LOCUS       NM_145158               3967 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus elastin microfibril interfacer 2 (Emilin2), transcript
            variant 1, mRNA.
ACCESSION   NM_145158
VERSION     NM_145158.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3967)
  AUTHORS   Fejza,A., Camicia,L., Carobolante,G., Poletto,E., Paulitti,A.,
            Schinello,G., Di Siena,E., Cannizzaro,R., Iozzo,R.V.,
            Baldassarre,G., Andreuzzi,E., Spessotto,P. and Mongiat,M.
  TITLE     Emilin2 fosters vascular stability by promoting pericyte
            recruitment
  JOURNAL   Matrix Biol 122, 18-32 (2023)
   PUBMED   37579864
  REMARK    GeneRIF: Emilin2 fosters vascular stability by promoting pericyte
            recruitment.
REFERENCE   3  (bases 1 to 3967)
  AUTHORS   Rose,K.P., Manilla,G., Milon,B., Zalzman,O., Song,Y., Coate,T.M.
            and Hertzano,R.
  TITLE     Spatially distinct otic mesenchyme cells show molecular and
            functional heterogeneity patterns before hearing onset
  JOURNAL   iScience 26 (10), 107769 (2023)
   PUBMED   37720106
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3967)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (bases 1 to 3967)
  AUTHORS   Da Ros,F., Persano,L., Bizzotto,D., Michieli,M., Braghetta,P.,
            Mazzucato,M. and Bonaldo,P.
  TITLE     Emilin-2 is a component of bone marrow extracellular matrix
            regulating mesenchymal stem cell differentiation and hematopoietic
            progenitors
  JOURNAL   Stem Cell Res Ther 13 (1), 2 (2022)
   PUBMED   35012633
  REMARK    GeneRIF: Emilin-2 is a component of bone marrow extracellular
            matrix regulating mesenchymal stem cell differentiation and
            hematopoietic progenitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3967)
  AUTHORS   Sa,Q., Hart,E., Nadeau,J.H. and Hoover-Plow,J.L.
  TITLE     Mouse chromosome 17 candidate modifier genes for thrombosis
  JOURNAL   Mamm Genome 21 (7-8), 337-349 (2010)
   PUBMED   20700597
REFERENCE   7  (bases 1 to 3967)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 3967)
  AUTHORS   Braghetta,P., Ferrari,A., De Gemmis,P., Zanetti,M., Volpin,D.,
            Bonaldo,P. and Bressan,G.M.
  TITLE     Overlapping, complementary and site-specific expression pattern of
            genes of the EMILIN/Multimerin family
  JOURNAL   Matrix Biol 22 (7), 549-556 (2004)
   PUBMED   14996434
REFERENCE   9  (bases 1 to 3967)
  AUTHORS   Amma,L.L., Goodyear,R., Faris,J.S., Jones,I., Ng,L., Richardson,G.
            and Forrest,D.
  TITLE     An emilin family extracellular matrix protein identified in the
            cochlear basilar membrane
  JOURNAL   Mol Cell Neurosci 23 (3), 460-472 (2003)
   PUBMED   12837629
  REMARK    GeneRIF: cochlear emilin-2 mRNA is expressed in the tympanic border
            cells and an antibody detected protein in the extracellular matrix
            surrounding the collagenous fibers in the cochlear basilar membrane
REFERENCE   10 (bases 1 to 3967)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY232991.1, AK155909.1 and BY582438.1.
            
            [WARNING] On Jul 10, 2024 this sequence was replaced by
            NM_145158.5.
