LOCUS       NM_021448               2789 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus elongator acetyltransferase complex subunit 2 (Elp2),
            transcript variant 1, mRNA.
ACCESSION   NM_021448
VERSION     NM_021448.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Zhang,S., Tu,D., Liu,W., Li,R., Jiang,M., Yuan,X., Luan,J., Li,H.,
            Lv,C. and Song,X.
  TITLE     circELP2 reverse-splicing biogenesis and function as a
            pro-fibrogenic factor by targeting mitochondrial quality control
            pathway
  JOURNAL   J Cell Mol Med 28 (3), e18098 (2024)
   PUBMED   38159063
  REMARK    GeneRIF: circELP2 reverse-splicing biogenesis and function as a
            pro-fibrogenic factor by targeting mitochondrial quality control
            pathway.
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Kojic,M., Gawda,T., Gaik,M., Begg,A., Salerno-Kochan,A.,
            Kurniawan,N.D., Jones,A., Drozdzyk,K., Koscielniak,A.,
            Chramiec-Glabik,A., Hediyeh-Zadeh,S., Kasherman,M., Shim,W.J.,
            Sinniah,E., Genovesi,L.A., Abrahamsen,R.K., Fenger,C.D.,
            Madsen,C.G., Cohen,J.S., Fatemi,A., Stark,Z., Lunke,S., Lee,J.,
            Hansen,J.K., Boxill,M.F., Keren,B., Marey,I., Saenz,M.S., Brown,K.,
            Alexander,S.A., Mureev,S., Batzilla,A., Davis,M.J., Piper,M.,
            Boden,M., Burne,T.H.J., Palpant,N.J., Moller,R.S., Glatt,S. and
            Wainwright,B.J.
  TITLE     Elp2 mutations perturb the epitranscriptome and lead to a complex
            neurodevelopmental phenotype
  JOURNAL   Nat Commun 12 (1), 2678 (2021)
   PUBMED   33976153
  REMARK    GeneRIF: Elp2 mutations perturb the epitranscriptome and lead to a
            complex neurodevelopmental phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Lu,S., Fan,H.W., Li,K. and Fan,X.D.
  TITLE     Suppression of Elp2 prevents renal fibrosis and inflammation
            induced by unilateral ureter obstruction (UUO) via inactivating
            Stat3-regulated TGF-beta1 and NF-kappaB pathways
  JOURNAL   Biochem Biophys Res Commun 501 (2), 400-407 (2018)
   PUBMED   29723529
  REMARK    GeneRIF: Elp2 role in the development of the ureter obstruction
            induced renal fibrosis.Elp2 regulates Stat3 and TGF-beta1 and
            NF-kappa B pathways in the renal fibrosis.
REFERENCE   5  (bases 1 to 2789)
  AUTHORS   Xu,C.P., Li,X., Hu,Y.J., Cui,Z., Wang,L., Liang,L., Zhou,Y.L.,
            Yang,Y.J. and Yu,B.
  TITLE     Quantitative proteomics reveals ELP2 as a regulator to the
            inhibitory effect of TNF-alpha on osteoblast differentiation
  JOURNAL   J Proteomics 114, 234-246 (2015)
   PUBMED   25486498
  REMARK    GeneRIF: Targeting ELP2 activity as a novel therapeutic option to
            limit the inhibition of osteoblast differentiation by inflammatory
            microenvironment.
REFERENCE   6  (bases 1 to 2789)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2789)
  AUTHORS   Ivanova,A.V., Ivanov,S.V., Zhang,X., Ivanov,V.N., Timofeeva,O.A.
            and Lerman,M.I.
  TITLE     STRA13 interacts with STAT3 and modulates transcription of
            STAT3-dependent targets
  JOURNAL   J Mol Biol 340 (4), 641-653 (2004)
   PUBMED   15223310
  REMARK    GeneRIF: STAT3 interacts with STRA13 and modulates transcription of
            STAT3-dependent targets.
REFERENCE   8  (bases 1 to 2789)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2789)
  AUTHORS   Hawkes,N.A., Otero,G., Winkler,G.S., Marshall,N., Dahmus,M.E.,
            Krappmann,D., Scheidereit,C., Thomas,C.L., Schiavo,G.,
            Erdjument-Bromage,H., Tempst,P. and Svejstrup,J.Q.
