LOCUS       NM_023876               6755 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 4 (Elp4),
            mRNA.
ACCESSION   NM_023876
VERSION     NM_023876.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6755)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6755)
  AUTHORS   Kojic,M., Gawda,T., Gaik,M., Begg,A., Salerno-Kochan,A.,
            Kurniawan,N.D., Jones,A., Drozdzyk,K., Koscielniak,A.,
            Chramiec-Glabik,A., Hediyeh-Zadeh,S., Kasherman,M., Shim,W.J.,
            Sinniah,E., Genovesi,L.A., Abrahamsen,R.K., Fenger,C.D.,
            Madsen,C.G., Cohen,J.S., Fatemi,A., Stark,Z., Lunke,S., Lee,J.,
            Hansen,J.K., Boxill,M.F., Keren,B., Marey,I., Saenz,M.S., Brown,K.,
            Alexander,S.A., Mureev,S., Batzilla,A., Davis,M.J., Piper,M.,
            Boden,M., Burne,T.H.J., Palpant,N.J., Moller,R.S., Glatt,S. and
            Wainwright,B.J.
  TITLE     Elp2 mutations perturb the epitranscriptome and lead to a complex
            neurodevelopmental phenotype
  JOURNAL   Nat Commun 12 (1), 2678 (2021)
   PUBMED   33976153
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6755)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
REFERENCE   4  (bases 1 to 6755)
  AUTHORS   Creppe,C., Malinouskaya,L., Volvert,M.L., Gillard,M., Close,P.,
            Malaise,O., Laguesse,S., Cornez,I., Rahmouni,S., Ormenese,S.,
            Belachew,S., Malgrange,B., Chapelle,J.P., Siebenlist,U., Moonen,G.,
            Chariot,A. and Nguyen,L.
  TITLE     Elongator controls the migration and differentiation of cortical
            neurons through acetylation of alpha-tubulin
  JOURNAL   Cell 136 (3), 551-564 (2009)
   PUBMED   19185337
REFERENCE   5  (bases 1 to 6755)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 6755)
  AUTHORS   Kleinjan,D.A., Seawright,A., Childs,A.J. and van Heyningen,V.
  TITLE     Conserved elements in Pax6 intron 7 involved in (auto)regulation
            and alternative transcription
  JOURNAL   Dev Biol 265 (2), 462-477 (2004)
   PUBMED   14732405
REFERENCE   7  (bases 1 to 6755)
  AUTHORS   Kleinjan,D.A., Seawright,A., Elgar,G. and van Heyningen,V.
  TITLE     Characterization of a novel gene adjacent to PAX6, revealing
            synteny conservation with functional significance
  JOURNAL   Mamm Genome 13 (2), 102-107 (2002)
   PUBMED   11889558
REFERENCE   8  (bases 1 to 6755)
  AUTHORS   Winkler,G.S., Petrakis,T.G., Ethelberg,S., Tokunaga,M.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     RNA polymerase II elongator holoenzyme is composed of two discrete
            subcomplexes
  JOURNAL   J Biol Chem 276 (35), 32743-32749 (2001)
   PUBMED   11435442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK168964.1, AK037104.1, AK039758.1, AK042006.1, AK140480.1 and
            AA914716.1.
