LOCUS       NM_001253812            2891 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 3 (Elp3),
            transcript variant 1, mRNA.
ACCESSION   NM_001253812
VERSION     NM_001253812.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Pereira,M., Ribeiro,D.R., Berg,M., Tsai,A.P., Dong,C., Nho,K.,
            Kaiser,S., Moutinho,M. and Soares,A.R.
  TITLE     Amyloid pathology reduces ELP3 expression and tRNA modifications
            leading to impaired proteostasis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166857 (2024)
   PUBMED   37640114
  REMARK    GeneRIF: Amyloid pathology reduces ELP3 expression and tRNA
            modifications leading to impaired proteostasis.
REFERENCE   3  (bases 1 to 2891)
  AUTHORS   Chen,D., Nemazanyy,I., Peulen,O., Shostak,K., Xu,X., Tang,S.C.,
            Wathieu,C., Turchetto,S., Tielens,S., Nguyen,L., Close,P.,
            Desmet,C., Klein,S., Florin,A., Buttner,R., Petrellis,G., Dewals,B.
            and Chariot,A.
  TITLE     Elp3-mediated codon-dependent translation promotes mTORC2
            activation and regulates macrophage polarization
  JOURNAL   EMBO J 41 (18), e109353 (2022)
   PUBMED   35920020
  REMARK    GeneRIF: Elp3-mediated codon-dependent translation promotes mTORC2
            activation and regulates macrophage polarization.
REFERENCE   4  (bases 1 to 2891)
  AUTHORS   Even,A., Morelli,G., Turchetto,S., Shilian,M., Bail,R.L.,
            Laguesse,S., Krusy,N., Brisker,A., Brandis,A., Inbar,S.,
            Chariot,A., Saudou,F., Dietrich,P., Dragatsis,I., Brone,B.,
            Broix,L., Rigo,J.M., Weil,M. and Nguyen,L.
  TITLE     ATP-citrate lyase promotes axonal transport across species
  JOURNAL   Nat Commun 12 (1), 5878 (2021)
   PUBMED   34620845
  REMARK    Erratum:[Nat Commun. 2021 Nov 12;12(1):6678. doi:
            10.1038/s41467-021-26998-y.. PMID: 34772940]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2891)
  AUTHORS   Rosu,A., El Hachem,N., Rapino,F., Rouault-Pierre,K., Jorssen,J.,
            Somja,J., Ramery,E., Thiry,M., Nguyen,L., Jacquemyn,M.,
            Daelemans,D., Adams,C.M., Bonnet,D., Chariot,A., Close,P.,
            Bureau,F. and Desmet,C.J.
  TITLE     Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent
            antitumor checkpoint in hematopoiesis
  JOURNAL   J Exp Med 218 (3) (2021)
   PUBMED   33507234
  REMARK    GeneRIF: Loss of tRNA-modifying enzyme Elp3 activates a
            p53-dependent antitumor checkpoint in hematopoiesis.
REFERENCE   6  (bases 1 to 2891)
  AUTHORS   Creppe,C., Malinouskaya,L., Volvert,M.L., Gillard,M., Close,P.,
            Malaise,O., Laguesse,S., Cornez,I., Rahmouni,S., Ormenese,S.,
            Belachew,S., Malgrange,B., Chapelle,J.P., Siebenlist,U., Moonen,G.,
            Chariot,A. and Nguyen,L.
  TITLE     Elongator controls the migration and differentiation of cortical
            neurons through acetylation of alpha-tubulin
  JOURNAL   Cell 136 (3), 551-564 (2009)
   PUBMED   19185337
  REMARK    GeneRIF: Silencing of histone acetyltransferase Elongator complex
            scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously
            delays the migration and impairs the branching of projection
            neurons.
REFERENCE   7  (bases 1 to 2891)
  AUTHORS   Chen,Y.T., Hims,M.M., Shetty,R.S., Mull,J., Liu,L., Leyne,M. and
            Slaugenhaupt,S.A.
  TITLE     Loss of mouse Ikbkap, a subunit of elongator, leads to
            transcriptional deficits and embryonic lethality that can be
            rescued by human IKBKAP
  JOURNAL   Mol Cell Biol 29 (3), 736-744 (2009)
   PUBMED   19015235
REFERENCE   8  (bases 1 to 2891)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   9  (bases 1 to 2891)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2891)
  AUTHORS   Chinenov,Y.
