LOCUS       NM_013736               4592 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus elongin A (Eloa), mRNA.
ACCESSION   NM_013736
VERSION     NM_013736.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4592)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4592)
  AUTHORS   Ardehali,M.B., Damle,M., Perea-Resa,C., Blower,M.D. and
            Kingston,R.E.
  TITLE     Elongin A associates with actively transcribed genes and modulates
            enhancer RNA levels with limited impact on transcription elongation
            rate in vivo
  JOURNAL   J Biol Chem 296, 100202 (2021)
   PUBMED   33334895
  REMARK    GeneRIF: Elongin A associates with actively transcribed genes and
            modulates enhancer RNA levels with limited impact on transcription
            elongation rate in vivo.
REFERENCE   3  (bases 1 to 4592)
  AUTHORS   Ardehali,M.B., Anselmo,A., Cochrane,J.C., Kundu,S., Sadreyev,R.I.
            and Kingston,R.E.
  TITLE     Polycomb Repressive Complex 2 Methylates Elongin A to Regulate
            Transcription
  JOURNAL   Mol Cell 68 (5), 872-884 (2017)
   PUBMED   29153392
  REMARK    GeneRIF: Polycomb repressive complex 2 modulates transcription of a
            subset of low expression target genes in part via methylation of
            EloA.
REFERENCE   4  (bases 1 to 4592)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
REFERENCE   5  (bases 1 to 4592)
  AUTHORS   Kawauchi,J., Inoue,M., Fukuda,M., Uchida,Y., Yasukawa,T.,
            Conaway,R.C., Conaway,J.W., Aso,T. and Kitajima,S.
  TITLE     Transcriptional properties of mammalian elongin A and its role in
            stress response
  JOURNAL   J Biol Chem 288 (34), 24302-24315 (2013)
   PUBMED   23828199
  REMARK    GeneRIF: Elongin A transcription elongation activity, but not its
            ubiquitination activity, is most important for its function in
            induction of transcription of ATF3 and p21.
REFERENCE   6  (bases 1 to 4592)
  AUTHORS   Yasukawa,T., Sugimura,K., Fukuda,M., Yamazaki,K., Kitajima,S.,
            Okumura,K. and Aso,T.
  TITLE     Functional characterization of a mammalian transcription factor,
            Elongin A
  JOURNAL   Biochem Biophys Res Commun 352 (1), 237-243 (2007)
   PUBMED   17112477
REFERENCE   7  (bases 1 to 4592)
  AUTHORS   de Buhr,M.F., Mahler,M., Geffers,R., Hansen,W., Westendorf,A.M.,
            Lauber,J., Buer,J., Schlegelberger,B., Hedrich,H.J. and Bleich,A.
  TITLE     Cd14, Gbp1, and Pla2g2a: three major candidate genes for
            experimental IBD identified by combining QTL and microarray
            analyses
  JOURNAL   Physiol Genomics 25 (3), 426-434 (2006)
   PUBMED   16705022
REFERENCE   8  (bases 1 to 4592)
  AUTHORS   Yamazaki,K., Aso,T., Ohnishi,Y., Ohno,M., Tamura,K., Shuin,T.,
            Kitajima,S. and Nakabeppu,Y.
  TITLE     Mammalian elongin A is not essential for cell viability but is
            required for proper cell cycle progression with limited alteration
            of gene expression
  JOURNAL   J Biol Chem 278 (15), 13585-13589 (2003)
   PUBMED   12604609
  REMARK    GeneRIF: a linkage between Elongin A function and cell cycle
            progression
REFERENCE   9  (bases 1 to 4592)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4592)
  AUTHORS   Aso,T., Amimoto,K., Takebayashi,S., Okumura,K. and Hatakeyama,M.
  TITLE     Structural organization and chromosome location of the mouse
            elongin A gene (Tceb3)
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 259-262 (1999)
   PUBMED   10575222
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL672076.10.