            
            On Jul 2, 2015 this sequence version replaced NM_023876.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168964.1, AK039758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK168964.1         1-42
            43-2432             AK037104.1         3-2392
            2433-3966           AK039758.1         2370-3903
            3967-5511           AK042006.1         1438-2982
            5512-5759           AK140480.1         1-248               c
            5760-6210           AK042006.1         3229-3679
            6211-6211           AA914716.1         361-361
            6212-6755           AK042006.1         3681-4224
FEATURES             Location/Qualifiers
     source          1..6755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.33 cM"
     gene            1..6755
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /note="elongator acetyltransferase complex subunit 4"
                     /db_xref="GeneID:77766"
                     /db_xref="MGI:MGI:1925016"
     exon            1..296
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            297..332
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            333..454
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            455..583
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            584..723
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            724..808
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            809..997
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1106
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1213
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..6755
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /note="major polyA site"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
     regulatory      6736..6741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
                     /note="hexamer: AATAAA"
     polyA_site      6755
                     /gene="Elp4"
                     /gene_synonym="A330107A17Rik; Paxneb"
ORIGIN      
        1 gactttgggg ctagctctga caggcccccc gctccagttc ccagagttcc gattgggtca
       61 tcgtaggagc ttcaagatgg cggcggcaga cacttgcggc gcgggtaccc tcagctcccg
      121 gtctgtggcg tccgaggcgg gtcagggcgg cacctctagt ttccagagga agggcaaggc
      181 ctctgggggc cccggagggg gccctcggct gctgtccatt gctggcacgc gaccgtcggt
      241 gcggaatgga caactgctgg tgtcaaccgg gctcccagcc ctggaccagc tcttaggtgg
      301 agggttagct gttggaacac ttcttctgat tgaagaggat aaatataata tctattcacc
      361 tttgctcttc aagtatttca tggcagaagg aatcatcaat gggcatactc tgttggttgc
      421 atctgccaaa gaaaatcctg ccaaaatttt acaggaactc cctgcaccac tacttgatga
      481 taatagtaaa aaggagcttg aagatgtaca cagtgctaaa accccagagc ctaatgtcaa
      541 catgaagata gcctggcggt accagttaca acccaagatg gaggtgggac cggtctcgtc
      601 gtcacgattt ggtcactatt atgatttatc aaaaaggatt ccttgggagc tactacagag
      661 ttcaaagtgg catggattct tccttccaga acacatctct ccagatctta aaggagaatc
      721 ctgttttttg tcctgtggct acatgaggct gcttgagttc attcagaaga gcgtttatgc
      781 tgaaggattt gatggagcta atccccagaa aaaacagaaa aacattttaa gaataggaat
      841 tcagaacctt ggctcaccgt tatggggaga tgacatttgc tgtaaagaaa actgtgacaa
      901 caatcacagg cttaccaagt tcctctacat tcttcgtggt cttctaagat cctcactgtc
      961 cgcctgcatc atcacgatgc cagcacatct tgtccagaat aaatcaatta ctactcgtgt
     1021 gagaaatttg tcagatacag tagttggtct ggaatccttt attggttcag agagagagac
     1081 taacccattg tataaggatt atcatggttt gatccatata cggaagattc ctcggcttaa
