LOCUS       NM_019423               3837 bp    mRNA    linear   ROD 20-FEB-2025
DEFINITION  Mus musculus ELOVL fatty acid elongase 2 (Elovl2), transcript
            variant 1, mRNA.
ACCESSION   NM_019423
VERSION     NM_019423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3837)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    GeneRIF: Regulation of meiotic telomere dynamics through membrane
            fluidity promoted by AdipoR2-ELOVL2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3837)
  AUTHORS   Rezaei,K., Bejoy,A.M., Rotarescu,R.D., Klievik,B.J. and
            Metherel,A.H.
  TITLE     Sex-dependent differences in tissue and blood n-3 PUFA levels
            following ALA or ALA + DHA feeding of liver-specific Elovl2-KO and
            control mice
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 201, 102621 (2024)
   PUBMED   38763083
  REMARK    GeneRIF: Sex-dependent differences in tissue and blood n-3 PUFA
            levels following ALA or ALA + DHA feeding of liver-specific
            Elovl2-KO and control mice.
REFERENCE   3  (bases 1 to 3837)
  AUTHORS   Yi,C., Yang,J., Zhang,T., Qin,L. and Chen,D.
  TITLE     Identification of Breast Cancer Subtypes Based on Endoplasmic
            Reticulum Stress-Related Genes and Analysis of Prognosis and Immune
            Microenvironment in Breast Cancer Patients
  JOURNAL   Technol Cancer Res Treat 23, 15330338241241484 (2024)
   PUBMED   38725284
REFERENCE   4  (bases 1 to 3837)
  AUTHORS   Osada,H., Toda,E., Homma,K., Guzman,N.A., Nagai,N., Ogawa,M.,
            Negishi,K., Arita,M., Tsubota,K. and Ozawa,Y.
  TITLE     ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and
            docosahexaenoic acid levels during photoreceptor degeneration and
            visual loss
  JOURNAL   Cell Death Dis 12 (5), 458 (2021)
   PUBMED   33963174
  REMARK    GeneRIF: ADIPOR1 deficiency-induced suppression of retinal ELOVL2
            and docosahexaenoic acid levels during photoreceptor degeneration
            and visual loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3837)
  AUTHORS   Hamano,F., Kuribayashi,H., Iwagawa,T., Tsuhako,A., Nagata,K.,
            Sagara,H., Shimizu,T., Shindou,H. and Watanabe,S.
  TITLE     Mapping membrane lipids in the developing and adult mouse retina
            under physiological and pathological conditions using mass
            spectrometry
  JOURNAL   J Biol Chem 296, 100303 (2021)
   PUBMED   33465374
  REMARK    GeneRIF: Mapping membrane lipids in the developing and adult mouse
            retina under physiological and pathological conditions using mass
            spectrometry.
            Erratum:[J Biol Chem. 2022 Sep;298(9):102427. doi:
            10.1016/j.jbc.2022.102427.. PMID: 36054952]
REFERENCE   6  (bases 1 to 3837)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   7  (bases 1 to 3837)
  AUTHORS   Leonard,A.E., Kelder,B., Bobik,E.G., Chuang,L.T., Lewis,C.J.,
            Kopchick,J.J., Mukerji,P. and Huang,Y.S.
  TITLE     Identification and expression of mammalian long-chain PUFA
            elongation enzymes
  JOURNAL   Lipids 37 (8), 733-740 (2002)
   PUBMED   12371743
REFERENCE   8  (bases 1 to 3837)
  AUTHORS   Ferdinandusse,S., Denis,S., Mooijer,P.A., Zhang,Z., Reddy,J.K.,
            Spector,A.A. and Wanders,R.J.
  TITLE     Identification of the peroxisomal beta-oxidation enzymes involved
            in the biosynthesis of docosahexaenoic acid
  JOURNAL   J Lipid Res 42 (12), 1987-1995 (2001)
   PUBMED   11734571
REFERENCE   9  (bases 1 to 3837)
  AUTHORS   Moon,Y.A., Shah,N.A., Mohapatra,S., Warrington,J.A. and Horton,J.D.
  TITLE     Identification of a mammalian long chain fatty acyl elongase
            regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 276 (48), 45358-45366 (2001)
   PUBMED   11567032
REFERENCE   10 (bases 1 to 3837)
  AUTHORS   Tvrdik,P., Westerberg,R., Silve,S., Asadi,A., Jakobsson,A.,
            Cannon,B., Loison,G. and Jacobsson,A.
  TITLE     Role of a new mammalian gene family in the biosynthesis of very
            long chain fatty acids and sphingolipids
  JOURNAL   J Cell Biol 149 (3), 707-718 (2000)
   PUBMED   10791983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126714.1, BC098215.1, BB277808.1 and BB279541.1.
