LOCUS       NM_178736               4709 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ELMO/CED-12 domain containing 2 (Elmod2), transcript
            variant 1, mRNA.
ACCESSION   NM_178736
VERSION     NM_178736.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4709)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4709)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4709)
  AUTHORS   Turn,R.E., Linnert,J., Gigante,E.D., Wolfrum,U., Caspary,T. and
            Kahn,R.A.
  TITLE     Roles for ELMOD2 and Rootletin in ciliogenesis
  JOURNAL   Mol Biol Cell 32 (8), 800-822 (2021)
   PUBMED   33596093
  REMARK    GeneRIF: Roles for ELMOD2 and Rootletin in ciliogenesis.
REFERENCE   4  (bases 1 to 4709)
  AUTHORS   Turn,R.E., East,M.P., Prekeris,R. and Kahn,R.A.
  TITLE     The ARF GAP ELMOD2 acts with different GTPases to regulate
            centrosomal microtubule nucleation and cytokinesis
  JOURNAL   Mol Biol Cell 31 (18), 2070-2091 (2020)
   PUBMED   32614697
  REMARK    GeneRIF: The ARF GAP ELMOD2 acts with different GTPases to regulate
            centrosomal microtubule nucleation and cytokinesis.
REFERENCE   5  (bases 1 to 4709)
  AUTHORS   Zhou,C.X., Shi,L.Y., Li,R.C., Liu,Y.H., Xu,B.Q., Liu,J.W., Yuan,B.,
            Yang,Z.X., Ying,X.Y. and Zhang,D.
  TITLE     GTPase-activating protein Elmod2 is essential for meiotic
            progression in mouse oocytes
  JOURNAL   Cell Cycle 16 (9), 852-860 (2017)
   PUBMED   28324667
  REMARK    GeneRIF: Elmod2 is the GTPase-activating protein essential to
            meiosis progression of mouse oocytes, most likely by regulating
            mitochondrial dynamics.
REFERENCE   6  (bases 1 to 4709)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084950.1 and AC122890.4.
            
            On Jan 7, 2010 this sequence version replaced NM_178736.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036746.1, BC079654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1856              AK084950.1         1-1856
            1857-4709           AC122890.4         186232-189084       c
FEATURES             Location/Qualifiers
     source          1..4709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.72 cM"
     gene            1..4709
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="ELMO/CED-12 domain containing 2"
                     /db_xref="GeneID:244548"
                     /db_xref="MGI:MGI:2445165"
     exon            1..137
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            138..285
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1025
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="ELMO domain containing 2"
                     /codon_start=1
                     /product="ELMO domain-containing protein 2"
                     /protein_id="NP_848851.3"
                     /db_xref="CCDS:CCDS22450.1"
                     /db_xref="GeneID:244548"
                     /db_xref="MGI:MGI:2445165"
                     /translation="MFVSLWEFFYGHFFRFWMKWLLRQMTGKCELQRIFDTYGGAQRT
                     YRIENSLTYSKNKVLQNATRVAQSELDRCIANIMKEKNICSEKDTSFQICMRTCLLQI
                     TGYKQLYHDVENVRKKPYDSANAQHEKMLLKLWSLLMPTKKLTARISKQWADIGFQGD
                     DPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSL
                     LKSEALKLHLYNFVPGVPTMEHFHQFYCYLVYEFDKFWLEEEPESIMYFNLYREKFHE
