LOCUS       NM_001405021            2668 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus ELMO/CED-12 domain containing 1 (Elmod1), transcript
            variant 1, mRNA.
ACCESSION   NM_001405021 XM_006511205
VERSION     NM_001405021.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Wagner,E.L., Im,J.S., Sala,S., Nakahata,M.I., Imbery,T.E., Li,S.,
            Chen,D., Nimchuk,K., Noy,Y., Archer,D.W., Xu,W., Hashisaki,G.,
            Avraham,K.B., Oakes,P.W. and Shin,J.B.
  TITLE     Repair of noise-induced damage to stereocilia F-actin cores is
            facilitated by XIRP2 and its novel mechanosensor domain
  JOURNAL   Elife 12, e72681 (2023)
   PUBMED   37294664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Turn,R.E., Hu,Y., Dewees,S.I., Devi,N., East,M.P., Hardin,K.R.,
            Khatib,T., Linnert,J., Wolfrum,U., Lim,M.J., Casanova,J.E.,
            Caspary,T. and Kahn,R.A.
  TITLE     The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to
            regulate ciliogenesis and ciliary protein traffic
  JOURNAL   Mol Biol Cell 33 (2), ar13 (2022)
   PUBMED   34818063
  REMARK    GeneRIF: The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia
            to regulate ciliogenesis and ciliary protein traffic.
            Erratum:[Mol Biol Cell. 2022 Jun 1;33(7):cor1. doi:
            10.1091/mbc.E21-09-0443_corr.. PMID: 35612986]
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Probert,F., Rice,P., Scudamore,C.L., Wells,S., Williams,R.,
            Hough,T.A. and Cox,I.J.
  TITLE     (1)H NMR metabolic profiling of plasma reveals additional
            phenotypes in knockout mouse models
  JOURNAL   J Proteome Res 14 (5), 2036-2045 (2015)
   PUBMED   25849460
REFERENCE   8  (bases 1 to 2668)
  AUTHORS   Pandey,A.K., Lu,L., Wang,X., Homayouni,R. and Williams,R.W.
  TITLE     Functionally enigmatic genes: a case study of the brain ignorome
  JOURNAL   PLoS One 9 (2), e88889 (2014)
   PUBMED   24523945
  REMARK    GeneRIF: Elmod1 has relatively high and selective expression in the
            brain but as of 2014 has not been well-studied with respect to CNS
            function or disease associations. It is part of the core brain
            ignorome. Elmod1 has a high cis-eQTL in hippocampus, hypothalamus,
            striatum. Hearing sensitivity trait in GeneNetwork.org also maps to
            the region containing Elmod1.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2668)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 2668)
  AUTHORS   Johnson,K.R., Longo-Guess,C.M. and Gagnon,L.H.
  TITLE     Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link
            small GTPase signaling to actin cytoskeleton dynamics in hair cell
            stereocilia
  JOURNAL   PLoS One 7 (4), e36074 (2012)
   PUBMED   22558334
  REMARK    GeneRIF: This finding connecting ELMOD1 deficiencies with
            stereocilia dysmorphologies establishes a link between the Ras
            superfamily of small regulatory GTPases and the actin cytoskeleton
            dynamics of hair cell stereocilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157476.2.
            
            On Apr 19, 2022 this sequence version replaced XM_006511205.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.103288.1,
                                           ERR3363658.3783837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC157476.2         87316-87628         c
            314-415             AC157476.2         59139-59240         c
            416-561             AC157476.2         48021-48166         c
            562-590             AC157476.2         47852-47880         c
            591-688             AC157476.2         46408-46505         c
            689-818             AC157476.2         43746-43875         c
            819-952             AC157476.2         38257-38390         c
            953-1021            AC157476.2         36691-36759         c
            1022-1045           AC157476.2         36233-36256         c
            1046-1096           AC157476.2         33614-33664         c
            1097-1230           AC157476.2         31884-32017         c
            1231-2668           AC157476.2         23748-25185         c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.35 cM"
     gene            1..2668
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /note="ELMO/CED-12 domain containing 1"
                     /db_xref="GeneID:270162"
                     /db_xref="MGI:MGI:3583900"
     exon            1..313
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            314..415
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1403
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /note="isoform 1 is encoded by transcript variant 1; ELMO
                     domain-containing protein 1; ELMO domain containing 1"
                     /codon_start=1
                     /product="ELMO domain-containing protein 1 isoform 1"
                     /protein_id="NP_001391950.1"
