LOCUS       NM_130450               5951 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus ELOVL fatty acid elongase 6 (Elovl6), mRNA.
ACCESSION   NM_130450
VERSION     NM_130450.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5951)
  AUTHORS   Jin,C., Wang,S., Sui,X., Meng,Q. and Wu,G.
  TITLE     Low expression of ELOVL6 may be involved in fat loss in white
            adipose tissue of cancer-associated cachexia
  JOURNAL   Lipids Health Dis 23 (1), 144 (2024)
   PUBMED   38760797
  REMARK    GeneRIF: Low expression of ELOVL6 may be involved in fat loss in
            white adipose tissue of cancer-associated cachexia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5951)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5951)
  AUTHORS   Garcia Corrales,A.V., Verberk,S.G.S., Haidar,M., Grajchen,E.,
            Dehairs,J., Vanherle,S., Loix,M., Weytjens,T., Gervois,P.,
            Matsuzaka,T., Lambrichts,I., Swinnen,J.V., Bogie,J.F.J. and
            Hendriks,J.J.A.
  TITLE     Fatty acid elongation by ELOVL6 hampers remyelination by promoting
            inflammatory foam cell formation during demyelination
  JOURNAL   Proc Natl Acad Sci U S A 120 (37), e2301030120 (2023)
   PUBMED   37669365
  REMARK    GeneRIF: Fatty acid elongation by ELOVL6 hampers remyelination by
            promoting inflammatory foam cell formation during demyelination.
REFERENCE   4  (bases 1 to 5951)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   5  (bases 1 to 5951)
  AUTHORS   Yoshida,K., Morishima,Y., Ano,S., Sakurai,H., Kuramoto,K.,
            Tsunoda,Y., Yazaki,K., Nakajima,M., Sherpa,M.T., Matsuyama,M.,
            Kiwamoto,T., Matsuno,Y., Ishii,Y., Hayashi,A., Matsuzaka,T.,
            Shimano,H. and Hizawa,N.
  TITLE     ELOVL6 deficiency aggravates allergic airway inflammation through
            the ceramide-S1P pathway in mice
  JOURNAL   J Allergy Clin Immunol 151 (4), 1067-1080 (2023)
   PUBMED   36592705
  REMARK    GeneRIF: ELOVL6 deficiency aggravates allergic airway inflammation
            through the ceramide-S1P pathway in mice.
REFERENCE   6  (bases 1 to 5951)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
REFERENCE   7  (bases 1 to 5951)
  AUTHORS   Nagarajan,R., Le,N., Mahoney,H., Araki,T. and Milbrandt,J.
  TITLE     Deciphering peripheral nerve myelination by using Schwann cell
            expression profiling
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8998-9003 (2002)
   PUBMED   12084938
REFERENCE   8  (bases 1 to 5951)
  AUTHORS   Matsuzaka,T., Shimano,H., Yahagi,N., Yoshikawa,T., Amemiya-Kudo,M.,
            Hasty,A.H., Okazaki,H., Tamura,Y., Iizuka,Y., Ohashi,K., Osuga,J.,
            Takahashi,A., Yato,S., Sone,H., Ishibashi,S. and Yamada,N.
  TITLE     Cloning and characterization of a mammalian fatty acyl-CoA elongase
            as a lipogenic enzyme regulated by SREBPs
  JOURNAL   J Lipid Res 43 (6), 911-920 (2002)
   PUBMED   12032166
  REMARK    GeneRIF: data indicate this elongase is a lipogenic enzyme
            regulated by SREBP-1, playing an important role in de novo
            synthesis of long-chain saturated and monosaturated fatty acids in
            conjunction with fatty acid synthase and stearoyl-CoA desaturase.
REFERENCE   9  (bases 1 to 5951)
  AUTHORS   Moon,Y.A., Shah,N.A., Mohapatra,S., Warrington,J.A. and Horton,J.D.
  TITLE     Identification of a mammalian long chain fatty acyl elongase
            regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 276 (48), 45358-45366 (2001)
   PUBMED   11567032
REFERENCE   10 (bases 1 to 5951)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK029029.1 and
            AC098732.3.
