LOCUS       NM_010128               2721 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus epithelial membrane protein 1 (Emp1), transcript
            variant 1, mRNA.
ACCESSION   NM_010128
VERSION     NM_010128.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Canellas-Socias,A., Cortina,C., Hernando-Momblona,X.,
            Palomo-Ponce,S., Mulholland,E.J., Turon,G., Mateo,L., Conti,S.,
            Roman,O., Sevillano,M., Slebe,F., Stork,D., Caballe-Mestres,A.,
            Berenguer-Llergo,A., Alvarez-Varela,A., Fenderico,N.,
            Novellasdemunt,L., Jimenez-Gracia,L., Sipka,T., Bardia,L.,
            Lorden,P., Colombelli,J., Heyn,H., Trepat,X., Tejpar,S., Sancho,E.,
            Tauriello,D.V.F., Leedham,S., Attolini,C.S. and Batlle,E.
  TITLE     Metastatic recurrence in colorectal cancer arises from residual
            EMP1+ cells
  JOURNAL   Nature 611 (7936), 603-613 (2022)
   PUBMED   36352230
  REMARK    GeneRIF: Metastatic recurrence in colorectal cancer arises from
            residual EMP1[+] cells.
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Bian,Q., Cheng,Y.H., Wilson,J.P., Su,E.Y., Kim,D.W., Wang,H.,
            Yoo,S., Blackshaw,S. and Cahan,P.
  TITLE     A single cell transcriptional atlas of early synovial joint
            development
  JOURNAL   Development 147 (14) (2020)
   PUBMED   32580935
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2721)
  AUTHORS   Ben-Porath,I., Kozak,C.A. and Benvenisty,N.
  TITLE     Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3),
            genes encoding membrane proteins related to Pmp22
  JOURNAL   Genomics 49 (3), 443-447 (1998)
   PUBMED   9615230
REFERENCE   7  (bases 1 to 2721)
  AUTHORS   Ben-Porath,I. and Benvenisty,N.
  TITLE     Characterization of a tumor-associated gene, a member of a novel
            family of genes encoding membrane glycoproteins
  JOURNAL   Gene 183 (1-2), 69-75 (1996)
   PUBMED   8996089
REFERENCE   8  (bases 1 to 2721)
  AUTHORS   Lobsiger,C.S., Magyar,J.P., Taylor,V., Wulf,P., Welcher,A.A.,
            Program,A.E. and Suter,U.
  TITLE     Identification and characterization of a cDNA and the structural
            gene encoding the mouse epithelial membrane protein-1
  JOURNAL   Genomics 36 (3), 379-387 (1996)
   PUBMED   8884260
REFERENCE   9  (bases 1 to 2721)
  AUTHORS   Taylor,V., Welcher,A.A., Program,A.E. and Suter,U.
  TITLE     Epithelial membrane protein-1, peripheral myelin protein 22, and
            lens membrane protein 20 define a novel gene family
  JOURNAL   J Biol Chem 270 (48), 28824-28833 (1995)
   PUBMED   7499407
REFERENCE   10 (bases 1 to 2721)
  AUTHORS   Tavtigian,S.V., Zabludoff,S.D. and Wold,B.J.
  TITLE     Cloning of mid-G1 serum response genes and identification of a
            subset regulated by conditional myc expression
  JOURNAL   Mol Biol Cell 5 (3), 375-388 (1994)
   PUBMED   8049528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122820.4.
            
            On Mar 21, 2007 this sequence version replaced NM_010128.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046299.1, AK168806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC122820.4         57535-57706         c
            173-283             AC122820.4         43349-43459         c
            284-380             AC122820.4         40640-40736         c
            381-521             AC122820.4         40396-40536         c
            522-2721            AC122820.4         37464-39663         c
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.25 cM"
     gene            1..2721
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /note="epithelial membrane protein 1"
                     /db_xref="GeneID:13730"
                     /db_xref="MGI:MGI:107941"
     exon            1..172
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            173..283
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..688
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /note="isoform a is encoded by transcript variant 1;
                     EMP-1; tumor-associated membrane protein"
                     /codon_start=1
                     /product="epithelial membrane protein 1 isoform a"
                     /protein_id="NP_034258.1"
                     /db_xref="CCDS:CCDS20647.1"
