LOCUS       NM_010330               2622 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus embigin (Emb), mRNA.
ACCESSION   NM_010330
VERSION     NM_010330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2622)
  AUTHORS   Mohamad,S.F., El Koussa,R., Ghosh,J., Blosser,R., Gunawan,A.,
            Layer,J., Zhang,C., Karnik,S., Dave,U., Kacena,M.A. and Srour,E.F.
  TITLE     Osteomacs promote maintenance of murine hematopoiesis through
            megakaryocyte-induced upregulation of Embigin and CD166
  JOURNAL   Stem Cell Reports 19 (4), 486-500 (2024)
   PUBMED   38458190
  REMARK    GeneRIF: Osteomacs promote maintenance of murine hematopoiesis
            through megakaryocyte-induced upregulation of Embigin and CD166.
REFERENCE   2  (bases 1 to 2622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2622)
  AUTHORS   Talvi,S., Jokinen,J., Sipila,K., Rappu,P., Zhang,F.P., Poutanen,M.,
            Rantakari,P. and Heino,J.
  TITLE     Embigin deficiency leads to delayed embryonic lung development and
            high neonatal mortality in mice
  JOURNAL   iScience 27 (2), 108914 (2024)
   PUBMED   38318368
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2622)
  AUTHORS   Newton,S., Aguilar,C., Bunton-Stasyshyn,R.K., Flook,M., Stewart,M.,
            Marcotti,W., Brown,S. and Bowl,M.R.
  TITLE     Absence of Embigin accelerates hearing loss and causes
            sub-viability, brain and heart defects in C57BL/6N mice due to
            interaction with Cdh23ahl
  JOURNAL   iScience 26 (10), 108056 (2023)
   PUBMED   37854703
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2622)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2622)
  AUTHORS   Bulleit,R.F., Cui,H., Wang,J. and Lin,X.
  TITLE     NMDA receptor activation in differentiating cerebellar cell
            cultures regulates the expression of a new POU gene, Cns-1
  JOURNAL   J Neurosci 14 (3 Pt 2), 1584-1595 (1994)
   PUBMED   7907365
REFERENCE   7  (bases 1 to 2622)
  AUTHORS   Okamoto,K., Wakamiya,M., Noji,S., Koyama,E., Taniguchi,S.,
            Takemura,R., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Muramatsu,M. et al.
  TITLE     A novel class of murine POU gene predominantly expressed in central
            nervous system
  JOURNAL   J Biol Chem 268 (10), 7449-7457 (1993)
   PUBMED   8463278
REFERENCE   8  (bases 1 to 2622)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
REFERENCE   9  (bases 1 to 2622)
  AUTHORS   Huang,R.P., Ozawa,M., Kadomatsu,K. and Muramatsu,T.
  TITLE     Developmentally regulated expression of embigin, a member of the
            immunoglobulin superfamily found in embryonal carcinoma cells
  JOURNAL   Differentiation 45 (2), 76-83 (1990)
   PUBMED   1965893
REFERENCE   10 (bases 1 to 2622)
  AUTHORS   Ozawa,M., Huang,R.P., Furukawa,T. and Muramatsu,T.
  TITLE     A teratocarcinoma glycoprotein carrying a developmentally regulated
            carbohydrate marker is a member of the immunoglobulin gene
            superfamily
  JOURNAL   J Biol Chem 263 (7), 3059-3062 (1988)
   PUBMED   2963822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ085726.1, BY077584.1, AK138271.1 and AK148540.1.
            
            On Apr 8, 2009 this sequence version replaced NM_010330.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148540.1, AK138271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                CJ085726.1         1-44
            45-52               BY077584.1         4-11
            53-2312             AK138271.1         2-2261
            2313-2622           AK148540.1         2141-2450
FEATURES             Location/Qualifiers
     source          1..2622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 65.4 cM"
     gene            1..2622
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="embigin"
                     /db_xref="GeneID:13723"
                     /db_xref="MGI:MGI:95321"
     exon            1..385
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1269
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="teratocarcinoma glycoprotein Gp-70; glycoprotein
                     70"
                     /codon_start=1
                     /product="embigin precursor"
                     /protein_id="NP_034460.3"
                     /db_xref="CCDS:CCDS26791.1"
                     /db_xref="GeneID:13723"
                     /db_xref="MGI:MGI:95321"
                     /translation="MRSHTGLRALVAPGYPLLLLCLLAATRPDPAEGDPTDPTFTSLP
                     VREEMMAKYSNLSLKSCNISVTEKSNVSVEENVILEKPSHVELKCVYTATKDLNLMNV
                     TWKKDDEPLETTGDFNTTKMGNTLTSQYRFIVFNSKQLGKYSCVFGEKELRGTFNIHV
