LOCUS       NM_001163102            1521 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus essential meiotic structure-specific endonuclease
            subunit 2 (Eme2), mRNA.
ACCESSION   NM_001163102
VERSION     NM_001163102.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Cajigas,I., Chakraborty,A., Swyter,K.R., Luo,H., Bastidas,M.,
            Nigro,M., Morris,E.R., Chen,S., VanGompel,M.J.W., Leib,D.,
            Kohtz,S.J., Martina,M., Koh,S., Ay,F. and Kohtz,J.D.
  TITLE     The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially
            Organizes Megabase Distant Genes in the Developing Forebrain
  JOURNAL   Mol Cell 71 (6), 956-972 (2018)
   PUBMED   30146317
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   Ciccia,A., Ling,C., Coulthard,R., Yan,Z., Xue,Y., Meetei,A.R.,
            Laghmani el,H., Joenje,H., McDonald,N., de Winter,J.P., Wang,W. and
            West,S.C.
  TITLE     Identification of FAAP24, a Fanconi anemia core complex protein
            that interacts with FANCM
  JOURNAL   Mol Cell 25 (3), 331-343 (2007)
   PUBMED   17289582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148623.1 and BC092228.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092228.1, SRR5189673.94250.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY148623.1         2-43
            43-1521             BC092228.1         1-1479
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1521
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /note="essential meiotic structure-specific endonuclease
                     subunit 2"
                     /db_xref="GeneID:193838"
                     /db_xref="MGI:MGI:1919889"
     exon            1..267
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1160
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /note="essential meiotic endonuclease 1 homolog 2"
                     /codon_start=1
                     /product="probable crossover junction endonuclease EME2"
                     /protein_id="NP_001156574.1"
                     /db_xref="CCDS:CCDS50023.1"
                     /db_xref="GeneID:193838"
                     /db_xref="MGI:MGI:1919889"
                     /translation="MAEVGPGRVTVSRLGRGLRLGHRRPQTWEISDSDGEGVPAREVG
                     TQAPSPAGERRAAAKALRADQVLGRLVVCVDPAVLEDAGSDILMEALGTLGCECRIEP
                     QHQARSLQWNVVRPDPAPSNVPLEAKAENEQEQLLLLEPQEFLQGAAQLTQITDPPCS
                     IPWLSPKSLTRSHLAVIGLDAYLWSHQLSSQKTWQLKKSKEAHARGAISWAEVEEILV
                     LLQLHANLDVLLMASWQELSQYVCAFTRALSQLPSKQHRDSQAFSFCTAGHWASGQQV
                     TRDGSGLRGVWWRQIRQFNRVSPAVADAVVTAFPSPRLLQQALLDCSTEQERLSLLAD
                     LPVKAHKGKQPRRVGPDLSRRICIFLTTTNPDLLLDLSS"
     exon            268..404
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            405..497
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..589
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            590..683
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..799
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..989
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1521
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /note="hexamer: GATAAA"
     polyA_site      1521
                     /gene="Eme2"
                     /gene_synonym="2810013J18Rik"
                     /note="major polyA site"
ORIGIN      
        1 atccgggtac gtccggaagc ttcaggaacg aaggacttat ggcggaggtt ggtcccggga
       61 gagtcacggt ctcgcgtctc ggtcggggcc tgcgtctcgg ccatcggcga cctcaaacct
      121 gggagatttc cgactcagac ggtgaaggtg tccccgctag ggaggtcggc acgcaagccc
      181 cgagtccagc aggagagcgc agagctgcag ccaaggcttt acgggcagat caggttctgg
      241 ggcgactggt ggtgtgcgtg gacccagctg tcctggaaga tgcaggctct gacatcctga
      301 tggaggcgct gggcacgcta ggctgtgaat gccgcatcga accgcagcac caggcccgca
      361 gcctgcagtg gaacgttgtc aggcccgacc cggcccccag caatgtgcct ctggaggcga
      421 aggctgaaaa tgagcaggaa cagttgctgc tgctggaacc ccaggaattt cttcagggtg
      481 ctgcgcagct gacccagatc acagatccac cttgctccat cccctggctt tctcccaaga
      541 gtctcacccg ctcccatctg gctgtcattg gactggacgc atacctgtgg tctcaccagc
      601 tcagttctca gaagacatgg caactaaaga agtcaaagga agcccatgcc aggggagcca
      661 tcagctgggc tgaggtggag gagatcctgg tgctgctgca gctccatgca aacctggatg
      721 tgctgctgat ggcttcgtgg caggagctga gtcagtacgt gtgtgccttc accagggccc
      781 tctcgcagct cccctcgaag cagcaccggg actcccaggc cttttctttc tgcacagcag
      841 ggcactgggc ctcaggccag caagtgacca gagatggctc tgggctcaga ggagtgtggt
      901 ggcgacaaat cagacagttc aaccgggtca gcccagctgt ggctgacgct gttgttactg
      961 ccttcccatc accccgcctt ttgcaacagg ctctcctgga ctgcagcaca gagcaagaac
     1021 gcctgagcct cctagctgat ctccctgtga aggcccacaa aggcaagcag cctcgcagag
     1081 tggggcctga cctctcacgc agaatctgta tcttcttgac aaccaccaac cctgacctcc
     1141 tgctggacct gagctcttga cctgtgccat cctggggtca cctcctgccc atcagtacaa
     1201 caggacaagt ctgcctaaga atctaattat tctgagaggc aggcaaggag gtttgggtcc
     1261 agcccatacc ttttcagact gtggtagata gactctgttg cctgatggtc aaatggaaat
     1321 accatgggag gtgggtgaga gggtaaggga agctgaggtg aatggaagag tggagggtag
     1381 tggccacttg gtgcaggagg cttagtagta ggcctgagtg ctgagttgta ctattacatc
     1441 ctcagagaga ggtgctcaga gatccaagcc aagctctctc aaagccgctg gacagagaca
     1501 gataaacaat agacacaggc a
//
