LOCUS       NM_134255               2802 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus ELOVL fatty acid elongase 5 (Elovl5), mRNA.
ACCESSION   NM_134255
VERSION     NM_134255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Vouilloz,A., Bourgeois,T., Diedisheim,M., Pilot,T., Jalil,A., Le
            Guern,N., Bergas,V., Rohmer,N., Castelli,F., Leleu,D., Varin,A., de
            Barros,J.P., Degrace,P., Rialland,M., Bleriot,C., Venteclef,N.,
            Thomas,C. and Masson,D.
  TITLE     Impaired unsaturated fatty acid elongation alters mitochondrial
            function and accelerates metabolic dysfunction-associated
            steatohepatitis progression
  JOURNAL   Metabolism 162, 156051 (2025)
   PUBMED   39454822
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Bae,S. and Moon,Y.A.
  TITLE     Deletion of Elovl5 leads to dyslipidemia and atherosclerosis in
            LDLR-deficient mice
  JOURNAL   Biochem Biophys Res Commun 690, 149292 (2024)
   PUBMED   38000296
  REMARK    GeneRIF: Deletion of Elovl5 leads to dyslipidemia and
            atherosclerosis in LDLR-deficient mice.
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Ferrero,E., Di Gregorio,E., Ferrero,M., Ortolan,E., Moon,Y.A., Di
            Campli,A., Pavinato,L., Mancini,C., Tripathy,D., Manes,M.,
            Hoxha,E., Costanzi,C., Pozzi,E., Rossi Sebastiano,M., Mitro,N.,
            Tempia,F., Caruso,D., Borroni,B., Basso,M., Sallese,M. and
            Brusco,A.
  TITLE     Spinocerebellar ataxia 38: structure-function analysis shows ELOVL5
            G230V is proteotoxic, conformationally altered and a mutational
            hotspot
  JOURNAL   Hum Genet 142 (8), 1055-1076 (2023)
   PUBMED   37199746
  REMARK    GeneRIF: Spinocerebellar ataxia 38: structure-function analysis
            shows ELOVL5 G230V is proteotoxic, conformationally altered and a
            mutational hotspot.
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Kieu,T.L., Pierre,L., Derangere,V., Perrey,S., Truntzer,C.,
            Jalil,A., Causse,S., Groetz,E., Dumont,A., Guyard,L., Arnould,L.,
            de Barros,J.P., Apetoh,L., Rebe,C., Limagne,E., Jourdan,T.,
            Demizieux,L., Masson,D., Thomas,C., Ghiringhelli,F. and Rialland,M.
  TITLE     Downregulation of Elovl5 promotes breast cancer metastasis through
            a lipid-droplet accumulation-mediated induction of TGF-beta
            receptors
  JOURNAL   Cell Death Dis 13 (9), 758 (2022)
   PUBMED   36056008
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Tripathy,S., Torres-Gonzalez,M. and Jump,D.B.
  TITLE     Elevated hepatic fatty acid elongase-5 activity corrects dietary
            fat-induced hyperglycemia in obese C57BL/6J mice
  JOURNAL   J Lipid Res 51 (9), 2642-2654 (2010)
   PUBMED   20488798
  REMARK    GeneRIF: Results establish a link between fatty acid elongation and
            hepatic glucose metabolism and suggest a role for regulators of
            Elovl5 activity in the treatment of diet-induced hyperglycemia.
REFERENCE   7  (bases 1 to 2802)
  AUTHORS   Moon,Y.A., Hammer,R.E. and Horton,J.D.
  TITLE     Deletion of ELOVL5 leads to fatty liver through activation of
            SREBP-1c in mice
  JOURNAL   J Lipid Res 50 (3), 412-423 (2009)
   PUBMED   18838740
  REMARK    GeneRIF: reduced ELOVL5 activity leads to hepatic steatosis, and
            endogenously synthesized PUFAs are key regulators of SREBP-1c
            activation and fatty acid synthesis in liver
REFERENCE   8  (bases 1 to 2802)
  AUTHORS   Wang,Y., Torres-Gonzalez,M., Tripathy,S., Botolin,D., Christian,B.
            and Jump,D.B.
