   Genomics 49 (3), 443-447 (1998)
   PUBMED   9615230
REFERENCE   10 (bases 1 to 3440)
  AUTHORS   Ben-Porath,I. and Benvenisty,N.
  TITLE     Characterization of a tumor-associated gene, a member of a novel
            family of genes encoding membrane glycoproteins
  JOURNAL   Gene 183 (1-2), 69-75 (1996)
   PUBMED   8996089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077260.1 and AC154311.2.
            
            On Aug 4, 2006 this sequence version replaced NM_007929.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077260.1, SRR1660817.9352.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-693               AK077260.1         3-695
            694-3440            AC154311.2         119621-122367
FEATURES             Location/Qualifiers
     source          1..3440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.54 cM"
     gene            1..3440
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /note="epithelial membrane protein 2"
                     /db_xref="GeneID:13731"
                     /db_xref="MGI:MGI:1098726"
     exon            1..157
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /inference="alignment:Splign:2.1.0"
     exon            158..320
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..761
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /note="EMP-2"
                     /codon_start=1
                     /product="epithelial membrane protein 2"
                     /protein_id="NP_031955.2"
                     /db_xref="CCDS:CCDS37250.1"
                     /db_xref="GeneID:13731"
                     /db_xref="MGI:MGI:1098726"
                     /translation="MLVILAFIIVFHIVSTALLFISTIDNAWWVGDSFSADLWRVCTN
                     STNCTEINELTGPEAFEGYSVMQAVQATMILSTILSCISFLIFLLQLFRLKQGERFVL
                     TSIIQLMSCLCVMIGASIYTDRRQDLHQQNRKLYYLLQEGSYGYSFILAWVAFAFTFI
                     SGLMYMILRKRK"
     exon            321..426
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /inference="alignment:Splign:2.1.0"
     exon            427..573
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /inference="alignment:Splign:2.1.0"
     exon            574..3440
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /note="hexamer: ATTAAA"
     polyA_site      3436
                     /gene="Emp2"
                     /gene_synonym="XMP"
                     /note="major polyA site"
ORIGIN      
        1 cgggcgggca gggaggcggg ctagggagag ggcggcaggg aggaggctcg gcagcccgga
       61 gggcggagga cgccgcgcag tcccagcccc aagcttcaaa acagccggcg cctcgcccca
      121 cgcgcagccc gccactgtgt ccagacgccc gtgcccggtt tggatttgtc tctcgccatc
      181 tttgtctcct catctctctt tggacttcct gctgccccct tggccttcac tgccctgtga
      241 acatgttggt gattcttgcc ttcatcattg tcttccacat cgtgtccacg gcactcctgt
      301 tcatttctac cattgacaat gcctggtggg taggcgacag cttctctgct gacctctgga
      361 gagtgtgcac caacagcaca aactgtaccg agatcaatga gctgaccggc cctgaagcgt
      421 ttgaaggtta ttctgtgatg caggcggtgc aggccaccat gatcctctcc accatcctct
      481 cctgcatctc cttcctcatc tttctgctcc agctcttccg cctcaagcag ggagagaggt
      541 tcgtcctgac gtccatcatc cagctcatgt cctgtctgtg tgtcatgatc ggagcttcca
      601 tctatacaga ccggcgccaa gaccttcacc aacagaacag aaaactctat tacctactgc
      661 aagaaggcag ctacggctac tctttcatcc tggcctgggt ggcctttgcc ttcactttca
      721 tcagcggcct catgtacatg atcctgagga agcgtaaata agtgtcagaa gtctgaccac
