LOCUS       NM_026305                508 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus elongin B (Elob), mRNA.
ACCESSION   NM_026305 XM_986312 XM_992341
VERSION     NM_026305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Zhang,Z., Huang,Q., Wang,Z., Zou,J., Yu,Z., Strauss Iii,J.F. and
            Zhang,Z.
  TITLE     Elongin B is a binding partner of the male germ cell nuclear
            speckle protein sperm-associated antigen 16S (SPAG16S) and is
            regulated post-transcriptionally in the testis
  JOURNAL   Reprod Fertil Dev 31 (5), 962-971 (2019)
   PUBMED   30811962
  REMARK    GeneRIF: These findings suggest that post-transcriptional
            regulation of Elongin B occurs in the testis, which is a common
            phenomenon during male germ cell development. As a major binding
            partner of SPAG16S, Elongin B may play an important role in
            spermatogenesis by modulating RNA maturation.
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Liefke,R., Karwacki-Neisius,V. and Shi,Y.
  TITLE     EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin
            Landscape
  JOURNAL   Mol Cell 64 (4), 659-672 (2016)
   PUBMED   27863226
  REMARK    GeneRIF: EPOP (E130012A19Rik) interacts with elongin B, elongin C,
            and USP7 to modulate the chromatin landscape.
            Erratum:[Mol Cell. 2017 Jan 5;65(1):202. doi:
            10.1016/j.molcel.2016.12.006.. PMID: 28061330]
REFERENCE   3  (bases 1 to 508)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
  REMARK    GeneRIF: EPOP (E130012A19Rik) functionally links elongin B, elongin
            C, and polycomb in pluripotent stem cells.
REFERENCE   4  (bases 1 to 508)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   5  (bases 1 to 508)
  AUTHORS   Kim,Y.K., Kwak,M.J., Ku,B., Suh,H.Y., Joo,K., Lee,J., Jung,J.U. and
            Oh,B.H.
  TITLE     Structural basis of intersubunit recognition in elongin BC-cullin
            5-SOCS box ubiquitin-protein ligase complexes
  JOURNAL   Acta Crystallogr D Biol Crystallogr 69 (Pt 8), 1587-1597 (2013)
   PUBMED   23897481
  REMARK    GeneRIF: Crystal structure shows interaction between SOCS2-elongin
            BC and Cullin-5.
REFERENCE   6  (bases 1 to 508)
  AUTHORS   Nastasi,T., Bongiovanni,A., Campos,Y., Mann,L., Toy,J.N.,
            Bostrom,J., Rottier,R., Hahn,C., Conaway,J.W., Harris,A.J. and
            D'Azzo,A.
  TITLE     Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin
            degradation during myogenesis
  JOURNAL   Dev Cell 6 (2), 269-282 (2004)
   PUBMED   14960280
REFERENCE   7  (bases 1 to 508)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 508)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   9  (bases 1 to 508)
  AUTHORS   Zhang,J.G., Farley,A., Nicholson,S.E., Willson,T.A., Zugaro,L.M.,
            Simpson,R.J., Moritz,R.L., Cary,D., Richardson,R., Hausmann,G.,
            Kile,B.T., Kent,S.B., Alexander,W.S., Metcalf,D., Hilton,D.J.,
            Nicola,N.A. and Baca,M.
  TITLE     The conserved SOCS box motif in suppressors of cytokine signaling
            binds to elongins B and C and may couple bound proteins to
            proteasomal degradation
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2071-2076 (1999)
   PUBMED   10051596
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2979. doi:
            10.1073/pnas.1507812112.. Kile, B J [corrected to Kile, Benjamin
            T]. PMID: 25956176]
REFERENCE   10 (bases 1 to 508)
  AUTHORS   Ko,M.S.
  TITLE     An 'equalized cDNA library' by the reassociation of short
            double-stranded cDNAs
  JOURNAL   Nucleic Acids Res 18 (19), 5705-5711 (1990)
   PUBMED   2216762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002868.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026305.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002868.1, BY703366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415124 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               AK002868.1         2-509
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17"
     gene            1..508
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /note="elongin B"
                     /db_xref="GeneID:67673"
                     /db_xref="MGI:MGI:1914923"
     exon            1..27
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..381
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /note="transcription elongation factor B (SIII),
                     polypeptide 2 (18 kDa, elongin B); transcription
                     elongation factor B polypeptide 2; SIII p18; elongin 18
                     kDa subunit; RNA polymerase II transcription factor SIII
                     subunit B"
                     /codon_start=1
                     /product="elongin-B"
                     /protein_id="NP_080581.1"
                     /db_xref="CCDS:CCDS57055.1"
                     /db_xref="GeneID:67673"
                     /db_xref="MGI:MGI:1914923"
                     /translation="MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRL
                     YKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDV
                     MKPQDSGGSANEQAVQ"
     exon            28..162
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..268
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..508
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      417..422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /note="hexamer: AATAAA"
     polyA_site      439
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /note="hexamer: AGTAAA"
     polyA_site      506
                     /gene="Elob"
                     /gene_synonym="0610040H15Rik; Tceb2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgagccag aagcagccgc cgggatggac gtgtttctca tgatccggcg ccacaagacc
       61 accatcttta cggacgccaa ggagtcgagc accgtgttcg aactgaagcg catcgtcgag
      121 ggcatcctca agcggccgcc agaggagcag cggctttaca aggatgacca gctccttgat
      181 gatggcaaaa ctctgggcga gtgtggcttc actagccaga cagcacggcc acaggcccca
      241 gccacagtgg gcctggcctt ccgagcagat gacaccttcg aagctctccg catcgagccc
      301 ttttccagcc ctccagagct tccagatgtg atgaagccac aggattctgg aggcagtgcc
      361 aatgaacaag ctgtgcagtg agggcctagg cctaccccct agagacccat ttccccaata
      421 aaaaaaattt ggctgtctac ctgattgact tttctgttcc ctcttgttca cagaactctt
      481 aaccccaagt aaagactaca gaccaatt
//
