LOCUS       NM_001357311             916 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ELF1 homolog, elongation factor 1 (Elof1), transcript
            variant 4, mRNA.
ACCESSION   NM_001357311 XM_017313506
VERSION     NM_001357311.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 916)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 916)
  AUTHORS   Tellier,A.P., Archambault,D., Tremblay,K.D. and Mager,J.
  TITLE     The elongation factor Elof1 is required for mammalian gastrulation
  JOURNAL   PLoS One 14 (7), e0219410 (2019)
   PUBMED   31276560
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 916)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 916)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 916)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163623.5 and AK003614.1.
            
            On Oct 25, 2017 this sequence version replaced XM_017313506.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All seven variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003614.1, AK002505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC163623.5         183315-183337       c
            24-910              AK003614.1         2-888
            911-916             AC163623.5         179128-179133       c
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 8.34 cM"
     gene            1..916
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /note="ELF1 homolog, elongation factor 1"
                     /db_xref="GeneID:66126"
                     /db_xref="MGI:MGI:1913376"
     exon            1..86
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            87..222
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..358
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /note="elongation factor 1 homolog (ELF1, S. cerevisiae)"
                     /codon_start=1
                     /product="transcription elongation factor 1 homolog"
                     /protein_id="NP_001344240.1"
                     /db_xref="CCDS:CCDS40559.1"
                     /db_xref="GeneID:66126"
                     /db_xref="MGI:MGI:1913376"
                     /translation="MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARN
                     TGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ"
     exon            223..916
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      911
                     /gene="Elof1"
                     /gene_synonym="1110011K10Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaagcgatat ttccgtttcc gttaggggcc ggaagttagc gtctcctggg tgaagcggcc
       61 ttggctgaga ggcagggctg gtacaagttt tattccctct gcagttatgg gacgaagaaa
      121 gtccaaacgg aagccgcccc caaaaaagaa gatgacaggc accctggaga cccagttcac
      181 ctgccctttc tgcaaccacg agaagtcttg tgatgtgaaa atggaccgtg ctcgaaacac
      241 tggagtcatc tcctgtactg tgtgcctaga ggaattccag acacccatca catacctgtc
      301 agaaccagtg gatgtgtaca gcgactggat agatgcctgc gaggcagcca atcagtagca
      361 aagtcaggga cctgctcctc cacagccccc atctggctac caatccagag acattccagg
      421 gctaggacag cccgccctct gcagatggga tggatgtgag tgagtagatt tcgtggctgc
      481 agatgtgact gtagggatgg aggcgagcga cactgggtct caccaagcag cccagggtgg
      541 cctcatggaa ccctgagcct caggtgactc tacaagcctt tgagttgctc ccatcttcag
      601 cccccaccct gcccccacac ttcaggctcc tgtcttctct ggtgacggtt cctgacatcc
      661 aggcaaggaa tagctgtggg acctcctgtc tcctcagcca cctcaccagc accttgccct
      721 tgggacctag actttctgtc cttcccagtc tcctagtgct tgtggtcgag gctactggcc
      781 acccaggtcc cctggctggg ctcggctggg gaacaccatt ttcttggttt gcctttgtag
      841 acaaggtagg ggctagttgg ggtacagctg tcattcattc atgagcccat caataaaaca
      901 gccagtgtgt atcccc
//
