LOCUS       NM_148941               3071 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ELOVL fatty acid elongase 4 (Elovl4), mRNA.
ACCESSION   NM_148941 NM_001145974
VERSION     NM_148941.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Kato,A., Ito,M., Sanaki,T., Okuda,T., Tsuchiya,N., Yoshimoto,R. and
            Yukioka,H.
  TITLE     Acsl1 is essential for skin barrier function through the activation
            of linoleic acid and biosynthesis of omega-O-acylceramide in mice
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (2), 159085 (2022)
   PUBMED   34813948
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Gorusupudi,A., Rallabandi,R., Li,B., Arunkumar,R., Blount,J.D.,
            Rognon,G.T., Chang,F.Y., Wade,A., Lucas,S., Conboy,J.C.,
            Rainier,J.D. and Bernstein,P.S.
  TITLE     Retinal bioavailability and functional effects of a synthetic
            very-long-chain polyunsaturated fatty acid in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33526677
  REMARK    GeneRIF: Retinal bioavailability and functional effects of a
            synthetic very-long-chain polyunsaturated fatty acid in mice.
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Mandal,M.N., Ambasudhan,R., Wong,P.W., Gage,P.J., Sieving,P.A. and
            Ayyagari,R.
  TITLE     Characterization of mouse orthologue of ELOVL4: genomic
            organization and spatial and temporal expression
  JOURNAL   Genomics 83 (4), 626-635 (2004)
   PUBMED   15028285
  REMARK    GeneRIF: ELOVL4 may play an important role in embryonic development
            and in maintaining normal physiology of retina and brain at later
            stages of development
REFERENCE   8  (bases 1 to 3071)
  AUTHORS   Zhang,X.M., Yang,Z., Karan,G., Hashimoto,T., Baehr,W., Yang,X.J.
            and Zhang,K.
  TITLE     Elovl4 mRNA distribution in the developing mouse retina and
            phylogenetic conservation of Elovl4 genes
  JOURNAL   Mol Vis 9, 301-307 (2003)
   PUBMED   12847421
  REMARK    GeneRIF: Elovl4 expression in developing retina follows a dynamic
            pattern. It switches from predominant ganglion cell expression in
            embryonic and early postnatal development to predominant expression
            in the photoreceptor inner segments
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3071)
  AUTHORS   Lagali,P.S., Liu,J., Ambasudhan,R., Kakuk,L.E., Bernstein,S.L.,
            Seigel,G.M., Wong,P.W. and Ayyagari,R.
  TITLE     Evolutionarily conserved ELOVL4 gene expression in the vertebrate
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 44 (7), 2841-2850 (2003)
   PUBMED   12824221
  REMARK    GeneRIF: The ELOVL4 gene is highly conserved throughout evolution
            and is expressed in the photoreceptor cells of the retina in a
            variety of different species
REFERENCE   10 (bases 1 to 3071)
  AUTHORS   Zhang,K., Kniazeva,M., Han,M., Li,W., Yu,Z., Yang,Z., Li,Y.,
            Metzker,M.L., Allikmets,R., Zack,D.J., Kakuk,L.E., Lagali,P.S.,
            Wong,P.W., MacDonald,I.M., Sieving,P.A., Figueroa,D.J.,
            Austin,C.P., Gould,R.J., Ayyagari,R. and Petrukhin,K.
  TITLE     A 5-bp deletion in ELOVL4 is associated with two related forms of
            autosomal dominant macular dystrophy
  JOURNAL   Nat Genet 27 (1), 89-93 (2001)
   PUBMED   11138005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288030.1, AK029065.1, AC124011.4 and AF277093.1.
            
            On or before Jun 14, 2012 this sequence version replaced
            NM_001145974.1, NM_148941.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277093.1, AK029065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               BY288030.1         1-140
            141-1925            AK029065.1         2-1786
            1926-2443           AC124011.4         50790-51307         c
            2444-3071           AF277093.1         2241-2868
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 45.6 cM"
     gene            1..3071
                     /gene="Elovl4"
                     /note="ELOVL fatty acid elongase 4"
                     /db_xref="GeneID:83603"
                     /db_xref="MGI:MGI:1933331"
     exon            1..367
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1206
                     /gene="Elovl4"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids protein
                     4; ELOVL FA elongase 4; 3-keto acyl-CoA synthase Elovl4;
                     very long chain 3-oxoacyl-CoA synthase 4; very long chain
                     3-ketoacyl-CoA synthase 4; elongation of very long chain
                     fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 4"
                     /protein_id="NP_683743.2"
                     /db_xref="CCDS:CCDS23376.1"
                     /db_xref="GeneID:83603"
                     /db_xref="MGI:MGI:1933331"
                     /translation="MGLLDSEPGSVLNAMSTAFNDTVEFYRWTWTIADKRVADWPLMQ