  TITLE     A second catalytic domain in the Elp3 histone acetyltransferases: a
            candidate for histone demethylase activity?
  JOURNAL   Trends Biochem Sci 27 (3), 115-117 (2002)
   PUBMED   11893502
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122274.4 and AC158983.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088457.1, SRR7974084.24200.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC122274.4         65046-65233         c
            189-288             AC122274.4         62627-62726         c
            289-427             AC122274.4         58379-58517         c
            428-498             AC122274.4         55011-55081         c
            499-562             AC122274.4         54236-54299         c
            563-631             AC122274.4         52869-52937         c
            632-786             AC122274.4         50046-50200         c
            787-948             AC122274.4         37433-37594         c
            949-1075            AC122274.4         35373-35499         c
            1076-1269           AC122274.4         32242-32435         c
            1270-1360           AC122274.4         23506-23596         c
            1361-1426           AC122274.4         21541-21606         c
            1427-1654           AC122274.4         19987-20214         c
            1655-1736           AC122274.4         19255-19336         c
            1737-2891           AC158983.2         2848-4002
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.33 cM"
     gene            1..2891
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /note="elongator acetyltransferase complex subunit 3"
                     /db_xref="GeneID:74195"
                     /db_xref="MGI:MGI:1921445"
     exon            1..188
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1813
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /EC_number="2.3.1.311"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongator complex protein 3; elongation protein 3 homolog;
                     tRNA uridine(34) acetyltransferase; protein lysine
                     acetyltransferase ELP3"
                     /codon_start=1
                     /product="elongator complex protein 3 isoform 1"
                     /protein_id="NP_001240741.1"
                     /db_xref="CCDS:CCDS56965.1"
                     /db_xref="GeneID:74195"
                     /db_xref="MGI:MGI:1921445"
                     /translation="MRQKRKGAKYVGQGRKGGSGFSEITGDLSPAELMMLTIGDVIKQ
                     LVEAHEQGKDVDLNKMKTKTAAKYGLASQPRLVDIIAAVPPHYRKILIPKLKAKPVRT
                     ASGIAVVAVMCKPHRCPHISFTGNICIYCPGGPDSDFEYSTQSYTGYEPTSMRAIRAR
                     YDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRSLHDALSGHTSN
                     NIHEAIKYSERSFTKCVGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARD
                     TNRGHTVKAACESFHLAKDSGFKVVTHMMPDLPNVGLERDIEQFIEFFENPAFRPDGL
                     KLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPL
                     VSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANG
                     GWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDP
                     TKFQHQGFGMLLMEEAERIAREEHGSGKMAVISGVGTRNYYRKIGYRLQGPYMVKMLK
                     "
     exon            189..288
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..427
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            428..498
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            499..562
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            563..631
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            632..786
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            787..948
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1075
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1269
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1360
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1426