            
            On Dec 8, 2007 this sequence version replaced NM_019423.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.68762.1, AK044770.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY126714.1         2-18
            18-3724             BC098215.1         1-3707
            3725-3760           BB277808.1         164-199
            3761-3837           BB279541.1         224-300
FEATURES             Location/Qualifiers
     source          1..3837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.38 cM"
     gene            1..3837
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /note="ELOVL fatty acid elongase 2"
                     /db_xref="GeneID:54326"
                     /db_xref="MGI:MGI:1858960"
     exon            1..49
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..925
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /EC_number="2.3.1.199"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongation of very long chain fatty acids protein 2; very
                     long chain 3-oxoacyl-CoA synthase 2; very long chain
                     3-ketoacyl-CoA synthase 2; 3-keto acyl-CoA synthase
                     Elovl2; sequence similarity to Cig30 2; ELOVL FA elongase
                     2; elongation of very long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3, yeast)-like 2; ELOVL family member 2; very long
                     chain fatty acid elongase 2"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 2 isoform 1"
                     /protein_id="NP_062296.1"
                     /db_xref="CCDS:CCDS36639.1"
                     /db_xref="GeneID:54326"
                     /db_xref="MGI:MGI:1858960"
                     /translation="MEQLKAFDNEVNAFLDNMFGPRDSRVRGWFLLDSYLPTFILTIT
                     YLLSIWLGNKYMKNRPALSLRGILTLYNLAITLLSAYMLVELILSSWEGGYNLQCQNL
                     DSAGEGDVRVAKVLWWYYFSKLVEFLDTIFFVLRKKTNQITFLHVYHHASMFNIWWCV
                     LNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTIT
                     HTLSAVVKPCGFPFGCLIFQSSYMMTLVILFLNFYIQTYRKKPVKKELQEKEVKNGFP
                     KAHLIVANGMTDKKAQ"
     exon            50..113
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            114..301
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..379
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..551
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..676
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..811
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..3837
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3701..3706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /note="hexamer: AATAAA"
     polyA_site      3724
                     /gene="Elovl2"
                     /gene_synonym="Ssc2"
                     /note="major polyA site"
ORIGIN      
        1 agaaggaagg cggctaccct ggacagcgca tcgcggccgc gcggccatgg agcagctgaa
       61 ggcctttgat aatgaagtca atgctttctt ggacaacatg tttggaccac gagattctcg
      121 agttcgcggg tggttcctgc tggactctta ccttcccacc ttcatcctca ccatcacgta
      181 cctgctctcg atatggctgg gtaacaagta catgaagaac aggcctgctc tgtctctcag
      241 gggcatcctc accttgtata acctcgcaat cacacttctt tctgcgtata tgctggtgga
      301 gctcatcctc tccagctggg aaggaggtta caacttgcag tgtcagaatc tcgacagtgc
      361 aggagaaggt gatgtccggg tagccaaggt cttgtggtgg tactacttct ccaaactagt
      421 ggagttcctg gacacgattt tctttgttct acgaaaaaag accaatcaga tcaccttcct
      481 tcatgtctat caccacgcgt ccatgttcaa catctggtgg tgtgttttga actggatacc
      541 ttgtggtcaa agcttctttg gacccaccct gaacagcttt atccacattc tcatgtactc
      601 ctactacggc ctgtctgtgt tcccgtccat gcacaagtac ctttggtgga agaagtacct
      661 cacacaggct cagctggtgc agttcgtact caccatcacg cacacgctga gtgccgtggt
      721 gaagccctgt ggcttcccct ttggctgtct catcttccag tcttcctata tgatgacgct
