LOCUS       NM_007925               3865 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus elastin (Eln), mRNA.
ACCESSION   NM_007925 XM_622913
VERSION     NM_007925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3865)
  AUTHORS   Waheed-Ullah,Q., Wilsdon,A., Abbad,A., Rochette,S., Bu'Lock,F.,
            Saed,A.A., Hitz,M.P., Brook,J.D. and Loughna,S.
  TITLE     Cyclin-dependent kinase 13 is indispensable for normal mouse heart
            development
  JOURNAL   J Anat (2024) In press
   PUBMED   39556044
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3865)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3865)
  AUTHORS   Murphy,M.P., Zieger,M., Henry,M., Meleady,P., Mueller,C.,
            McElvaney,N.G. and Reeves,E.P.
  TITLE     Citrullination, a novel posttranslational modification of elastin,
            is involved in COPD pathogenesis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 327 (4), L600-L606 (2024)
   PUBMED   39137524
  REMARK    GeneRIF: Citrullination, a novel posttranslational modification of
            elastin, is involved in COPD pathogenesis.
REFERENCE   4  (bases 1 to 3865)
  AUTHORS   Navneet,S., Ishii,M. and Rohrer,B.
  TITLE     Altered Elastin Turnover, Immune Response, and Age-Related Retinal
            Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1
            Overexpression
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 34 (2024)
   PUBMED   39028977
  REMARK    GeneRIF: Altered Elastin Turnover, Immune Response, and Age-Related
            Retinal Thinning in a Transgenic Mouse Model With RPE-Specific
            HTRA1 Overexpression.
REFERENCE   5  (bases 1 to 3865)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
REFERENCE   6  (bases 1 to 3865)
  AUTHORS   Lindahl,P., Karlsson,L., Hellstrom,M., Gebre-Medhin,S.,
            Willetts,K., Heath,J.K. and Betsholtz,C.
  TITLE     Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of
            distal spreading of alveolar smooth muscle cell progenitors during
            lung development
  JOURNAL   Development 124 (20), 3943-3953 (1997)
   PUBMED   9374392
REFERENCE   7  (bases 1 to 3865)
  AUTHORS   Wydner,K.S., Sechler,J.L., Boyd,C.D. and Passmore,H.C.
  TITLE     Use of an intron polymorphism to localize the tropoelastin gene to
            mouse chromosome 5 in a region of linkage conservation with human
            chromosome 7
  JOURNAL   Genomics 23 (1), 125-131 (1994)
   PUBMED   7829060
REFERENCE   8  (bases 1 to 3865)
  AUTHORS   Gacheru,S., McGee,C., Uriu-Hare,J.Y., Kosonen,T., Packman,S.,
            Tinker,D., Krawetz,S.A., Reiser,K., Keen,C.L. and Rucker,R.B.
  TITLE     Expression and accumulation of lysyl oxidase, elastin, and type I
            procollagen in human Menkes and mottled mouse fibroblasts
  JOURNAL   Arch Biochem Biophys 301 (2), 325-329 (1993)
   PUBMED   8096378
REFERENCE   9  (bases 1 to 3865)
  AUTHORS   Fazio,M.J., Mattei,M.G., Passage,E., Chu,M.L., Black,D.,
            Solomon,E., Davidson,J.M. and Uitto,J.
  TITLE     Human elastin gene: new evidence for localization to the long arm
            of chromosome 7
  JOURNAL   Am J Hum Genet 48 (4), 696-703 (1991)
   PUBMED   2014796
REFERENCE   10 (bases 1 to 3865)
  AUTHORS   Schurr,E., Skamene,E., Morgan,K., Chu,M.L. and Gros,P.
  TITLE     Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1
            identifies conserved linkage of structural protein genes between
            murine chromosome 1 and human chromosome 2q
  JOURNAL   Genomics 8 (3), 477-486 (1990)
   PUBMED   1981051
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091250.2, AK041860.1 and
            AA183434.1.
            
            On Aug 22, 2015 this sequence version replaced NM_007925.3.
            
            Summary: This gene encodes elastin, the extracellular matrix
            protein that forms a major structural component of several tissues
            including lungs and arterial walls. Cleavage of the signal peptide
            from the encoded precursor generates soluble tropoelastin which
            undergoes lysine-derived crosslinking to form elastin polymers.