            
            On May 1, 2007 this sequence version replaced NM_013736.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036592.1, AK145994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AL672076.10        200662-200760       c
            100-156             AL672076.10        193511-193567       c
            157-263             AL672076.10        191981-192087       c
            264-1443            AL672076.10        189340-190519       c
            1444-1558           AL672076.10        188861-188975       c
            1559-1714           AL672076.10        188357-188512       c
            1715-1812           AL672076.10        188157-188254       c
            1813-1993           AL672076.10        186891-187071       c
            1994-2105           AL672076.10        186223-186334       c
            2106-2284           AL672076.10        185282-185460       c
            2285-4592           AL672076.10        182481-184788       c
FEATURES             Location/Qualifiers
     source          1..4592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     gene            1..4592
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /note="elongin A"
                     /db_xref="GeneID:27224"
                     /db_xref="MGI:MGI:1351315"
     exon            1..99
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2346
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /note="transcription elongation factor B polypeptide 3;
                     SIII p110; elongin 110 kDa subunit; RNA polymerase II
                     transcription factor SIII subunit A1"
                     /codon_start=1
                     /product="elongin-A"
                     /protein_id="NP_038764.2"
                     /db_xref="CCDS:CCDS18798.1"
                     /db_xref="GeneID:27224"
                     /db_xref="MGI:MGI:1351315"
                     /translation="MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSILPITVDILV
                     ETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNSEAEDQDFEKNNSRKRPRDAL
                     QREEELEGNYQESWKPSGSRSYSPEHRQKKHKKLSEPERPHKVAHSHEKRDERKRCHK
                     VSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEEDQEPIISHQKPGKVHSNTFQ
                     DRLGVSHLGEQGKGAVSHHKQHRSSHKEKHPADAREDEKISAVSREKSHKASSKEESR
                     RLLSGDSAKEKLPSSVVKKDKDREGSSLKKKFSPALDVASDNHFKKPKHKDSEKAKSD
                     KNKQSVDGVDSGRGTGDPLPKAKEKVPNHLKAQEGKVRTNADGKSAGPLHPKAEETDV
                     DDEFERPTMSFESYLSYDQPRKKKKKVVKTSSTALGEKGLKKKDSKSTSKNLNSAQKL
                     PKVNENKSEKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIHANYRPLPSLELIPSFQP
                     KRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIF
                     EVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYES
                     WREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKF
                     GTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSNFHSSPEELAYDGPSTSSAHLAPVAS
                     SSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR"
     exon            100..156
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            157..263
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1443
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1558
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1714
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1812
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1993
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2105
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2284
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..4592
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2637..2642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /note="hexamer: AATAAA"
     polyA_site      2669
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggccg cgccagtgac agcgatggcg gcggagtcgg cgctccaagt tgtggagaag
       61 ctccaggcgc gcctggctgc gaacccggac cccaagaagc tattgaaata tttgaagaaa
      121 ctttccatct tacctatcac agtagacatt cttgtggaga ctggggtagg gaaaacagtg
      181 aacagctttc ggaagcatga gcaagtagga aactttgcca gagacctggt ggcccagtgg
      241 aagaagctgg ttccagtaga gcgaaatagt gaggccgagg atcaggattt tgagaagaac
      301 aattcccgta agcgtcccag agatgctctt cagagggagg aggagttgga ggggaactac
      361 caggaaagct ggaaaccctc tggtagccgg tcctacagcc ctgagcacag acagaaaaaa
      421 cacaaaaaac tttctgagcc tgaaaggcct cacaaagtgg ctcacagtca cgagaagaga
      481 gatgaaagga agaggtgtca caaagtgtca ccaccatatt cttcagaccc cgagtcatct
      541 gactatggcc atgttcaatc ccctccacct tcaagtcctc atcaaatgta tacagacctc
      601 tccaggtccc cagaggagga ccaggagccc atcatctcac accagaagcc aggaaaagtc
      661 cacagtaata cctttcagga cagactaggg gttagtcacc tgggtgaaca aggaaaaggg
      721 gctgttagcc accacaagca gcacagatct tcacacaagg agaagcaccc tgcagatgcc
