LOCUS       NM_029001               5453 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ELOVL fatty acid elongase 7 (Elovl7), mRNA.
ACCESSION   NM_029001
VERSION     NM_029001.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5453)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 5453)
  AUTHORS   Tanno,H., Sassa,T., Sawai,M. and Kihara,A.
  TITLE     Production of branched-chain very-long-chain fatty acids by fatty
            acid elongases and their tissue distribution in mammals
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (1), 158842 (2021)
   PUBMED   33069870
  REMARK    GeneRIF: Production of branched-chain very-long-chain fatty acids
            by fatty acid elongases and their tissue distribution in mammals.
REFERENCE   3  (bases 1 to 5453)
  AUTHORS   Han,W., Gao,S., Barrett,D., Ahmed,M., Han,D., Macoska,J.A., He,H.H.
            and Cai,C.
  TITLE     Reactivation of androgen receptor-regulated lipid biosynthesis
            drives the progression of castration-resistant prostate cancer
  JOURNAL   Oncogene 37 (6), 710-721 (2018)
   PUBMED   29059155
  REMARK    GeneRIF: High Elovl7 expression is associated with progression of
            castration-resistant prostate cancer.
REFERENCE   4  (bases 1 to 5453)
  AUTHORS   Moruzzo,D., Nobbio,L., Sterlini,B., Consalez,G.G., Benfenati,F.,
            Schenone,A. and Corradi,A.
  TITLE     The Transcription Factors EBF1 and EBF2 Are Positive Regulators of
            Myelination in Schwann Cells
  JOURNAL   Mol Neurobiol 54 (10), 8117-8127 (2017)
   PUBMED   27889898
REFERENCE   5  (bases 1 to 5453)
  AUTHORS   Duteil,D., Tosic,M., Lausecker,F., Nenseth,H.Z., Muller,J.M.,
            Urban,S., Willmann,D., Petroll,K., Messaddeq,N., Arrigoni,L.,
            Manke,T., Kornfeld,J.W., Bruning,J.C., Zagoriy,V., Meret,M.,
            Dengjel,J., Kanouni,T. and Schule,R.
  TITLE     Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose
            Tissue
  JOURNAL   Cell Rep 17 (4), 1008-1021 (2016)
   PUBMED   27760309
REFERENCE   6  (bases 1 to 5453)
  AUTHORS   He,D., Marie,C., Zhao,C., Kim,B., Wang,J., Deng,Y., Clavairoly,A.,
            Frah,M., Wang,H., He,X., Hmidan,H., Jones,B.V., Witte,D., Zalc,B.,
            Zhou,X., Choo,D.I., Martin,D.M., Parras,C. and Lu,Q.R.
  TITLE     Chd7 cooperates with Sox10 and regulates the onset of CNS
            myelination and remyelination
  JOURNAL   Nat Neurosci 19 (5), 678-689 (2016)
   PUBMED   26928066
REFERENCE   7  (bases 1 to 5453)
  AUTHORS   Lau,C.G. and Marikawa,Y.
  TITLE     Morphology-based mammalian stem cell tests reveal potential
            developmental toxicity of donepezil
  JOURNAL   Mol Reprod Dev 81 (11), 994-1008 (2014)
   PUBMED   25269881
REFERENCE   8  (bases 1 to 5453)
  AUTHORS   Sassa,T., Ohno,Y., Suzuki,S., Nomura,T., Nishioka,C., Kashiwagi,T.,
            Hirayama,T., Akiyama,M., Taguchi,R., Shimizu,H., Itohara,S. and
            Kihara,A.
  TITLE     Impaired epidermal permeability barrier in mice lacking elovl1, the
            gene responsible for very-long-chain fatty acid production
  JOURNAL   Mol Cell Biol 33 (14), 2787-2796 (2013)
   PUBMED   23689133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049118.1, AK018616.1, AC161252.2 and BQ175164.1.
