LOCUS       NM_010926               4908 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ER membrane protein complex subunit 8 (Emc8), mRNA.
ACCESSION   NM_010926 XM_489534
VERSION     NM_010926.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4908)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4908)
  AUTHORS   Guna,A., Volkmar,N., Christianson,J.C. and Hegde,R.S.
  TITLE     The ER membrane protein complex is a transmembrane domain insertase
  JOURNAL   Science 359 (6374), 470-473 (2018)
   PUBMED   29242231
REFERENCE   3  (bases 1 to 4908)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4908)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 4908)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 4908)
  AUTHORS   Bachman,N.J., Wu,W., Schmidt,T.R., Grossman,L.I. and Lomax,M.I.
  TITLE     The 5' region of the COX4 gene contains a novel overlapping gene,
            NOC4
  JOURNAL   Mamm Genome 10 (5), 506-512 (1999)
   PUBMED   10337626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103360.9.
            
            On Feb 5, 2019 this sequence version replaced NM_010926.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164130.1, AK143131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AC103360.9         32627-32957
            332-408             AC103360.9         39854-39930
            409-478             AC103360.9         41640-41709
            479-573             AC103360.9         42092-42186
            574-4908            AC103360.9         42466-46800
FEATURES             Location/Qualifiers
     source          1..4908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 69.98 cM"
     gene            1..4908
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /note="ER membrane protein complex subunit 8"
                     /db_xref="GeneID:18117"
                     /db_xref="MGI:MGI:1343095"
     exon            1..331
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..408
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /inference="alignment:Splign:2.1.0"
     exon            409..478
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..4908
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /note="hexamer: ATTAAA"
     polyA_site      990
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /note="major polyA site"
     regulatory      4050..4055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
                     /note="hexamer: AATAAA"
     polyA_site      4085
                     /gene="Emc8"
                     /gene_synonym="Cox4nb; Fam158b; Noc4"
ORIGIN      
        1 agacgttttc cggccgaccg gctgaggcgg gaggccgcgg ccggaggtgc gagagcgtca
       61 cggcgtgcag cggagggtcg tggcggagga ccgcggtgcg tgggtcgcga tgcccggcgt
      121 gaagctgact acgcaggcct actgcaagat ggtgctccac ggcgccaagt acccgcactg
      181 cgccgtcaac gggctcctgg tggccgagag gcagaggccg cgcaaggagc atcctcccgg
      241 agcgggcagc cacacgctct tcgtggactg catcccgctc ttccacggca cgctggctct
      301 gacgcccatg ctggaggtgg cgctcaccct gattgactcg tggtgcaaag acaacagcta
      361 tgtgatcgct ggctattacc aagctaatga gcgtgtgaag gatgccagcc caaaccaggt
      421 ggcagaaaag gtggcctcca ggatcgcaga gggcttcggt gatgccgcac tcatcatggt
      481 ggacaatgcc aagttcacga tggactgcgc agcgcccacg atccacgtgt acgagcagca
      541 cgagaacagg tggcggtgca gagacccaca ccacgactac tgtgaagatt ggccggaggc
      601 acagaggatc tcagcttcac tcctggacag ccgctcctac gaaacactcg tggattttga
      661 taatcatctg gacgacattc ggagcgactg gacaaacccg gagatcaaca aagcagttct
      721 gcacctgtgc tagacaagga ccacactaca gcgaagacgg aagcatattt ttacatttat
      781 agaggaatag taggttagcc ggaagggaag ctgcaagtgt gccttggagg gggtgcggtc
      841 ggcatccttc agggcggggc tgtggagaac tgtgggtcgc ctaggctttg gtttcttagt
      901 cctgtactgc ccgatcccgc ccgtcagctc tttctgcttg tgccaggtca ttcccattaa
      961 acagttctat ctagcctttt gtaatcctga gaagtgtaca cggtgtacct tactctttac
     1021 tctggtgagt gtgtggggct tctcagccta agcccgcgcc aggcatcctg aaatactggg
     1081 gcagccagca tctgagcagc caagcagatg tggggctgga gctgcactac ttcacaggcc
     1141 gcaccgtggg attagacagc actgttgcct gagaaacctc gctgcacagt gagcacagca
     1201 cactggtgac aagagcagag gtcccaagag aagccaaggc cacgaacatt cccaaagcca
     1261 gttcctcctg actccgctac tccacatctt cagagtgaga gctgctttgt gtttaaaatg
     1321 ggggggaggg gtgagcttaa ccccccacga tgtcccaagc agtgtccttg ttagcttgga
     1381 tcatttgacc atcttaggaa atagcatgca ggctctttgg tacattgtac attgtccttt