                     /db_xref="GeneID:13730"
                     /db_xref="MGI:MGI:107941"
                     /translation="MLVLLAGLFVVHIATAIMLFVSTIANVWMVADYANASVGLWKNC
                     TGGNCDGSLSYGNEDAIKAVQAFMILSIIFSIISLVVFVFQLFTMEKGNRFFLSGSTM
                     LVCWLCILVGVSIYTHHYAHSEGNFNSSSHQGYCFILTWICFCFSFIIGILYMVLRKK
                     "
     exon            284..380
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..521
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /inference="alignment:Splign:2.1.0"
     exon            522..2721
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /note="hexamer: TATAAA"
     polyA_site      2721
                     /gene="Emp1"
                     /gene_synonym="I-8-09; TMP"
                     /note="major polyA site"
ORIGIN      
        1 acggggaaaa gaaaccgccc atcacacacc ccagcacatc agcccaggaa acttataacc
       61 tcgggagtca ggtccctccc ctcactgtgg ttgcaaatct cctgaagaga ggaccagacc
      121 agcagcctgc tctaccaccc agggcatctg cctctctcac tggatactcc agaattctct
      181 actcagaagt caccaaaaag ccaagatgtt ggtgctactg gctggtctct ttgtggtcca
      241 cattgccact gccattatgc tgtttgtctc caccattgcc aacgtctgga tggttgcaga
      301 ttacgcaaat gcatctgtag ggctttggaa gaactgcact ggtggtaact gcgacggctc
      361 cctgtcctac ggcaatgaag atgctatcaa ggcagtgcaa gccttcatga tcctctccat
      421 catcttctcc atcatctccc ttgtggtctt cgtgttccag ctcttcacta tggagaaggg
      481 aaaccggttc ttcctctcag ggtccaccat gctggtgtgc tggctgtgta tcctggttgg
      541 agtgtcaatc tacactcatc attacgccca cagcgaaggg aacttcaact ccagcagcca
      601 ccaaggctat tgtttcatcc tgacctggat ctgcttctgt ttcagcttca tcatcggcat
      661 actctatatg gtcctgagga agaaataagc cgaatacgct catgggcgtc tgggggcggg
      721 gtgggctggg taggaggaag caacctaacc tgggagggaa gcaggagtca ctgtgtagga
      781 ataacagaga ggggaggggg gtggggagag ggaaggaaga gggggagagg cccaaaccca
      841 aaccatatct ggggcggtgg gattctctac tgccaagcac ccatccttgg aagaaagttg
      901 ttggctgata tgctgatgct tccttgacgt caccagagag tcctcctcta gccaccaaat
      961 atggccccgt ccatcctcaa ttacatacac tcggggcctc cccagctgcc ataccactgg
     1021 cgccactctt gagggtggct gctgggtcac acactgaggt cttccacatc catattatca
     1081 agttctgatg gtggttcagg tcttagcaag agcagatatt gctctatgct gaggctaagt
     1141 ctggaagcca ctttgtcctt gtgacctaaa aacaaacatc aaatccagat cccatgtgcc
     1201 tgtagtggga gctttggcca ggaagccaat gtgcatattt ggtggccttt ctaacaaaag
     1261 tataggaaga gagatggttt gtaagttcaa gctgatggaa ttggtttagc caagaaatgg
     1321 aagtttctac cccagaggat cttggagaca ggtggggaca ggcagtgctc ctcagtcacg
     1381 tgtcaccgag ctgtcccaca tggaggcctc ctattgtgaa ctttgctaga ctctcactta
     1441 cagccaaggc agcttttctg gagtttttct agattctcta gagccaaaga tgataatgcc
     1501 tcacaaaaca tagggtcaaa gcatatgccc accgcagtgc tatagtaagt ttgtgggttt
     1561 ttaggattcc cccaaagcac tcaatgtatc ttgtatatgt aacaggggag aaatgcatgt
     1621 gttcctttga catacaattc tgaactagga atatttgagg aagtccaatg atgaccaaca
     1681 acactgggga ccagaatata acatctaaat gcagtagtca ctattgcttt gacctgggct
     1741 ggagtggtct cctctcaaca gctttcatca cactattttc cagctaaaga tggcaaagct
     1801 gtaagccaat taacatatac accaacctaa actaaagaac cagtcctgag ggtgtgagaa
     1861 aggtgctatc tggttatgga ttattaagca aaccgtattt catttatgtt gagaagagaa
     1921 tgcctgccct cagggaaaaa aatgtcattg tgtgagatga ataaagtcct ggtgatgggc
     1981 agacagtttc tcttttaaaa caggagaaac tcttagggca tccagacaga tggtagctaa
     2041 attgttgggg ctgcaggggt attcctgtat aagacttaga ggtagtatga tatctcagat
     2101 ttctgcctta aagggctttc tttttagaaa tagtttcttt tattgccctt agaagatcac
     2161 ccccaggaag agtatgagct atcttttcta catttctttt cctaggaata ttcttatcca
     2221 tttcttatat acatttcttt tgggagggag tttttatgct atagttgctg gtatttatgt
     2281 aaagggacca ttactaagtg tatttctcta gcatattatg tttaagggac tgttcaaggt
     2341 aggttactga actgccgggc tgatgttaga gacactggcc agaaaagcta taataagttc
     2401 ttaaattata atttgatcac tatacatttg ttctatgctg ccttatgttc ataagaatat
     2461 caacagacag ctagagccag aaaaagatag tcacattttg ttaaaaagtt gaattatgac
     2521 tggagtgaac cgtgcattcc cttgcctttt actttttttc tgtgacattt acgtctcatg
     2581 taatttgcat cgcattggtg ggttattcta gtactgtatt tggcttcttc attaatagga
     2641 tatttcacat actataattg taaatatttt gatacaaatg tttataactc tagggatata
     2701 aaaacaaatt ctgattccct a
//