      781 agagaggatg agaagatctc tgctgtgagc agagagaagt cacacaaagc ctcttccaaa
      841 gaggaaagcc gaagactact gtcaggggac agtgccaagg agaagctgcc ctctagtgtt
      901 gttaagaaag acaaggacag agaaggcagc agtctcaaga agaagttttc acctgcctta
      961 gatgttgctt cagacaacca ctttaaaaag cccaaacaca aggactccga gaaagccaaa
     1021 tctgacaaaa acaagcagag tgtagatggc gtggactcag gacgagggac aggagaccca
     1081 ttgcccaaag ccaaggagaa agttcccaac cacctgaagg ctcaggaggg gaaagtaaga
     1141 actaacgcag atggaaagtc agcaggcccg ctccacccta aagcggagga gacagatgtg
     1201 gacgatgagt ttgagcggcc cacgatgtcc ttcgagtcct acctcagcta tgaccagccc
     1261 cggaagaaaa agaagaaggt tgtgaaaacg tccagtacag cacttggaga aaaaggactt
     1321 aaaaaaaagg actctaaaag cactagtaaa aacttgaact cagctcagaa attgcccaaa
     1381 gtcaacgaaa acaagtcaga gaagttgcag ccagctggag ccgaacccac caggcctcga
     1441 aaggtcccta ctgatgtgct gccagcattg ccagacatcc ccttacctgc cattcatgcc
     1501 aactaccggc cccttccttc ccttgagttg attccctcct ttcagccaaa gcgaaaagct
     1561 ttctcttcac cccaggaaga agaagaagct gggttcacag gacgcagaat gaattctaag
     1621 atgcaggtgt attctggttc caagtgtgcc tatctcccca aaatgatgac attgcaccag
     1681 cagtgtatcc gggtgcttaa gaataatatt gactctatct ttgaagtagg aggagtcccc
     1741 tattctgttc ttgaacctgt cttggagagg tgcacacctg atcagctcta ccggatagag
     1801 gaatgcaatc atgtattaat tgaagaaaca gatcagttgt ggaaagttca ctgtcaccga
     1861 gactttaagg aagaaaggcc agaagagtat gagtcctgga gggagatgta cctgaggctt
     1921 caggacgcca gagagcagcg gctgcgcctg ctcacaaaca acatccgctc tgctcatgcc
     1981 aataagccaa agggacgaca agcaaagatg gcttttgtca actctgtggc caagccacca
     2041 agagatgtcc gaagaaggca ggagaagttt ggaaccgggg gagcagctgt tcctgagaaa
     2101 gtcaggataa agccagcgcc atatacaaca ggaagcagcc atgttcctgc cagcaacagc
     2161 agcagcaact tccactccag tcctgaggag ctggcctatg atgggcccag tactagcagt
     2221 gcccacttag ctcctgtggc cagcagttct gtttcctatg atcccaggaa accagctgtg
     2281 aagaaaattg ctccgatgat ggccaagacc attaaagcat tcaagaacag attctcccgg
     2341 cgataaacag gacttgcctt ggaggttgag tctggaagca ggaatacagg gacggtgggg
     2401 acaggagaag aggatatcta cagaagaccc atatcttttg ctttgtggaa cttttggcct
     2461 cttgactcct gtacacttcc atgtgtccca ctgtgtgcct cagccctgca ccctgcttgt
     2521 agcacacttc agatttctga agacagtatg agcctcagtc ctactgagga ctttaagatc
     2581 agttatactt ttgttgctaa ttagcatctt tgtaaactat aagacatagt tttaataata
     2641 aatattgccc ccagatgtat ttataataac cccagggttt tttgtttttt tttttccttt
     2701 tttttgtttt tttctttttg tcctctatat ttagcctttt actttccagg tcctttatta
     2761 aagttagatg agcctagcaa aagccattct tgtcctgggt cagctcttct gagtagacac
     2821 tggtcaaagg gcaccttcag agccagtgtg ttgctccaag cccatataca gggccaggag
     2881 tgagagtgcc agaatgcctg tcctccagcg agcctccctg ttaaaccctc agagttcctt
     2941 gatgggcgct tttctttctt cagtagtgtt tgctaaagaa ggctgtttgc aaagtctata
     3001 gtcctttgtg catcatcttc aaatcacact cctcttccct gttttcaggc ttgctggagg
     3061 acagaccctt aagatatgaa tttatgtagg acctcagcag ttttataatc ctagtttctg
     3121 gttcagtatt ttacatacac acctgccctt attttgcctt tccctgcact gtggggaaac
     3181 agacatagca gggcttttgt agctctgagt gtgattttgg ggggttgaaa tgccagcact
     3241 ttattctctt gttctctatg aattcctacc aggagtgaat gatttaaagc actgtagtgc
     3301 tgtggaactt gcttttgttt gaaaggaaag gtgctgatgt gcccagagga acggtattgt
     3361 gctgtggcca gcagagaact ctgtgcagcc tccgccttct gagtgttggc cttgggaagg
     3421 gtggatggtc accctggtcc cagccaacca gttcaggagg aagattccct atttctaggt
     3481 cgcataaggg caaggttaga gctaggagga tagtgccagc ttcttccttc ctgtcagaaa
     3541 acgtggaaga ggactcaatt ggctatgagc caggtgaaag acactatgaa cttgagggga
     3601 cagacagcac tggcactgtg cctatcctgt tttagcaccc tcaagacctc aggctagtga
     3661 agactcccaa ggcagtccag gaaacctgca cagataaagc taggcccacc ttactgtgca
     3721 ttgctatgct gggtccctgt tgccatggga cacaggtatt gctaagtaaa acattgtttc
     3781 tcttggttgc ttgtttcacc ataccacctc tcagcctgac ctcaaactct aacatcaggt
     3841 ctcttagctg acgttaaagg gacatttgta ctaggagcca ggcccctgct gtctagaaca
     3901 gcctcctttc taggtgttga ccacctcaga tttatgcctt agctgtgttt caagacttcc
     3961 ctttgccatt ttttcctatt gcaggttcga ttgtgtatga tttaattccc tttaggaatt
     4021 tgtaggccta gggaaagaaa ggacatgcat ttgcccgtcc caatgtcagc atctggtttg
     4081 gcacacaaag atttctgagg cacccagttt acctagagcc agattttcta gcccttcaag
     4141 agtgtctgtg tcagggatag gactgctgag aacagtgagg gcccagtgag cagctgtctc
     4201 cacagtccct caccccatgc acaatggcca caaagcagac acagtcatgt tcaacttttg
     4261 gtcacatttg tgaagactcg tgcaatgttt tctgtgctac actacataca ggtcacacat
     4321 gatggactag ccctttacat acagatgaca catacagaat agccctttgc gatccttggc
     4381 gttccaaggg ctctcagggg ctcactttct ctgttttgga ggcaggagga gcaggagtga
     4441 gcaccaccct gctctgcatt tgtattttgg tcccaaaatg taaatacaat tttctatgtt
     4501 acttttttgt ggtaactaca agatgaatat tttaattaga taagttatac aaaaaggaaa
     4561 atcccatgtc taaataaaaa gcaaaaaaat tc
//