     1441 gtgaatgctc tacagggaga accgtgccat ttcttgggct tcgtgaagct gctaacagcg
     1501 ttccctgtgt tcttactaag tggggaagcc agggtctcct tagtgagtgg actctgagtg
     1561 tgctttctgc cctgtattcg acattttgct cttgtctttt gtttgctggt tggcttttgt
     1621 tgttgtttgg aggaagtgtt tagttttgtt tggttaagaa tatcccttta tgatcgtgct
     1681 tggcgtggtg ttcactagga aggagcctgg ccttggccag gcagtggtcc ctcagccttt
     1741 gcttcttaag tacgttgatc cccacccctc caacacccct gagccttcta aactgacttc
     1801 ctctgtgtgg gaacacagga cctgttctga aaaaaactaa cttgtcaaag cactcttgcc
     1861 tagctttgac tcctgccttg tgttcaggga ggctgctcta cagtgtggct agcaagtggt
     1921 cctaatggag cagaacccag ggcctcgccc aggagaaacc acctatactc gggcggacct
     1981 tgtaacctct ctccagcacc tgccctttgt cctggttata tttctgttgc tctgatgagg
     2041 caccaaaact actgtggaga gggaatggtt catttcacct tataactcag atggaagggg
     2101 aggcggctgg aggcaggaac tgaagcagag gtcacagagg ggctgcttac tgtcctgatc
     2161 tccatggcct gttcagccgg cttccttatg taactcagga ccacagtcaa gggcaacagt
     2221 tccttaattg atagtccctc ttctttgtgt caagttggca aaaactaact agcattgtat
     2281 tagggctctc agactgacag aatggggaga aggggatgac agcatttatt agtcacaggc
     2341 tgtggtccaa ttatcccagc aacagctgtc tcccattggg tagtccaaga tttccctgtt
     2401 gagtctgcaa gtccctgtct cagctggtct taagtatatg cacagcgtat atgcacagcg
     2461 tgggctccag tgcagtggtg ttagagggat ggagttgcca gtgagcaagg gtgagcaggc
     2521 atgggtgagc agaaggtgtg gccaggctca agctggggtt ttccaactcg gatccagtca
     2581 agaaaaatcc ctcacaggtg tgcccagcag cttggggtgt agttagttaa ttccatataa
     2641 tgtaatatag tgattccaag tcgtacagtc aagttaacga ccaagaatag ctatcacaga
     2701 cgtcattatt aagccatagc ctttcttgtt tatctcccaa cttgcttctg gtcagtgttt
     2761 agcccaacaa tagaaactaa actaggactt cattaacaag tgcgcatgca gtacaaactc
     2821 aaatacaaac tttttaaaca ttccaaaaaa ctaggatttt gaaggtcagg attttgaagg
     2881 tcccaccata aagcaataat gaagagagag actgtctagc cagctttaaa atcgcggtgt
     2941 ctgtgtatca ctttaaaaac atttaatgag ctgggtggtg gtggcgcatg cctttaatcc
     3001 tagcacttgg gaggcagagg caggtgaatt tctgagttag aggtcagcct ggtctacata
     3061 gtgaattcca ggacagccgg ggctatacag agaaaccctg tctcgaaaaa accgggaaaa
     3121 aaaaaaacca tttaatgaat tttccactta atttttgttt tgtagccttg gctggtctag
     3181 aacttggtgt gtagaccagg cctcctgggc ctgggattca agcagctttt cacttctagg
     3241 attgcctttc atgatggggg ctagagagcc ggctcagcgg ttgagagagc ttgctgctct
     3301 tgcaaggtca aattcctgac tccaacatga cagctcacaa ctgtctgaac ccttcactgg
     3361 taccaggcac catggggtgc acagagagat acatgcaggc aaaaacaccc atacacgaag
     3421 aataaatcca agactttttt tttttaattg cctttaagaa ttaaggctac taagccaggc
     3481 ttggtgatac ttgcctttca tctcggcact ctagaagcag ggagatgttg ttcagttcgg
     3541 cttggtctac acagttccag gacagctggg gttatataga gagactctgc tgataagtaa
     3601 atatttaagg atactagcca agcatggtgg catataccaa tgatcctagc gctcaggctg
     3661 agacagtaga attgccacaa gtgtggccag cctgggctac attgagtccc aagacaacct
     3721 gaggctagaa tgaggacctg tctcaaaaca acaggaaata ataccaaagg atactaatat
     3781 ggtaagacag gcaacagcct cttcgggaac caagtggaga gctgcttagg agaagctgat
     3841 tttgctaatt tgtgtggggt acttaggggt gtgtggggtg ctgaccagcc taagtgtgtg
     3901 tgcctggtgc ccgtggatta gaaagcagct tggaagtcct gggaaagtct gtacggccag
     3961 caggatggcc cagcagatga agccacctta agacccacat gtgagagtgc acaggtcctc
     4021 cacacgtgca ctgtgacgca cggttgataa ataaatgtta tttttgaaag cctctgtata
     4081 atcaacatca tgtattccag gagcttattt ttgatgtctg gagaaacctg ttgtttctgt
     4141 atgatacttc ccacttatct cgggttaggc gggaagctca atagcagggg tccggcaagc
     4201 tctaaggcga aggcatgaat taagtggctt ggtgggggca gggtgtgaga atatctgtgg
     4261 tgtgtgtttt ggggggccag ctgtgagagt atctggtgtg tgagtgtggt tgtgggggag
     4321 gttgtggtgc tagaggttga actaggacct catatatgtt cagtgaacac tataccctgt
     4381 gatatattca tcctcaggca ttgtgtgtgc ttgtgatctc ctcagcaaga cctgtgtcgt
     4441 ccatcacagc tgtttctgag agcgtccatc tccgaggctc tctgttatct gcccctggga
     4501 gggatctggg caattctgag ttggatgcaa tcttggaccc tcctaggttc cccaactagg
     4561 ccccttaagg gaaatggctt agaaacctgc caactgatgc caacagccac acacacacca
     4621 cagcagtcca gaatgggttg ggtgagcccc atttgctaca ctgtagttct gtggcccagg
     4681 gcatgtttct gtccacaacc ctccaataac acccactggc agggccatgc acagcaaaga
     4741 acatgctcac agtgggggta tattcaggtg atactgagaa agcttttaga tgctaattaa
     4801 catctagaat gtattgctgg ttcggtcaga tgcattctga gggcaccagg ccatgacaat
     4861 atgtatcgaa aggcaaagtg aataaaacat tcaactgctg gcacagct
//