      781 cctcccacag ggtggcatcc atggtcacat aaccattttg tatataatca ttttttgtgt
      841 tttttctagc aaacatattg tttcctttaa aagcttttat gaagaagaag aaggagaagg
      901 agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag aaggagaaga
      961 agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag aaagaataga
     1021 gacagagaag gagtttctgc attcttggga tcacaaacca gaccatgaaa gctggcattc
     1081 agaatgcctg cctaccaaaa gtctcagcaa ggcccagcaa gctccacagg atgcttttca
     1141 agggtggctc tgtggtgtgg gtacggccaa aggtggggaa agccagtctt tgggagcaga
     1201 ctctttgtag gagtctgccc ttccctcttc ccctgcccac tccactctga cagccacagg
     1261 tggaatgatg agggcccaaa tgtgggacat ctatgctcag atattaaacc taagctcacg
     1321 taagaagtgg gcaaagactg gccctggttt gtctgtaaga gacccagagt ttcccaaccc
     1381 ccctgccatg agctaggtca tcacactaat ttgttgatgt ttgctcctgt ttgccttaag
     1441 gatagtgacc cttgcctgac gcagatgtca tgtttaggca ttaagtgtcc ataggtcatt
     1501 ccgtagggca tctagtacac gtcggttcac aaatctactt ccaagaccct cagaatcctt
     1561 cattaaaggg ctgggcctgg gtgtctgaat ttctgatgag ctccctgcaa tatggttaaa
     1621 tgcactataa ctggaggtca gagccttaga accgggggga gcagagccac cttgtaaatg
     1681 ttatcaggct aatcacaatg agatggcccc actgctagct acgtctcagc ctccatcagc
     1741 tcttgctgcc tcttccacag ctgcttacat ctgggacact tgtgccccat tcccaggcca
     1801 tacaagcctg gaaggtgggc tggacagcct cctccctgac ctacatggga aggtctctcc
     1861 ttttcttccc gccctttttt ctaatgtgga tgcttccatt aatcctctgt ttctggagcc
     1921 ttggaagatc tgtcttccat tcattcatcc acccatccat cattcaacat gaatgggtca
     1981 tgtcacgtgt tgggtgcaag ggatactctt tcaaaacaat ccctcacgag actcacagtc
     2041 tagtgaagag cacacgccag aaaccaatta gagaagctac caaccacgat ggaacatcag
     2101 ggattcaaaa cctcggggtg agagggagcc tactttctct gtgttcttct aagagccctg
     2161 atggctctcg attgctctga acagaggtcc acttggtcca gtgctatcat gggtagtgcc
     2221 cacgaggttt ccccagagaa tactactgta gagcattcta tactccccac agggagacag
     2281 gaaaggattc ccagagccat ggctcttaag atggtcctcg aaggaaaatc cagtcatttc
     2341 caagtgggcc ctgaaccctg aggctatggg gaggtcttca gaagtcctgg aagagtgaca
     2401 acacccgagt cccaggagct ctgtgatggc aaccttctcc cttgaacacc cttttccatt
     2461 tttgagcatc gagttggaga ggtgattctg ggacagggtg tgtatatttg tgttgtttaa
     2521 acacattcac atgtaagctg cctgagggga ggggatgttt gcctctagct cagtcccagt
     2581 ggagctgggg ggatgatgag tctgagtggc tttagggcca tcattgacac cacctcagta
     2641 caaacggact cccctccctt cctccctctc ttctatcctc ctttccttcc ttcccttagc
     2701 agggctgcca aggtgatatg ggacagcgac agggcaaacg atcacctgtt gccttaatga
     2761 actttccaca gctcactgct ggctaggtcg tagagtttct ccttgtcttg tgaggcccaa
     2821 ggaaggaggc caatctaaag tgtcctccat accttcccct tgggggcttt tctgtaatac
     2881 ttgtttaaaa attgttctga tgatcatgat ggaaacagac agaccacctt agaaccagag
     2941 gcctgaaagc ctgacctgac cagcacagat tcccacttca gaaccccagg gctatggaag
     3001 tgcccttgtc caacgctatg ggaatagtcc tgtgggttgt ctctgcttgc cactgtggcc
     3061 agcattccag tgcctacagc cacctgtgcc tacagccacc tgtgccatga gaagtgcctc
     3121 tcctgctcta tgccctgcat ttgggatgct aagaagaggt gagggtgtga gcgagaacag
     3181 atccaccctt ctcctaggta ggatcagctc tcaattggtg cttatcacta gttatcaaag
     3241 aacagcagag acagctgcgt tatccaagaa gcaagtatta ggaccaaaac ctgttactgt
     3301 atttaaagga actttagttt gcgtatctta catttttata aagtactgta attcaggggg
     3361 tggggtatgc aacagagaca gactaaccca tgtttgtcat ttgcattaaa attattttgg
     3421 gtctctgttt aaagaatttg
//
