LOCUS       NM_001253700             969 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 5 (Elp5),
            transcript variant 3, mRNA.
ACCESSION   NM_001253700 NR_027977
VERSION     NM_001253700.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Freeman,S., Mateo Sanchez,S., Pouyo,R., Van Lerberghe,P.B.,
            Hanon,K., Thelen,N., Thiry,M., Morelli,G., Van Hees,L.,
            Laguesse,S., Chariot,A., Nguyen,L., Delacroix,L. and Malgrange,B.
  TITLE     Proteostasis is essential during cochlear development for neuron
            survival and hair cell polarity
  JOURNAL   EMBO Rep 20 (9), e47097 (2019)
   PUBMED   31321879
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Close,P., Gillard,M., Ladang,A., Jiang,Z., Papuga,J., Hawkes,N.,
            Nguyen,L., Chapelle,J.P., Bouillenne,F., Svejstrup,J., Fillet,M.
            and Chariot,A.
  TITLE     DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and
            migration of melanoma cells as subunits of Elongator
  JOURNAL   J Biol Chem 287 (39), 32535-32545 (2012)
   PUBMED   22854966
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Creppe,C., Malinouskaya,L., Volvert,M.L., Gillard,M., Close,P.,
            Malaise,O., Laguesse,S., Cornez,I., Rahmouni,S., Ormenese,S.,
            Belachew,S., Malgrange,B., Chapelle,J.P., Siebenlist,U., Moonen,G.,
            Chariot,A. and Nguyen,L.
  TITLE     Elongator controls the migration and differentiation of cortical
            neurons through acetylation of alpha-tubulin
  JOURNAL   Cell 136 (3), 551-564 (2009)
   PUBMED   19185337
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Spanjaard,R.A., Lee,P.J., Sarkar,S., Goedegebuure,P.S. and
            Eberlein,T.J.
  TITLE     Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important
            growth regulator of melanoma
  JOURNAL   Cancer Res 57 (22), 5122-5128 (1997)
   PUBMED   9371513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12, AA646690.1, BE862527.1 and CD741073.1.
            
            On Nov 30, 2011 this sequence version replaced NR_027977.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses an alternate start codon,
            compared to variant 1. The encoded isoform (2) has a distinct and
            shorter N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU520475.1, SRR7652917.1228945.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL596185.12        91892-91975         c
            85-285              AA646690.1         1-201
            286-591             BE862527.1         44-349
            592-969             CD741073.1         1-378               c
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.94 cM"
     gene            1..969
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="elongator acetyltransferase complex subunit 5"
                     /db_xref="GeneID:54351"
                     /db_xref="MGI:MGI:1859017"
     exon            1..117
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            118..178
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            179..259
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..753
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="isoform 2 is encoded by transcript variant 3;
                     dermal papilla-derived protein 6 homolog; retinoic
                     acid-induced protein 12; retinoic acid induced 12;
                     elongator complex protein 5"
                     /codon_start=1
                     /product="elongator complex protein 5 isoform 2"
                     /protein_id="NP_001240629.1"
                     /db_xref="GeneID:54351"
                     /db_xref="MGI:MGI:1859017"
                     /translation="MSTAGDNSLVEQVRVLGLLHEELHGPGSMGALNTLAHTEVTLSG
                     KVDQTSASILCRRPQQRATYQTWWFSVLPDFSLTLHEGLPLRSELHPDHHTTQVDPTA
                     HLTFNLHLSKKEREARDSLTLPFQFSSEKQKALLHPVPSRTTGHIFYEPDAFDDVDPE
                     DPDDDLDI"
     exon            260..441
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            442..537
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            538..638
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     exon            639..955
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="hexamer: AATATA"
     polyA_site      955
                     /gene="Elp5"
                     /gene_synonym="Derp6; Rai12"
                     /note="major polyA site"
ORIGIN      
        1 gttggaagca atcgtaagtg ccccgcctcc tcggtggtga cgacatcaga aggcgtcctg
       61 aggcgtcaga gatgctggac tcgttgttgg ccatcggtgg tttggtgctt ttgcgagatt
      121 ccgtggagtg ggaagggcgt agtctcctga aggctcttat caagaaatct gcacttcgtg
      181 gggagcaggt ccacgttctg ggctgtgaag tgagcgaaga agagtttcgc gaaggtttcg
      241 actctgatgt caacagccgg tgataactcc ctagtagagc aggtgcgtgt cctgggcctc
      301 ctacatgaag agcttcatgg cccaggctcc atgggagcac tgaacaccct tgctcacaca
      361 gaggtgactc tgagtggtaa agtggaccag acctcagcct ccatcctctg tcgaaggccc
      421 caacaacgtg caacttacca gacttggtgg ttctccgttc ttcctgactt cagcctgact
      481 ctccatgaag ggcttcccct ccgttctgag ctacacccgg atcatcacac aacccaggtg
      541 gatcccactg ctcatttgac ctttaacctt cacttatcca agaaagaaag agaagccaga
      601 gacagcctca ctctgccttt ccagttcagc tctgaaaaac agaaagctct gctgcatccg
      661 gtacccagcc ggaccactgg ccacatcttc tatgagccag atgcttttga tgatgtggac
      721 ccagaagacc cagatgatga cctagatatt tgacagacaa atggcagagg aaggctgtgg
      781 gctcagaacc accctgctgt tggcagactc taccttgtcc cttgtccttt gttactttgt
      841 ctgcagaagc tgtgtcgtga gccaaggagc agcatcaagc taggatgagt gtgatgaggg
      901 catagtgtgt gcccatttct aataaaatat atatgtgtgt gtgtgtcaat caaaaaaaaa
      961 aaaaaaaaa
//
