LOCUS       NM_001114361            5445 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus echinoderm microtubule associated protein like 4
            (Eml4), transcript variant 1, mRNA.
ACCESSION   NM_001114361
VERSION     NM_001114361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5445)
  AUTHORS   Zhang,X., Chen,M.H., Wu,X., Kodani,A., Fan,J., Doan,R., Ozawa,M.,
            Ma,J., Yoshida,N., Reiter,J.F., Black,D.L., Kharchenko,P.V.,
            Sharp,P.A. and Walsh,C.A.
  TITLE     Cell-Type-Specific Alternative Splicing Governs Cell Fate in the
            Developing Cerebral Cortex
  JOURNAL   Cell 166 (5), 1147-1162 (2016)
   PUBMED   27565344
REFERENCE   3  (bases 1 to 5445)
  AUTHORS   Blasco,R.B., Karaca,E., Ambrogio,C., Cheong,T.C., Karayol,E.,
            Minero,V.G., Voena,C. and Chiarle,R.
  TITLE     Simple and rapid in vivo generation of chromosomal rearrangements
            using CRISPR/Cas9 technology
  JOURNAL   Cell Rep 9 (4), 1219-1227 (2014)
   PUBMED   25456124
REFERENCE   4  (bases 1 to 5445)
  AUTHORS   Houtman,S.H., Rutteman,M., De Zeeuw,C.I. and French,P.J.
  TITLE     Echinoderm microtubule-associated protein like protein 4, a member
            of the echinoderm microtubule-associated protein family, stabilizes
            microtubules
  JOURNAL   Neuroscience 144 (4), 1373-1382 (2007)
   PUBMED   17196341
REFERENCE   5  (bases 1 to 5445)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 5445)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167969.2 and AC164634.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144604.1, SRR1660813.120453.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AC167969.2         148415-148723
            310-492             AC164634.3         161106-161288       c
            493-622             AC164634.3         149579-149708       c
            623-796             AC164634.3         145883-146056       c
            797-925             AC164634.3         143963-144091       c
            926-951             AC164634.3         143289-143314       c
            952-984             AC164634.3         143066-143098       c
            985-1108            AC164634.3         131160-131283       c
            1109-1258           AC164634.3         129869-130018       c
            1259-1328           AC164634.3         126616-126685       c
            1329-1439           AC164634.3         125258-125368       c
            1440-1535           AC164634.3         123059-123154       c
            1536-1670           AC164634.3         120534-120668       c
            1671-1806           AC164634.3         120240-120375       c
            1807-1958           AC164634.3         116762-116913       c
            1959-2084           AC164634.3         115157-115282       c
            2085-2216           AC164634.3         114941-115072       c
            2217-2284           AC164634.3         114252-114319       c
            2285-2373           AC164634.3         109697-109785       c
            2374-2471           AC164634.3         107719-107816       c
            2472-2559           AC164634.3         98181-98268         c
            2560-2658           AC164634.3         97566-97664         c
            2659-2789           AC164634.3         93980-94110         c
            2790-5445           AC164634.3         90953-93608         c
FEATURES             Location/Qualifiers
     source          1..5445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 52.69 cM"
     gene            1..5445
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /note="echinoderm microtubule associated protein like 4"