            Mice lacking the encoded protein exhibit defective lung
            development, and die of an obstructive arterial disease resulting
            from subendothelial cell proliferation and reorganization of smooth
            muscle. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051649.1, AK041860.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC091250.2         91586-91654         c
            70-3850             AK041860.1         2-3782
            3851-3865           AA183434.1         312-326
FEATURES             Location/Qualifiers
     source          1..3865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.76 cM"
     gene            1..3865
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /note="elastin"
                     /db_xref="GeneID:13717"
                     /db_xref="MGI:MGI:95317"
     exon            1..167
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2665
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /note="tropoelastin"
                     /codon_start=1
                     /product="elastin precursor"
                     /protein_id="NP_031951.2"
                     /db_xref="CCDS:CCDS19725.1"
                     /db_xref="GeneID:13717"
                     /db_xref="MGI:MGI:95317"
                     /translation="MAGLTAVVPQPGVLLILLLNLLHPAQPGGVPGAVPGGLPGGVPG
                     GVYYPGAGIGGLGGGGGALGPGGKPPKPGAGLLGTFGAGPGGLGGAGPGAGLGAFPAG
                     TFPGAGALVPGGAAGAAAAYKAAAKAGAGLGGVGGVPGGVGVGGVPGGVGVGGVPGGV
                     GVGGVPGGVGGIGGIGGLGVSTGAVVPQVGAGIGAGGKPGKVPGVGLPGVYPGGVLPG
                     TGARFPGVGVLPGVPTGTGVKAKAPGGGGAFAGIPGVGPFGGQQPGVPLGYPIKAPKL
                     PGGYGLPYTNGKLPYGVAGAGGKAGYPTGTGVGSQAAAAAAKAAKYGAGGAGVLPGVG
                     GGGIPGGAGAIPGIGGIAGAGTPAAAAAAKAAAKAAKYGAAGGLVPGGPGVRLPGAGI
                     PGVGGIPGVGGIPGVGGPGIGGPGIVGGPGAVSPAAAAKAAAKAAKYGARGGVGIPTY
                     GVGAGGFPGYGVGAGAGLGGASPAAAAAAAKAAKYGAGGAGALGGLVPGAVPGALPGA
                     VPAVPGAGGVPGAGTPAAAAAAAAAKAAAKAGLGPGVGGVPGGVGVGGIPGGVGVGGV
                     PGGVGPGGVTGIGAGPGGLGGAGSPAAAKSAAKAAAKAQYRAAAGLGAGVPGFGAGAG
                     VPGFGAGAGVPGFGAGAGVPGFGAGAGVPGFGAGAVPGSLAASKAAKYGAAGGLGGPG
                     GLGGPGGLGGPGGLGGAGVPGRVAGAAPPAAAAAAAKAAAKAAQYGLGGAGGLGAGGL
                     GAGGLGAGGLGAGGLGAGGLGAGGLGAGGLGAGGGVSPAAAAKAAKYGAAGLGGVLGA
                     RPFPGGGVAARPGFGLSPIYPGGGAGGLGVGGKPPKPYGGALGALGYQGGGCFGKSCG
                     RKRK"
     exon            168..230
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            231..266
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..299
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            300..329
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            330..365
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..467
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..629
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            630..692
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            693..740
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            741..812
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..842
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            843..914
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..956
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1001
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1049
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1139
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1199
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1346
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1400
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1490
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1538
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1640
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1700
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1841
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1901
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2060
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2099
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2201
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2264
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2405
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2444
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2495
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2540
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2570
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2621
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..3851
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3581..3586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3608
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /note="major polyA site"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3851
                     /gene="Eln"