      781 ggtcatcctg ttcttaaact tctatattca gacataccgg aaaaagccag tgaagaaaga
      841 gctgcaagag aaagaagtga agaatggttt ccccaaagcc cacttaattg tggctaatgg
      901 catgacggac aagaaggctc aataaaatga agtgccgggg aacacaaact gaggtggtgg
      961 cggcggcggc ggcggcagca aacagacgag cttgttttaa agcagagact gaatagaaag
     1021 ttgtatgttt tagcataaac taattccttt tgagtttgta aatcatttgt acccagaatg
     1081 tattataata tattgctatt aggttactct actaactgga gccatgccga cctctacaaa
     1141 ccttgaacag gtgcacagcc ccctctccgg agcgctttgt aatgccttat tcacgtcgaa
     1201 aaccaggaga ctcgggcttc gtttcttcat ggcaagtctt cagagttaat tttctttaga
     1261 tgtgtaaaac tgttcattgt agtgtaaatg tcagggtctg ttctagtcta tgtcaagcaa
     1321 taactgtcag tgcataaatc gattagtctg ctgttgctta aggcagcagc cccaggcagc
     1381 atttaagcgg gatccttagc aagacagaat ccagcaaaac cctttcccct ctcaagccag
     1441 gagtctcatc tgctacattt tttttaacca cctctgattt ccaacttagt gatgtggtaa
     1501 tgaaattcgt ttgtcttcaa tatagtttga agattagtca ttccatgaag gaacagcctc
     1561 ttgagctggg tatggtggca cccatctgtg agtccagcat ttgggtattg agacagccta
     1621 gggtacacag gcacaagacc ctgtctcaac cagaaaagaa aaatgtgttt gccaaatcat
     1681 aactcagggg ctttgaacag agctgtctct gtttcaattg gcatccttgc tcatccattc
     1741 ctgtctacct cccttgttag tctagatttc tggagttatg ttccccacat ccaaagccag
     1801 tgtctacata cagctgccat gccctttctg aacaaaggct ggagttgtcc aattgcagtt
     1861 cttcttcgca tagaaatgca attggaatat ttacaaatca taatcaacag agccccaggg
     1921 gcaaaataga cattctattt gtcagctgtt gctgctgagc ctgctggtga acaccattgc
     1981 aagcagttgc tgagcctgct ggtgaacacc attgcaagca gttgctgagc ctgctcgtga
     2041 acaccattgc aagccattgc tgtcaagctt catgagttaa atttaactgt tagagaggag
     2101 aaaagcatag cagtcatttg gaacgatctc gtggggtggg actaagccat aatgatgtgt
     2161 ctggctcaag cagcaatgct gtccctgctc agaactgtgg tctctgtgga gaacctagta
     2221 cagagcctga gcaaggcaat ggaccacctc cttttcctca aactgatgga tcaccactgt
     2281 taatctatac caggtgtgaa aaagggcatt tcccaaaaca tacacaaaac acaacttact
     2341 ctatttcccc tccatttcag caaatgtgtt cttggttcat ggcactggca cccagcgcat
     2401 gggcaccagg taggtgttcc tcgagtgcca acggcggggc ctgcccaccc ctgtcttcct
     2461 ttctgggcaa gctcccattt taacttttcc ctgttaaaaa ttgtactgat gttttaaact
     2521 cgtaactata ccacccttct cactggtgta ttttgaaaac caccacagtc cgatgtcctg
     2581 tgccatgtct gtcattcctg ttgaacagac tcttcctgtc tggtgaccac ctatgcttca
     2641 gtgcattttc taaacaattt ctcaaactga tctgctcccg ggtgctttct taccaccatc
     2701 tctggtgact tagcctcaaa ttggtgtttt tctttcccaa gaattcatct taagggttag
     2761 ctttgagtat gttactgtcc ttctatgaca agaccaaagg aacaaactcc ttggtgaatc
     2821 tggagttcag ctttagtttt caaacacaat ctgaaatctg ttagtaaaat gaattctggg
     2881 taaaaatgag actcaagagg catcactggc cattgtacca gattattcct gctcgccagt
     2941 gagaggcgtt taagtcgcgc tgtgcatcgt accttcagtt taggctgttt tcatgacctc
     3001 acatctgtgt agcacaaagg gtgttatctt cctatagcag atcaacagtg gcagctcaca
     3061 gtaccagcca gctttagacc tcccagtgca aagcccagcg cagcactaag ccttaagcca
     3121 cccaagggct gacacaccat gcagagctac gaaatctgtg ctgagaaaat gccatctgga
     3181 aagattttta acccattcat tcttagtgtg aattttctaa aatagaagta taaaaaaaaa
     3241 gtctctataa tctgatagga aaccgtcttt tcccaagtga attccctttt attcatgaga
     3301 acaaaagtac ttagatacta taaaacctta atttccccaa cttttaaaat aaaatggaat
     3361 atttgctgaa tgaattaagc atagaaaatg tcaacccatc agaattatat ttatacatat
     3421 tggtggataa gttcttgtct tcccacatca gagaattttt ttttaaacca aaatgggcag
     3481 aatagcattt tgtatgttag agaccattct tttctagtcc ttccaaacat tcctgtgtca
     3541 cttaagaatg ttagtagagg tcgcttcttt ggaaattgag gacttttttt tttcctttga
     3601 aagtatggca tctgaagaac acagtatcat gactcgggtg gaaagggagg cagaagccat
     3661 ttttctttta gatgaaaagc attctgtgtg attgttgtat aataaattga tttttacact
     3721 aaaacatctt gcaacttttc ttatttggtt caaagaaact aaaatgtggg cctgtgcagt
     3781 attccaagtg gcctattatt cagagattat ttaccaataa agtgatatat tagtgat
//
