LOCUS       NM_207706               4636 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus engulfment and cell motility 2 (Elmo2), transcript
            variant 2, mRNA.
ACCESSION   NM_207706
VERSION     NM_207706.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Tang,Y.C., Ponsin,K., Graham-Paquin,A.L., Luthold,C., Homsy,K.,
            Schindler,M., Tran,V., Cote,J.F., Bordeleau,F., Khadra,A. and
            Bouchard,M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Sato,Y., Sato,A., Mizuno,S., Hirota,J.N., Fujima,S., Ishii,C.,
            Sano,Y. and Furuichi,T.
  TITLE     Comparative gene expression analysis of the engulfment and cell
            motility (ELMO) protein family in the mouse brain
  JOURNAL   Gene Expr Patterns 34, 119070 (2019)
   PUBMED   31521773
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Weng,Z., Situ,C., Lin,L., Wu,Z., Zhu,J. and Zhang,R.
  TITLE     Structure of BAI1/ELMO2 complex reveals an action mechanism of
            adhesion GPCRs via ELMO family scaffolds
  JOURNAL   Nat Commun 10 (1), 51 (2019)
   PUBMED   30604775
  REMARK    GeneRIF: Study demonstrated that an evolutionarily conserved
            fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is
            specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of
            the ELMO family scaffolds. The crystal structures of ELMO2-RAE and
            its complex with BAI1 uncover the molecular basis of BAI/ELMO
            interactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4636)
  AUTHORS   Ho,E., Ivanova,I.A. and Dagnino,L.
  TITLE     Integrin-linked kinase and ELMO2 modulate recycling endosomes in
            keratinocytes
  JOURNAL   Biochim Biophys Acta 1863 (12), 2892-2904 (2016)
   PUBMED   27627840
  REMARK    GeneRIF: Ilk and ELMO2 modulate recycling endosomes in
            keratinocytes undergoing intercellular adhesion mediated through
            cell-cell contacts, including E-cadherin-based adherens junctions.
REFERENCE   6  (bases 1 to 4636)
  AUTHORS   Sun,Y., Ren,W., Cote,J.F., Hinds,P.W., Hu,X. and Du,K.
  TITLE     ClipR-59 interacts with Elmo2 and modulates myoblast fusion
  JOURNAL   J Biol Chem 290 (10), 6130-6140 (2015)
   PUBMED   25572395
  REMARK    GeneRIF: Collectively, our studies demonstrate that formation of an
            Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
REFERENCE   7  (bases 1 to 4636)
  AUTHORS   Ho,E., Irvine,T., Vilk,G.J., Lajoie,G., Ravichandran,K.S.,
            D'Souza,S.J. and Dagnino,L.
  TITLE     Integrin-linked kinase interactions with ELMO2 modulate cell
            polarity
  JOURNAL   Mol Biol Cell 20 (13), 3033-3043 (2009)
   PUBMED   19439446
  REMARK    GeneRIF: Resutls show that the interaction with ELMO2 and RhoG is
            essential for the ability of ILK to induce front-rear cell
            polarity.
REFERENCE   8  (bases 1 to 4636)
  AUTHORS   Katoh,H., Fujimoto,S., Ishida,C., Ishikawa,Y. and Negishi,M.
  TITLE     Differential distribution of ELMO1 and ELMO2 mRNAs in the
            developing mouse brain
  JOURNAL   Brain Res 1073-1074, 103-108 (2006)
   PUBMED   16443196
REFERENCE   9  (bases 1 to 4636)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   10 (bases 1 to 4636)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045428.1, AK032033.1, AK035710.1 and AI666775.1.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023954.1, AK032033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK045428.1         2-63
            63-340              AK032033.1         36-313
            341-522             AK045428.1         342-523
            523-3397            AK032033.1         496-3370
            3398-4620           AK035710.1         1748-2970
            4621-4636           AI666775.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.53 cM"
     gene            1..4636
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="engulfment and cell motility 2"
                     /db_xref="GeneID:140579"
                     /db_xref="MGI:MGI:2153045"
     exon            1..62
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            63..175
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2296
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     engulfment and cell motility protein 2; CED-12 homolog A"
                     /codon_start=1
                     /product="engulfment and cell motility protein 2 isoform