                     /db_xref="GeneID:78798"
                     /db_xref="MGI:MGI:1926048"
     exon            1..309
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..3251
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EMAP-4"
                     /codon_start=1
                     /product="echinoderm microtubule-associated protein-like 4
                     isoform 1"
                     /protein_id="NP_001107833.1"
                     /db_xref="CCDS:CCDS50192.1"
                     /db_xref="GeneID:78798"
                     /db_xref="MGI:MGI:1926048"
                     /translation="MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAA
                     LADVLRRLAISEDHVASVKKSMPSKGQPSLREAISMSCITNGSGISRKQNHTSSVSIA
                     RKETLSSAAKSGTEKKKEKPQGQREKKEDSHSNDQSPQIRASPSPQPSSQPLQINRQT
                     PESKSSAPIKSIKRPPTAEKSHNSWENSDDSRNKLMKTVSTSKLISKVIKNADKHKDV
                     IVNQAKMSTREKNSQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWVY
                     GYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVRCLAVHPDKIR
                     IATGQIAGVDKDGRPLQPHVRVWDSVSLTTLHVIGLGTFERGVGCLDFSKADSGVHLC
                     VIDDSNEHMLTVWDWQKKSKIAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWS
                     GNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTMVEPPPGKGPKG
                     VYQINRQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNLEREIEVPDQYGTI
                     RAVAEGRAEQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQD
                     RQVCMWNSVEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIH
                     TDGNEQLSVMRYSVDGTLLAVGSHDNFIYLYTVLENGRKYSRYGKCTGHSSYITHLDW
                     SPDNKHIMSNSGDYEILYWDIENGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGS
                     DGTDINALVRSHNRRVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHN
                     DSHLISTGGKDMSIIQWKLVEKLPVPQNEVITDASVTKTPASSSETARPSNSPPLPPS
                     LPLTGTAEEESRMGSSPTLVENSLEQIAEPSEEQSEWGSEDLGVVIDEEPASELSETQ
                     GATELPEEERGITPLC"
     exon            310..492
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            493..622
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            623..796
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            797..925
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            926..951
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..984
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1108
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1258
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1328
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1439
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1535
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1670
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1806
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1958
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2084
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2216
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2284
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2373
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2471
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2559
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2658
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2789
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..5445
