LOCUS       NP_038764                773 aa            linear   ROD 02-MAY-2024
DEFINITION  elongin-A [Mus musculus].
ACCESSION   NP_038764
VERSION     NP_038764.2
DBSOURCE    REFSEQ: accession NM_013736.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 773)
  AUTHORS   Ardehali,M.B., Damle,M., Perea-Resa,C., Blower,M.D. and
            Kingston,R.E.
  TITLE     Elongin A associates with actively transcribed genes and modulates
            enhancer RNA levels with limited impact on transcription elongation
            rate in vivo
  JOURNAL   J Biol Chem 296, 100202 (2021)
   PUBMED   33334895
  REMARK    GeneRIF: Elongin A associates with actively transcribed genes and
            modulates enhancer RNA levels with limited impact on transcription
            elongation rate in vivo.
REFERENCE   3  (residues 1 to 773)
  AUTHORS   Ardehali,M.B., Anselmo,A., Cochrane,J.C., Kundu,S., Sadreyev,R.I.
            and Kingston,R.E.
  TITLE     Polycomb Repressive Complex 2 Methylates Elongin A to Regulate
            Transcription
  JOURNAL   Mol Cell 68 (5), 872-884 (2017)
   PUBMED   29153392
  REMARK    GeneRIF: Polycomb repressive complex 2 modulates transcription of a
            subset of low expression target genes in part via methylation of
            EloA.
REFERENCE   4  (residues 1 to 773)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
REFERENCE   5  (residues 1 to 773)
  AUTHORS   Kawauchi,J., Inoue,M., Fukuda,M., Uchida,Y., Yasukawa,T.,
            Conaway,R.C., Conaway,J.W., Aso,T. and Kitajima,S.
  TITLE     Transcriptional properties of mammalian elongin A and its role in
            stress response
  JOURNAL   J Biol Chem 288 (34), 24302-24315 (2013)
   PUBMED   23828199
  REMARK    GeneRIF: Elongin A transcription elongation activity, but not its
            ubiquitination activity, is most important for its function in
            induction of transcription of ATF3 and p21.
REFERENCE   6  (residues 1 to 773)
  AUTHORS   Yasukawa,T., Sugimura,K., Fukuda,M., Yamazaki,K., Kitajima,S.,
            Okumura,K. and Aso,T.
  TITLE     Functional characterization of a mammalian transcription factor,
            Elongin A
  JOURNAL   Biochem Biophys Res Commun 352 (1), 237-243 (2007)
   PUBMED   17112477
REFERENCE   7  (residues 1 to 773)
  AUTHORS   de Buhr,M.F., Mahler,M., Geffers,R., Hansen,W., Westendorf,A.M.,
            Lauber,J., Buer,J., Schlegelberger,B., Hedrich,H.J. and Bleich,A.
  TITLE     Cd14, Gbp1, and Pla2g2a: three major candidate genes for
            experimental IBD identified by combining QTL and microarray
            analyses
  JOURNAL   Physiol Genomics 25 (3), 426-434 (2006)
   PUBMED   16705022
REFERENCE   8  (residues 1 to 773)
  AUTHORS   Yamazaki,K., Aso,T., Ohnishi,Y., Ohno,M., Tamura,K., Shuin,T.,
            Kitajima,S. and Nakabeppu,Y.
  TITLE     Mammalian elongin A is not essential for cell viability but is
            required for proper cell cycle progression with limited alteration
            of gene expression
  JOURNAL   J Biol Chem 278 (15), 13585-13589 (2003)
   PUBMED   12604609
  REMARK    GeneRIF: a linkage between Elongin A function and cell cycle
            progression
REFERENCE   9  (residues 1 to 773)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 773)
  AUTHORS   Aso,T., Amimoto,K., Takebayashi,S., Okumura,K. and Hatakeyama,M.
  TITLE     Structural organization and chromosome location of the mouse
            elongin A gene (Tceb3)
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 259-262 (1999)
   PUBMED   10575222
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL672076.10.
            
            On Jun 9, 2003 this sequence version replaced NP_038764.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036592.1, AK145994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     Protein         1..773
                     /product="elongin-A"
                     /note="transcription elongation factor B polypeptide 3;
                     SIII p110; elongin 110 kDa subunit; RNA polymerase II
                     transcription factor SIII subunit A1"
                     /calculated_mol_wt=87031
     Region          37..>119
                     /region_name="TFSII"
                     /note="transcription elongation factor S-II; TIGR01385"
                     /db_xref="CDD:273592"
     Region          <37..76
                     /region_name="TFIIS_I"
                     /note="N-terminal domain (domain I) of transcription
                     elongation factor S-II (TFIIS); similar to a domain found
                     in elongin A and CRSP70; likely to be involved in
                     transcription; domain I from TFIIS interacts with RNA
                     polymerase II holoenzyme; cd00183"
                     /db_xref="CDD:238107"
     Region          81..477
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            195
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63187; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            309
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14241; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            430
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Site            515
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14241; propagated from
                     UniProtKB/Swiss-Prot (Q8CB77.3)"
     Region          521..680
                     /region_name="Activation domain.
                     /evidence=ECO:0000250|UniProtKB:Q63187"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CB77.3)"
     Region          549..558
                     /region_name="BC-box.
                     /evidence=ECO:0000250|UniProtKB:Q63187"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CB77.3)"
     Region          565..663
                     /region_name="Elongin_A"
                     /note="RNA polymerase II transcription factor SIII
                     (Elongin) subunit A; pfam06881"
                     /db_xref="CDD:462026"
     Region          671..747
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CB77.3)"
     CDS             1..773
                     /gene="Eloa"
                     /gene_synonym="110kDa; Tceb3; Tceb3a"
                     /coded_by="NM_013736.4:25..2346"
                     /db_xref="CCDS:CCDS18798.1"
                     /db_xref="GeneID:27224"
                     /db_xref="MGI:MGI:1351315"
ORIGIN      
        1 maaesalqvv eklqarlaan pdpkkllkyl kklsilpitv dilvetgvgk tvnsfrkheq
       61 vgnfardlva qwkklvpver nseaedqdfe knnsrkrprd alqreeeleg nyqeswkpsg
      121 srsyspehrq kkhkklsepe rphkvahshe krderkrchk vsppyssdpe ssdyghvqsp
      181 ppssphqmyt dlsrspeedq epiishqkpg kvhsntfqdr lgvshlgeqg kgavshhkqh
      241 rsshkekhpa daredekisa vsrekshkas skeesrrlls gdsakeklps svvkkdkdre
      301 gsslkkkfsp aldvasdnhf kkpkhkdsek aksdknkqsv dgvdsgrgtg dplpkakekv
      361 pnhlkaqegk vrtnadgksa gplhpkaeet dvddeferpt msfesylsyd qprkkkkkvv
      421 ktsstalgek glkkkdskst sknlnsaqkl pkvnenksek lqpagaeptr prkvptdvlp
      481 alpdiplpai hanyrplpsl elipsfqpkr kafsspqeee eagftgrrmn skmqvysgsk
      541 caylpkmmtl hqqcirvlkn nidsifevgg vpysvlepvl erctpdqlyr ieecnhvlie
      601 etdqlwkvhc hrdfkeerpe eyeswremyl rlqdareqrl rlltnnirsa hankpkgrqa
      661 kmafvnsvak pprdvrrrqe kfgtggaavp ekvrikpapy ttgsshvpas nsssnfhssp
      721 eelaydgpst ssahlapvas ssvsydprkp avkkiapmma ktikafknrf srr
//