  TITLE     Purification and characterization of the human elongator complex
  JOURNAL   J Biol Chem 277 (4), 3047-3052 (2002)
   PUBMED   11714725
REFERENCE   10 (bases 1 to 2789)
  AUTHORS   Collum,R.G., Brutsaert,S., Lee,G. and Schindler,C.
  TITLE     A Stat3-interacting protein (StIP1) regulates cytokine signal
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10120-10125 (2000)
   PUBMED   10954736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK168370.1 and AK034457.1.
            
            On Mar 23, 2007 this sequence version replaced NM_021448.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034457.1, AK147826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2769              AK168370.1         2-2770
            2770-2789           AK034457.1         2769-2788
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.18 cM"
     gene            1..2789
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /note="elongator acetyltransferase complex subunit 2"
                     /db_xref="GeneID:58523"
                     /db_xref="MGI:MGI:1889642"
     exon            1..172
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2530
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     signal transducer and activator of transcription
                     interacting protein 1; signal transducer and activator of
                     transcription 3 interacting protein 1; elongator complex
                     protein 2; STAT3-interacting protein 1; elongation protein
                     2 homolog"
                     /codon_start=1
                     /product="elongator complex protein 2 isoform 1"
                     /protein_id="NP_067423.2"
                     /db_xref="CCDS:CCDS29103.1"
                     /db_xref="GeneID:58523"
                     /db_xref="MGI:MGI:1889642"
                     /translation="MVSSVLEVSHVFCCPNRVRGALSWNTGPGGLLAFGTSCSVVLYD
                     PQKKVVITNLNGHTARVNCLQWIRTEDGSPSNELVSGGSDNRVIHWELENNQVLKSVR
                     LQGHEGPVCAVHAIYQSGPSEGEQHALIASAASDSTVRIWSKKGSEVKYLQTLSFRDG
                     FVLSVCLAILPGTNVPVLACGDDDCRIHLYIQQDDQFQKALSLCGHEDWIRGVEWATF
                     GRDLFLASCSQDCLIRIWRLYMKPASFETKDGSLRLKENTFTIKDGGVRTTVAVTLET
                     VLAGHENWVNAVHWQPSFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVG
                     EVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQWAPEIVISGHFDGVQD
                     LMWDPEGEFIITTSTDQTTRLFAPWKKKDQKDRSQVTWHEIARPQIHGYNIKCLAMID
                     RFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLCDDQDLPEGATVPALGLSNK
                     ALFQGDIASQPFEEDELISPAFGSPQVTFQPAVLNEPPTEDHLLQNTLWPEIQKLYGH
                     GYEIVCVACNNSKTLLASACKASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSP
                     DDKFLLAVSRDRTWSLWKRQDATSSEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDNK
                     YFFTGSRDKKVVVWGECKSSHNPMEHPIRPCSSILDVGSSVTAVSVCPVLNPAQRYIV
                     AIGLESGKICIYSWNKTNQEINDWTSCVETNPSQSHSLGIRRLCWKSCSDDDDDDDDD
                     DTEQSEEGPEWLHFASCGEDHTVKIYRVNRRAL"
     exon            173..251
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..322
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..479
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..557
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..622
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..689
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..827
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..923
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1024
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1156
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1315
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1504
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1571
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1664
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1722
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1795