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5422..5427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /note="hexamer: GATAAA"
     polyA_site      5434
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
     polyA_site      5445
                     /gene="Eml4"
                     /gene_synonym="4930443C24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcggc gcggcgcggc gcggcgctca cggctgcggc ttaggagaga gagagagaga
       61 gggagagagg ccgggcaggc ggcgggcggc gcggctctca acctgattga ccgactgacc
      121 ctcggggctg acgggctgac cggcggacgg cggcggcggg agtcggaagc cgcgccgggc
      181 gacgctgaga accggcgggt caggtcccgc ggccgccgca cggtcggggc gctgaatgaa
      241 gcgcccgccc cgctgagccc cgagcccggc gcggtccccg caagatggac ggtttcgccg
      301 gcagcctcga tgatagtatt tctgctgcaa gtacctctga cgttcaagac cgcctctcag
      361 ctcttgagtc acgagttcaa caacaagaag atgaaatcac tgtgctaaag gcagcattgg
      421 ctgatgtttt gaggcgtctt gcaatctctg aagatcatgt agcctcagtg aaaaagtcca
      481 tgccaagtaa aggccaacca agccttcgag aagctatttc tatgtcctgt ataaccaatg
      541 gaagtggtat aagcagaaaa cagaatcata ccagctctgt atcaatagca agaaaagaaa
      601 ctctttcttc agctgctaaa agtggtacag aaaaaaagaa agaaaagcca caaggacaga
      661 gagaaaaaaa agaggattct cattctaatg atcagagccc acaaattcga gcgtcacctt
      721 ctccccagcc ctcttcacag cctctccaaa taaacagaca aactccagag agcaagagtt
      781 ctgctcccat caaaagcata aaacgtccac caacagctga aaagtcacat aactcatggg
      841 aaaattcaga tgatagtcgt aataaattaa tgaaaacggt ttcaacatca aaactaatat
      901 caaaggttat aaaaaatgca gacaaacata aagatgtcat cgtcaatcaa gcaaaaatgt
      961 caacccggga aaaaaacagc caagaaggag aatatattaa aatgtttatg cgaggtcggc
     1021 caattacaat gttcattcct tcggatgttg acaactatga tgacatcaga acagaactgc
     1081 ctccagagaa gctcaaactg gagtgggtat acggttatcg aggaaaggac tgtagagcga
     1141 atgtatacct gcttcccaca ggggagatag tttattttat cgcctcagtg gtagtcctgt
     1201 ttaattatga ggagaggact cagcgacact acctgggtca tacagactgt gtgagatgcc
     1261 ttgctgtaca tcctgacaag attagaattg caactggaca gatagccgga gtagacaaag
     1321 atggaaggcc tctgcaaccc catgtcaggg tgtgggattc agtaagtctt accacactgc
     1381 atgttattgg acttggaact tttgagcgtg gagtaggatg cctggatttt tcaaaagcag
     1441 attcaggtgt tcatttatgc gttattgatg actccaatga gcacatgctt actgtatggg
     1501 actggcagaa aaaatcaaaa atcgcagaaa taaagacaac aaacgaagtt gttttggctg
     1561 tagaattcca cccaacagat gcaaatacaa taataacatg tggtaaatct catatttttt
     1621 tctggacctg gagtggcaac tcactaacaa gaaaacaggg aatttttggg aaatatgaaa
     1681 aaccaaaatt cgttcagtgt ttggcattct tggggaatgg agatgttctc actggagact
     1741 cgggtggagt catgctgatc tggagcaaaa cgatggtaga gcccccgccc gggaaaggac
     1801 ctaaaggtgt gtatcagatc aacagacaaa tcaaagctca tgatggcagt gtgtttacac
     1861 tttgtcagat gagaaatggg atgctattaa ctggaggcgg aaaagacaga aaaataattt
     1921 tgtgggatca tgatctgaac cttgaaagag aaatagaggt tcctgatcag tatggcacca
     1981 ttagagcagt tgcagaggga agggcagaac agttcttagt aggcacatca cgaaacttta
     2041 ttttacgggg aacgtttaat gatggcttcc aaatagaagt ccagggtcat acagatgaac
     2101 tctggggcct tgcaacacat cccttcaaag atttgctctt gacgtgtgct caggacaggc
     2161 aggtgtgcat gtggaactca gtggagcaca ggctggagtg gaccaggctt gtggacgaac
     2221 caggacactg tgcagacttt catccaagcg gtacagtggt agccattgga acgcactcag
     2281 gcaggtggtt tgttctggat gcagaaacaa gagatctggt gtcaatccac acggatggca
     2341 atgagcagct gtctgtgatg cgctactcag tagatggcac tcttctggct gtgggctctc
     2401 atgacaactt tatttacctc tacacagtct tagaaaacgg aagaaaatac agcagatatg
     2461 gaaagtgcac tggacattct agctacatca cacaccttga ctggtcccca gacaataagc
     2521 atataatgtc taactcgggt gactacgaga tactgtactg ggacattgaa aatggctgca