            
            On Oct 26, 2017 this sequence version replaced NM_145158.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155918.1, AK171015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY232991.1         3-48
            47-3956             AK155909.1         1-3910
            3957-3967           BY582438.1         332-342
FEATURES             Location/Qualifiers
     source          1..3967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..3967
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /note="elastin microfibril interfacer 2"
                     /db_xref="GeneID:246707"
                     /db_xref="MGI:MGI:2389136"
     exon            1..294
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3376
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; elastin microfibril interface located protein
                     2; EMILIN-2; basilin"
                     /codon_start=1
                     /product="EMILIN-2 isoform 1 precursor"
                     /protein_id="NP_660140.1"
                     /db_xref="CCDS:CCDS37686.1"
                     /db_xref="GeneID:246707"
                     /db_xref="MGI:MGI:2389136"
                     /translation="MCQETPPRPRAPSRWTPALLALLALGGAGLCHASSQPGYHARPS
                     ARNKNWCAYIVNKNVSCTVQEGSESFIQAQYNCPWNQMPCPSALVYRVNFRPRFVTRY
                     KIVTQLEWRCCPGFRGPDCQEGPKDHMKTPRPPSARPKNNLKKATDTDPSQVSQPKKT
                     LSPTNAVEPGQVADAKQGPPELQQSKVQVLEEKVVRLTRMVLDLQSTVVGLKENLKHT
                     IQDDGRKEPDSWLGPLHPQPTPDSPLAGDAEPSQLPGIPSSKESGMKDIKSELAEVKD
                     TLKTKSDKLEELDGKVKGYEGQLKQLQEAAQGPTVTMTTNELYQAYVDSKIDALREEL
                     MEGMDRKLADLKNTCEYKLVGLQQQCDDYGSSYLGVIELIGEKEASLKKDIADLRAQL
                     QDPVAQPSCCNGQKSSDFGPQIKALDQKIERVAEATRMLNGRLDNEFDRLSVPEPDAD
                     FDARWTELDARINVTEKNAEEHCFYIEETLRGTINGEVDDLRKLLNEKIHSLEDRLGI
                     VLQAANSSDVELTPMGPALPEQPGAENEQVLMELSRLKDKVQVVEDFCLQSLPHGIDG
                     ALPSVEDLTHVSLSLLESLNDTMHRQFQETSHSIQKLQEDVNALHSQLNHSECTGTYL
                     QNGVSDSRTGDSMEASGFTKTGEQERTVGTVPSPGTPAAPCCGQLEERWQKLQNQMLA
                     ELDTCKESAHGVQSGVSAIEGRVFQLEQTCRRLDTISGSLQRIKEGLGKHVGSLWNCI
                     RQMNGTLKSHSRDISGLKNSVQQFYSHVFQISTDLQDLVKFQPSATEEPSEATEGPSG
                     KTPLESTRPSEEAPTEPPRLTPLPEDPAGPPQTGQQPVLPQRPLQPPPLPAWPGRTGL
                     PFLPGSSGVIMETGEAGPPGRMGVSGRGLPRGVDGQMGQGPIHSSEGYAGAPGYPKSP
                     PVTTPGVPLPTLVSFSAGLTQKPFPSDGGVVLFNKVLVNDGDVYNPNTGIFTAPYDGR
                     YLITATLTPERDTYVEAVLSVSNASVAQLHTAGYRREFLEYHRPPGAVHTCGGPGAFH
                     LIVHLKAGDGVNVVVTGGRLAHTDFDEMYSTFSGVFLYPFLSHL"
     exon            295..417
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            418..593
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            594..2507
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2876
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2909
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3038
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3960
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3939..3944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /note="hexamer: AATAAA"
     polyA_site      3960
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcacc cggggggacc tgtgcgtcat tgagggaccg cggagcggcc agtgcggagg
       61 cgtggggacg aagagccaga ggggccgccg agcgcccgag cccgctgccg gttcccgcgg
      121 ccccgccgcc tgcagccttg tggggctcaa gatgtgtcag gagaccccgc cccgaccccg
      181 agcacccagt cgctggacgc cggccctgct ggccctgctg gccctgggcg gcgcgggact
      241 gtgccacgcg agctcgcagc ctgggtacca cgcgaggccc agtgccagga acaaaaactg
      301 gtgcgcctac atcgtgaata agaacgtgag ctgcacggta caggagggaa gcgagagttt
      361 tattcaagct cagtacaact gtccctggaa ccagatgccc tgtccatccg ccctggtgta
      421 tcgggtaaac tttagaccca gatttgtcac tagatacaag atagtgacac agttggaatg
      481 gagatgctgt cctggcttta gaggaccaga ctgccaagaa ggtcccaaag accacatgaa
      541 gaccccccgg cccccatcag ctcgaccaaa aaacaacctg aagaaagcca cagatacaga
      601 tccaagccaa gtttctcagc ctaagaaaac gttgtcccca acaaatgcag tggaaccagg
