LOCUS       NM_001039176            1833 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus ELOVL fatty acid elongase 1 (Elovl1), transcript
            variant 1, mRNA.
ACCESSION   NM_001039176
VERSION     NM_001039176.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Sassa T and Kihara A.
  TITLE     Involvement of omega-O-acylceramides and protein-bound ceramides in
            oral permeability barrier formation
  JOURNAL   Cell Rep, 112363 (2023) In press
   PUBMED   37054712
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P,
            Rufen-Blanchette U, Munch AE, Blum JA, Fine J, Neal MC, Bruce KD,
            Gitler AD, Chopra G, Liddelow SA and Barres BA.
  TITLE     Neurotoxic reactive astrocytes induce cell death via saturated
            lipids
  JOURNAL   Nature 599 (7883), 102-107 (2021)
   PUBMED   34616039
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Tanno H, Sassa T, Sawai M and Kihara A.
  TITLE     Production of branched-chain very-long-chain fatty acids by fatty
            acid elongases and their tissue distribution in mammals
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (1), 158842 (2021)
   PUBMED   33069870
  REMARK    GeneRIF: Production of branched-chain very-long-chain fatty acids
            by fatty acid elongases and their tissue distribution in mammals.
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Miyamoto M, Itoh N, Sawai M, Sassa T and Kihara A.
  TITLE     Severe Skin Permeability Barrier Dysfunction in Knockout Mice
            Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide
            Production
  JOURNAL   J Invest Dermatol 140 (2), 319-326 (2020)
   PUBMED   31356814
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Edagawa M, Sawai M, Ohno Y and Kihara A.
  TITLE     Widespread tissue distribution and synthetic pathway of
            polyunsaturated C24:2 sphingolipids in mammals
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (12), 1441-1448
            (2018)
   PUBMED   30251650
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Frankel WN, Yang Y, Mahaffey CL, Beyer BJ and O'Brien TP.
  TITLE     Szt2, a novel gene for seizure threshold in mice
  JOURNAL   Genes Brain Behav 8 (5), 568-576 (2009)
   PUBMED   19624305
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN,
            Roop DR, Wertz P and Andersen B.
  TITLE     The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates
            epidermal terminal differentiation and interacts functionally with
            LMO4
  JOURNAL   Dev Biol 299 (1), 122-136 (2006)
   PUBMED   16949565
REFERENCE   8  (bases 1 to 1833)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 1833)
  AUTHORS   Asadi A, Jorgensen J and Jacobsson A.
  TITLE     Elovl1 and p55Cdc genes are localized in a tail-to-tail array and
            are co-expressed in proliferating cells
  JOURNAL   J Biol Chem 277 (21), 18494-18500 (2002)
   PUBMED   11891222
  REMARK    GeneRIF: elucidation of structure and regulation
REFERENCE   10 (bases 1 to 1833)
  AUTHORS   Tvrdik P, Westerberg R, Silve S, Asadi A, Jakobsson A, Cannon B,
            Loison G and Jacobsson A.
  TITLE     Role of a new mammalian gene family in the biosynthesis of very
            long chain fatty acids and sphingolipids
  JOURNAL   J Cell Biol 149 (3), 707-718 (2000)
   PUBMED   10791983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627212.21, CJ094566.1, BY773043.1, CN455861.1, AK003743.1,
            BM445297.1 and BY689799.1.
            
            [WARNING] On Oct 18, 2023 this sequence was replaced by
            NM_001039176.3.
            
            On Sep 24, 2013 this sequence version replaced NM_001039176.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006735.1, SRR5189682.127191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL627212.21        116988-116998
            12-47               CJ094566.1         2-37
            48-432              BY773043.1         2-386
            433-944             CN455861.1         170-681
            945-1478            AK003743.1         716-1249
            1479-1621           BM445297.1         226-368
            1622-1622           BY689799.1         188-188
            1623-1833           BM445297.1         370-580
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.61 cM"
     gene            1..1833
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /note="ELOVL fatty acid elongase 1"
                     /db_xref="GeneID:54325"
                     /db_xref="MGI:MGI:1858959"
     exon            1..130
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..190
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..381
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..462
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..519
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..625
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..762
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1818
                     /gene="Elovl1"
                     /gene_synonym="Ssc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccaggg caggagtctc aaagagccag gctcctggag tggaagagag agagaggcag
       61 aacttgcccc tgagaagaag ggaggagaga ggctggaggt gaagcactgg aagaaggcag
      121 gaggctggag agtccttagc caggatggag gctgttgtga acttgtacca cgagctgatg
      181 aagcatgcgg atccccggat ccaaagctac cctctgatgg ggtccccctt gctaataaca
      241 tccatccttc tgacctatgt gtacttcatc ctatcgcttg ggcctcgaat catggctaat
      301 cggaagccct tccaacttcg aggcttcatg attgtctaca atttctcact ggtgatactc
      361 tccctctaca ttgtctatga gtttctgatg tctggttggc tgagtaccta cacctggcgc
      421 tgtgacccca tagacttttc caatagccct gaagcacttc ggatggttcg agtggcctgg
      481 ctcttcatgc tttccaaggt cattgagctg atggacacag tgatatttat cctccggaag
      541 aaggacgggc aagtgacctt cctccatgtc ttccaccact cggtgcttcc ctggagttgg
      601 tggtggggga taaaaattgc tccaggagga atgggctcct tccatgccat gataaactcc
      661 tctgtacatg tcgtcatgta cctctactat ggattgtctg cccttggccc tgtggcccag
      721 ccctaccttt ggtggaagaa acatatgact gccattcagc tgatccagtt tgtcctggtc
      781 tcactgcaca tcagccaata ctacttcatg cccagctgca actaccagta ccccatcatc
      841 atccacctca tctggatgta tggcaccatc ttcttcatac tgttctccaa tttctggtat
      901 cactcttaca ccaaggggaa gcggctgccc cgtgcagttc agcaaaatgg agctccagct
      961 accaccaagg tcaaggccaa ctgagaagca tggcctagac attgcccacc taagtgcctc
     1021 aggactgcac cttgggcagc atccacaagt gtcctctcta cctacacccg tgaccagggc
     1081 tctgtggtca ggactgagca ggcggactgg ctctcccctc cccacagctg gtccacaggg
     1141 gccactgttc ccatcccttc tcccagccag ctccagggat gtggcctcac tgctgtctgc
     1201 caccagaact ggaggctgaa agggctggac acttacttcc ccctccctgc cttaaacttg
     1261 ggagaggaac actcagggct ggccggcacg cacccgggtc ttgtggcctt tctcctcaca
     1321 ctgaagaggt cagcaataat ctgtcactgt ggactcaggc tcccttctca ctccacatgg
     1381 aagcatgagc ttcgggccaa aggtcagaat gggcaggcag caggcctgga agtcaggctg
     1441 tgcgctcact tgtgtcttaa ttaaagtgac gggaaaccac tgagattgtg tgtgtgtgta
     1501 aatgaggtgc gggacacagc tttagctctg gcttgtttac aaacaaaagg gatgggtggt
     1561 agtgcatgcg gtaattccag ctcctgggga gggtacaaag caggaagctc aaaagagcct
     1621 gaaccctgtc tcaaaagaaa aatgatgctc agtaggcagg gctctgggtt tggtccccta
     1681 aactacaaaa ataatataaa aaggggggtt gccaagtcta gctctagtca gagtagggga
     1741 agcatgtagg aaggatgctg ggacataagg aagatacgaa ctttattaga aaaaataaaa
     1801 taaaaacaag aaaggaaaaa aaaaaaaaaa aaa
//