     1141 taacttgact tgtgatgaat cggatgtcaa agacttagct tttaagttaa aaaggaagct
     1201 gttcaccatt gagcgactgc atttgcctcc agacttgtca gacacagtgg gccgttcaag
     1261 caaacaggat ctggcagcat ccaccgcgcg gctgggtgca ggctgtagct ccatggccga
     1321 aggcaagaag cacctggact tctagggacc ctccgtagtc accgagtgcg aagttatctg
     1381 acactctgat taggactgct agtagttcat gtaaacattt gtcttaatga tctgaccctc
     1441 cagactttga gaaatacaag gtcacaaagt ggagccacca tccttaagtt tgagttgttt
     1501 catgatttat ttttttctac tgacttttgt acaaacataa tatggcagaa atactgccat
     1561 ttgacattta gctgctgtgg gttttttttt aaaatactaa ttacttttta aataaacacc
     1621 caaaaaatcc ccaaaataca gtttgcctta gagttgtcat tagttcaagt ggactatagc
     1681 aatgggatga tggtgacttg tgtcttatgg taacaggcat ggcacacccc atagagtgta
     1741 gaacattgaa ttcaagttgt gtgtgaatac atttcagatg actttgtttt tgaaaaaatc
     1801 actaccaaga ctttttttca aagaatattt tgtttgctag tatttgaaag agttagcatt
     1861 tgtgcatccc attgttgaaa atggtgaaga caaaaatcat atgtggtgat tcagtctgca
     1921 ttacccagca cattagacaa tacatccagg acttgatggg aagcaggcag gaagactctg
     1981 aagttctggg taattgacgt cagcactgta acattgtgtc aacagacaaa attcaagctg
     2041 gcagctccac taatgccggg gtcctagaga tgtgtactga agcctggtga gcaagttata
     2101 taatctaggt ctaagacaac gtaagtaact gagacacact cagacttcca ttgtgccttt
     2161 gttaaccagg agcactggct gagcctgtaa atgatatctg accatgcaaa atgtctcggg
     2221 gacacagcat atggagcagg ttttcctgaa aaacactggg ctttggggtc atgggtccat
     2281 agtcttgaag ggtttgacaa gccatagata aacagtggaa gccagaaagc cacttgtgtg
     2341 tgtttaagaa ctccagtttt tttaaaagat atttaacatc ttttggtaga aattgaattt
     2401 tcaaataaat tagaatattt taaagcacct ttaactagca ttttaagcag tttcctttta
     2461 atataccaca aattatactc tattttctct tgacaacatt gtcgaaaaca aagactaggt
     2521 ttttaaaact gtctcaccaa tatgatgaat gtcagtcact ttaaaaaaaa agcccagtgt
     2581 agcataaaca cgcactgtat acagttctca ttcagaatta gaataattga atcaatgaca
     2641 gtgatttgcc aggatgtcaa atctctccat catatcctgt cactaccagt ttattttttg
     2701 tgataaaatc aaaaagacaa ctattttgtc accaggactc attagcacta aaaaatcagg
     2761 ttgatttttt ttttttttta gaatgtctgg tttatttttt ttaatctctt taaattctca
     2821 agacaaattc ttccccattt tcttttcaaa ataaagtttt agaattgatc tgtcagttaa
     2881 aattaaagga cttttgtatt aaagaagggt acttttaata tttaaaacaa cctcaaaaat
     2941 tgatttcctc tataaatttt aagtcttgtt gcagaggtac ccaggaagtc ctgctgtcct
     3001 ctaatgggtt gtgaataaac tgaagtgaat gcttgattgt tttaataact aacctttctc
     3061 ttaccctgtt gtgattcatt ttacacaaac acacaacagc acaatttctt ggcagttagc
     3121 tctgaaaagg aagtgtgagg ccatcaggtg tgtaaattat tctaaaatat ctaatgagtc
     3181 attggtttct ttcttgattc ctatatctaa aaaattaaca attgactact agtagttatg
     3241 tgctttgcaa atagctaaat tcccttgaaa ttgagtgaac atatttgaac cctcagttta
     3301 aatagagatt aaacttttca aagttaataa acccacattt taaataaata cagtacctgg
     3361 actttccaaa aatactacat ttactgcttt atttttcaga ctcagtcagc atattttaat
     3421 actgctacta ctaaaaataa taatgacaac aaaaagacac tgctattgga aatagatgta
     3481 tggcatattt tatttttttt tttgtcctct gacaaaaacc cagtctaaaa atatgttttc
     3541 ctttatttgg aaatttttgt tctctaatac tgcacaactt cctacatgaa aatattggcc
     3601 ttcaaaatgc taacacacac acacaagcac atgtccttct aatatattat gaaatgtaca
     3661 ctctattcat agtttttaac ttgtcttgag tataaatact taataacact gtcagagtaa
     3721 ctgaactgtc tttgtatcag catcgcagtg catgaagcct gaggccctgt gaagtgattc
     3781 attcctctgc tagatctgcc tttccttaac atgggtaaag attttgacca ctctaggtta
     3841 acaaggtata tggatctgag accatcagat tttaatagcc acgagacaag atcacttttc
     3901 tcagcttttt tacttattcg ttagcacttc cccaggaaga agcttgtaaa gtaaaggcga