                     RIKGLLMDCNAVLTLKT"
     exon            286..314
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            315..412
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..542
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..676
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            677..745
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            746..879
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            880..4709
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1330
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="major polyA site"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4315
                     /gene="Elmod2"
                     /gene_synonym="9830169G11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagcctccg tgcggacttc cgggtcgcgg tgttcgcagg gagcgctcca cgtagagcgt
       61 cgtttccgtt gccggtgttt gcagctgggg aaaccgaggc agtgccagct tccccctagt
      121 tcttccgctc ctgtgaggga aacatgttcg tgtctctgtg ggagtttttc tatggacact
      181 ttttccgatt ttggatgaaa tggctcttac ggcagatgac tgggaaatgt gaattgcagc
      241 gaatttttga cacctatgga ggggcacaga ggacctacag aatagaaaat tccttgacat
      301 attccaagaa taaggtccta cagaatgcaa cacgagttgc ccagagtgaa ctggacaggt
      361 gtatagcgaa catcatgaag gaaaagaaca tctgctccga gaaggacaca agttttcaga
      421 tctgcatgcg gacgtgctta ctgcagataa ctggctataa acagctctac cacgatgtag
      481 aaaatgtgag gaaaaagccc tatgactctg ccaatgcaca gcacgagaag atgctcctca
      541 agctttggag tcttctgatg ccaacgaaaa agttgacggc ccggatctcc aagcagtggg
      601 cagacattgg tttccaaggt gacgatccca aaacagactt cagaggcatg ggcatactcg
      661 gactgatcaa tctcgtgtat ttcagtgaaa actacaccag cgaagcgcat cagattctct
      721 cccgctcaaa tcaccccaaa ttagggtatt cttatgcaat agttggaatc aaccttacag
      781 agatggctta tagcttactg aagagcgagg ccctgaagct tcacctctac aactttgtcc
      841 ctggggtacc aacgatggag cacttccacc agttttactg ttaccttgtc tatgaatttg
      901 acaagttttg gcttgaggaa gagccagaaa gcattatgta cttcaacttg tacagagaga
      961 agtttcacga gcggatcaaa ggactcttga tggattgcaa tgctgtgctc actttgaaaa
     1021 catgaaccat ccgtgtatct tcactttcta ccacattttg cacacacaac agaatttata
     1081 tgttattata gaaattatct gattaactac actcatataa tttcctacaa aaatacttca
     1141 gaaactctat ttaagaaagc tagcggacaa tcagtgtatg tttacagttg tttatacact
     1201 gttctccaaa ggtcccttac ccttccaaag agcccttccg gaggtacatg aactacagtt
     1261 tggaacttgg gtcttagcct gttagtttaa aagtataaat caggtatatt tatagttagc
     1321 caattgatca caatgtgcac aagtctgttg tcattttatg tgtggtgctc ccaagctggt
     1381 gtctttttga aaattctgca gggtcattgt ttgctctgga agtggctttt gaatgccctt
     1441 tgtcttttta tttctaggca aatcagcaca gggtgccctc tgaggctttc tttgtgtctt
     1501 tagctcttgt caagatgtcc tgtccttgga gcagagggca catgactctg tcagggaagg
     1561 tggacaatca tggcttcctt ttgatttttc tggtcactga ctaaagaacc gagacgtggc
     1621 agtactgatg gctgcttctt acttataagt agcccgtgtg ggaggtttta tcctaaggag
     1681 tctaggcatt tactccaggt cagtatttgt ttttatcagc tgtagaagga accttcctca
     1741 gagccccctg ggagaacccc gcctgtgtgt ttagaaagga ggtgcctctg ctgagaaaat
     1801 ctggactgca tttgaaacat agtttctttt tcgataaaac tgtctttgaa acttacacaa
     1861 gaagaaaacc gagagctttt tagacatctg ttccctatca ttggtgtgtt tgacctgctg
     1921 ttcacttttg cttgcccttg atttgactct ggtgtttctg ggtaatattg tagggacctg
     1981 ggttagtggg ctgggacatg ctaccatagc ctggatcatg actgtgcatt tttgtatagc
