LOCUS       NM_001081381            2082 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 6 (Elp6),
            mRNA.
ACCESSION   NM_001081381 XM_902998
VERSION     NM_001081381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2082)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2082)
  AUTHORS   Gaik,M., Kojic,M., Stegeman,M.R., Oncu-Oner,T., Koscielniak,A.,
            Jones,A., Mohamed,A., Chau,P.Y.S., Sharmin,S., Chramiec-Glabik,A.,
            Indyka,P., Rawski,M., Biela,A., Dobosz,D., Millar,A., Chau,V.,
            Unalp,A., Piper,M., Bellingham,M.C., Eichler,E.E., Nickerson,D.A.,
            Guleryuz,H., Abbassi,N.E.H., Jazgar,K., Davis,M.J.,
            Mercimek-Andrews,S., Cingoz,S., Wainwright,B.J. and Glatt,S.
  TITLE     Functional divergence of the two Elongator subcomplexes during
            neurodevelopment
  JOURNAL   EMBO Mol Med 14 (7), e15608 (2022)
   PUBMED   35698786
REFERENCE   3  (bases 1 to 2082)
  AUTHORS   Freeman,S., Mateo Sanchez,S., Pouyo,R., Van Lerberghe,P.B.,
            Hanon,K., Thelen,N., Thiry,M., Morelli,G., Van Hees,L.,
            Laguesse,S., Chariot,A., Nguyen,L., Delacroix,L. and Malgrange,B.
  TITLE     Proteostasis is essential during cochlear development for neuron
            survival and hair cell polarity
  JOURNAL   EMBO Rep 20 (9), e47097 (2019)
   PUBMED   31321879
REFERENCE   4  (bases 1 to 2082)
  AUTHORS   Kojic,M., Gaik,M., Kiska,B., Salerno-Kochan,A., Hunt,S.,
            Tedoldi,A., Mureev,S., Jones,A., Whittle,B., Genovesi,L.A.,
            Adolphe,C., Brown,D.L., Stow,J.L., Alexandrov,K., Sah,P., Glatt,S.
            and Wainwright,B.J.
  TITLE     Elongator mutation in mice induces neurodegeneration and
            ataxia-like behavior
  JOURNAL   Nat Commun 9 (1), 3195 (2018)
   PUBMED   30097576
  REMARK    GeneRIF: a single point mutation in the gene encoding Elongator
            complex subunit 6 causing Purkinje neuron degeneration and an
            ataxia-like phenotype in the mutant wobbly mouse, is reported.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2082)
  AUTHORS   Miao,G., Zhao,Y.G., Zhao,H., Ji,C., Sun,H., Chen,Y. and Zhang,H.
  TITLE     Mice deficient in the Vici syndrome gene Epg5 exhibit features of
            retinitis pigmentosa
  JOURNAL   Autophagy 12 (12), 2263-2270 (2016)
   PUBMED   27715390
REFERENCE   6  (bases 1 to 2082)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   7  (bases 1 to 2082)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ073544.1, AK075986.1, BM943556.1 and BE448281.1.
            
            On Apr 21, 2007 this sequence version replaced XM_902998.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075986.1, BC048732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CJ073544.1         1-4
            5-1287              AK075986.1         2-1284
            1288-1763           BM943556.1         184-659
            1764-2082           BE448281.1         71-389
FEATURES             Location/Qualifiers
     source          1..2082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.91 cM"
     gene            1..2082
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /note="elongator acetyltransferase complex subunit 6"
                     /db_xref="GeneID:72341"
                     /db_xref="MGI:MGI:1919349"
     exon            1..158
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..905
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /note="transmembrane protein 103; UPF0405 protein C3orf75
                     homolog; elongator complex protein 6 homolog"
                     /codon_start=1
                     /product="elongator complex protein 6"
                     /protein_id="NP_001074850.1"
                     /db_xref="CCDS:CCDS52937.1"