     3961 ttcttctatt ctctgtcttt ttattttaat gactggaaca tatacataca cttacagcaa
     4021 gggcatgtgg ggcaaaccat cgcttaagcc cattattaat gtcacctcca agatctcatg
     4081 ttattatgtc caaagatagt caccatcaat agggtccgaa ttaagcaaaa gatttacact
     4141 ttgattttga aaaatgagca gtttagtcat ctgtgacaaa aaaaaagtta ctaaaaaaca
     4201 gaataatgta tatttggcat cagttaacca aacatagaga caaaaagatc ttctggataa
     4261 cattaaggcc cagagcacaa agaataaaaa tgctcggtgc cttctgtgat ggcagacatt
     4321 cacaggacga ggctgaacgc taacgctcta gacagagttc tgagaagcct gcctaggatg
     4381 tttcctttaa gtagaaagag gagatgatgt gagcagtgtg gagaagccgg ttgttcacca
     4441 gataaaagtc gtctcgaggt gtagctttgg aggagaggaa atcctcacag tttcataaca
     4501 gcgcatggca aaattatttt cacctaaagc agcgttctca acctataagt catgacctct
     4561 taaaatcgaa acagcctttc acaggggtcg ttcctgcata tcagatgttt gcattgcagt
     4621 tcataatagt agcaagattg cagttatgaa gtagcaatgc ggtaatttta tgattggggt
     4681 caccccaaca tgaggaactc tattaaagag tcacagcatt gggaaagctg acagaccact
     4741 gccctagagt gattcacctg taattctgtt cacccaatgt ctctcagtca gtgataaaat
     4801 gtaatctgta tgcaccaaga tgtcataaaa tttggtcttt gtcctggaaa atgaccctaa
     4861 aatatcccta cagattttct attgacaaat ctataaatat aactgtcagt aaataaacaa
     4921 atgaaaatga ccactgggaa tcacaactcc cagatactgg gatgacacag cctgggatat
     4981 agacagctca tctctctagg gtgcatgtgg gaagaaggca aagctcatct tgctgaacca
     5041 gagacacccg catctgagct tccttccttt gggatatacc agactgtccc actgcactct
     5101 ggcagcctgg accctctgat gacttgtata tgtctcagac tgcacacatc catatcctca
     5161 gctttcatgt cactcccagg tcttgcaccc agaatgccct gtgcctttct gtctgtgtgc
     5221 tctattcagc agggccatgg gccagcacag gatgcctgac accagcccaa atcacagcca
     5281 gttgaaaact gctctctttt tttttcaagg aataagtaaa ccagccagca gaggctacaa
     5341 cacagctctt ctctgacagt tccctcaaca cttgtccctc agggaacggg aggctgcaaa
     5401 atatcaggag gtggaagtgt ctgcaagggt gatttgtacc aacagaggat atgtgccagc
     5461 aggcagtgtg ggctgacatg gacaacaact gtgcatgcac gcacacacac acatgcatac
     5521 gcacacacac acacacacac acacacacac acactgcaat ccagttagga tgctatctcc
     5581 ggacatgaag caactccact agaataaaat ggatctcaat gatctgttca gaagtaccac
     5641 atagatgtcg aactgcaagg ttatgttgaa atcctccaat caatttattt ctgatcattt
     5701 gccttttgcg atttacaaaa ccaaaaatcc tcagagttgg gagtcagtga agtgccttcc
     5761 ccctaggatg agtctccttg tatttttaat ctaggtggcc aggaccccag agtttctctc
     5821 tctcaagctc gctgaagaaa atgtgtctat gtgacttaag tgttgcacag aacaggcaga
     5881 aaatagcagg caggcctttt tctaaccaac aaaagcttcc ttttttttct ctccattgct
     5941 tgggctcagg cactcctgcc ctgcatgctg ccactttaaa catgatcaga tctgtgcttc
     6001 ttcgcaaatg acaactgacc aacaatgggc cctgcttcat agatttggga atgtttggct
     6061 taagctgcca atgactgaag gcctttaact cccaccggcc agtcacagtc cgctttgttg
     6121 ttgtctctta gtgtgtctgt gctcattatt ccttgacatg caacatcccc tccaccctcc
     6181 aaccacccac cacagcaccg aaagcaagac acacatggga gcagctggag gggttcaatg
     6241 ggagccgatg cctcttatgc aaagagtggg gagacaggac agcaagaagg gttatctgag
     6301 attggcaaca gctgtcagag gatcttgttt aagaactcaa cctttgaata tgactgtagt
     6361 ggaatcattg tggggattgg ttgcccaggt taaaaatgcc agctctaatt caaaacaatt
     6421 cctagtgaat cccttgttgc atttttttaa ttacttctac actttgagct ttaaaatcaa
     6481 ataaatagat aaatttgaaa tattactatt ttctgtacac attgtgggat gcagacctac
     6541 atacagctag ctgtgttttg ttttaggttt ttttacaata cattaccaac ttctgatatc
     6601 tgtaaaaatt atttctttga ggaccatcag gttgtaaaat ggaatatatg aaagtaacca
     6661 ttgatttagg acattaacct aatgtgggaa caaaatttgt aacaccacac tataaggtta
     6721 aaaagaaaat agtgtaataa agaaaataca aaggc
//
