LOCUS       NM_175101               1958 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ER membrane protein complex subunit 3 (Emc3), mRNA.
ACCESSION   NM_175101
VERSION     NM_175101.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Tang,X., Wei,W., Snowball,J.M., Nakayasu,E.S., Bell,S.M.,
            Ansong,C., Lin,X. and Whitsett,J.A.
  TITLE     EMC3 regulates mesenchymal cell survival via control of the mitotic
            spindle assembly
  JOURNAL   iScience 26 (1), 105667 (2022)
   PUBMED   36624844
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Huang,M., Yang,L., Jiang,N., Dai,Q., Li,R., Zhou,Z., Zhao,B. and
            Lin,X.
  TITLE     Emc3 maintains intestinal homeostasis by preserving secretory
            lineages
  JOURNAL   Mucosal Immunol 14 (4), 873-886 (2021)
   PUBMED   33785873
  REMARK    GeneRIF: Emc3 maintains intestinal homeostasis by preserving
            secretory lineages.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Cao,X., An,J., Cao,Y., Lv,J., Wang,J., Ding,Y., Lin,X. and Zhou,X.
  TITLE     EMC3 Is Essential for Retinal Organization and Neurogenesis During
            Mouse Retinal Development
  JOURNAL   Invest Ophthalmol Vis Sci 62 (2), 31 (2021)
   PUBMED   33605987
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Zhu,X., Qi,X., Yang,Y., Tian,W., Liu,W., Jiang,Z., Li,S. and Zhu,X.
  TITLE     Loss of the ER membrane protein complex subunit Emc3 leads to
            retinal bipolar cell degeneration in aged mice
  JOURNAL   PLoS One 15 (9), e0238435 (2020)
   PUBMED   32886670
  REMARK    GeneRIF: Loss of the ER membrane protein complex subunit Emc3 leads
            to retinal bipolar cell degeneration in aged mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Xiong,L., Zhang,L., Yang,Y., Li,N., Lai,W., Wang,F., Zhu,X. and
            Wang,T.
  TITLE     ER complex proteins are required for rhodopsin biosynthesis and
            photoreceptor survival in Drosophila and mice
  JOURNAL   Cell Death Differ 27 (2), 646-661 (2020)
   PUBMED   31263175
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Guna,A., Volkmar,N., Christianson,J.C. and Hegde,R.S.
  TITLE     The ER membrane protein complex is a transmembrane domain insertase
  JOURNAL   Science 359 (6374), 470-473 (2018)
   PUBMED   29242231
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Tang,X., Snowball,J.M., Xu,Y., Na,C.L., Weaver,T.E., Clair,G.,
            Kyle,J.E., Zink,E.M., Ansong,C., Wei,W., Huang,M., Lin,X. and
            Whitsett,J.A.
  TITLE     EMC3 coordinates surfactant protein and lipid homeostasis required
            for respiration
  JOURNAL   J Clin Invest 127 (12), 4314-4325 (2017)
   PUBMED   29083321
  REMARK    GeneRIF: EMC3 was essential for the processing and routing of
            surfactant proteins, SP-B and SP-C, and the biogenesis of the
            phospholipid transport protein ABCA3.
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK075595.1.
