LOCUS       NP_001074850             266 aa            linear   ROD 28-JAN-2025
DEFINITION  elongator complex protein 6 [Mus musculus].
ACCESSION   NP_001074850 XP_908091
VERSION     NP_001074850.1
DBSOURCE    REFSEQ: accession NM_001081381.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 266)
  AUTHORS   Gaik,M., Kojic,M., Stegeman,M.R., Oncu-Oner,T., Koscielniak,A.,
            Jones,A., Mohamed,A., Chau,P.Y.S., Sharmin,S., Chramiec-Glabik,A.,
            Indyka,P., Rawski,M., Biela,A., Dobosz,D., Millar,A., Chau,V.,
            Unalp,A., Piper,M., Bellingham,M.C., Eichler,E.E., Nickerson,D.A.,
            Guleryuz,H., Abbassi,N.E.H., Jazgar,K., Davis,M.J.,
            Mercimek-Andrews,S., Cingoz,S., Wainwright,B.J. and Glatt,S.
  TITLE     Functional divergence of the two Elongator subcomplexes during
            neurodevelopment
  JOURNAL   EMBO Mol Med 14 (7), e15608 (2022)
   PUBMED   35698786
REFERENCE   3  (residues 1 to 266)
  AUTHORS   Freeman,S., Mateo Sanchez,S., Pouyo,R., Van Lerberghe,P.B.,
            Hanon,K., Thelen,N., Thiry,M., Morelli,G., Van Hees,L.,
            Laguesse,S., Chariot,A., Nguyen,L., Delacroix,L. and Malgrange,B.
  TITLE     Proteostasis is essential during cochlear development for neuron
            survival and hair cell polarity
  JOURNAL   EMBO Rep 20 (9), e47097 (2019)
   PUBMED   31321879
REFERENCE   4  (residues 1 to 266)
  AUTHORS   Kojic,M., Gaik,M., Kiska,B., Salerno-Kochan,A., Hunt,S.,
            Tedoldi,A., Mureev,S., Jones,A., Whittle,B., Genovesi,L.A.,
            Adolphe,C., Brown,D.L., Stow,J.L., Alexandrov,K., Sah,P., Glatt,S.
            and Wainwright,B.J.
  TITLE     Elongator mutation in mice induces neurodegeneration and
            ataxia-like behavior
  JOURNAL   Nat Commun 9 (1), 3195 (2018)
   PUBMED   30097576
  REMARK    GeneRIF: a single point mutation in the gene encoding Elongator
            complex subunit 6 causing Purkinje neuron degeneration and an
            ataxia-like phenotype in the mutant wobbly mouse, is reported.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 266)
  AUTHORS   Miao,G., Zhao,Y.G., Zhao,H., Ji,C., Sun,H., Chen,Y. and Zhang,H.
  TITLE     Mice deficient in the Vici syndrome gene Epg5 exhibit features of
            retinitis pigmentosa
  JOURNAL   Autophagy 12 (12), 2263-2270 (2016)
   PUBMED   27715390
REFERENCE   6  (residues 1 to 266)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   7  (residues 1 to 266)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ073544.1, AK075986.1, BM943556.1 and BE448281.1.
            
            On Apr 21, 2007 this sequence version replaced XP_908091.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075986.1, BC048732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.91 cM"
     Protein         1..266
                     /product="elongator complex protein 6"
                     /note="transmembrane protein 103; UPF0405 protein C3orf75
                     homolog; elongator complex protein 6 homolog"
                     /calculated_mol_wt=29195
     Region          2..251
                     /region_name="ELP6"
                     /note="Elongation complex protein 6; pfam09807"
                     /db_xref="CDD:462909"
     CDS             1..266
                     /gene="Elp6"
                     /gene_synonym="2610001P13Rik; 2610002I17Rik; Tmem103"
                     /coded_by="NM_001081381.1:105..905"
                     /db_xref="CCDS:CCDS52937.1"
                     /db_xref="GeneID:72341"
                     /db_xref="MGI:MGI:1919349"
ORIGIN      
        1 mfpelnnlls ttpdkteqgt ltllcdaktd gsflvhhfls fylkanckvc fvalvqsfsh
       61 ynivgqklgv sltaardrgq lvfleglkss vevlfhsqde phplqflrea gtgnlqslyt
      121 fiqdtlkpad seespwkypv llvdnlsvll slgvgavavl dfmqycratv ccelkgnvva
      181 lvhdtegatd egndtllngl shqshlilra eglatgfckd vhgqlsilwr rpsrstaqra
      241 qsltyqykiq dknvsffakg mspavl
//