     2041 tttattctcc aaagtctcag gagggcagca agtattgtcg aggattctat gtgaggggat
     2101 tctaatgggg tggtttcctc ttggcatgct ttagcaattt gttctcagag caaaacaaaa
     2161 agagcctaaa gataagaaag atgattggac ttagaagcac tgagtacgtc ccgtggaaac
     2221 cagtctacaa catgataggt taacctaaaa catggtgctg ttttgcacat cttttaatat
     2281 caggtattta aagactagct tgtgtgatag cggaaagttt gctgttttct cacaatttgt
     2341 tcatgttttc tgtcaagcct gtcttcccac ttgtggggtt ggggggagag agcaagcatg
     2401 agaaagtcat gtgcagtacg gatgtcccat cagagagcca cagctggagt gttgtatagc
     2461 actgtgttgc agagcatggg ttcaaattgc ttttccttaa ggaagataaa acttttttta
     2521 aaagtagctt tgttttataa tactagaaag gattcagctt ttcagtatta taggaattta
     2581 ataattgatt tcttataggg gacttgttga ccctggtaat acagtaattt catttttgag
     2641 aaatcttttg tcacccaggt tttaggatgc attgtgtacc aaaaccctaa caaggagccc
     2701 atggttacca ttgttgtcca ctgtattata gtgtgaagtc ctccatggaa agcagctgtg
     2761 ttagtcttta acttttgtgc taaaagtact tatgcatgta ttttaatctt tgagcagcct
     2821 agatcttgaa ctgatttaac tctttatcag catatgtaac aaaaagcata cttgaagtat
     2881 gaaagaggaa gtaataataa taataataag taattatttt ctggcagaaa aaaatctcta
     2941 atgatgttaa gaacatattg tcatggtttg gttaatgtca cagtccttaa atcctccttt
     3001 gtacattaca gatattgttt gttttttttt gtttgtttgt ttatttgtta aaattatcat
     3061 tagccatttc agataattat atagtgaact gatgtgttag ccaattccag cttcaaagtt
     3121 ctgatcttct gggagcttga ctgtcactag ttgtatacta gaatggttcc cttacttgca
     3181 gcagacatca gaacttcatg cagttttaaa acgcatgttt agatgctccc ctgtgtctag
     3241 gacttgtaaa attacaatgt agcaattggt agtaatggca ttgaagtaca agaaagttac
     3301 gttattttag attaaatcca gtagaatcga tgtggagatg gattcttgta catgtgacga
     3361 tgaaaatatt tcaccagtga caagagcagc ataagaatag aaccacaaca tttaacagtt
     3421 gagatgctct gaaagacaat cttttaaaca tgggagacac ttgggtatca tggatcctag
     3481 accaggctct ttgtaaataa atgtaacagt acaggtaggt ataaaaatga actagcacca
     3541 tttatagttc aaaactcaga ctgtttttct aaaaaatttc ttccctgttt attcttcctt
     3601 tctattttat agctacttag atttgtgtta ctttttatgg aaatgtatgc agcgtttatt
     3661 cttccctcag tgttagccat cattcatatc attctgtccc ttgagaatat tcagcaaaag
     3721 ggattttgat tacaggtttt gctcaaagaa aaacaatttc ttgggtgtga aaagcagctc
     3781 ttcatttctg cagcagaggg gagcaacagc atagaagatg gagctttgcc taggaaggtg
     3841 atggtttatt attgtgctca taactggggg ccacagctgc atccccagca caggtgctct
     3901 actctaatcc acaaaggatg gtgcatctgg ggaggctttg tcgtcacgtt catgtgtact
     3961 gcctctccac acaaatggct tttaaatgaa gatggctctt tcacactctg agaaagatca
     4021 tgatgtgtat ttttgttttc tgtctccaat ttttgatgag ataaaagttt aaatgtagtg
     4081 gaggtaggac ccaacaacca cattgacgtt ggtagagtag ttctatgttt tgttaaaagt
     4141 actgacaaat atttaagttg tagtgttccc tggagggaaa gcaccagttg gtaacttaaa
     4201 tttttgtctc ttttgcatca agcatttgaa tttcatgtaa aagcaatagt gtgagatgtg
     4261 acgtcctttt gtttgtgatg ttaagtgaga gaataaaatc acagctgaaa ctgttgaaag
     4321 cctttctgtg gatgcttgag ctgcccctca tccctattta agtcgtttga gttcaggaaa
     4381 caatgcttgc ttaagttaca ggtgagttgt aacacacaga cttgtgactc ttaaatcact
     4441 ttgtaattat ataagatgat attggctcag agtaagtggc tctgagactc aaagtatatt
     4501 ttacaagaag ccaccatttc acccaaactc atcccattcc accccgtttt caccaaaggt
     4561 agaagtgatt catacacaca ttttccttta caatgtttcc tggttctatt tatatactaa
     4621 tactcaattt gtacagttgc atggcattcc agtatgtgct tttgtagatg tattttattt
     4681 tgaaataata aactcttcat agagcagtc
//