            
            On Apr 8, 2006 this sequence version replaced NM_130450.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY053453.1, AB072039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               AK029029.1         3-575
            574-5951            AC098732.3         142434-147811
FEATURES             Location/Qualifiers
     source          1..5951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 58.05 cM"
     gene            1..5951
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /note="ELOVL fatty acid elongase 6"
                     /db_xref="GeneID:170439"
                     /db_xref="MGI:MGI:2156528"
     exon            1..110
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /inference="alignment:Splign:2.1.0"
     exon            111..231
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..946
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids protein
                     6; fatty acyl-CoA elongase; long chain fatty acid
                     elongase; myelin-associated SUR4 protein; 3-keto acyl-CoA
                     synthase Elovl6; ELOVL family member 6, elongation of long
                     chain fatty acids; long chain fatty acyl elongase; ELOVL
                     FA elongase 6; very long chain 3-oxoacyl-CoA synthase 6;
                     very long chain 3-ketoacyl-CoA synthase 6"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 6"
                     /protein_id="NP_569717.1"
                     /db_xref="CCDS:CCDS38632.1"
                     /db_xref="GeneID:170439"
                     /db_xref="MGI:MGI:2156528"
                     /translation="MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFI
                     FGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQS
                     FYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMV
                     AGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFN
                     WMQHDNDQCYSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKVKKATKAE"
     exon            232..363
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /inference="alignment:Splign:2.1.0"
     exon            364..515
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /inference="alignment:Splign:2.1.0"
     exon            516..5951
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5922..5927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /note="hexamer: AATAAA"
     polyA_site      5951
                     /gene="Elovl6"
                     /gene_synonym="FAE; LCE"
                     /note="major polyA site"
ORIGIN      
        1 gatggacaaa cgtgcgggca ctaagaccgc aaggcattca tttcctccta cggtggatgc
       61 ggacgctggg aggagagccc ctgagctagg agctgggagc agaggcgcag agaacacgta
      121 gcgactccga agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt
      181 cgaaaagcag ttcaacgaga acgaagccat ccaatggatg caggaaaact ggaagaagtc
      241 tttcctgttt tctgcgctgt acgctgcctt tatctttggt ggtcggcatc tgatgaacaa
      301 gcgagccaag tttgaacttc ggaagccgct cgtgctctgg tcgctgactc ttgccgtctt
      361 cagtatattc ggtgctcttc gaactggtgc ttacatgctg tacattctga tgaccaaagg
      421 cctgaagcag tcagtttgtg accagagttt ttacaatgga cctgtcagca aattctgggc
      481 ttatgcattt gtgctcagca aagcacccga actaggtgac acgatattca tcattctgag
      541 gaaacagaaa ctgatcttcc tgcactggta ccaccacatc actgtgctcc tgtactcctg