            
            On Apr 25, 2009 this sequence version replaced NM_029001.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049118.1, BC005602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK049118.1         1-27
            28-2068             AK018616.1         3-2043
            2069-5431           AC161252.2         78393-81755
            5432-5453           BQ175164.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..5453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 59.69 cM"
     gene            1..5453
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="ELOVL fatty acid elongase 7"
                     /db_xref="GeneID:74559"
                     /db_xref="MGI:MGI:1921809"
     exon            1..97
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            98..229
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1011
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids-like 7;
                     elongation of very long chain fatty acids protein 7; ELOVL
                     family member 7, elongation of long chain fatty acids;
                     3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; very
                     long chain 3-oxoacyl-CoA synthase 7; very long chain
                     3-ketoacyl-CoA synthase 7"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 7"
                     /protein_id="NP_083277.3"
                     /db_xref="CCDS:CCDS36779.1"
                     /db_xref="GeneID:74559"
                     /db_xref="MGI:MGI:1921809"
                     /translation="MAFSDLTSRTVRFYDNWIKDADPRVEDYLLMSSPLPQTIILGLY
                     VYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGTGYSFRCDIV
                     DYSQSPRAMRMVHTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWF
                     GVKFAAGGLGTFHAFLNTAVHVVMYSYYGLCAMGPAYQKYLWWKKHLTSLQLVQFVLV
                     TIHIGQIFFMEDCNYQYPVFLYIIMSYGCIFLLLFLHFWYRAYTKGQRLPKTLENGNC
                     KSKRH"
     exon            230..420
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            421..501
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            502..558
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..664
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..801
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..5439
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2408
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3390
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5216
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
     regulatory      5414..5419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5439
                     /gene="Elovl7"
                     /gene_synonym="9130013K24Rik"
ORIGIN      
        1 gtccgcagcc ccggcagcag gggccgctgt gagagctgcg ctcgcactgc ccgccgccgc
       61 cctcggctcc cgcgcgcgct gctcgcccct cggcgcgatc ttaagctcgt ttctgcactg
      121 ttttaccgaa gaacccatta aaagggccgg tgaatcttgc ggaaaatggc gttcagtgat
      181 cttacatcga ggactgtgcg tttttatgat aattggatca aagatgctga tccgagagtt
      241 gaagactatc tcctcatgtc ctcgcctctg ccacaaacca tcatcctggg cctctatgtc
      301 tattttgtta cgtctctggg accaaagctc atggagaacc ggaagccctt tgaactcaag