                     SPWPTISISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSY
                     NAGYSYICQSVDYSNDVNEVRIAGALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVY
                     HHCTMFTLWWIGIKWVAGGQAFFGAQMNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYL
                     TMLQLVQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYTRTYNEPKQS
                     KTGKTATNGISSNGVNKSEKALENGKPQKNGKPKGE"
     exon            368..555
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..636
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..808
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..936
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     exon            937..3054
                     /gene="Elovl4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3028..3033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl4"
                     /note="hexamer: AATACA"
     polyA_site      3050
                     /gene="Elovl4"
                     /note="major polyA site"
ORIGIN      
        1 gcggccacgt gatgcgggcg aggggattgg agctgcggca gcgcgcggcg acagagagga
       61 gcagcgctgg gcgctcgtgg ctggtcctcc tcctcctccg ccctccggct tcttgtctct
      121 gctgttcgcc gctgctctcc gcctgcatcc ccagtcgcgg cgcctggagg aggaggagac
      181 gccgctgcca gcagggttcc cgccgcagtc gcccacggtc catcggagcc tctcttctcg
      241 ccgctgctcg tacctctcct cgccaagatg gggctgctgg actcagagcc cggcagcgtc
      301 ctgaacgcga tgtccacggc attcaacgac accgtggagt tctatcgctg gacctggacc
      361 attgcagata aacgtgtagc agactggccg ctgatgcagt ctccatggcc aacgataagc
      421 ataagcacgc tctatctcct gttcgtgtgg ctgggtccaa agtggatgaa agaccgcgag
      481 ccgttccaaa tgcgcttagt actcataatc tataattttg gcatggtttt gcttaacctt
      541 ttcatcttca gagagctatt catgggatca tacaacgcag gatacagcta tatttgccag
      601 tcagtggatt attctaatga tgttaatgaa gtcaggatag ctggcgccct gtggtggtat
      661 tttgtatcga aaggcgttga gtatttggac acagtgtttt ttatcctgag gaagaaaaac
      721 aaccaagtct ccttccttca cgtgtaccac cactgcacca tgttcactct gtggtggatt
      781 ggaatcaagt gggtggctgg aggccaagcg tttttcgggg cccagatgaa ctctttcatc
      841 cacgtgatca tgtactccta ctatgggctg actgcgttcg gcccctggat ccagaaatat
      901 ctttggtgga agcgatacct gaccatgctg cagctggtcc agttccacgt gaccatcgga
      961 cacacagcac tgtctctcta caccgactgc cccttcccca agtggatgca ctgggctctg
     1021 atcgcctacg ccatcagctt catcttcctc ttcctcaact tctacactcg gacatacaat
     1081 gagccgaagc agtcaaaaac cggaaagacg gccacgaatg gtatctcatc gaacggcgtg
     1141 aataaatcag agaaagcgtt agaaaacggg aaaccccaga aaaacgggaa gccaaaagga
     1201 gagtaaattg aactgggcct taaccggtag acagtgagga aactcctgtg tcattttaaa
     1261 aagttcaggg gcaacagaag cagagggtct gggctgggga gaaaggcaga tagggtcttt
     1321 gcccttcaga ctgagtaaac ttttcaatat atggtaccca gatgttttat ttatgaagtt
     1381 tttattttaa agtttttttt tattagcctt catgttgtcc agaccaaagc aaccccaatg
     1441 tgaccttgga gcctctcctc ctgttcacat ccgcctgtgc aatgggtgga aattttgcct
     1501 atcttccatt tactctttcc tcagtctgaa ctttacatga tcacagaaac ataatttcat
     1561 gaaaaaaaat ttttttttcc taaatcacta gttttcgatt ggttgcaaat cagttacctg
     1621 acattttctt gttcagagac agaacaagaa aatacagttg aatttggacc catttactga
     1681 cccttgtggt caaacctttc cacctctagt ccgaatattc ccttttggat gtaattaaat
     1741 ttgaaagctc tgcaaaatct ctgtagaatc tagaggcctg ttgaggacaa tgttgatgtt
     1801 gttgttgatg atgatgatgg tgttggtgaa gataagaaag aataacagta aaatcctgtc
     1861 ttgtgaccca taggccacca cgatttacgg cacaaatcac tgtgggaaac aatatatctc
     1921 tctctatttt tttgtaatga ggaaggtagc ctttgaatac tcctattatt agcagaaatg
     1981 aattatgaga attaagatta ttgtacgatt gaaacatgaa agaaatcatg tctttgttag
     2041 caacatctaa ggtagtcaca tttacatgca cttagaactc cgagggggga tggatttttt
     2101 tatcagggct ttccttgttt tgatttgtgg ctattgctga tttttttcgt acgtggacat
     2161 acacctacct cttctgttgg aaagaacatt taaaatgaaa taaattttac ttaaaaaaaa
     2221 aatcaaggag tcctctaatg taaattttaa ttttaacttt ccaatttact ttttattttt
     2281 ttttattttt atttacaaat agctcaacca aacatttctg tgatgttatc catctctttc
     2341 aatgtgtcta attctgagca atgcttgtgt ccccttgtga ctatgttgca aaaaaaaaaa
     2401 aatcttcctt attaactaga aaagaagtgt aaacgcattt tggtgcaata tcttgactcc
     2461 ttggtgctaa tgattgcaaa attcagtgct tgccgctaca aggtgttact tactaataca
     2521 agatgagaaa aattgagacc aagccagatc tctcaagtcc aatgtggtgt ttacaaacta
     2581 tgtatctcat gtcattgaaa cgggtgaccg gaagactgca gaagagacgt tgttccactt
     2641 tttttttttt tttacacaga ttaatttgtt atgggcgtca cagagagatc atatggaaag
     2701 aggaaatgtg acaaaaatta gcatgaatat ttctaaatct tccaacttgt caaatctgca
     2761 tgtgtgggat gtctgctgtt tgtacagact ttcagaacat tttgtaaatt ataaagtatt
     2821 tattgtgcgt tgagattcca ttccccctca aaggcatgca gtcaccaaca ttacgggaac
     2881 agcagcacag ggaatagtgc tgtttaagag gagctacact ttgtttcttg ccagtgtgta
     2941 atgactagag atgtgtaaat ctttgcgaac attctgtact ggctccccag accccttcac
     3001 tccctgctct ccgatttcag cacaataaat acactacagc tgtgggaaaa gtgaaaaaaa
     3061 aaaaaaaaaa a
//
