LOCUS       NM_182840               3588 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus elastin microfibril interfacer 3 (Emilin3), transcript
            variant 1, mRNA.
ACCESSION   NM_182840
VERSION     NM_182840.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Imhof,T., Korkmaz,Y., Koch,M., Sengle,G. and Schiavinato,A.
  TITLE     EMILIN proteins are novel extracellular constituents of the
            dentin-pulp complex
  JOURNAL   Sci Rep 10 (1), 15320 (2020)
   PUBMED   32948785
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Lacko,L.A., Hurtado,R., Hinds,S., Poulos,M.G., Butler,J.M. and
            Stuhlmann,H.
  TITLE     Altered feto-placental vascularization, feto-placental malperfusion
            and fetal growth restriction in mice with Egfl7 loss of function
  JOURNAL   Development 144 (13), 2469-2479 (2017)
   PUBMED   28526753
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Corallo,D., Schiavinato,A., Bizzotto,D., Milanetto,M.,
            Guljelmovic,M., Keene,D.R., Sengle,G., Braghetta,P. and Bonaldo,P.
  TITLE     EMILIN3, an extracellular matrix molecule with restricted
            distribution in skin
  JOURNAL   Exp Dermatol 26 (5), 435-438 (2017)
   PUBMED   27892605
  REMARK    GeneRIF: dispensable for hair follicle growth and maintenance
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Schiavinato,A., Becker,A.K., Zanetti,M., Corallo,D., Milanetto,M.,
            Bizzotto,D., Bressan,G., Guljelmovic,M., Paulsson,M., Wagener,R.,
            Braghetta,P. and Bonaldo,P.
  TITLE     EMILIN-3, peculiar member of elastin microfibril interface-located
            protein (EMILIN) family, has distinct expression pattern, forms
            oligomeric assemblies, and serves as transforming growth factor
            beta (TGF-beta) antagonist
  JOURNAL   J Biol Chem 287 (14), 11498-11515 (2012)
   PUBMED   22334695
  REMARK    GeneRIF: characterization of the expression and biochemical
            properties of EMILIN-3
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Gallardo,T.D., John,G.B., Shirley,L., Contreras,C.M., Akbay,E.A.,
            Haynie,J.M., Ward,S.E., Shidler,M.J. and Castrillon,D.H.
  TITLE     Genomewide discovery and classification of candidate ovarian
            fertility genes in the mouse
  JOURNAL   Genetics 177 (1), 179-194 (2007)
   PUBMED   17660561
  REMARK    GeneRIF: Transcripts highly enriched in ovary; gene identified as
            candidate female fertility factor.
REFERENCE   8  (bases 1 to 3588)
  AUTHORS   Doi,M., Nagano,A. and Nakamura,Y.
  TITLE     Molecular cloning and characterization of a novel gene, EMILIN-5,
            and its possible involvement in skeletal development
  JOURNAL   Biochem Biophys Res Commun 313 (4), 888-893 (2004)
   PUBMED   14706625
REFERENCE   9  (bases 1 to 3588)
  AUTHORS   Braghetta,P., Ferrari,A., De Gemmis,P., Zanetti,M., Volpin,D.,
            Bonaldo,P. and Bressan,G.M.
  TITLE     Overlapping, complementary and site-specific expression pattern of
            genes of the EMILIN/Multimerin family
  JOURNAL   Matrix Biol 22 (7), 549-556 (2004)
   PUBMED   14996434
REFERENCE   10 (bases 1 to 3588)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY139070.1 and BC057619.1.
            
            On Mar 27, 2014 this sequence version replaced NM_182840.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054738.1, BU512497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY139070.1         2-12
            12-3588             BC057619.1         1-3577
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 80.98 cM"
     gene            1..3588
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /note="elastin microfibril interfacer 3"
                     /db_xref="GeneID:280635"
                     /db_xref="MGI:MGI:2389142"
     exon            1..332
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /inference="alignment:Splign:2.1.0"
     exon            333..455
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..679
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /inference="alignment:Splign:2.1.0"
     exon            680..3558
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3540..3545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /note="hexamer: ATTAAA"
     polyA_site      3558
                     /gene="Emilin3"
                     /gene_synonym="1110013O17Rik; EMILIN-3; EMILIN-5;
                     EMILIN-T; Emilin5"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgagt agccccggcc actcggcggg acgcagcggc cgcacagctc caggcggccg