            
            On Apr 6, 2007 this sequence version replaced NM_175101.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075595.1, BC004641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1958              AK075595.1         2-1959
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.78 cM"
     gene            1..1958
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /note="ER membrane protein complex subunit 3"
                     /db_xref="GeneID:66087"
                     /db_xref="MGI:MGI:1913337"
     exon            1..311
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..942
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /note="partial optokinetic response b; transmembrane
                     protein 111"
                     /codon_start=1
                     /product="ER membrane protein complex subunit 3"
                     /protein_id="NP_780310.1"
                     /db_xref="CCDS:CCDS20425.1"
                     /db_xref="GeneID:66087"
                     /db_xref="MGI:MGI:1913337"
                     /translation="MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKL
                     TQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMT
                     DPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLT
                     LDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAF
                     KTEWEALELTDHQWALDDVEEELMARDLHFEGMFKKELQTSIF"
     exon            312..369
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            370..463
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            464..568
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            569..650
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            651..730
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            731..813
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1958
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1300..1305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /note="hexamer: AGTAAA"
     polyA_site      1328
                     /gene="Emc3"
                     /gene_synonym="0610039A15Rik; Pob; Tmem111"
                     /note="major polyA site"
ORIGIN      
        1 agttgacggc ctggcggccc agctggaaac agtgcgcgga gaaagctagg ctgccccaga
       61 ttccacgcca gccagactga ggggcgggtg aaggcccgga gccgaaagcc gggaggaacc
      121 caactcctcc cgacccgcag cgaactctca gcgaagatgg cggggcccga gctgctgctt
      181 gactccaaca tccgcctctg ggtggtcctg cccatcgtta tcatcacttt cttcgtgggc
      241 atgatccgcc actacgtgtc aatcctactg cagagcgaca agaagctcac ccaggaacaa
      301 gtgtctgaca gtcaggtcct aattcgaagc agagtcctca gggaaaatgg aaaatacatt
      361 cccaagcagt ctttcttaac acgaaaatat tacttcaaca acccagagga tggatttttc
      421 aaaaaaacaa aaaggaaggt tgtgccacct tcccccatga cagaccccac catgctcaca
      481 gacatgatga aagggaatgt cacaaatgtc ctcccaatga ttcttatcgg cggatggatc
      541 aacatgacgt tttcaggctt tgtcacaact aaggtcccgt ttccactgac acttcgcttc
      601 aagcctatgc ttcagcaagg aatagagctg ctcacactag acgcatcctg ggtgagttct
      661 gcatcctggt acttcctcaa tgtgtttggg ctccggagca tttactctct aatcctgggc
      721 caagataacg ccgccgacca gtcacgaatg atgcaggagc agatgacagg agcagcgatg
      781 gccatgcctg cagacaccaa caaagctttc aagacagagt gggaagcttt ggaactgaca
      841 gatcaccagt gggcgctcga tgatgtggaa gaagaactca tggccagaga cctccacttt
      901 gaaggcatgt tcaaaaagga actacagacg tccatattct aaccacatgc ggggtcagct
      961 gtgtccggaa cttgcagtag cacttaacct tgtaacttcc gtggagctgg agcctctgag
     1021 aataaaaagg agggtgcagg ggctggcggg tgcagcaagg ctcattcttg tctgagctgg
     1081 gttccccttt atgttggaaa ctagaggaaa aggagttgtg ggtgactgct gtcttaaagt
     1141 ttgtgattgt tccttcaggt gactctagta aggacgtcag agaaagggga gaccccatgc
     1201 tactgagaat agctcaaccc ttagcaaaaa ctccgtgctt ggaaagagca ttgtcagtta
     1261 tagcagttac tatgttcggt cagcctgact tccagccaca gtaaactcct gttttcttag
     1321 gatccaaaca ccctgcattt taccttgaat ttcttgtttg tatttttaac tttctttaca
     1381 cacgtaatat acttttctct accacaattt agaaactatg gctgagcagc acagcgctcc
     1441 ccgcactgtt cacttgagcc tacaaaggac gcagagaact ggtgtggccc aacattgctg
     1501 aaataaactc tttgcagagt ggatccccag ggccggggca gactcagcaa acttttcata
     1561 tctcttcata cttagtccag tgaaaacagg tgaccctgag gcacagccag actctcaagt
     1621 gcctttgggc tcatcagaga caggttacat atacaagttc ttgattggaa cttgaggaaa
     1681 tatcaactct atcggccagt caatggtgct gtgctgtaaa tggctactca tttgaacgaa
     1741 tgacctcatc ccagttcctc tgggcaggag agaacttacc actgttgggg caagaggaca
     1801 gtttctggtg gatatgtaga ttaaggtgcc caggagtcct ctgaccaggg aagtgttagg
     1861 gtgccatttc tgtaccaaaa gctgggtgtg ttgcatgtta agcactgtag ccaagaacaa
     1921 gcgactcttg actcttaatt aaacagccct gttttctc
//
