LOCUS       NM_001253692            2220 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ELMO/CED-12 domain containing 3 (Elmod3), transcript
            variant 2, mRNA.
ACCESSION   NM_001253692
VERSION     NM_001253692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2220)
  AUTHORS   Turn,R.E., Hu,Y., Dewees,S.I., Devi,N., East,M.P., Hardin,K.R.,
            Khatib,T., Linnert,J., Wolfrum,U., Lim,M.J., Casanova,J.E.,
            Caspary,T. and Kahn,R.A.
  TITLE     The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to
            regulate ciliogenesis and ciliary protein traffic
  JOURNAL   Mol Biol Cell 33 (2), ar13 (2022)
   PUBMED   34818063
  REMARK    GeneRIF: The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia
            to regulate ciliogenesis and ciliary protein traffic.
            Erratum:[Mol Biol Cell. 2022 Jun 1;33(7):cor1. doi:
            10.1091/mbc.E21-09-0443_corr.. PMID: 35612986]
REFERENCE   3  (bases 1 to 2220)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2220)
  AUTHORS   Li,W., Feng,Y., Chen,A., Li,T., Huang,S., Liu,J., Liu,X., Liu,Y.,
            Gao,J., Yan,D., Sun,J., Mei,L., Liu,X. and Ling,J.
  TITLE     Elmod3 knockout leads to progressive hearing loss and abnormalities
            in cochlear hair cell stereocilia
  JOURNAL   Hum Mol Genet 28 (24), 4103-4112 (2019)
   PUBMED   31628468
  REMARK    GeneRIF: Finding associates Elmod3 deficiencies with stereocilia
            dysmorphologies and reveals that they might play roles in the actin
            cytoskeleton dynamics in cochlear hair cells, and thus relate to
            hearing impairment.
REFERENCE   5  (bases 1 to 2220)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   6  (bases 1 to 2220)
  AUTHORS   Sevajol,M., Reiser,J.B., Chouquet,A., Perard,J., Ayala,I., Gans,P.,
            Kleman,J.P. and Housset,D.
  TITLE     The C-terminal polyproline-containing region of ELMO contributes to
            an increase in the life-time of the ELMO-DOCK complex
  JOURNAL   Biochimie 94 (3), 823-828 (2012)
   PUBMED   22177965
  REMARK    GeneRIF: The data demonstrate the ability of the SH3 domain of
            DOCK180 to interact with ELMO1, regardless of the presence of the
            polyproline-containing C-terminal end.
REFERENCE   7  (bases 1 to 2220)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY074266.1, AK084010.1 and BE944793.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 enconde the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.218255.1, AK084010.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY074266.1         2-71
            71-2192             AK084010.1         2-2123
            2193-2220           BE944793.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..2220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..2220
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /note="ELMO/CED-12 domain containing 3"
                     /db_xref="GeneID:232089"
                     /db_xref="MGI:MGI:2445168"
     exon            1..92
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            93..373
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1465
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /note="RNA binding motif and ELMO domain 1; RNA-binding
                     motif and ELMO domain-containing protein 1"
                     /codon_start=1
                     /product="ELMO domain-containing protein 3"
                     /protein_id="NP_001240621.1"
                     /db_xref="CCDS:CCDS20243.1"
                     /db_xref="GeneID:232089"
                     /db_xref="MGI:MGI:2445168"
                     /translation="MSETSCSFFIEKEFQDGQLENVSAGLSSSYKDKGALMAFRGIPI
                     SELTNHGILQALTAETNGWQPGVVSEEVLRAQEEWEVVDTIHPDIESGVHCQQPGQLI
                     SFNEALEHFQSVDLSSFKKRIQPTIQRTGLAALRHCLFGPPKLHQGLREERDLVLTIA
                     QCGLDSQNPTHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGAGFLAL
                     LHLLYLVMDSKTFLMAQEIFRLSHHHIQQFPFCLMSVNITRIAIQALREECLSRECNR
                     RQKVIPVVNSFYAATFLHLARVWRTQQKTILDSGFVLKDLEALAKKSPKRLLKTLDDY
                     LAQVSKGQTSLLEAHKRPGSQGPHSRDLTFTGVCDLQSHSFESAGLI"
     exon            374..448
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            449..518
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            519..587
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            588..679
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            680..803
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            804..926
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1057
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1134
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1262
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2204
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /note="hexamer: AATAAA"
     polyA_site      2195
                     /gene="Elmod3"
                     /gene_synonym="C330008I15Rik; Rbed1; RBM29"
                     /note="major polyA site"
ORIGIN      
        1 gtagttctag cgcgagacag gcgacactgc acggctgcgc gaaaaggggg atgtgggatc
       61 ccccccttac cggaacgctg gggacgcgtc cgactgaggc tccacggttc ccaggggctc
      121 ctttcaggac tcatagaaac ctcctgcacc ttggtgatgg cacagaggga ctgttatttt
      181 tccttggaac ctgaatgact gctgagaagg aaggcgaaaa taaagtgctt gtctctcctg
      241 gtgacttcgg gccgcagcgc aggctgtcgt attgagcccc ttttagaacc cgaggacaag
      301 acccacctga acatgagtca tgagtgaaac atcttgctct ttttttattg agaaagaatt
      361 tcaagatggg cagctagaaa atgtctctgc tgggctctct tcatcgtaca aggacaaggg
      421 tgcactcatg gctttcagag gaattcctat ctccgagctg acgaaccatg gcattctcca
      481 ggccctgacg gcagaaacca atgggtggca gccaggtgtt gtgagtgaag aggtcctcag
      541 agcccaggaa gagtgggaag tggtggacac catccatcca gacatagaga gtggagtcca
      601 ctgccagcag cctggccagc tcatctcctt caacgaggcc ctggagcact tccagagtgt
      661 ggacctttcc tctttcaaga aaagaatcca gcccactatt caaaggactg ggctcgccgc
      721 cctccggcat tgccttttcg ggccgccaaa gctgcaccag ggtcttcggg aagaaagaga
      781 cttggttctc accattgctc agtgtggcct ggacagccaa aacccaacgc atggccgagt
      841 gctccagacc atctacaaga agctgactgg ctccaagttc gactgtgccc ttcacggaga
      901 ccattgggaa gacctgggct tccagggagc aaacccagcc acagacctcc ggggggcagg
      961 cttcctggcc ctcctgcacc tactctacct ggtcatggac tcaaagacgt ttctgatggc
     1021 ccaggagatc ttccgcctgt ctcatcacca tatccagcaa ttccccttct gtttgatgtc
     1081 tgtgaacatc acccgcattg ccatccaggc cttgagagag gagtgtctct ccagggagtg
     1141 taatcggcgg cagaaggtca tcccggtggt gaacagcttc tacgcggcta ctttccttca
     1201 tctggctcgc gtgtggagga cccagcagaa gactatttta gactcaggct ttgtcctcaa
     1261 agacttggaa gcgttggcca agaagagccc aaaacgactg ctcaagaccc tggatgacta
     1321 cctcgcccag gtgtcaaagg gacagacctc cttgttggag gcacacaagc gccctggatc
     1381 acagggacct cactccaggg atctcacttt cacaggcgtg tgtgacctgc agtctcactc
     1441 attcgagagt gcagggttga tctgacccac cacggagaga ccaggacagg ctgggtcgct
     1501 ggggctctct gaactaaaga atcatgtctg ggccaaagcc cttcgtgccc ctgcagatga
     1561 gactaggagg ctcccgggtg tgtgtagtga cacccacgcc cacatttcta catcagcaga
     1621 gcacattcag gcagctagaa ttaccccccc atgccgtcct ccaagcacgg agtcttctgt
     1681 ccttcccagc tggactccac ttcacagggt tggactcctg atatctcagt ggaactgaac
     1741 agagcacagg gccagacagc cctatcagaa ttgcctacac gtctgcacct agaggcagag
     1801 accctggaag caacagccaa gattctgact cccaacagct gtccccagtg tctgtggttg
     1861 gaattggaag gacagagaca gcaatatctt cagccatcag ggggcagcac aacacagaaa
     1921 aagtgactga taggcaggtc ctctcttcct ccagccaccg atttttcaag acacttgttt
     1981 ccaccctacc cttctcctct ttcccctccc tctcctttgc ccaccattgt ttgtaatcta
     2041 gaaatgggta ctcggctggc tagactagtc attgagcgtc ccacccccaa cgcccacagg
     2101 ctggagcgcc tatggagacc actacctatc taccctggct gagaggcaaa ggaaactcac
     2161 ccaccagcag ttttagaata aaggaattgt tgtaatctct ggtaaaaaaa aaaaaaaaaa
//