  TITLE     Elevated hepatic fatty acid elongase-5 activity affects multiple
            pathways controlling hepatic lipid and carbohydrate composition
  JOURNAL   J Lipid Res 49 (7), 1538-1552 (2008)
   PUBMED   18376007
  REMARK    GeneRIF: Elovl5-induced changes in hepatic fatty acid content
            affect multiple pathways regulating hepatic lipid and carbohydrate
            composition
REFERENCE   9  (bases 1 to 2802)
  AUTHORS   Olson,L.E., Zhang,J., Taylor,H., Rose,D.W. and Rosenfeld,M.G.
  TITLE     Barx2 functions through distinct corepressor classes to regulate
            hair follicle remodeling
  JOURNAL   Proc Natl Acad Sci U S A 102 (10), 3708-3713 (2005)
   PUBMED   15728386
REFERENCE   10 (bases 1 to 2802)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162451.1, AK045274.1 and CF748582.1.
            
            On Sep 19, 2009 this sequence version replaced NM_134255.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162451.1, AK051580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2020              AK162451.1         2-2021
            2021-2779           AK045274.1         2000-2758
            2780-2802           CF748582.1         243-265
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.36 cM"
     gene            1..2802
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /note="ELOVL fatty acid elongase 5"
                     /db_xref="GeneID:68801"
                     /db_xref="MGI:MGI:1916051"
     exon            1..162
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..228
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1070
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /EC_number="2.3.1.199"
                     /note="homolog of yeast long chain polyunsaturated fatty
                     acid elongation enzyme; fatty acid elongase 1; elongation
                     of very long chain fatty acids protein 5; 3-keto acyl-CoA
                     synthase Elovl5; ELOVL FA elongase 5; very long chain
                     3-oxoacyl-CoA synthase 5; very long chain 3-ketoacyl-CoA
                     synthase 5; ELOVL family member 5, elongation of long
                     chain fatty acids"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 5"
                     /protein_id="NP_599016.2"
                     /db_xref="CCDS:CCDS23355.1"
                     /db_xref="GeneID:68801"
                     /db_xref="MGI:MGI:1916051"
                     /translation="MEHFDASLSTYFKAFLGPRDTRVKGWFLLDNYIPTFVCSVIYLL
                     IVWLGPKYMKNRQPFSCRGILQLYNLGLTLLSLYMFYELVTGVWEGKYNFFCQGTRSA
                     GESDMKIIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNW
                     VPCGHSYFGATLNSFIHVLMYSYYGLSSIPSMRPYLWWKKYITQGQLVQFVLTIIQTT
                     CGVFWPCSFPLGWLFFQIGYMISLIALFTNFYIQTYNKKGASRRKDHLKGHQNGSVAA
                     VNGHTNSFPSLENSVKPRKQRKD"
     exon            229..416
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..494
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..666
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..791
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..926
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..2781
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /note="hexamer: ATTAAA"
     polyA_site      2778
                     /gene="Elovl5"
                     /gene_synonym="1110059L23Rik; HELO1"
                     /note="major polyA site"
ORIGIN      
        1 ttgtgacgtc acggtcagcc cacgccgggg ttgaagctgc cgggcgcctt cctcttgcat
