LOCUS       NM_133749               1072 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Mus musculus ER membrane protein complex subunit 7 (Emc7), mRNA.
ACCESSION   NM_133749
VERSION     NM_133749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Guna,A., Volkmar,N., Christianson,J.C. and Hegde,R.S.
  TITLE     The ER membrane protein complex is a transmembrane domain insertase
  JOURNAL   Science 359 (6374), 470-473 (2018)
   PUBMED   29242231
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Tang,X., Snowball,J.M., Xu,Y., Na,C.L., Weaver,T.E., Clair,G.,
            Kyle,J.E., Zink,E.M., Ansong,C., Wei,W., Huang,M., Lin,X. and
            Whitsett,J.A.
  TITLE     EMC3 coordinates surfactant protein and lipid homeostasis required
            for respiration
  JOURNAL   J Clin Invest 127 (12), 4314-4325 (2017)
   PUBMED   29083321
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   O'Brien,K.P., Tapia-Paez,I., Stahle-Backdahl,M., Kedra,D. and
            Dumanski,J.P.
  TITLE     Characterization of five novel human genes in the 11q13-q22 region
  JOURNAL   Biochem Biophys Res Commun 273 (1), 90-94 (2000)
   PUBMED   10873569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL683897.5 and
            AL731840.17.
            
            On Mar 21, 2007 this sequence version replaced NM_133749.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278128.1, BC080668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AL683897.5         175321-175596
            277-396             AL683897.5         179756-179875
            397-535             AL683897.5         183097-183235
            536-616             AL683897.5         185033-185113
            617-648             AL683897.5         187277-187308
            649-1072            AL731840.17        2001-2424
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.02 cM"
     gene            1..1072
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /note="ER membrane protein complex subunit 7"
                     /db_xref="GeneID:73024"
                     /db_xref="MGI:MGI:1920274"
     exon            1..276
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..769
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /note="UPF0480 protein C15orf24 homolog; endoplasmic
                     reticulum membrane protein complex subunit 7"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane protein complex
                     subunit 7 precursor"
                     /protein_id="NP_598510.1"
                     /db_xref="CCDS:CCDS16555.1"
                     /db_xref="GeneID:73024"
                     /db_xref="MGI:MGI:1920274"
                     /translation="MAGALWGFFSVLLLLLSGDAHSSEVPGAAAEGPGGSGVGLGDRF
                     KIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVISPAY
                     KFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFL
                     MNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFS
                     SKSSGKSSSGSSKTGKSGAGKRR"
     exon            277..396
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..535
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..616
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1072
                     /gene="Emc7"
                     /gene_synonym="2900064A13Rik; c11orf3; ORF3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggacttcc gggccgtagg cctgactcct cagagctgct gtcatggcgg gtgctctgtg
       61 gggtttcttc tccgtcctgc ttctgttatt atcaggagat gcccacagct cggaggtgcc
      121 tggggctgct gccgagggcc cgggaggtag tggggtcggc ctgggagatc gttttaagat
      181 cgagggacgt gcggttgttc cgggggtgaa gcctcaggac tggatctccg cggcccgagt
      241 gctggtagac ggagaagagc atgtcggctt ccttaagaca gatgggagct ttgtggttca
      301 tgatattccc tctggctctt atgtagtgga agttatttct cctgcttaca agtttgaccc
      361 tgtccgagtc gatatcactt caaaaggaaa aatgcgagca agatatgtga attacatcaa
      421 aacgtcagaa gtggtcagat taccctatcc tctccaaatg aaatcttcag gtccaccttc
      481 ttactttatt aagagggaat cgtggggctg gacagacttt ctgatgaacc caatggttat
      541 gatgatggtt ctcccgttat tgatatttgt gcttctgcct aaagtggtga acacaagtga
      601 tcctgacatg agacgggaga tggagcagtc aatgaacatg ttgaattcca accatgaatt
      661 gcctgatgtc tctgagttta tgaccagact cttctcttca aagtcctctg gcaaatctag
      721 tagtggcagc agtaaaacag gcaaaagcgg agctggcaaa aggaggtagt caggccaccg
      781 ctgccatggc acaaactggg ctaccccggg tggcatccga gtcttgatgg aaagccgtgt
      841 gaagtgacta ctgtaagcca agtcatcctg aggttgatct cgtgcaactg ttgtctctgt
      901 taacttctta acacatgttt tgtacttggt acacaagaaa aacccagctt tcatcctttg
      961 tatgaggtca atattaatgt cactgaatta attacagtgt cctatagaga atgacattaa
     1021 taaattatat gaagtactat acattatgta tattaaagaa atcttaatcc ag
//