                     /db_xref="GeneID:72341"
                     /db_xref="MGI:MGI:1919349"
                     /translation="MFPELNNLLSTTPDKTEQGTLTLLCDAKTDGSFLVHHFLSFYLK
                     ANCKVCFVALVQSFSHYNIVGQKLGVSLTAARDRGQLVFLEGLKSSVEVLFHSQDEPH
                     PLQFLREAGTGNLQSLYTFIQDTLKPADSEESPWKYPVLLVDNLSVLLSLGVGAVAVL
                     DFMQYCRATVCCELKGNVVALVHDTEGATDEGNDTLLNGLSHQSHLILRAEGLATGFC
                     KDVHGQLSILWRRPSRSTAQRAQSLTYQYKIQDKNVSFFAKGMSPAVL"
     exon            159..237
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     exon            238..308
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     exon            309..427
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     exon            428..629
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     exon            630..776
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2064
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /note="hexamer: AATAAA"
     polyA_site      1287
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /note="major polyA site"
ORIGIN      
        1 gatcacgcat gcgcgctttc tcgcgctcgc gagcacggtc ttgtgggtgc tgttcttgga
       61 ccttcattct ttctgtagaa ccataatttt tatcccagtt cacgatgttt ccggaactca
      121 acaaccttct cagcaccacc ccagacaaga ccgagcaggg gacgctgact ctcctctgtg
      181 acgctaagac agatggcagc ttccttgtgc accacttcct ttccttctac ctgaaagcta
      241 attgtaaagt ctgctttgtg gcacttgtcc agtccttcag ccattacaat attgtgggac
      301 agaaactggg tgtcagcttg acagcggctc gggacagagg gcagcttgtg ttcctggagg
      361 gtctcaagtc ctctgtggag gtcctcttcc actctcagga cgagcctcac cccctgcagt
      421 ttctcaggga ggctggtaca ggaaacctgc agtcactgta tacgtttatt caggacaccc
      481 tgaagcctgc ggacagtgag gagtccccat ggaagtaccc agtgctgttg gtggacaacc
      541 tcagtgtgct gctgagcctg ggcgtggggg cagtcgctgt gctggacttc atgcagtact
      601 gcagagccac ggtgtgctgc gaactgaagg gaaacgtggt agcccttgtg catgacactg
      661 agggcgctac ggatgagggg aatgacaccc tgctgaacgg cctcagccat caaagccacc
      721 tgatcctgcg ggctgagggc ctggccactg gattctgcaa ggacgtgcat gggcagctga
      781 gcatcctctg gcggaggccg tcgcggtcca cagcccagcg ggctcaaagt ctcacttacc
      841 aatacaagat acaggacaag aatgtgtcct tttttgccaa aggaatgtct cctgctgttc
      901 tgtgacctga tttgggacaa ctgaagtgac tttggacagt taagaagcac cctggctgaa
      961 cactcgtcag gcttgactgc agctccgctg tgaccaggga ggatggcgct gtgagggtgt
     1021 gcccgctttg tctccagggc tctgcttagg aaacacagtg aggaactgca cgtggcttat
     1081 gctgagagag gctgcaaggt gaaccccagc agagccaacc tttggggcat cccacatgac
     1141 tccagcctca cctgcctgtt tttggaggtt gtgccattaa gagccactgt agatagaagg
     1201 aggccatcag gaggttgtct tgaatggcag ccatcctggc tgacagctag gacaatgagg
     1261 cagaataaag aaggttccca cacaggcttc ctggaggttg tcttttttat atttcacttc
     1321 ccttttacat ggggactttt ccttgaagtc cagtaaggag atgggcttgg aaatggaggt
     1381 gaggacactc ggggctcaga gcaggctgag gacaattgag ctggaactgg actccaaagc
     1441 cgtacctgcc agcctgcact catggagacc agggtcaggt gtccccaccc tcacccactg
     1501 aaggtgtaaa cctgcttctg tctctgcagc ttggcctgta tgctggagtc ctagccatca
     1561 aaagcatggc actgggacct tgaatgaggg agaggggagt atgactttga gaagagtaag
     1621 aaagtgtctt tgctgcctgg ttagaaggat catggtgagt tactgtaatg catctttgaa
     1681 gacagtgggg acaagaggaa ggaggtcttg gaaccagtct ttttggtctg tgtgtctgtg
     1741 tgtctgtgtg ttttggaggg caaattgaga ctaggtttct tctatgtagc ccttgctggc
     1801 ctggaacttg ctatgtagac taggctggcc tggagctcac agagattccc ctgcctctgc
     1861 ctccaaaatg ctgggattag aggttacagt accatgtctg ataagagaaa ggaatattta
     1921 tcccagcgtc ctgagatgat cctgatcaca cctcgttccg tagtaaaggt cacctcagag
     1981 ggaatgaata caaggagggc tctcttaaaa tttgtgcgtt gtttttacat gtaaatgaat
     2041 ccactaataa aactaaaaat tttaaaaaaa aaaaaaaaaa aa
//