       61 aaccagcgcg ctccgggggt cggtcgcgag tggccgcggg agcccggagg gcgagcggag
      121 gatcccccgc gggaggcacc ccgagggaca gagtgacgac cgagcgcgat gggccgccgt
      181 ctgtccgtgt ggctgtgcac cgtcgcggcg ctgctctcgg gggcgcaggc caagggcacc
      241 cctctcctcg cgcggcccgc acagcccagt gcctcccgtt acagcctcta caccaccgga
      301 tggcgtccgc ggctgcgccc ggggccacac aagtctctct gtgcctatgt ggtacacaga
      361 aatgtgacct gcgtcctaca agaaggagca gagagctata taaaggctga gtaccggaac
      421 tgtgggtggg gacccaactg cccttcaaca gtcaggtacc gcacagtgtt cagacccaga
      481 tacaagattg gctacaagac cgtgacagac ctggcgtggc gctgctgccc tggtcttact
      541 ggggaaagct gccctgaaca cctcacagac catggagcca ccccacccca ccaggagcca
      601 gagcctcaga ttcccttggg gcagctgggc ccaggtccca ggccttctcc ttacagcaga
      661 gaggccccgc gcccccgtgg aagaaaaggc caagggccgt ttggtgagcg gctagaacag
      721 cgcctgtcgc aagcatatgg caccctgagt ggattggtag ccagccacga gaatcccaat
      781 aggatcactg gtgactccag ggcccctgtc gtacctatag gctttggggt catccccgag
      841 ggtcttgtgg ccccagaaga cagaggcaga ggaccactca tccctcctct gagtgagatc
      901 ctgagcaagg tcacagaggt gagcaacaca ttacagacca aggtgcagct gttagatgag
      961 gtgcgtgggc tggccctggg gcatgaggct cacctgcagc ggctccggga agccccgcca
     1021 tccccgctga cctccttagc gctcctagag gaatacgtgg accagcggct gcagcgactc
     1081 tgggggagcc tgctggatgg ctttgagcag aagctgcaag gtgtccagag cgagtgtgac
     1141 cttcgggtgc aagaggtgcg gcagcaatgt gaggagggcc aggcagccag ccagcgcttg
     1201 catcagagcc tcgatggccg agagcttgcc ttgcgtcggg agctctccca gctgggcact
     1261 cagctgcagg gcttgactct gactggtggg ggcacctgct gcagccaact ggctttgatc
     1321 agtgcccggg tggacagcct tgagaggaac ctgcaggctg tcactgagac ccaaggtggc
     1381 ccgggcaccc tggccgcgga tgagcttgcg cgcctctctg cagctatgct tcagggaggt
     1441 gtggacgggc tgcttgaagg ccttgagact atcaatggga cagagaatgg agcaaggggc
     1501 tgctgtctga gaatggaggt ggggggctgg ggtgtcggtg gcttcgggtc cacgctggaa
     1561 cagcgagtgc agagcctaga ggagcggctg gcaactctga ccggagagct aagccccgag
     1621 agtgccatac cagacagatc agcgcggccg cttgttcatt cagaactagc agtactggaa
     1681 caaaggctgg tgtccctgga gacctcgtgc accccaagta ccaccacagc catcctggac
     1741 aacctcgtgg cagaggtgaa ggcctggcag agccggagcg aggctctcct acaccaggtg
     1801 gctcgtcaca ctgccctgct ccaacagctc aatggcacgg tagctgaagt ccaggggcag
     1861 ctggcagaag ggacaggcag ctcactgcaa ggggagatca ctctcttgaa agtcaacctg
     1921 aactcagtga gcaagtcact cacgggcctc agcgactctg tcagccagta ctctgatgcc
     1981 ttctcggctg ccaacacatc cctggatgaa cgagaacgaa gagtggaagc cgaggtccac
     2041 accatccagg aacagatcag cagccagggc tcacggcttc aggctggcca caggcaggtc
     2101 ctgaacctgc gaggggagct ggagcaactc aaggctggca tggccaatgt ggctagaggg
     2161 ttgagccgct gccgggacac agcccaggaa ctccagcata cagtgggcca ctttgaccag
     2221 agggtggccc aagtggaagg agcatgtgag aggttgggcc tgttggcaac ccacctgaac
     2281 agtctgccta ctgagcagct gaggtccagg gagggcctgt ggggccacat agacaagctg
     2341 aaccacacat tggcccagca cacgcaggat atcgcccggc tccgggatga cctgttggac
     2401 tgcagagctc agctggctga ggtgaggcca gggcgagctg actaggatcg atgcacagaa
     2461 agcgaaagtg cagatcccac caaccctggg aatatcatcc cagagatcaa ctctacctgg
     2521 aaacaccttc cagccctccc tgactgtttc agccatcaaa agtcaccctc agagctgcag
     2581 cctggacaat tcagggtaac agtcaaggtg agctacacgg gatgctgtct caagagtcaa
     2641 ggcaaggacg ccatgcccga acccaaagct gggcttctga gatggcacgc tgcatcgtct
     2701 gcgcgtcctc ttatttgcag acacactgga gttagcaact gtgcagtttc ctgaccaagt
     2761 ctcagacaag cttgcccact gttcccttta ctaaccaggg accagtcaca gcactcgggg
     2821 ggtggggagg tggggcatct cttcctttgt ccctgagctt ctagccttag atactggatg
     2881 aggtttctac aggaagatga tgcccactgg acctctctgg cagtttcata ggtgctattt
     2941 ctgaactaaa gaccagaggc cacctgaggt ttccagctcc ccacacatcc ttcagaacag
     3001 aacaaaagcc cagcggccca gccaagagcg ctccatattc cttttgatct tgcctcgtga
     3061 tgagggtgca ggcagctgta gaatcccaaa gaagggatcc aaacaatgtt tgaagacccc
     3121 accccaattt atcttttttc tttgatttca caaatacacc cacccacacg gtcctctctc
     3181 cagttagagg aaaatctctc ccacccacta tggtcagtac cgcttgccaa gggcagcctt
     3241 agagtatgct gaggcagacc ccaggaaagg ggctggcact gaatgaaaag gaagctaagc
     3301 ttttaaacgt ccacgcaaaa ccccagcctc gcaaggaact tcacaaactg gagagaagct
     3361 ggggtggaag ccattgagga aaacacatgt gtttagagag agactgacca tttctgctga
     3421 ggctcctggc ctcagtttcc cccaatgcac cctgggcctg ccgtgctgtt tgtctctccc
     3481 actgccctgc attcagtgtt tgccctccac tctgatgtgg attggaaaac aggctaagga
     3541 ttaaaccttt taaccggtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