                     2"
                     /protein_id="NP_997589.1"
                     /db_xref="CCDS:CCDS17076.1"
                     /db_xref="GeneID:140579"
                     /db_xref="MGI:MGI:2153045"
                     /translation="MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLP
                     NPEYYTLRYADGPQLYVTEQTRNDIKNGTILQLAVSPSRAARQLMERTQSSSMETRLD
                     AMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDH
                     GIVSWDMVSVTFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVG
                     QLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDKHLNPLDLPVTDMANAFAQKHLR
                     SIILNHVIRGNRPIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRI
                     AFDAESDPSNVPGSGTEKRKAMYTKDYKMLGFTNHINPALDFTQTPPGMLALDNMLYL
                     AKVHQDTYIRIVLENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMF
                     FTHDRAFEELFGICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFK
                     SKLRSLSYSEILRLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSS
                     FRKIGNRRRQERFWHCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTG
                     KDCPHMKEKSALKQNKEVLELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDM
                     SSELTKSDLDTLLSMEMKLRLLDLENIQIPEAPPPVPKEPSSYDFVYHYG"
     exon            176..216
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            217..289
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            290..340
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            341..522
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            523..622
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            623..774
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            775..853
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            854..889
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            890..940
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1063
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1198
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1303
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1412
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1549
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1713
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1826
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1934
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2017
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2095
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..4626
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="major polyA site"
     regulatory      4601..4606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="hexamer: AATAAA"
     polyA_site      4626
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
ORIGIN      
        1 agacggggcc agtggagcgg cggcgggacg cgggcgcgga gctgggcctc ggcgggtgcc
       61 gggcagctgt gtcttgaaga agggcccgcc gggaacaatg ccgcctccgt ctgacattgt
      121 caaagtggcc atcgagtggc caggtgctaa cgcccagctc cttgaaattg accagaaacg
      181 gccgctggca tccatcatca aggaggtgtg cgatgggtgg tcactgccga acccggagta
      241 ctacaccctc cgctatgcag atgggcctca gctctacgtc acggagcaga cccgaaatga
      301 cattaagaac gggacaatct tacaactggc cgtctccccg tcccgggctg cacgccagct
      361 gatggaaagg acccagtcat ctagtatgga gacccggctg gatgccatga aggagttggc
      421 taagctctca gctgacgtga ctttcgccac ggagttcatt aacatggacg gcatcattgt
      481 gctgacgagg ctcgtggaga gtgggaccaa gctcctgtcc cactacagtg agatgctggc
      541 attcaccctg actgccttct tagagctcat ggatcatggc attgtctcct gggacatggt
      601 ttcagtcacc tttattaagc agattgcagg gtacgtgagc cagcccatgg tcgatgtgtc
      661 catcctccag cggtccctgg ccatcctaga gagcatggta ctaaacagcc agagcctgta
      721 ccagaagata gcggaggaga tcaccgtggg acagctcatc tcccacctgc aggtctccaa
      781 ccaggagatc cagacctacg ccattgctct gattaacgcg ctgttcctga aggcccccga
      841 agacaagaga caggacaagc accttaaccc tctagacctg cccgtcactg acatggccaa
      901 tgcctttgca cagaagcacc ttcggtccat aatcctgaac catgtgatca gagggaatcg
      961 tccaatcaaa acagagatgg cccatcagct gtatgtcctt caggtcttga cctttaacct
     1021 tctggaagaa agaatgatga ccaagatgga tcccaatgac caggctcaga gagacattat
     1081 atttgaactg aggaggattg ccttcgacgc agagtctgac cccagcaacg tccccgggag
