LOCUS       NP_660140               1074 aa            linear   ROD 05-MAY-2025
DEFINITION  EMILIN-2 isoform 1 precursor [Mus musculus].
ACCESSION   NP_660140
VERSION     NP_660140.1
DBSOURCE    REFSEQ: accession NM_145158.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1074)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1074)
  AUTHORS   Fejza,A., Camicia,L., Carobolante,G., Poletto,E., Paulitti,A.,
            Schinello,G., Di Siena,E., Cannizzaro,R., Iozzo,R.V.,
            Baldassarre,G., Andreuzzi,E., Spessotto,P. and Mongiat,M.
  TITLE     Emilin2 fosters vascular stability by promoting pericyte
            recruitment
  JOURNAL   Matrix Biol 122, 18-32 (2023)
   PUBMED   37579864
  REMARK    GeneRIF: Emilin2 fosters vascular stability by promoting pericyte
            recruitment.
REFERENCE   3  (residues 1 to 1074)
  AUTHORS   Rose,K.P., Manilla,G., Milon,B., Zalzman,O., Song,Y., Coate,T.M.
            and Hertzano,R.
  TITLE     Spatially distinct otic mesenchyme cells show molecular and
            functional heterogeneity patterns before hearing onset
  JOURNAL   iScience 26 (10), 107769 (2023)
   PUBMED   37720106
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1074)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (residues 1 to 1074)
  AUTHORS   Da Ros,F., Persano,L., Bizzotto,D., Michieli,M., Braghetta,P.,
            Mazzucato,M. and Bonaldo,P.
  TITLE     Emilin-2 is a component of bone marrow extracellular matrix
            regulating mesenchymal stem cell differentiation and hematopoietic
            progenitors
  JOURNAL   Stem Cell Res Ther 13 (1), 2 (2022)
   PUBMED   35012633
  REMARK    GeneRIF: Emilin-2 is a component of bone marrow extracellular
            matrix regulating mesenchymal stem cell differentiation and
            hematopoietic progenitors.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1074)
  AUTHORS   Sa,Q., Hart,E., Nadeau,J.H. and Hoover-Plow,J.L.
  TITLE     Mouse chromosome 17 candidate modifier genes for thrombosis
  JOURNAL   Mamm Genome 21 (7-8), 337-349 (2010)
   PUBMED   20700597
REFERENCE   7  (residues 1 to 1074)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (residues 1 to 1074)
  AUTHORS   Braghetta,P., Ferrari,A., De Gemmis,P., Zanetti,M., Volpin,D.,
            Bonaldo,P. and Bressan,G.M.
  TITLE     Overlapping, complementary and site-specific expression pattern of
            genes of the EMILIN/Multimerin family
  JOURNAL   Matrix Biol 22 (7), 549-556 (2004)
   PUBMED   14996434
REFERENCE   9  (residues 1 to 1074)
  AUTHORS   Amma,L.L., Goodyear,R., Faris,J.S., Jones,I., Ng,L., Richardson,G.
            and Forrest,D.
  TITLE     An emilin family extracellular matrix protein identified in the
            cochlear basilar membrane
  JOURNAL   Mol Cell Neurosci 23 (3), 460-472 (2003)
   PUBMED   12837629
  REMARK    GeneRIF: cochlear emilin-2 mRNA is expressed in the tympanic border
            cells and an antibody detected protein in the extracellular matrix
            surrounding the collagenous fibers in the cochlear basilar membrane
REFERENCE   10 (residues 1 to 1074)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126942.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171309.1, AK155878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     Protein         1..1074
                     /product="EMILIN-2 isoform 1 precursor"
                     /note="elastin microfibril interface located protein 2;
                     EMILIN-2; basilin"
                     /calculated_mol_wt=113873
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3456
     mat_peptide     34..1074
                     /product="EMILIN-2. /id=PRO_0000007818"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
                     /calculated_mol_wt=113873
     Region          48..118
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Site            58
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          121..184
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          219..264
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          264..581
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          265..>393
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Site            463
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Site            514
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Site            586
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Site            615
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          627..661
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
     Site            636
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Site            744
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          <780..>924
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          783..865
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          851..911
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          893..917
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K482.1)"
     Region          929..1067
                     /region_name="C1q"
                     /note="C1q domain; cl23878"
                     /db_xref="CDD:420072"
     Site            995
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K482.1)"
     CDS             1..1074
                     /gene="Emilin2"
                     /gene_synonym="FOAP-10"
                     /coded_by="NM_145158.5:102..3326"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS37686.1"
                     /db_xref="GeneID:246707"
                     /db_xref="MGI:MGI:2389136"
ORIGIN      
        1 mcqetpprpr apsrwtpall allalggagl chassqpgyh arpsarnknw cayivnknvs
       61 ctvqegsesf iqaqyncpwn qmpcpsalvy rvnfrprfvt rykivtqlew rccpgfrgpd
      121 cqegpkdhmk tprppsarpk nnlkkatdtd psqvsqpkkt lsptnavepg qvadakqgpp
      181 elqqskvqvl eekvvrltrm vldlqstvvg lkenlkhtiq ddgrkepdsw lgplhpqptp
      241 dsplagdaep sqlpgipssk esgmkdikse laevkdtlkt ksdkleeldg kvkgyegqlk
      301 qlqeaaqgpt vtmttnelyq ayvdskidal reelmegmdr kladlkntce yklvglqqqc
      361 ddygssylgv ieligekeas lkkdiadlra qlqdpvaqps ccngqkssdf gpqikaldqk
      421 iervaeatrm lngrldnefd rlsvpepdad fdarwtelda rinvteknae ehcfyieetl
      481 rgtingevdd lrkllnekih sledrlgivl qaanssdvel tpmgpalpeq pgaeneqvlm
      541 elsrlkdkvq vvedfclqsl phgidgalps vedlthvsls lleslndtmh rqfqetshsi
      601 qklqedvnal hsqlnhsect gtylqngvsd srtgdsmeas gftktgeqer tvgtvpspgt
      661 paapccgqle erwqklqnqm laeldtckes ahgvqsgvsa iegrvfqleq tcrrldtisg
      721 slqrikeglg khvgslwnci rqmngtlksh srdisglkns vqqfyshvfq istdlqdlvk
      781 fqpsateeps eategpsgkt plestrpsee aptepprltp lpedpagppq tgqqpvlpqr
      841 plqppplpaw pgrtglpflp gssgvimetg eagppgrmgv sgrglprgvd gqmgqgpihs
      901 segyagapgy pksppvttpg vplptlvsfs agltqkpfps dggvvlfnkv lvndgdvynp
      961 ntgiftapyd grylitatlt perdtyveav lsvsnasvaq lhtagyrref leyhrppgav
     1021 htcggpgafh livhlkagdg vnvvvtggrl ahtdfdemys tfsgvflypf lshl
//