       61 cgcggctgca gcttgcttct gttcccgcgc ccgcttgcac atcctcctgc tcgcgcggtc
      121 ctgctgccgt ccggtgctcc ccgtagccgc tcaggcagag aggttttaaa atggaacatt
      181 tcgatgcgtc actcagtacc tatttcaagg ccttcctggg cccccgagat acaagagtca
      241 aaggatggtt cctcctggac aattacatcc ctacgtttgt ctgttctgtt atttacttac
      301 tcattgtatg gctgggacca aaatacatga agaaccggca gccgttctct tgccgaggca
      361 tcctgcagtt gtataacctt ggactcaccc tgctgtctct ctacatgttc tatgagttgg
      421 tgacaggtgt gtgggaaggc aaatacaact ttttctgcca gggaacacgc agcgcgggag
      481 aatccgatat gaagatcatc cgcgtcctct ggtggtacta cttctccaaa ctcatcgaat
      541 tcatggacac ctttttcttc atccttcgca agaacaacca ccagatcacc gtgctccatg
      601 tctaccacca cgctaccatg ctcaacatct ggtggtttgt gatgaactgg gttccctgcg
      661 gccattcata ttttggtgcg acactcaaca gcttcatcca tgtcctcatg tactcgtact
      721 atggtctgtc ctccatcccg tccatgcgtc cctacctctg gtggaaaaag tacatcactc
      781 aagggcagct ggtccagttt gtgctgacaa tcatccagac gacctgcggg gtcttctggc
      841 catgctcctt ccctctcggg tggctgttct tccagattgg atacatgatt tccctgattg
      901 ctctcttcac aaacttctac attcagactt acaacaagaa aggggcctct cggaggaaag
      961 accacctgaa gggccaccag aacgggtctg tggccgccgt caacggacac accaacagct
     1021 tcccttccct ggaaaacagc gtgaagccca ggaagcagcg aaaggattga caagccgagc
     1081 cgaagcctcc agaccgcggc gtgtgattgt aagcacagcg tgacttgtgc cctgacgctc
     1141 atagcagctg ctgtcactag tctggcccta ctatctgcag tgtgactcat gtaggacctt
     1201 cttcatcagt tcaaaacccc tagaatatgt atacagatta tacaaagtag gcatacgatt
     1261 ttctcacatt tctgggctct catcgacccc cgcgctagac tgtggaaagg gaatgttctt
     1321 gtagtataca acactgctgt tgccttatta gttgtaacac gataggtgct gaattgtggt
     1381 tcacaattta aaacactgta atccaaactt ttttttttta actgtagacc atgcatgtga
     1441 ttgtaaattt gtacaatgtt gttaacagta gaaaaacaca catgccttaa gacttaaaaa
     1501 agcagggccc agagcttgtt agtttaatta gggtatgttt caactttgta ttattcattt
     1561 gtattagctc tgtttagaaa aatcaaatgt atgatttatg aaacaagtgt gtgatgtgta
     1621 acttcaagtg acttggagat gcgaaatctg atggcaccct tggttttata acgatggctt
     1681 taaataagca ggttcaagtc tagtggaaca gtcagtttaa ctttttaaca gatcttattt
     1741 ttttattttg agtgccacta ttaatgtgtt taaagaggtg gggaaagggt ccaaagcgtc
     1801 tggagacact tacgtacctg tccctggtcc cccagaggct agggtgacta taagagtagg
     1861 tcacttttca cttctgaagt gcttagtgtt tttatacagg agataaaaag gccattcgac
     1921 ttcccaccac ttggagagag agaactacct ttcaggaaag gtgacgagac atttattatc
     1981 tgacagacac acacacacac acacacagtg ataagggact ggttacctgg gtccacattt
     2041 ttttttattc ttttctgtag tgctactttg acatacactt ccttttaaaa tgtgcctaat
     2101 ttaccaagag accaggaagc accataagca ttttgaggta aaatttaaga gctggagcgc
     2161 gcaggaactg ggtgtttggg agcaaccgct tttttcagtg tgaatcatgg tggcatctgt
     2221 aatttttttc tgattagcac ctaaagatcg gtttaaagtg cttggactgc ttatcctaaa
     2281 atcgtgtcta gtgcgctcga ggcatcggtc atacaaatgg ggactctttt catgtgtgtc
     2341 atttttaaag tgttgaaagc ttagcctttg aataccttct gcattggtaa aaaatccatg
     2401 gaaccactca tggcacatct taggagatga ttgacaatgt ataaactaat tgtgggtttg
     2461 atatttatgt aaataccagt ttaccatgct ttaattttgc acattcatat tacaaggagc
     2521 cagttggtcc taattagcct tgtgggtttt ctgtttggaa ggagttgcgg catctgttta
     2581 catttccctt gtcagatcta gaatgtgtgt atgtgtgtgt cttctcccta ggtacccgtc
     2641 tgcaggtgtc tttacatatc tcaatacaaa aattataaca tttgatagtg tgctgtcaaa
     2701 gtgtgcttag ctcatctgga tatacccaca ctgttaaata atgtctaaac attaatcatt
     2761 aaaacctttt tgattacccg taaaaaaaaa aaaaaaaaaa aa
//