      601 gtactcctac aaagacatgg tcgctggggg tggttggttc atgactatga actatggcgt
      661 gcatgccgtc atgtactctt actacgcctt gcgggctgcg ggtttccgag tctcccggaa
      721 gtttgccatg ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtcattaa
      781 ctacctggtc ttcaactgga tgcagcatga caacgaccag tgctactccc actttcagaa
      841 catcttctgg tcctcgctca tgtacctcag ctaccttgtg ctcttctgcc atttcttctt
      901 tgaggcctac atcggcaaag tgaagaaagc cacgaaggct gagtagtgtc agggctgagg
      961 aggaagtcat agctcagggt catcacgaaa aataatcgac aaaagaaaaa tggcacaagg
     1021 aatcccatat ggtgcagcta aaacaaaaca aaacatccgt atgagcaggc acgaggccca
     1081 aggcagcttg ggactgaaga ttaggttgta agtttatgat cctttctggg tgaggactcg
     1141 ctgagtgcaa ctcttatctc aaagcacggc tgctgagggg accccttccc tctggcctgt
     1201 caactctaga acacactaga tgcaaaggca gccacgggca aagagattgg gcagagatta
     1261 gtggacggcc agcaaaacac tgcaggaagc aggtgggggg aggaatctac tcagcctttt
     1321 tgttttgttt tgttttgttt tgttttgttt ttctctaagg ataaaggagt ttcccctttt
     1381 caaacgatgt gagcacacac acacacacac acacacacac acacacacac acacacgcaa
     1441 tcttttcaac acgaaaccag agctaaaaga aaagataaac atgggagaga cagggtttct
     1501 atctgggaca gcaatgcttt tgcaaaaggc taggcctttt aaagaaaggt gagcttgtaa
     1561 ctccttgata aaagatgtct taattatttt tactgcaact gaaagtaaag aggtagagcc
     1621 tttccccttc tgcacagcct cagggcttgt atgttcgcta caaccaaaca caggacagta
     1681 cttcccccat gatactttat tactgggaga aagaaacccc tgtagttgaa acaccacact
     1741 gacaactgtt atttctgctc tccgacgaga attcaagcat ccgttgttca gttgccccaa
     1801 actttaggac ggaggagtaa atgcagaact gaaagggaag aagctcagct ggctggcttg
     1861 aaaatggagt cttgtaccat gtgtaacaaa tgccagccca tcgtccctgg agctgaacag
     1921 ggaggaaggg ctatgggcag agactagagc cggattcatc caatgtgcag acagcgtgtt
     1981 cgcctccctc cctgttcgac ctcacacata atcctggctt tctaaatgag gccctgtgac
     2041 acactctgtg ctttctatat ttttgtgact ttcaaacaca gatctgcagg gctctgcctg
     2101 atttggggta aacactgtgt ttctgcagcc tctgcatttg ctcccttcag cagtgcagag
     2161 gcttgagaag tgccctctgc tggcttagtg agaagcttca acaaacactt cacagtaggt
     2221 tgaaataact gaccactaag ggcctgcgga gattaaaccc taagttctaa gtgctgtcaa
     2281 acacctgaca tatatttgac caaatcagaa gagagagaga acctctatgc ttcaagtaag
     2341 cgtcataaat tttttaagtg actttcactt gagaactcag aaagtcaatg tattaagagc
     2401 catattctga aagaaagaaa gagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     2461 aagaaagaaa gaaagaaaga aagaaaaaga aagaaagaaa gaagcaagct agacaatgtt
     2521 aactgtaata tttcagtcct ctacaagcca aataaatgtg tcgatgttcc taatatttca
     2581 aagacgcaat tacataaagt tgttcaatgt gatataatag tattctaatt ggttaagtag
     2641 tttaatgatt aggcaaacta gcagaaacaa ttagaggctg ctacaccacg tagattatac
     2701 acacatagcc acgtacgtga ggtacacgga gctataaagc tcaaatcaat agtaacacga
     2761 tttttggcta gcagaaacta tcacctatct tcctttactt gagagtgtac agtaaaaggg
     2821 attttttttc aaattatttt tatattattt tagctttaat tgtgctgtca ttcatggaac
     2881 agctgctcag cagccttcct gtgagagatg acaggggtgt tttcgtgtgg cttgtttacg
     2941 tgtggaattg gaaaagaata aaatctgatt cccttctgtg ggaatgggat caagggtaga
     3001 caaaggaccc atgtagatca agtcataact gaacgaccag ggaagggagc caggcggggg
     3061 cgggagtcag ctgtggcttt catgttacca ttgtgtggtg gctgatggac gggacgtggt
     3121 tggagggatg ttttcttact tggggtagaa gttaaccgga gatgaaagtc tagaagccac
     3181 tctgtccagt ggaatcttag ggtgtacttg ttcctttgag ctttgtaaat gcacaatagt
     3241 gtacaataat aagcctttcc cttgccttat ggaagaaagt gagcaagata atgaaaacca