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1654
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1736
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2891
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="Elp3"
                     /gene_synonym="2610507P14Rik; KAT9"
                     /note="major polyA site"
ORIGIN      
        1 atggtacagt cgctgtgttt tcacgacagt cccgggcggc tttacggctg ctaagtttct
       61 ccgccttcta aaccgcggta acgtggtggc atattgctac gccagcgcag agatgaggca
      121 aaagaggaaa ggtgcaaaat acgtgggaca agggcgcaag ggaggaagtg gattctctga
      181 gatcacaggg gacctcagcc cggctgagct gatgatgctg actataggag acgttatcaa
      241 gcagctggtt gaagctcatg agcaggggaa agacgtcgat ctaaataaga tgaaaaccaa
      301 gacagctgcc aagtatggcc ttgcgtccca gccccgcctg gtggatatca tcgctgcagt
      361 ccctcctcac tatcgaaaga tcttgattcc taagctaaag gcgaagcccg tcaggactgc
      421 cagtgggatc gctgttgtgg ctgtgatgtg caaaccccac agatgtccac acatcagttt
      481 cacagggaat atatgtatat actgccccgg aggacctgac tccgattttg agtattcaac
      541 ccagtcttac acgggctatg agccaacttc catgagagct atccgtgcta gatatgaccc
      601 ttttctgcag acaagacacc ggatagagca gctaaagcag cttggtcaca gtgtggataa
      661 ggtggagttc atcgtgatgg gtggaacgtt catggccctt ccagaagagt acagagatta
      721 tttcatccga agtttacacg atgctttatc aggccatact tcaaacaata ttcacgaggc
      781 aatcaagtat tctgagagaa gcttcacaaa gtgtgttgga attacaattg agaccagacc
      841 tgattattgc atgaagcggc acctaagtga catgttgact tatggctgca caaggctgga
      901 gatcggagtg cagagtgtct atgaagatgt ggccagagat accaacaggg gccatactgt
      961 gaaggcagcg tgtgaatctt tccacctggc caaagattct ggtttcaaag tggtgacgca
     1021 tatgatgcct gacctgccga acgtgggact ggagagagac attgagcagt ttatagaatt
     1081 tttcgagaac cctgcttttc gtcctgatgg tttgaagctc tacccaaccc tggttatccg
     1141 tggaactggt ctgtatgagc tgtggaaatc aggaaggtac aggagctatt ctcccagtga
     1201 cctgattgag ctggtggctc ggatcctagc ccttgtgccc ccgtggactc gtgtgtaccg
     1261 ggtgcagaga gacatcccaa tgccccttgt cagctcagga gtggagcatg gcaacctgcg
     1321 cgagctggca tttgcaagaa tgaaggatct tggaatacag tgccgtgatg tgagaaccag
     1381 ggaggttgga atccaagaaa ttcatcacag agtgcggcca taccaggtcg agttggtacg
     1441 gagagattat gttgccaatg gtggctggga aactttcctg tcctacgaag atcctgatca
     1501 ggacattctg attggcctcc taaggctgcg gaagtgctct gaggaaacct tccggtttga
     1561 actgggtgga ggtgtttcca tagtccgaga gctacacgtg tatggaagtg tggtccctgt
     1621 gagcagccgg gatcccacta aatttcagca tcaggggttc ggcatgctgc tgatggaaga
     1681 ggcagagaga atcgctcggg aagagcatgg atctgggaaa atggcagtta tatcaggggt
     1741 cggcacaaga aattattacc gaaagattgg ctacagatta caaggcccct acatggtaaa
     1801 gatgctaaaa taatgaccac ccagtctacc ttcttgcagc atcctccctg acagaagatt
     1861 caagtgcagt ctcagcagag gctgaggagg taaacggcct gcacactcct ggacggtcct
     1921 ctgccctccc cctgtggtgg ctgccgctca ctactctgac ccctgtgaca gaggccaaac
     1981 ccacctcttt atgtgcccat ggggcctctt ctggctttaa ggcttaaacg atttttccag
     2041 tttctaaatt ctgcatgaag gctgcaggtg acccattttg gctcagacgc tgtgaccaga
     2101 gcaaatcaac tcctttggcc atcgtcactc gtgattgtca tctgaggggc agcctcggga
     2161 gaagattatt tatatatcca aagacgaaag ccagactgca gcacagacaa gctgtcagac
     2221 atgactccct gccctttaac tacatgcaca ttcaccctgg aatttagaaa atgagctttg
     2281 cactggaaat ctcagtggct gtgccgtgtc ttgaaatgtg ctgtgtttgg agaaagaaga
     2341 gctgaggtag tgggttgtgt taatatgctt gatgccggcc gtctctagcc caatcctgtc
     2401 agaagcttgc cctgaccagg gccatcttgg aagcctttcc tttgtctcac gtctgtgaaa
     2461 gtctgtatgt ccatacccct gacacctgca ggacagtgtg aactaccttc agcatgctgg
     2521 gctagcttgt gccagccagt tcatctgtcc tgagcagaca tggtccagaa tccacagcta
     2581 gagccggagg ccctggtcag gaccaggcca tgctcagaag cttctctgca tgttagttct
     2641 gtaaagtaga tagtgttgat ggtgctgcat gaagaaggta ggagttaggc tagtgtgtgg
     2701 aaggaggcct gtctgacctg catggaggga catgggcttt ccagagcctt catcaccatt
     2761 cagtttgtcc cctgaggagg ccaggctctg agtgacagcc catctcgcct gggcatctgt
     2821 cctttccagc agtgtttagt gaaaactgtt ccctaaaagg tctgaaaaat aaagtcttta
     2881 acataaaaga g
//