      361 aaagcgatga taacgtacaa ttttttcata gtactgtttt ctgtgtatat gtgttatgag
      421 tttgtgatgt ctggctgggg tacaggttac tcgtttcgat gtgacattgt tgactattct
      481 cagtcgccaa gagcaatgag gatggtgcac acctgctggc tttattactt ctccaaattc
      541 atcgagctgt tagacactat cttttttgtt ctgcgtaaga aaaacagcca agtgactttc
      601 cttcatgtct tccatcatac gatcatgccg tggacctggt ggtttggagt caaatttgct
      661 gcaggtggtc tgggaacatt ccatgccttt ttaaatacag ctgtgcacgt ggtcatgtat
      721 tcttactatg ggttatgtgc aatgggacca gcctaccaga agtatttatg gtggaaaaaa
      781 catttgacat ctttgcagct tgtccagttt gttcttgtca ctatccacat aggccagatc
      841 ttcttcatgg aggactgcaa ttaccagtac ccagtttttc tgtatatcat catgagttac
      901 ggatgcatct tcctgctgct ctttctccac ttttggtacc gtgcttacac caagggtcag
      961 aggttgccca aaactctaga aaatggaaat tgcaaaagca agcgccacta aaatacagac
     1021 acaacctgaa tttacaatgg agactgatat cttgccttcc ttgacaatca agacatactt
     1081 gcctatgcag tgcattttgt atatttttca aaaccaagag cttgtatttt tatgataagt
     1141 tatttgggtt tctgatctct gagagtccaa agctcccaga taagtcttct cagtggaaga
     1201 gcctggaaca gccaggaggt ttcatgttgc ctttcaaacc aatcagaggt cttaatacat
     1261 cttgctacat caagaggagg gtatgaagta atgtagtgct ctcctaggaa ccccagaaat
     1321 gatgacaaat actagctatt ttgaacatgg acagaggtcc acagagtacg atagattcct
     1381 cctgcttgat gtgggaaccc ctgatgctgg gttctgtctg tcactcatcc cttatgttca
     1441 gacaacatta cactcgttct agggctcagt tctgaagtgc taacacaagt gaagcctaag
     1501 tggattcttg ataagctctc attctaaatt tgttaatggt aagtttgaat ggtcttctgg
     1561 gtcattgcca caagatctgc ccataagact tcctcccaac tcatgcacaa gctgttagag
     1621 gctgtgatgc tatggtatcc gcactgatgc ctttgagccc aaggtggagg taactttatg
     1681 ttgcaaacaa gatgatttgt ctcaacggtt aatgaacgct ttgctaatga cgattctaca
     1741 attaacttct gtgcatatct gaaaagaggg atgtgtgaat aaaaaaaaaa agaatagact
     1801 gttggattca atgaggaaag gtataatctg ttgcagtata ataacactct ctgatatgtc
     1861 ctggtttaag ggattgtttt gccaaagtaa gtgttggtta gatatttaag tgttcatgtg
     1921 attggcttac ctcaggtgct tctgaatcac atattaattt ttgaatatct actatgcaaa
     1981 cggcttatga agcaaccaga gttgagtggt gccgagtatc agaggcaaga tttggttaac
     2041 aaataaacaa ggggtgttat gtcctgagag ataaagacac tgaattatga ttgtgtgtgt
     2101 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gatttccatt tcttcagacc tataagccat
     2161 attgtgaagg gctgagattc atgtggcatt ccctaacccc cacccccttt aaaaatgcca
     2221 ctttctagaa tttccttctt ctttccggtg aaccagaaca acttagcaat acttggacgc
     2281 ttgtgaagat gtcaatatta tttccttttc ctcttcggag aacttttcaa aatcagtaca
     2341 ccttggtcat gggcgccaca caacgttgct cattttgcaa taaagcctga gtcctcattg
     2401 accataaact atgagttttg cctgccctct cctgatccat tactctgtct ccacattcat
     2461 tcagtttata aagttattcg ccattaagtg gcctttagtg attccacatg cttacaatga
     2521 gaagcgagga tgataggctt ttcatattaa aaaaaaaaaa ttttaaaaag gccacagaca
     2581 agccgagctg cagggaacgg ctgtgctagt ctgtcgctgt gaaggtctca gggatccatg
     2641 ttttcctact ttgactctgt gtgtccagcc tgggttaaga tgggatggga tggtagacac
     2701 tggcacatac acaagcaatc ccaaagactc aaacagggca aagacccaac ggaattgaaa
     2761 atagagacta agacaggagg ttttgattta tttcctcttc ttgctccata ccctctccac
     2821 ccctcctcta agtatttaaa atgtctgatg tgcccacaga ctgagagcaa cattgtgaca