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1988
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2110
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2244
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2352
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2789
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2771
                     /gene="Elp2"
                     /gene_synonym="Epl2; Statip1; StIP1"
                     /note="major polyA site"
ORIGIN      
        1 gcgggaggag ctcggccatt gaccacctag catcatggtt tcttctgtgc tggaggtgtc
       61 tcatgtgttt tgctgcccga accgggttcg aggagctttg agttggaata ccgggcccgg
      121 aggactcctg gctttcggca catcctgctc cgttgtgctc tatgaccctc agaaaaaagt
      181 ggttattacc aatctgaatg gccacaccgc tcgagtcaac tgcctgcagt ggatacgtac
      241 agaggatggc tccccttcca atgagctggt gtctggagga tctgacaatc gggtgattca
      301 ttgggaacta gagaataatc aggttttaaa atcagtccgt ctccaaggcc atgaaggacc
      361 tgtttgtgct gtgcacgcta tttaccagag tgggccatcc gaaggggagc agcatgcgct
      421 gatagcttct gcagcttcag attctactgt gcgaatctgg tctaaaaagg ggtctgaagt
      481 caaatacctt cagaccttga gcttcaggga tggattcgtt ctttctgtct gcctggctat
      541 tttgcctggt actaatgtgc cagtattagc atgtggtgat gatgactgca gaattcactt
      601 atatattcaa caggatgacc agtttcagaa agctctttct ctctgcggac acgaggactg
      661 gataagaggc gtggaatggg caacctttgg tagagacctt ttcctagcaa gctgctcaca
      721 ggactgccta ataagaatat ggagactgta tatgaaacca gcatctttcg aaaccaagga
      781 tggtagttta aggctgaagg aaaacacgtt cactataaag gatggcggtg ttagaacaac
      841 ggttgcggtt accctggaga cagtgctggc tggacacgaa aactgggtaa acgcagttca
      901 ttggcagcct tcattttaca aagatggtgt tctgcagcag ccagtgagac tgctgtctgc
      961 ctccatggac aaaaccatga ttctctgggc tccagatgaa gagtcagggg tttggttaga
     1021 acaggtccga gtaggtgaag taggtggaaa taccctgggg ttttatgatt gccagttcgg
     1081 tgaaaatggc accatgatca tcgctcatgc attccacgga gcactgcacc tttggaaaca
     1141 gagtaccgta aacccaaggc agtgggctcc agagattgtc atttcaggtc acttcgatgg
     1201 cgtccaagac ctgatgtggg atccagaggg agagttcatc atcactacca gcaccgatca
     1261 gaccactcgc cttttcgctc catggaagaa gaaggaccag aaggaccgat cacaggtcac
     1321 ttggcatgag atcgcaaggc ctcagataca tggatacaac atcaagtgtt tggcgatgat
     1381 tgatcggttt cagtttgtgt ctggagcaga cgagaaagtt cttcgtgttt tttctgctcc
     1441 tcggaatttt gtggaaaatt ttagtgtcat ttccagacag tcactaagtc acatgctctg
     1501 tgatgaccaa gatcttccag aaggagccac tgttcctgca ttagggctgt caaataaagc
     1561 tctctttcag ggagacatag cctctcagcc ctttgaggag gatgaactca taagccctgc
     1621 ctttgggtct ccccaggtga cctttcagcc cgctgtcctt aatgaacctc ccactgagga
     1681 tcaccttctg cagaacaccc tgtggcctga gattcagaaa ctgtacggac atggctatga
     1741 gatagtttgt gtggcctgta acaattccaa gactctactt gcctctgctt gtaaggcatc
     1801 tcagaaggag cacgcagcta tcattctttg gagcacggca tcttggaaac aagtgcagag
     1861 tcttgctttc cacactctga ctgtcacaca gatgacattc tcacctgatg acaagttctt
     1921 actggctgtt tccagagatc gaacctggtc tttgtggaag agacaggatg cgacttcctc
     1981 ggagtttgat ccatttttta gtctctttgc attcaccaac aaaattactt ctgtgcatag
     2041 tagaatcatt tggtcttgtg actggagtcc tgataacaag tacttcttca ctggaagtcg
     2101 agacaaaaag gtggttgtct ggggcgagtg taagtccagc cataacccca tggagcaccc
     2161 gatccgtccc tgctcctcga tcctggatgt gggcagttct gtgacagctg tcagtgtctg
     2221 ccctgtgctt aacccagccc agagatacat tgttgcaatt ggattagaga gtgggaagat
     2281 ttgtatatac tcctggaaca agaccaacca agaaatcaat gactggacca gctgtgtaga
     2341 aacaaatcca agccagagtc acagcctggg tatcagaagg ttatgctgga agagctgcag
     2401 cgatgacgac gacgatgatg acgatgacga caccgagcag agtgaagagg ggccggagtg
     2461 gttgcatttt gcaagctgtg gcgaggacca taccgtgaag atttacaggg ttaacagacg
     2521 cgcactgtga agacttgact gcaccctccc catcttgatt gtcttaagtg tttgttatgt
     2581 aaatagatcc cctttcttta ccttcgtgat tgattgagtt tccctgtcta ctatgtgttg
     2641 aagcccatgg atgctccccc ttgtcatatg gtatatatat aaccaccctg aaccttaccc
     2701 atgctgtcaa agatgcctgg atgtacctct gtgcgttcca aattaagaac attttttaaa
     2761 tttgtgccca actttgtctg attttgcct
//