      661 tcaggttgca gatgcaaagc aaggccctcc ggaacttcag caatccaaag tccaggtgct
      721 ggaggagaag gtcgtccgac tcaccaggat ggtgctggat ctccagtcca ccgtggtagg
      781 cctgaaggag aacctcaaac acaccattca agatgatggc agaaaagagc cagactcctg
      841 gctcggtccc ctgcacccac agccaacgcc tgacagcccc cttgcggggg acgcagagcc
      901 gagccagctt cccggaatcc ccagcagcaa ggaatctggt atgaaggaca tcaagtctga
      961 gttggctgag gtcaaagaca cactgaagac caagagtgac aagctagaag agctggacgg
     1021 gaaggtgaag ggctatgaag gacagctcaa gcagctgcag gaggcggctc agggtcccac
     1081 ggtcaccatg acaaccaatg agctgtacca agcctatgtg gatagcaaga tcgatgccct
     1141 gagggaggag ctcatggaag gcatggaccg gaagctggct gacctgaaga atacgtgcga
     1201 gtacaagctg gtggggctcc agcagcagtg tgatgactac ggcagcagct acctcggagt
     1261 gatagagctg atcggggaga aggaggcgag cctgaaaaaa gacattgctg acctgcgagc
     1321 ccagctgcag gatcctgtag cccaaccaag ctgttgcaat ggtcaaaaga gcagcgattt
     1381 cggcccacag atcaaggcgc tagaccagaa aatcgagaga gttgccgagg ccaccaggat
     1441 gctgaatgga cggctggaca atgagttcga ccgcctctcc gttccagagc cagacgcaga
     1501 ctttgatgcg agatggaccg agctcgacgc aaggatcaat gtgacggaga agaacgcaga
     1561 ggagcattgc ttttacattg aggagaccct gcgggggacc atcaacggcg aagtggatga
     1621 cttgaggaag cttctgaatg agaagatcca ctccctggaa gaccgtctgg gaattgttct
     1681 gcaagcggct aacagctcag acgtggagtt gacacccatg ggcccagcct tgccagagca
     1741 gccaggggca gagaatgagc aggtcctaat ggagttgagc cgcctgaagg acaaagttca
     1801 agtggttgag gacttctgcc tgcagagctt gccccacggg atagatggag ctttgcctag
     1861 tgtagaggac ctcacgcatg tcagcctgag ccttttagaa tccctcaatg atacgatgca
     1921 caggcagttc caagaaacga gtcacagcat ccagaaactc caagaggacg tcaatgccct
     1981 ccattctcaa ctgaatcact ccgaatgtac ggggacttac ttgcagaacg gagtgagcga
     2041 cagccgaaca ggtgacagca tggaagcaag tgggtttact aagacagggg agcaagagag
     2101 gacagtgggg actgtcccgt ctcctgggac ccccgcggct ccatgctgtg gtcagctgga
     2161 ggagcgctgg cagaagctgc agaaccaaat gttggctgag ctagacacgt gtaaggagag
     2221 tgctcacggg gttcagagtg gggtgtctgc gatcgagggc agggtgttcc agctggagca
     2281 gacatgcaga aggctggata ccatctcagg gagtctgcag aggatcaagg aggggctcgg
     2341 taagcatgtg ggcagcttgt ggaactgcat ccggcagatg aacgggacgc tcaaatcgca
     2401 ctccagagac atctctggcc tcaagaattc tgtgcagcaa ttctatagcc atgttttcca
     2461 gatttctacc gacttgcaag atctggtcaa gtttcagcca tcagcaacag aggaaccctc
     2521 agaagcaacc gagggaccgt ctgggaagac tcccctagaa tccaccagac cttcagagga
     2581 ggcccccact gaaccacccc ggctgacccc actgccagaa gaccctgcag gaccaccaca
     2641 gacaggccag cagccagtat tgccccagag gcccctgcag ccaccacctt tgcctgcctg
     2701 gcctggtcgc acggggttgc ccttcttgcc tggctctagt ggcgtcatca tggagactgg
     2761 agaggcgggg cctccaggca ggatgggcgt gtccggaagg ggcctgcctc ggggagtgga
     2821 tggccagatg gggcaggggc ccattcatag ctcggaaggc tatgcagggg caccaggcta
     2881 ccccaagtca cctcctgtaa ccaccccagg ggtgccgctg cccactctgg tgtccttttc
     2941 agccggtctt acccagaagc cttttcccag cgatggaggc gttgttctct tcaataaggt
     3001 gctggtgaac gatggggatg tatacaaccc caacactggg atcttcaccg caccatacga
     3061 cgggcgctac ttgatcacag ccaccctcac ccctgagaga gacacctatg tggaagccgt
     3121 cctgtctgtc tccaacgcca gtgttgccca gctgcacacg gctgggtaca ggagagagtt
     3181 cctggaatac catcgtcccc ctggggctgt gcatacctgt gggggcccgg gggccttcca
     3241 cctcattgtg cacttgaagg caggagatgg agtcaatgtt gtggtgactg ggggcagact
     3301 ggctcacaca gactttgatg aaatgtactc caccttcagt ggtgttttct tgtacccttt
     3361 cctttctcac ctctagggag accaggaagg gaagaaaggc tgtgaaaact ccaaagcttt
     3421 aatatatttg gtttatgtaa ctggagcact gatctagctt gctgcacaca ctctgcctgc
     3481 ccccaggata aaagcctgcc atccctcgtt tccagacagc tgtggaagtg acacatggtt
     3541 acttctgtca ctggacaacc agaagactcg ttatgtcccc ttggctggaa gctggcttct
     3601 cctgtgccgc ctataagcca gctctgctcg aagttcttgg gttgaatcta cttggtgctg
     3661 ttccgactgg cctgggcctg atgcagctgg aagacactgt agcggatgcg cctctctaca
     3721 ctgcacgtag aagatttaaa cactgaagtg cttatgtggc ctggacccag agagtttaac
     3781 atgggctgtt gttccacact tggttgctgt taccgtctgg tactgatctc tgttcccctg
     3841 ggccctgcta ccaaggtgga tgtgagagac attatttatg aaacttgcca ggctccttaa
     3901 atgacatgta caatataagt gcaaagacag ggagcgtcaa taaagatgtt ggaatcacta
     3961 aaaaaaa
//