     2881 taccacagtc ttaactatat gaatgaagga gggaggtgga agttacatgg aaacagatta
     2941 aggttgacag tcagtgtccc ccaggtaagt gttcctggag cagagtgagt gtcactggtt
     3001 gtagggtttg tgtaagcagt attcggtcaa gtggagtttc taatggggtt tacctacttt
     3061 tcaggacttt attgtcttta aatttgcttg cctaataagc aaaaagccca gctattaagt
     3121 atagtttatt ataaaagttc tgtgggccct tgaggtccaa tatatatgat ataaatacaa
     3181 aatttaaatt atctgtaggg tattatgact ttctgtctac atacttaatg agaattctaa
     3241 tttgagtata tactgcattg tttcatagtt tgggaaatta tgagattgta tccctcggct
     3301 atctcttatt tctgtttact ttttaatgac tgtggaagtt ttgagaagtt ggacttgctc
     3361 tctttgctat aataaatctg tggcatcata tggacatgtg tgtgtgtgtg tgtgtgtgtg
     3421 tgtgtgtgtg tgtgtgcgcg cgtgcgtctc attttggaat ctagctgctt tgatttgccc
     3481 atgtgagtga ttctaaatct gaatattctc ttagtcaaag cacttggcat acttgctgtc
     3541 atgtgcttgc tgtcttcaga gagagtattg tgctggatga gagtggttca aaatgcccac
     3601 tggaattgcc tgtatcttat caccccgcag atggatgttc aaacagcaca gcataggtac
     3661 aacaggaggc catgtcctgc cattcacaaa ttcaaaaaac tattatgaag gcatttgaag
     3721 gcgagtatgt attatgtaaa atgtgtaaaa tccaaaatgg atagtaggtt agtagaccag
     3781 atgtctgcaa ataacacggg gctcaagaga tggctcagtg gttaagagac cttatcgttt
     3841 tggcagagga cctgggtttg gttcttactt gacaactcac aactgtctgt aactctagtt
     3901 ccaaaggatc caacatttac tcctggcctc cacaggcatc aggcacaccc actgtgctca
     3961 cacaaacaca caaacgaaca cttataacct aaataaataa gaacttaaaa aaataatttt
     4021 gtcatgtcta actgaaataa cagtttctag gtaccgatca cctacgtttg ttaaaacaac
     4081 tgatggctga atgccgggga agttggggat ggtgactgag gctggtgcag tctgaaccca
     4141 ctgatcttct caataccgat caaagtgaga tgcccaagtg ctcttttctt tttttaacat
     4201 gctattggat tatgaaatct ctttgcccca gtttgtgttt tgaattgaat ctaaatttct
     4261 atttcttttt ttgtttgttt gtttgttttg ttttgttttt cggtttttcg agacagggtt
     4321 tctctgtata gtcctggttg tcttggaact cactttgtag accaggctgg ccttgaactc
     4381 agaagtctgc ctgcctctgc ctcccgagtg ctgggattaa aggcgtgcgc caccacacct
     4441 ggcttaaatt tctgtttcta aatcagtaat gataataata ataattctgt tgatatagga
     4501 agatatttaa agagacaaag tagatcaaat cagccatata caaggtagta aattatagga
     4561 gtttcatcag acaagtggcc caatttattc accaaaagtg accttaaagg gacaaaaagt
     4621 caaaaatggg agagggggct atgaattcca gtggcagaga acatgcccag catggcctag
     4681 cctccatccc ctgcatcacc acaaggaaac tgaagtaaag acatggaaga aagtctagta
     4741 acttgagacc taaaattcaa caatccagta tttggatata aatttaaaca aaccaattat
     4801 aagaggattt taaaataatt acacatggca taaatattag atgatactaa gaaactaata
     4861 ctggatatta tctctgtact gcagccagac ttttgaaaag ttctaatcca tgaagatata
     4921 cgtgtatgcc cgtgtgtgtt gtgtataatt gacagttgtc tggctgtgac cttttaatat
     4981 aattctccat gttgtggtga cccccaaaca taaaattatt tttgttgtac ttcataactg
     5041 taattttgct gctgttatta atcttcatgt aactatctga tctacagccc ctgtgaaagg
     5101 ggctgagacc cacagattga gaaacatctg ctctaggtga acagtttatc cataagaaaa
     5161 cagtcaaatg taaagaatga agccttaaga tcaataaata tacacgtgtc tgtgcattag
     5221 ttgctattga aagaaggctt ggactgacag catggctcag caggtcaaag ggcttgctgc
     5281 caaatgtgac agcctaagtt ccattcccca ggacctctac atggtggaaa gagaaaactg
     5341 actccagaaa gttgtcctct gacctccgca cacacactcc atagtacaca tgtgcagtcc
     5401 tcccaaataa ataaataaat gcatttttaa agtttaaaaa aaaaaaaaaa aaa
//
