LOCUS       NM_172760               2407 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus engulfment and cell motility 3 (Elmo3), mRNA.
ACCESSION   NM_172760
VERSION     NM_172760.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Sato,Y., Sato,A., Mizuno,S., Hirota,J.N., Fujima,S., Ishii,C.,
            Sano,Y. and Furuichi,T.
  TITLE     Comparative gene expression analysis of the engulfment and cell
            motility (ELMO) protein family in the mouse brain
  JOURNAL   Gene Expr Patterns 34, 119070 (2019)
   PUBMED   31521773
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On Jan 25, 2023 this sequence version replaced NM_172760.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058752.1, AK037067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC124584.5         87650-87871         c
            223-263             AC124584.5         87472-87512         c
            264-336             AC124584.5         87292-87364         c
            337-387             AC124584.5         87051-87101         c
            388-557             AC124584.5         86714-86883         c
            558-657             AC124584.5         86526-86625         c
            658-809             AC124584.5         86289-86440         c
            810-888             AC124584.5         86113-86191         c
            889-939             AC124584.5         85966-86016         c
            940-1062            AC124584.5         85762-85884         c
            1063-1194           AC124584.5         85546-85677         c
            1195-1296           AC124584.5         85344-85445         c
            1297-1405           AC124584.5         85139-85247         c
            1406-1542           AC124584.5         84894-85030         c
            1543-1706           AC124584.5         84644-84807         c
            1707-1819           AC124584.5         84445-84557         c
            1820-1924           AC124584.5         84261-84365         c
            1925-2007           AC124584.5         84072-84154         c
            2008-2094           AC124584.5         83900-83986         c
            2095-2407           AC124584.5         83502-83814         c
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2407
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /note="engulfment and cell motility 3"
                     /db_xref="GeneID:234683"
                     /db_xref="MGI:MGI:2679007"
     exon            1..222
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2307
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /note="engulfment and cell motility 3, ced-12 homolog"
                     /codon_start=1
                     /product="engulfment and cell motility protein 3"
                     /protein_id="NP_766348.3"
                     /db_xref="CCDS:CCDS22598.1"
                     /db_xref="GeneID:234683"
                     /db_xref="MGI:MGI:2679007"
                     /translation="MAPPRNVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDAWSLT
                     HPEHYALQFADGHRKYITENNRLEIKNGSILCLSTAPDLKAQQLLGRLQNTSREGCCE
                     VLRNLVLLASDMTFAQEVISRDGLQKLSTIIENGDDLGEMLALGLRAFLELMEHGVVS
                     WETLSISFVRKVISYVNMNLMDASVQPLALRLLESVTLSSPALGQLVKSEVPLDRLLV
                     HLQVMNHQLQTKAMALLTALLQGASPTERKEMLDHLWKKNLRQFIYKNIIHSATPMGD
                     EMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQRDQLQALRQAAFEPEGESLGTGLSAD
                     RRRSLCVREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSR
                     EDKHECPFARSSIQLTALLCELLRVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLL
                     NKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTE
                     RLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISSRRRQDKLWFCCL
                     SPNHKVLQYGDVEEGAKPPTLESLPEQLPVADIRALLMGKDCPHVREKGSGKQNKDLY
                     ELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSALLGSTMGSELTRLDLEQLLTME
                     TKLRLLELENVPIPEQPPPVPPPPTNFNFCYDYSITEP"
     exon            223..263
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            264..336
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            337..387