     2581 aactaatcag gaaccgatca gattgcaagg acatcgattg gacaacatat acctgtgtgc
     2641 taggcttcca agtctttggg gtgtggccgg aagggtccga tggaacagac atcaacgcac
     2701 tggttcgatc ccacaacaga agagtgatcg cagtggccga tgatttctgc aaagttcatc
     2761 tctttcagta cccctgctcc aaagccaagg ctcccagtca caagtacagt gcccacagca
     2821 gccatgtgac caacgtcagt tttactcata atgacagtca cctaatttca actggtggga
     2881 aggatatgag catcattcag tggaagcttg tggaaaagtt acctgtgcct caaaacgagg
     2941 tcataacaga cgccagtgtg accaaaaccc ctgcctcttc ctctgaaact gccaggccgt
     3001 ctaactctcc tccactgcct ccttctctac cgttaactgg gacggctgaa gaggaaagca
     3061 ggatgggcag ctcccccaca ctagtggaga acagcctgga gcagatcgca gagcccagcg
     3121 aggagcagag cgagtggggt agcgaagacc ttggtgtggt gattgatgaa gagcctgcta
     3181 gtgagttaag tgagacacag ggagcaactg agctgcctga ggaggagcga ggcataacac
     3241 ccctgtgcta aaacccaggc tgcagggctc ctctgccacc cgtgaccccg tgacgtgatg
     3301 gggccaggta acgggccggg cagtggtgag gtcactgtga atggaggttt gtttcccatg
     3361 agatcggaca ctgtccgcag tccgatatgc caccagtgag ctagagcaat ccaggagact
     3421 gtttggtaga tgttcacaac ttcaccaaac ttaaatagca ggaggagact ggcaggtgag
     3481 tgtgtccaag aaatccacat ttgtgctgca gatactggaa accaaactgc agctgcagcc
     3541 attggaagaa acctgttacc tgaatgcgat ttcctccatt ttctcaacag ctggaggcct
     3601 ctcaggcacc atcgctcgag tggctgctgg ctctcaagct gccatttttt cctgatgcaa
     3661 aaaatgaaag caggcaaaag tgctgtcatt gtgataccgt cccactcaga tgtctaacgg
     3721 gagcttgctt aaggggaatg ttagcattgc caagtgcgat ggtgttgcct ttccatggga
     3781 tattgcattt tcttacacta cccgagatgt ccagacgtgc ttggtaggag gctactccct
     3841 aggtgctgcc tttctaagtt ctgacgagga gcagccctca gtggcttgtg tacagattgc
     3901 tctatcccag aagcaagcct tggtttgttg aagagctttt catgtatagt aaaccatgat
     3961 tctgagagaa tcgattctcc aaggagtcct tcactggcct aaacattctg taatgttggg
     4021 cattcaaggg aatggaagaa aacaaaccac atgcctttaa cagatgaact gtaatgacga
     4081 cctgctaact gctagccttc agcgctatct gttccctcac acagtcgcta agtggtcaaa
     4141 ttggtgcttg aaattcattg gtctagttgt aatttttata caaattacac caagagataa
     4201 gatgtctttt ttttacagaa gtgtaatagt cacagtgccg cttataggct gcacgcaccc
     4261 cttgcggatg tgctatctgt gggcatttcc tcctcctgtg agccttgcag cccttgtatg
     4321 gcggctttgg tctgggcagt gcatgtgtta gtagtgtacg tgggcaggtc gggctttcta
     4381 agctttgtca gataactatt tttcctaagt atgtgtttcc tactccagtg attgacaagt
     4441 gtgcattgcc tatgtttgtt tatactttaa ttacaaaact atttttttta acttcctaca
     4501 ttgttttcct acttttttgt tgttggatta tgtaactttt cctaagttca gaagtcttaa
     4561 gtgtgcaagc gtttatgtga ccgtgccatt ccagagtgca tcagaactgt catcccttcc
     4621 aggaccttct caggagtaac acatcaggta tgtcatcagc gctgggaacc gtgaacgcca
     4681 aggacactcg ccactattca cacgctgtgc cgagggtgtg tggagggaca acagagagca
     4741 gtgtatctga gtaagatgca cacatcgaag tgcgttcaaa gtctgtgtct aggtatatat
     4801 gtccgtgtag ctctctcctt ttgtttacag ctttttttaa ttaagtggaa aaaataaaaa
     4861 taaaaaatcc tcacctcaac ataggtctct ttcaaaggga gatttcaagc cacctgactt
     4921 cttcagttta gtcttcaccc agggtcagag cgcacagctt caggcatctc tgtccaccag
     4981 ctagcagtgg agatgaaatc aagaccttgc aaaatggata ctaggagatg aacaacaatt
     5041 caacgtgctt ctctcagtgc ctggaggatg cagctctcca cacgcaggga ctttatttgg
     5101 ggacatctgt cacctttggg gttgccatgg ccaatgagat ttataatcat gatcctcttg
     5161 ggtggtagtt ccaaagacac tactaatgtg cagagagcgc tccggcctct ggtgctggcc
     5221 actactgttt cctgtcagtc agatctgtga taatggttgg aaggatgtgg gattatgaaa
     5281 ctgcttttgt tttgttgggt tttttttttt ttgttttgtt ttgtttttag aaaacttgtg
     5341 aatgaaaatg aacccaagtg tttcacgtga agatgagcca tttctatcat gcattccgat
     5401 gtcatggcag aaaattttga agataaaaaa ataagataat caaaa
//