                     PKAHGKKKSLIAYVGDSTVLKCVCQDCLPLNWTWYMGNETAQVPIDAHSNEKYIINGS
                     HANETRLKIKHLLEEDGGSYWCRATFQLGESEEQNELVVLSFLVPLKPFLAILAEVIL
                     LVAIILLCEVYTHKKKNDPDAGKEFEQIEQLKSDDSNGIENNVPRYRKTDSADQ"
     exon            386..475
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            476..668
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            669..754
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            755..882
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1162
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1196
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1251
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..2622
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="hexamer: ATTAAA"
     polyA_site      1466
                     /gene="Emb"
                     /gene_synonym="Gp70"
     regulatory      2278..2283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="hexamer: AATAAA"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="hexamer: ATTAAA"
     polyA_site      2308
                     /gene="Emb"
                     /gene_synonym="Gp70"
                     /note="major polyA site"
     polyA_site      2324
                     /gene="Emb"
                     /gene_synonym="Gp70"
ORIGIN      
        1 gattcggcgc cgaggttgca cagcacatcc gggcgcgccg gtagcgggct gcgggctgca
       61 taattgatgg aaggccggcg caattgcgct gggagcgtct cgggggtgga ggccagggcg
      121 gccgggcccc tcccactcgg tttattctcg agtgtcctgt ccccaggact ggcagtgggc
      181 gcccagttac cagcaagtgt acacagggac caacggagac ggatcgcagc gagctgaggg
      241 tgccttagcg acctcctgga cagacccgcc cgcgccatgc gctcgcacac tggcctgagg
      301 gcgcttgtgg cgcctggtta cccgctcctc cttctatgtc ttctggcggc gacgcgccct
      361 gatccggctg agggcgatcc cacagatcca acttttacaa gtctacctgt tcgagaagaa
      421 atgatggcga aatactcaaa cctttcctta aagagctgta atatctcagt gacggaaaag
      481 tccaatgtat cagtagaaga gaacgtaatt ttggaaaagc cttctcatgt ggaactcaaa
      541 tgcgtgtaca cagcaactaa ggatttgaac ttgatgaatg tgacttggaa gaaagatgat
      601 gagccccttg agactacggg tgacttcaat acaactaaaa tgggcaacac cttaaccagt
      661 cagtacaggt tcatcgtttt taatagcaaa caattgggaa aatattcttg tgtctttgga
      721 gaaaaggaac taagagggac ctttaacatc cacgtaccca aagctcatgg gaaaaaaaag
      781 tcgttgatcg cttacgtggg ggattctact gtgctgaagt gtgtatgtca agattgtctt
      841 cctttaaatt ggacttggta catgggtaat gaaaccgcac aggttcccat tgacgctcac
      901 tcgaatgaaa agtatatcat caatggttcc catgccaatg aaacaaggct caagattaag
      961 catcttttgg aggaagatgg aggatcctac tggtgtcgtg ccaccttcca gttaggggag
     1021 agtgaggagc agaatgagct ggttgtgctg agcttcctgg tgcccctcaa gccatttctg
     1081 gccatacttg ccgaagtcat cctcttggtg gccatcattc tgctttgtga agtgtacaca
     1141 cacaagaaaa agaatgaccc agatgctggg aaagaatttg aacaaattga acagctgaaa
     1201 tcagatgata gcaatggcat agaaaacaat gtcccccggt acagaaaaac tgactctgca
     1261 gatcagtgaa tacagaaaga gcatctcgcc ctgggaagaa gtacagcgtt ggagtttgta
     1321 cttcagcttc cttattttag atttttaaaa gacaaagatg ccctcaacgt gcacagaagt
     1381 agctttatga acaatatagt ccatctccta cctaaagatg tactttcatt ttgtaattgc
     1441 tttccattaa agcaaggtca attgtttcag ctgtgttctg tgagctgtaa cctagataat
     1501 aaactcccct ctgtgggtac agggtggaca ccagcaaaat cacttaataa tccacaaata
     1561 aatatcgccg aagatctgtt tattaccaaa gaatttatta aagagaaagc gtttgccagt
     1621 tgtcttaagt gtttgcctcc accagacatc ttacctatag aagtatttat cacagttttc
     1681 atgtgaagtg tatccagtgt tgagtgtgat ttctctagga aatggaaagt atgctttcaa
     1741 tatcggtggc tacactgcag tctagacact aagataaact tgtgctctat aaataatggt
     1801 gcaaagtaag ggagttcaaa tgcttgtgcc atggccacta cattaccaga gcttctcatc
     1861 ttcattgcac tcatttctgc tctttctatc ccaagccgaa gagcttccca gccttaagta
     1921 gaacattttc cttgttcttt gtcattgggg tttggacttc aatagtcttc agaggccaga
     1981 tccacgttgt cacagtacaa ccccgctcgc tacctgcatg cctttgtggc tcatggtttc
     2041 tgggtgcctt tatgtgccat ctctttcctg gtaccatacc tggctaaaat gcattcttag
     2101 tgttttccaa taataattcc tttgtctagt atacaggagg actagtgcac tatctttatg
     2161 ttgctgcgaa tgccttagac ttaacttcaa aattgtatct gagatacttt atgaacttag
     2221 aaccaaatca cgtcagaatt ttaatggaca tggaaacttg tcaatggttt taaatgaaat
     2281 aaaatgtgcc ttggatggtt ggattaaatg tcccttgtgc tgctggcttt tgtgatacac
     2341 tgcctgggaa aacagggcta caaagagaga ccaacttggg atgatagtta aaaacaaaaa
     2401 acaaaacaaa acaaaaaaaa acatggttct tggtgattct gggattagag gttgggtaaa
     2461 aagagtccac cggtttaaaa atggaaatgt atagaagtgt atgccttttg tgttagttat
     2521 gaaaagtgta agatttctgg tggggaaaat tatgtagcat cttatttgac taatgtttac
     2581 caatatttat tagcaaaaat aatacatagg aagtagttat gg
//