                     /db_xref="GeneID:270162"
                     /db_xref="MGI:MGI:3583900"
                     /translation="MKHFLRMLIQVCLYFYCKFLWRCMKFVMRKLTGRCELQRICYGT
                     KPGASRTMKIETSLRDSKSKLLQTSVSVHPDAIEKTIDDIMELKKINPDINPQLGISL
                     QACLLQIVGYRNLIADVEKLRREPYDSDNPQHEEMLLKLWELLKPNTPLESRVSKQWC
                     EIGFQGDDPKTDFRGMGLLGLYNLQYFAERDATVAQQVLSDSVHPKCRDITKEEISKF
                     SKIEWEKKKMDKAIGYSFAIVGINITDLAYNLLVSGALKTHFYNIAPEAPTLSHFQQT
                     FCYLMHEFHKFWIEEDPMDIMEFNRVREKFRKRIIKQLQNPDMALCPHFAASEGLINM
                     "
     exon            416..561
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            562..590
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            591..688
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            689..818
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            819..952
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1021
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1045
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1096
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1230
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..2668
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2419..2424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /note="hexamer: AAGAAA"
     polyA_site      2432
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /note="hexamer: AATAAA"
     polyA_site      2668
                     /gene="Elmod1"
                     /gene_synonym="4831417L10"
                     /note="major polyA site"
ORIGIN      
        1 agtagccgcc agcgtcttgc tcccagggaa acctctgcac gccctcccca gctgctctcg
       61 gtcgcctcct ctctgcccgc tgcccagggt gcaacccggc ttgcagggct ccacgcgacc
      121 cagattcccg ccccgccccc gcccctcccg cgcccgcagc cagtgcggca gccgcggccg
      181 cctctgtcca gcatccgctc ggggaccagc cgcggcgatc acggtcgcta gtgcgtagca
      241 ggagcgaagg cggagatgga gaccacactg ttgcgatccc agagctgctg agcccaccac
      301 tgtctctgct ccgcccacac ttactttgca aaagcaaatt tggaagcagt tgcttgaaga
      361 cagttggcgt agcatccgga gagtcaaacg cctgcaaaat gaagcacttc ctgaggatgt
      421 tgatccaggt gtgcctgtat ttttattgta aatttttgtg gcgctgcatg aagtttgtga
      481 tgcggaaact caccggaagg tgtgaactgc aaaggatttg ctacggcacc aaacctggag
      541 cttccagaac catgaaaatt gaaacgtcac tgagagattc aaaaagcaag ctgttgcaga
      601 catccgtgag tgttcatcct gatgctattg aaaagactat tgatgacatc atggaattga
      661 aaaaaattaa ccctgacatc aatccacagt tggggatctc tctccaggct tgcctcctgc
      721 aaatcgtggg ttacagaaac ctcattgcag atgtggaaaa actgcgcaga gaaccctatg
      781 attccgacaa cccccagcat gaagagatgc ttctgaagct atgggagctc ctgaagccca
      841 acactccact ggagtctcgg gtttcgaagc agtggtgtga gatcggcttc caaggcgatg
      901 atccgaaaac agatttccga ggaatgggtc ttctgggact ttacaatttg caatattttg
      961 cagaacggga tgccaccgtg gctcagcagg tcctctccga ctctgtccat ccaaaatgca
     1021 gggatatcac taaggaggaa ataagcaaat tcagcaaaat agaatgggaa aagaaaaaga
     1081 tggataaagc cattgggtac tcctttgcaa ttgtgggcat caatatcacc gacctggcat
     1141 ataatctgct cgtgagcggc gctctaaaaa cacacttcta caacattgcc cccgaagctc
     1201 cgacactgtc tcacttccaa caaacattct gctatttgat gcacgagttt cacaagtttt
     1261 ggattgaaga ggaccccatg gacataatgg agtttaatcg cgtgagggag aaattccgca
     1321 agaggatcat aaaacagctg cagaacccag atatggcgct gtgcccgcat tttgctgcat
     1381 cggaaggttt aatcaacatg tagtgcccac actggtttca atgaataccc cagaacactg
     1441 cctcattgtc atcctagatc tctgcttagg tgacagctca cacacctaat gcacataagt
     1501 gactatatat atatatatat atatatatat atatatatat atatatgcat gccttttggt
     1561 acagtatttt catctcttgg tcattattcc aagattcccc caaaatcacc atttctggag
     1621 catcaaccct ccagtgattg ctcacattgt ggcattgtgc agtgttaaca tctgtccttg
     1681 gcacccaggt atgaaaaaag ttttctattt ttttagattt ttttctcccc ccccccatca
     1741 ttccatatta aaaatgtata ataattctct agctgtaatt tgtacgtaag agagttagct
     1801 gaatctcgtt ctgtgttcct atttattaaa atgtctcacg aagactgctg ctagcctctc
     1861 aagctggacc cttgcttgta cctcatttgg gtaaagcata agacttttaa aataatacag
     1921 acacatgata agccaaactc ttcctgcaca tataactgca cttcaccaga atgtaatgag
     1981 gctataagaa attagcttaa ataggaacca tccttgtgtg aaatcctgcc gaactgtagc
     2041 ctaacttaac cacagtacaa ctgtgtccta gtcatcagga tagaaaacta ctactattct
     2101 cccatcgctt catggcttgg atgtctaaat atgtgtatga tgctcggagc ccccagaaaa
     2161 gaagccatat ctttccaagg ctgcaaaggg tttctcacta tctgactctt gctgaaccca
     2221 gacttagttc ttagcactcc ccagatctga gtatccttgc ttaggggatt gagtgctgac
     2281 tggtttgttt ctatgttgag gggcaatatt ttaaaacttt tgtcaagaaa atgtgttaga
     2341 acacaggaac ctaagcaatg ataccatgca atatttcctg aaattagcat ccttgtatcg
     2401 gtggaagaag tggcttggaa gaaaaaaaac aagatcatcc tcaaactgct aagaatcatc
     2461 ttctttaaaa tgtaatttag tttggaatta tgactgtagt ctgttgaata gtatttacca
     2521 tggtatttca tacccgtggt attttatact ttgggactat cgattttagt attattagat
     2581 gtttgtgtaa tcacttgctt atttaaataa attttgagta ctgcctaact gtcagtatat
     2641 gaataaattg catatcattc tacagtaa
//
