LOCUS       NM_007703               1879 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus ELOVL fatty acid elongase 3 (Elovl3), transcript
            variant 1, mRNA.
ACCESSION   NM_007703 XM_903277
VERSION     NM_007703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Creasy,K.T., Ren,H., Jiang,J., Peterson,M.L. and Spear,B.T.
  TITLE     Elongation of very long chain fatty acids-3 (Elovl3) is activated
            by ZHX2 and is a regulator of cell cycle progression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G582-G592 (2023)
   PUBMED   37847682
  REMARK    GeneRIF: Elongation of very long chain fatty acids-3 (Elovl3) is
            activated by ZHX2 and is a regulator of cell cycle progression.
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Sun,Z., Wu,K., Feng,C. and Lei,X.G.
  TITLE     Selenium-dependent glutathione peroxidase 1 regulates transcription
            of elongase 3 in murine tissues
  JOURNAL   Free Radic Biol Med 208, 708-717 (2023)
   PUBMED   37726091
  REMARK    GeneRIF: Selenium-dependent glutathione peroxidase 1 regulates
            transcription of elongase 3 in murine tissues.
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Qin,Z., Wang,P., Chen,W., Wang,J.R., Ma,X., Zhang,H., Zhang,W.J.
            and Wei,C.
  TITLE     Hepatic ELOVL3 is dispensable for lipid metabolism in mice
  JOURNAL   Biochem Biophys Res Commun 658, 128-135 (2023)
   PUBMED   37030067
  REMARK    GeneRIF: Hepatic ELOVL3 is dispensable for lipid metabolism in
            mice.
REFERENCE   4  (bases 1 to 1879)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1879)
  AUTHORS   Fonseca,T.L., Russo,S.C., Luongo,C., Salvatore,D. and Bianco,A.C.
  TITLE     Inactivation of Type 3 Deiodinase Results in Life-long Changes in
            the Brown Adipose Tissue Transcriptome in the Male Mouse
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35238380
REFERENCE   6  (bases 1 to 1879)
  AUTHORS   Rieger,D.K., Reichenberger,E., McLean,W., Sidow,A. and Olsen,B.R.
  TITLE     A double-deletion mutation in the Pitx3 gene causes arrested lens
            development in aphakia mice
  JOURNAL   Genomics 72 (1), 61-72 (2001)
   PUBMED   11247667
REFERENCE   7  (bases 1 to 1879)
  AUTHORS   Semina,E.V., Murray,J.C., Reiter,R., Hrstka,R.F. and Graw,J.
  TITLE     Deletion in the promoter region and altered expression of Pitx3
            homeobox gene in aphakia mice
  JOURNAL   Hum Mol Genet 9 (11), 1575-1585 (2000)
   PUBMED   10861284
REFERENCE   8  (bases 1 to 1879)
  AUTHORS   Tvrdik,P., Asadi,A., Kozak,L.P., Nuglozeh,E., Parente,F.,
            Nedergaard,J. and Jacobsson,A.
  TITLE     Cig30 and Pitx3 genes are arranged in a partially overlapping
            tail-to-tail array resulting in complementary transcripts
  JOURNAL   J Biol Chem 274 (37), 26387-26392 (1999)
   PUBMED   10473596
REFERENCE   9  (bases 1 to 1879)
  AUTHORS   Tvrdik,P., Asadi,A., Kozak,L.P., Nedergaard,J., Cannon,B. and
            Jacobsson,A.
  TITLE     Cig30, a mouse member of a novel membrane protein gene family, is
            involved in the recruitment of brown adipose tissue
  JOURNAL   J Biol Chem 272 (50), 31738-31746 (1997)
   PUBMED   9395518
REFERENCE   10 (bases 1 to 1879)
  AUTHORS   Jacobsson,A., Stadler,U., Glotzer,M.A. and Kozak,L.P.
  TITLE     Mitochondrial uncoupling protein from mouse brown fat. Molecular
            cloning, genetic mapping, and mRNA expression
  JOURNAL   J Biol Chem 260 (30), 16250-16254 (1985)
   PUBMED   2999153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U97107.1 and AA241332.1.