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            388..557
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            558..657
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            658..809
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            810..888
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            889..939
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1062
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1194
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1296
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1405
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1542
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1706
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1819
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1924
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2007
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2094
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2407
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="Elmo3"
                     /gene_synonym="9930107J06; CED-12; Ced12"
                     /note="major polyA site"
ORIGIN      
        1 cctttgggaa ggcctcggag cccgatcagg agtgggaacc tgggctgtga gtgcaggcta
       61 caagtcctag accctagacc gggtgcactc tcggcgggag gtggcacatt agtgccaagt
      121 gccagcggcc accgcggctg gactatggcg cccccgcgga atgtggtgaa gattgctgtt
      181 cagatgtctg acgccatccc acagcttatc cagctagacc aggcaaagcc cctggccact
      241 gtactgaagg aggtgtgtga cgcgtggagc ctgactcatc cggagcacta tgccctgcag
      301 tttgctgatg ggcacaggaa atacatcaca gagaataacc gcttggagat caagaatgga
      361 agcatcctgt gtctcagcac tgccccagat ctgaaggccc agcagctact gggtagactg
      421 cagaatacaa gtcgtgaagg gtgctgtgaa gtcctgagaa acctggtcct gctggcctca
      481 gacatgacct ttgcccagga ggtcatcagt cgtgatgggc ttcagaaact aagcaccatc
      541 attgaaaatg gggatgacct aggggagatg ctggcccttg gtctaagggc tttcttggag
      601 ctcatggaac acggtgtagt gtcctgggag acactcagca tctcctttgt caggaaggtg
      661 atatcttatg tgaacatgaa cctgatggat gcctctgtcc agcccctggc tctgagactg
      721 ctggagagtg tgaccttgag cagtcctgcc ctgggccagc tggtgaagag tgaggtgcca
      781 ctggataggc tgctggtgca cctgcaagta atgaaccacc agctgcaaac caaggccatg
      841 gctctgttga cggccctgct gcagggagcc agccccactg aacgcaagga aatgcttgac
      901 cacctatgga agaagaatct tcgccagttc atctacaaga acatcatcca cagtgcaaca
      961 cccatgggtg acgagatggc tcatcacttg tatgtgctgc aggctcttac cctagggctg
     1021 ctggagccac ggatgcggac accacttgat ccctacagcc aggaacagcg ggaccagctg
     1081 caggctctgc gccaggcagc ctttgaacca gagggggagt ccttgggcac agggctcagt
     1141 gcagaccgcc gccggtctct ctgtgtccga gagttccgca agttaggctt ctctaacagc
     1201 aacccagccc aggacctgga gcgtgtgccc cccggcctgc tggccctgga caatatgctc
     1261 tacttctcca gacatgcacc aagtgcatac agtcggtttg tgttggagaa cagtagccga
     1321 gaggacaagc atgaatgccc ctttgcccgg agcagcatcc agctgacagc gttgctgtgt
     1381 gagctgctcc gtgttgggga gccttgctcc gagacagccc aggacttctc gcccatgttc
     1441 ttcagccaag accacagttt ccatgagctc ttctgtgtgg ctatccagct actgaataag
     1501 acctggaagg agatgcgggc aacacaggaa gattttgaca aggtgatgca agtggttcgg
     1561 gagcagctgg cccgtaccct ggctctgaag cccacctccc tggagctctt tcgaaccaaa
     1621 gtgaatgccc tcacctatgg ggaagtgttg aggctgcggc agacagagcg gctgcaccag
     1681 gagggcacgc tggcccctcc tatactggaa ttgcgagaga aactgaagcc agagctcatg
     1741 ggcttaatcc gccagcagcg tttgctccga ctctgtgaag gaatgctctt ccgcaagatc
     1801 agcagccgga gacgacagga caagctatgg ttttgctgtt tatcccccaa ccacaaagta
     1861 ctgcagtatg gggatgtgga ggagggtgcc aagcccccta ccctagaaag cctacctgaa
     1921 cagctccctg tggcagacat cagggcactc ctaatgggca aggactgccc ccatgtccgg
     1981 gagaagggct ctgggaagca gaacaaggac ctgtatgagc tggctttctc catcagctat
     2041 gaccacgggg aggaagaagc atacctcaac ttcattgccc cctccaaacg ggatttctac
     2101 ctgtggacag acgggctaag tgccctgctg ggcagtacca tgggcagtga gctgactcgg
     2161 ctagacctgg agcagctgct cactatggag accaagttgc ggttgttgga actggagaac
     2221 gtgcccattc ctgagcagcc tcccccagta cccccacccc ctaccaactt taacttctgc
     2281 tatgactaca gcatcactga gccgtgactc aagttaggcc acagttgata ctgctatagc
     2341 agccacgaaa tcacagacaa cctgactagg agagcctcta acagaaataa agttagcctg
     2401 gcttata
//