                     /gene_synonym="E030024M20Rik"
ORIGIN      
        1 ctcacagcag cctaccaggc agcaattacg ctttggggat aaaacgaggc gctgagagca
       61 ggctggggca gtcctccccg agatggcggg tctgacagcg gtagtcccgc agcctggcgt
      121 cttgctgatc ctcttgctca acctcctcca tcccgcgcag cctggagggg ttccaggagc
      181 tgtgcctggc ggacttcctg gtggagttcc cggtggagtc tattatccag gggctggtat
      241 tggaggcctg ggaggaggag gaggagctct gggacctgga ggaaaaccac ctaagccagg
      301 tgccggactt ctgggaacgt ttggagcagg tcctggagga cttggaggtg ctggcccggg
      361 tgcaggtctc ggggcctttc ctgcaggcac cttcccaggg gcaggagctc tggtgcccgg
      421 gggagcagca ggggctgctg cggcttataa agctgccgcc aaagctgggg ctgggcttgg
      481 tggcgttggc ggagtcccag gtggtgttgg cgttggtgga gttccaggtg gtgttggagt
      541 tggcggagtc ccaggtggtg ttggagttgg tggagtccct ggcggtgttg gtggtattgg
      601 tggcatcggt ggcttaggag tctcgacagg tgctgtggtg ccccaagtcg gagctggcat
      661 cggagctgga ggaaagcctg ggaaagttcc tggtgttggt cttccaggtg tatacccagg
      721 cggagtgctc ccaggaacag gagctcggtt ccctggtgtg ggggtgctcc ctggagttcc
      781 cactggcaca ggagtcaaag ccaaggctcc aggtggaggt ggtgcttttg ctggaatccc
      841 aggggtcgga ccctttgggg gtcagcagcc tggtgtccca ctgggttatc ccatcaaagc
      901 accaaagctg ccaggtggct acggactgcc ctataccaat gggaaattgc cctatggagt
      961 agctggtgca gggggcaagg ctggctaccc aacagggaca ggggtcggat cccaggcggc
     1021 ggcggcagca gctaaagcag ccaagtatgg tgctggggga gctggagtcc tccctggtgt
     1081 tggagggggt ggcattcctg gtggtgctgg cgcaattcct gggattggag gcattgcagg
     1141 cgctggaact cctgcagcag cagctgctgc aaaggctgct gctaaggctg ctaagtatgg
     1201 agctgctgga ggtttagtgc ctggtggacc aggagttagg ctcccaggtg ctggaatccc
     1261 aggtgttggt ggcattcctg gtgttggtgg catcccaggt gttgggggcc ctggtattgg
     1321 aggtccaggc attgtgggtg gaccaggagc tgtgtcacca gctgcagctg ctaaagctgc
     1381 tgccaaagct gccaaatacg gagccagagg tggagttggc atcccgacat atggggttgg
     1441 tgctggtggc tttcctggct atggtgttgg agctggagca ggacttggag gtgcaagccc
     1501 agctgctgct gctgccgccg ccaaagctgc taagtatggt gctggaggag ctggagccct
     1561 gggaggcctg gtgccaggtg cagtaccagg tgcactgcca ggtgcagtac cagctgtgcc
     1621 gggagctggt ggagtgccag gagcaggtac ccctgcagct gcagctgctg ccgccgccgc
     1681 taaagcagcc gccaaagcag gtttgggtcc tggtgttggt ggggttcctg gtggagttgg
     1741 tgttggtggg attcccggtg gagttggtgt tggtggggtt cctggtggag ttggccctgg
     1801 tggtgttact ggtattggag ctggtcctgg cggtcttgga ggagcagggt caccggctgc
     1861 cgctaaatct gctgctaagg cagctgccaa agcccagtac agagctgccg ctgggcttgg
     1921 agctggtgtc cctggatttg gggctggtgc tggtgtcccc ggatttgggg ctggtgctgg
     1981 tgtccccgga tttggggctg gtgctggtgt ccccggattt ggggctggtg ctggtgtccc
     2041 tggatttgga gctggagcag tacctggatc gctggctgca tccaaagctg ctaaatatgg
     2101 agcagcaggt ggccttggtg gccctggagg tctcggtggc cctggaggtc tcggtggacc
     2161 tggaggactt ggtggggctg gtgttcccgg tagagtagca ggagctgcac cccctgctgc
     2221 tgccgctgct gctgccaaag ctgctgctaa ggctgcccag tatggccttg gtggagccgg
     2281 aggattggga gccggtggac tgggggccgg tggactggga gccggtggac tgggagctgg
     2341 tggactggga gccggtggac tgggagctgg tggactggga gccggtggac tgggagctgg
     2401 tggaggtgtg tcccctgctg cagctgctaa ggcagccaaa tatggtgctg ctggccttgg
     2461 aggtgtccta ggagccaggc cattcccagg tggaggagtt gcagcaagac ctggctttgg
     2521 actttctccc atttatccag gtggtggtgc tgggggcctg ggagttggtg gaaaaccccc
     2581 gaagccctat ggaggagccc ttggagccct gggataccaa ggtgggggct gctttgggaa
     2641 atcctgtggc cggaagagaa agtgatcttc tggggacccc tgactcgcga cctcatcaac
     2701 gttggtgcta ctgcttggtg gagaatgtaa accttctatg accaccccct cctccatccc
     2761 cctgaccccc acctgggagg ggacaacagg ccagtggcct tggaaaccca caggacaagg
     2821 aaatcagaca gcagcagcca tgcagcccta accagaaact ccccccaccc tatatcagag
     2881 gccagggcgg gtgtcccatc tcttcccacc caggagctcc cccccacagt ctccatctcc
     2941 aagggaaatt ggtgctacat gttggtgctt cttctttgtg gggggaggga ggagggaagg
     3001 gtatcccagg ggggattgcc cccttccctg aagcccctct attaagatgg tgcacacctt
     3061 tgttgggcag tcccacctcc ccctgcccac caggagccat tcctggctgc atcccattgg
     3121 tacccaaata ccggaagcct tgacgatgga tttggtgaca tgatccctct ctctttggtt
     3181 cccctgtccc tgcctcctgt tacctaaagc tacttcccac atctgggaca ccctggagtc
     3241 agatggctcc tcacactggg aatagctccc ttgttcttat ggaatccacc tgccatccac
     3301 ccatccacct actcatccat ccatccatcc atccatccat ccgtccatct tgactgccta
     3361 gtaccactaa gctggctggg catacccact atcaacctgg ttcacctgtc atggcagcct
     3421 gtccccgtcc ccaccacaca ccccgatcct ggcctagggt gcaaagggtt gtgtgggctg
     3481 gttgtcccca catgcagtac tgtaaccccg ttcttcctgg agccactctt acagagcatg
     3541 tctcaccacc ccacctcttt gtgtttcgct gtgatagatc aataaaatat tttatttttt
     3601 gtcctggata tttggggatg atgtttgatt gttggtgtgc tctttgggtt tatttttgtg
     3661 gctaattggg gagagagaga gagaaaaaaa aatttctaat ctggggagct atatcctcag
     3721 gagaaaattc attttaatcg ctttggtata actctggatg aaacacacat ttaaaaaaaa
     3781 atcaaaaacg aaataagaaa agagaattaa ttgctctagc aatgactaat aaatataaac
     3841 tttttaaagg caaaaaaaaa aaaaa
//