            
            On Dec 7, 2007 this sequence version replaced NM_007703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97107.1, BC016468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1555              U97107.1           1-1555
            1556-1879           AA241332.1         48-371              c
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..1879
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /note="ELOVL fatty acid elongase 3"
                     /db_xref="GeneID:12686"
                     /db_xref="MGI:MGI:1195976"
     exon            1..275
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..987
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /EC_number="2.3.1.199"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongation of very long chain fatty acids-like 3; very
                     long chain fatty acid elongase 3; elongation of very long
                     chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3;
                     elongation of very long chain fatty acids protein 3;
                     cold-inducible glycoprotein of 30 kDa; 3-keto acyl-CoA
                     synthase Elovl3; cold inducible glycoprotein 30; ELOVL FA
                     elongase 3; very long chain 3-oxoacyl-CoA synthase 3; very
                     long chain 3-ketoacyl-CoA synthase 3"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 3 isoform 1"
                     /protein_id="NP_031729.1"
                     /db_xref="CCDS:CCDS29871.1"
                     /db_xref="GeneID:12686"
                     /db_xref="MGI:MGI:1195976"
                     /translation="MDTSMNFSRGLKMDLMQPYDFETFQDLRPFLEEYWVSSFLIVVV
                     YLLLIVVGQTYMRTRKSFSLQRPLILWSFFLAIFSILGTLRMWKFMATVMFTVGLKQT
                     VCFAIYTDDAVVRFWSFLFLLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLLFTSFG
                     YKNKVPSGGWFMTMNFGVHSVMYTYYTMKAAKLKHPNLLPMVITSLQILQMVLGTIFG
                     ILNYIWRQEKGCHTTTEHFFWSFMLYGTYFILFAHFFHRAYLRPKGKVASKSQ"
     exon            276..407
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..559
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..1879
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /note="major polyA site"
     polyA_site      1879
                     /gene="Elovl3"
                     /gene_synonym="Cig30; CIN-2"
                     /note="major polyA site"
ORIGIN      
        1 gagcgggctg gttagcagcg cacgtgccag gctccggggc ccttctgctt atacacaatt
       61 tctttctgtc ctgggtttct tcgtccctga gacccactcc atcttctact tctttggctc
      121 tcgcccagct ccctacccca agctctgtaa ctcgtcgtct gcaaaatcga aatggacaca
      181 tccatgaatt tctcacgcgg gttaaaaatg gacctgatgc aaccctatga cttcgagacg
      241 tttcaggact taaggccctt tttggaggag tactgggtaa gctcatttct catagtggtc
      301 gtctatctgt tgctcatcgt tgttggccag acctacatga gaacgcggaa gagcttcagc
      361 ttgcagaggc ctctcatcct ctggtccttc ttcctggcaa tattcagtat cctgggtact
      421 ctgaggatgt ggaagtttat ggcaacagtg atgtttacag tgggcctcaa gcaaaccgtg
      481 tgctttgcca tctacacgga tgacgccgta gtcagattct ggtcctttct ctttcttctc
      541 agcaaggttg ttgaactggg agacacggcc ttcatcatcc tgcgtaagcg tccactcatc
      601 tttgtccact ggtaccacca cagcacagtg ctactgttca caagctttgg atacaagaac
      661 aaagtgcctt cgggtggctg gttcatgacc atgaactttg gcgtccattc tgtcatgtac
      721 acttactaca ctatgaaggc tgccaaactg aagcatccta atcttctccc catggtcatc
      781 accagcctgc agattctgca gatggttctg ggcaccatct ttggcatact gaattacatc
      841 tggaggcagg agaaaggatg ccacacaaca acggaacact tcttctggtc ttttatgcta
      901 tatgggacct atttcatcct attcgctcac ttcttccacc gagcctacct caggcccaag
      961 ggcaaagttg catccaagag ccaatgagag taggaaagaa agatggagcc tcagccgttc
     1021 ctccgtggca ctaagggtat gggagaatga ttagggtacc tccctgtatg gtttccccca
     1081 tgggatatgt accctcaaag ttgcaggaag ctatgacaac caagaaatgt cacccttggg
     1141 gatagggggt gtgtggtttg gtactttgat gtttctgtct ttaatgtgaa ggaaaaccaa
     1201 gccctaggaa ggagatagga ctgaggtcct taaaatggag ttatttatat ttatatttag
     1261 aaatctttct cttcttgctc tatttttaaa agaggtcaac atgatcttga ggatttgtgg
     1321 acttggaggg gaggggagag tggactgact ctgtggtagg aggaggctga ctctggggag
     1381 tgagtgatct gcaggggggg agcctgaggg tgtgtggaag gacagaggca cacacaaaca
     1441 ctcaataaga attctaggcc tggtaggcgc ttaataaatg tcttttacag actagaagtt
     1501 tattgctgtt agagacccaa gcctctgaaa ggaacagtga gaaacaagtc ctaaaatcat
     1561 aggctaaact gcagaagaga tcgctgcgtg gaagcacggg tgaccagacc taccggctgt
     1621 cctcccagag accaccaggt ggcgtcgcag caccagcaga gaacgatccc tgtcagctag
     1681 ctggtcacac caagcttcat actcctttta ctccaggaga ccctgcttcc ctatcctgga
     1741 ggaaaggagt gagacggcaa ccttagaagc ctggacgctc actcggttcc tgtacatcca
     1801 gctgtccttt tggacaatgg gaaggatgaa gggaaggagg gctcaaccgc aagtctgaat
     1861 catcaggcct ttgacagtc
//
