LOCUS       NM_018740               1447 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 5 (Elp5),
            transcript variant 1, mRNA.
ACCESSION   NM_018740
VERSION     NM_018740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1447)
  AUTHORS   Freeman,S., Mateo Sanchez,S., Pouyo,R., Van Lerberghe,P.B.,
            Hanon,K., Thelen,N., Thiry,M., Morelli,G., Van Hees,L.,
            Laguesse,S., Chariot,A., Nguyen,L., Delacroix,L. and Malgrange,B.
  TITLE     Proteostasis is essential during cochlear development for neuron
            survival and hair cell polarity
  JOURNAL   EMBO Rep 20 (9), e47097 (2019)
   PUBMED   31321879
REFERENCE   2  (bases 1 to 1447)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   3  (bases 1 to 1447)
  AUTHORS   Creppe,C., Malinouskaya,L., Volvert,M.L., Gillard,M., Close,P.,
            Malaise,O., Laguesse,S., Cornez,I., Rahmouni,S., Ormenese,S.,
            Belachew,S., Malgrange,B., Chapelle,J.P., Siebenlist,U., Moonen,G.,
            Chariot,A. and Nguyen,L.
  TITLE     Elongator controls the migration and differentiation of cortical
            neurons through acetylation of alpha-tubulin
  JOURNAL   Cell 136 (3), 551-564 (2009)
   PUBMED   19185337
REFERENCE   4  (bases 1 to 1447)
  AUTHORS   Spanjaard,R.A., Lee,P.J., Sarkar,S., Goedegebuure,P.S. and
            Eberlein,T.J.
  TITLE     Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important
            growth regulator of melanoma
  JOURNAL   Cancer Res 57 (22), 5122-5128 (1997)
   PUBMED   9371513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152582.1 and CD776986.1.
            
            On Jul 2, 2009 this sequence version replaced NM_018740.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152582.1, ERR3363658.2717405.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1433              AK152582.1         5-1437
            1434-1447           CD776986.1         5-18                c
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.94 cM"
     gene            1..1447
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="elongator acetyltransferase complex subunit 5"
                     /db_xref="GeneID:54351"
                     /db_xref="MGI:MGI:1859017"
     exon            1..29
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            30..378
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..1235
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dermal papilla-derived protein 6 homolog; retinoic
                     acid-induced protein 12; retinoic acid induced 12;
                     elongator complex protein 5"
                     /codon_start=1
                     /product="elongator complex protein 5 isoform 1"
                     /protein_id="NP_061210.2"
                     /db_xref="CCDS:CCDS24926.1"
                     /db_xref="GeneID:54351"
                     /db_xref="MGI:MGI:1859017"
                     /translation="MLDSLLAIGGLVLLRDSVEWEGRSLLKALIKKSALRGEQVHVLG
                     CEVSEEEFREGFDSDVNSRLVYHDLFRDPLNWSKPGEAVPEGPLKALRSMCKRTDHGS
                     VTIALDSLSWLLCHIPCVTLCQALHALSQQNGDPGDNSLVEQVRVLGLLHEELHGPGS
                     MGALNTLAHTEVTLSGKVDQTSASILCRRPQQRATYQTWWFSVLPDFSLTLHEGLPLR
                     SELHPDHHTTQVDPTAHLTFNLHLSKKEREARDSLTLPFQFSSEKQKALLHPVPSRTT
                     GHIFYEPDAFDDVDPEDPDDDLDI"
     exon            379..439
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            440..520
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            521..741
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            742..923
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1019
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1120
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1437
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1408..1413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="hexamer: AATATA"
     polyA_site      1437
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="major polyA site"
ORIGIN      
        1 gacttcgcgt gggctgcagg ccgaaacagg ttcgaacctt cttcgggatt ggagctcgtg
       61 agacctctgt ccttgtcccc atcccactga taactgttcc aacggccctt ctggctccag
      121 tcatggtgca agagtagatt aaggatgttg tctctaggac tgtgtacaga gactctggag
      181 cggcccctcc gtgtaagccc cctgagaata cggagcataa aaaaaccagg ctcctctttc
      241 cggactttgc ggtcctttaa ggttggaagc aatcgtaagt gccccgcctc ctcggtggtg
      301 acgacatcag aaggcgtcct gaggcgtcag agatgctgga ctcgttgttg gccatcggtg
      361 gtttggtgct tttgcgagat tccgtggagt gggaagggcg tagtctcctg aaggctctta
      421 tcaagaaatc tgcacttcgt ggggagcagg tccacgttct gggctgtgaa gtgagcgaag
      481 aagagtttcg cgaaggtttc gactctgatg tcaacagccg cctggtttac catgacctct
      541 tcagagaccc tcttaactgg tcaaagcctg gagaagctgt ccctgaaggt cctctaaaag
      601 ccttgaggtc catgtgcaaa aggacagacc atggctcagt caccattgcc cttgactctc
      661 tcagctggct gctgtgtcac attccctgtg ttacactctg tcaagcccta catgctctga
      721 gccagcaaaa tggagaccca ggtgataact ccctagtaga gcaggtgcgt gtcctgggcc
      781 tcctacatga agagcttcat ggcccaggct ccatgggagc actgaacacc cttgctcaca
      841 cagaggtgac tctgagtggt aaagtggacc agacctcagc ctccatcctc tgtcgaaggc
      901 cccaacaacg tgcaacttac cagacttggt ggttctccgt tcttcctgac ttcagcctga
      961 ctctccatga agggcttccc ctccgttctg agctacaccc ggatcatcac acaacccagg
     1021 tggatcccac tgctcatttg acctttaacc ttcacttatc caagaaagaa agagaagcca
     1081 gagacagcct cactctgcct ttccagttca gctctgaaaa acagaaagct ctgctgcatc
     1141 cggtacccag ccggaccact ggccacatct tctatgagcc agatgctttt gatgatgtgg
     1201 acccagaaga cccagatgat gacctagata tttgacagac aaatggcaga ggaaggctgt
     1261 gggctcagaa ccaccctgct gttggcagac tctaccttgt cccttgtcct ttgttacttt
     1321 gtctgcagaa gctgtgtcgt gagccaagga gcagcatcaa gctaggatga gtgtgatgag
     1381 ggcatagtgt gtgcccattt ctaataaaat atatatgtgt gtgtgtgtca atcaaaaaaa
     1441 aaaaaaa
//