     1141 tgggactgaa aagcgcaagg ccatgtatac caaggactat aaaatgctgg gcttcaccaa
     1201 ccatatcaac ccagccttgg acttcaccca gactcctcct ggaatgctgg cgctggacaa
     1261 catgctgtac ctggctaaag tccaccagga cacctacatc cggatcgtgc tggagaacag
     1321 cagtcgggag gacaaacacg agtgtccgtt cggccgcagt gccatcgagc tcaccaagat
     1381 gctctgtgag atcctgcagg tcggggagct ccctaatgaa gggcgcaatg actaccaccc
     1441 catgttcttc acccacgacc gagccttcga ggaactcttc gggatctgca tccagctgct
     1501 gaacaagacc tggaaggaga tgagggcgac agccgaggat ttcaacaagg ttatgcaagt
     1561 tgtccgagag cagatcaccc gggctctgcc ctctaaaccc aactctttgg atcagttcaa
     1621 gagtaaactt cgtagcctga gctactcaga aattctgcgg ttgcgccagt ctgagaggat
     1681 gagccaggat gatttccagt ccccaccaat tgtggagctt cgagagaaga tacagcctga
     1741 gatcctggag ctgatcaagc aacagcgcct caaccggcta tgcgagggca gcagcttccg
     1801 gaaaatcggg aaccgtcgtc ggcaagagag gttctggcac tgccgcttgg cactgaacca
     1861 caaggttttg cattacggtg acttggatga caaccctcaa ggggaggtga cattcgaatc
     1921 cctgcaggag aaaattcctg ttgcagatat taaggccatt gttactggaa aagactgtcc
     1981 tcacatgaaa gagaagagtg ccctgaaaca gaacaaggag gtgttggaat tggccttctc
     2041 catcctgtat gatcctgatg agacactgaa tttcattgct cccaacaagt atgagtactg
     2101 catctggatt gatggactca gcgctctcct ggggaaggat atgtccagcg agctaaccaa
     2161 gagcgacttg gacacgctgc tgagcatgga gatgaagctg cggcttctgg acttggagaa
     2221 cattcagatc cccgaggcgc cacctccggt ccccaaggag cccagcagct atgacttcgt
     2281 ctatcactat ggctgagcgg gaagggactg gggcccagga gagacactgg cagcccacgc
     2341 cacttgtaca aactctgtag tgattgtggt aactactcct cagagccagt gggacccaga
     2401 gcttctctct gtcccatcca ccaggagtca tgaagtcagg gcatgctgcc ctcctcagca
     2461 ccacagagcc tgggtcgggc ttggaggggt gaactcatga ggctcctgcc tcccgctctg
     2521 cgtcacatct gcatctggta ctggacctac tgacagccat cccctttcct ttcaagtctc
     2581 ctctctggtt tgttggagag cccatgtggg ccaaagctgg tccatgaaag gctgaccatg
     2641 ggggcaagag gcctggggag ctcggtgaga gcctcggagt gactgtcttc aggtggctca
     2701 ggcaagaaca ggccttgagc tcctgcttaa taggtctctg agggctcatc ccagcctcgt
     2761 cctgtgcctc atgctgctgc ctctggggtt tggccctacc atgtctagtc tctagagaca
     2821 cccgtctctc ttgtccttgc aggtatcagg acaggtagta attttgcccc aagccctcag
     2881 cctcatcctg gccaggcaga ggcctccagc ctgagtcctg ctctcttagg ctttaggaat
     2941 gaacactgca gggaaaggca ggctgaggcc tctggctccc cctacccctc cagtcctctc
     3001 tcttccttgc tgaggcacaa tattcccatg ccccctcagt tacaggcccc tccgtttgct
     3061 tccctcctgc ctcagacagg ggtgttgcct tccctttctc cccttcctgg cgctgtggtt
     3121 tgtgccatta gccatgattt cacagcggct ggggccacag ctgtgccacg gccttcattg
     3181 gtgctgcagc actggaagcc cacgcgcaca gcctctttcc ttggacgcat gttaccatgg
     3241 tggtattcag tactggtagc ctggcatggt gggtactacc cagtgaagag tgtactatat
     3301 attttcttta ctataggcca tacttataca gacatgtata tatatttata taagatcttc
     3361 ctatcttagg atagaatgtt taagggaaaa taaaatcaag aacaaaactg tagtgctctc
     3421 agtcatgagc tgtgagtgta accagagagc agccaggagc ttcctgtcag tgatgtgttt
     3481 tcaataaata ctctttcatg tagactgctt cctatccaca cctcttcctc tgcacttatt
     3541 ccctgtccca agggtgagga gcggcctgac agccttcatt tcagtgtgcc tgggagcatg
     3601 tggagagctc ccagccactc tgagagcatc tccctctccc ctcatctctc ctgctcttgt
     3661 catgcgcaaa ctactcacac ctgctggcta aggatgctca cagcttgtgc tacaggacag
     3721 agcgttttct gctcagtcgt gctgggtaca acgtggaaag gcatactgta cacccccaag
     3781 aacccatcct ccctttttcc cctgccaggg acacagccag ggaacagctc gagtacttgt
     3841 gcctttcaaa gaagacatgt tccgcacccc gcatgttgcc tgcagttagt gcccagcttg
     3901 ccagctggtg ctttaagctg gtgctcccat cagcagcctt ggtagctggg aggtttgaat
     3961 gaaggcagtg atgaaaatag atacttcccc ttgcctcagt cagaaggggg tgaggacagg
     4021 cgctttcaga aggcatagaa agtgcatgca acgcaggctt tgagggctga acgaagccaa
     4081 gaccttgggc tgcgatgggc accattgtag gtctcaggaa gcattgaatc aacgaatgct
     4141 ttcgtgatgc cagctggcaa cagcctacag cagcagtgtg cacaaagcac agcttacacg
     4201 ctggccttga gccttctgct aggagccagg agcccagcca agtcatgtgc aaggattcct
     4261 gtttgcagcc agtcctagta gagcccggat gagcagacgc cgagaactgg gccagctcgg
     4321 gtctgcagcc ctagcttgca tggcttagag gttatcttgc ccacatactc tgtacctgaa
     4381 atgagtcaaa tccaggtgtg ctaaattggt gttctgcggc cactgtaacc tgcttccctg
     4441 ggctcccggt aagactagat ccttcttacc cccttccttt tgggttccat ttcctctgcg
     4501 atgaacttca cgtactcagc ctattgaata attctcacaa atttataggc atacgcaatg
     4561 tcacaaagtg tccattatca ctttgccagg acgttttact aataaaattt aatggttgtc
     4621 atgtcaaaaa aaaaaa
//