     3301 agaagccacc tatcagttga attgagtcta atcaaaaggc cagcctgagg ctcctctggt
     3361 cggttcagtt taatttagat atttaccata gaatacaggt acaatatgga aatctcataa
     3421 gcataaactt taaaacgact aagctatgct tccaaagcac tttagtctca gtgttcttcg
     3481 cttcatgctc tctccacttg taaaataact tagacttttc attcgcagga tgagtatata
     3541 ataattaagt ttccaaacca gctaaactgt agctacaggc aattccagtg ttcaccatgg
     3601 gaagaaaaag ccacatgttt ttttaaaaac acagaattct gatataggct cagcacacag
     3661 tttttaacat atcagcttag ctgctctaat tgtatcaaga tacgaggctg gaccactggc
     3721 ctatgacaca tctaaaacct gccagaattg actgccacgt agataatact gctgtcagtg
     3781 aacattccgg gcaagcaagt ttttgtagct gccccactat gctgcaatag attatctttc
     3841 tattgaagat ttctcgctgc attccaatcc cagtgtggtg aaaacttaat tcctggattg
     3901 aatgaacaca aatccaaggt ttcatataaa cgcagtgcgg tcactaggtc tgagcatcaa
     3961 ctcaaatgtg ttgagtttgc aatgaaattc tagtgagaat cactccattc acacagtagg
     4021 agatttttat ctggaccttc tagtgtcaac tgtgaggaga aacaacaact atcattatta
     4081 tttatttatt gtatttatat ccaatgccag gccaaagtat tgatttagat caagcagtgc
     4141 ccttcccccc ctcccaaccc cccatctttc taatccttct gcactataga aagtcaagac
     4201 tggaggggaa atccatattc attgctgcag gggaaagcag gtttattaat cctcccgctg
     4261 tctttatgag accgattgac caatgtagct caggcagaag tttcatgtgg gtgggatatc
     4321 tacaggagcc taggaaaaca cttccagaga agataaccac agactgttgt ttttgttcat
     4381 ttgttttata tcttcatggt aagataagcc tgtcacggag ttacaaggca ccatgacact
     4441 aaggtagaat gttccagaag tctggctacc ttcccaggct gctcagttac ctgggagtgt
     4501 ctagttacta tcttgttctg acgagaggag cttttgctca agaactgcca gatacagaca
     4561 ccaagtcagc cctggcacac tctacaacct ccgggcatag gtaatgggtc tttgactatt
     4621 ggattgcctc agtgtcaagt gagttcctag aagaagagac cgagtaggct ccacccccca
     4681 gactccacca cactctgagt tgcattggca ggatcggtgt ctagacacag ttctttgtga
     4741 agtgtcaatg ctagagacag ttgtgaggag atcatgatga cagcccagaa ctttctagcc
     4801 ttcaaatgca tccttttcca gtctttgttt tgataacagc tattttgcta tcagtttggg
     4861 acaacagtag agtctgtggc catgtgatct acagcttatg atcacacagc tcccatttcc
     4921 tggtgcctga gatcccagcc atcagaaagt gatttgggtg agaattcaca acatatatgt
     4981 cacctctgca tattgaagtg acatctaata aaacaaggac gtcctatttt gtctgaaccc
     5041 gctgaatgaa gctctgttat cctagttagt cattgggccg ccatcctctg tacccgatag
     5101 tgacacaaaa cagatgtcgg tgcctgtaca agaattctca gtgcctgttg tgacagactg
     5161 tgcttagaag aaacattcgt gagccataaa gcaggaacca cagatgaaag ggccagttaa
     5221 aagtccacct gctccaagta tcatagaaaa cccaaaagcc tgttgtataa tctggtattg
     5281 tccccatccc cagatgcttt gaaaactagg attctcagag catggatacc cacgcttcca
     5341 tcttcccaca aacatttcct agagttgtac tggtgggtgc agcgcctagg tggttggttg
     5401 ggggaagtct tggaagctgt actttgattg caggtcaagc aaagccaaat ccagatattt
     5461 ctgtgtcact caccagttgt ccatgtccac ccacaaaaca attgtattat agtcaagttg
     5521 tcctagctga ttggtcctca aataaggatg caactatgtt tgcaacccag ttaggacaca
     5581 tttgaaagaa cctgactcac tagcatctaa acaatatcat ttccccaatg cttggtggca
     5641 cttcagactt ttgttctcct ggttgatcaa ggtgttgcct ggtggtgccg cctcctagtg
     5701 tgaatatttc agttaagtgt gggtctgagc atgaccgggc tgggcttagc tcactgctac
     5761 ttggaaaatg actggcattc tgcttcctag gccctaaacc catattcaga gggaaaattc
     5821 actatcaagc ctcacagcga aatcacagca gtgttggaat tcttattttc aagtgcttat
     5881 ctcacaacat tgaaaaatat ttttggtgta ttaagattta aaataaagtc atcataactt
     5941 ttgatttaaa a
//
