LOCUS       NM_080287               4600 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus engulfment and cell motility 2 (Elmo2), transcript
            variant 3, mRNA.
ACCESSION   NM_080287
VERSION     NM_080287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4600)
  AUTHORS   Tang,Y.C., Ponsin,K., Graham-Paquin,A.L., Luthold,C., Homsy,K.,
            Schindler,M., Tran,V., Cote,J.F., Bordeleau,F., Khadra,A. and
            Bouchard,M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   2  (bases 1 to 4600)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4600)
  AUTHORS   Sato,Y., Sato,A., Mizuno,S., Hirota,J.N., Fujima,S., Ishii,C.,
            Sano,Y. and Furuichi,T.
  TITLE     Comparative gene expression analysis of the engulfment and cell
            motility (ELMO) protein family in the mouse brain
  JOURNAL   Gene Expr Patterns 34, 119070 (2019)
   PUBMED   31521773
REFERENCE   4  (bases 1 to 4600)
  AUTHORS   Weng,Z., Situ,C., Lin,L., Wu,Z., Zhu,J. and Zhang,R.
  TITLE     Structure of BAI1/ELMO2 complex reveals an action mechanism of
            adhesion GPCRs via ELMO family scaffolds
  JOURNAL   Nat Commun 10 (1), 51 (2019)
   PUBMED   30604775
  REMARK    GeneRIF: Study demonstrated that an evolutionarily conserved
            fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is
            specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of
            the ELMO family scaffolds. The crystal structures of ELMO2-RAE and
            its complex with BAI1 uncover the molecular basis of BAI/ELMO
            interactions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4600)
  AUTHORS   Ho,E., Ivanova,I.A. and Dagnino,L.
  TITLE     Integrin-linked kinase and ELMO2 modulate recycling endosomes in
            keratinocytes
  JOURNAL   Biochim Biophys Acta 1863 (12), 2892-2904 (2016)
   PUBMED   27627840
  REMARK    GeneRIF: Ilk and ELMO2 modulate recycling endosomes in
            keratinocytes undergoing intercellular adhesion mediated through
            cell-cell contacts, including E-cadherin-based adherens junctions.
REFERENCE   6  (bases 1 to 4600)
  AUTHORS   Sun,Y., Ren,W., Cote,J.F., Hinds,P.W., Hu,X. and Du,K.
  TITLE     ClipR-59 interacts with Elmo2 and modulates myoblast fusion
  JOURNAL   J Biol Chem 290 (10), 6130-6140 (2015)
   PUBMED   25572395
  REMARK    GeneRIF: Collectively, our studies demonstrate that formation of an
            Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
REFERENCE   7  (bases 1 to 4600)
  AUTHORS   Ho,E., Irvine,T., Vilk,G.J., Lajoie,G., Ravichandran,K.S.,
            D'Souza,S.J. and Dagnino,L.
  TITLE     Integrin-linked kinase interactions with ELMO2 modulate cell
            polarity
  JOURNAL   Mol Biol Cell 20 (13), 3033-3043 (2009)
   PUBMED   19439446
  REMARK    GeneRIF: Resutls show that the interaction with ELMO2 and RhoG is
            essential for the ability of ILK to induce front-rear cell
            polarity.
REFERENCE   8  (bases 1 to 4600)
  AUTHORS   Katoh,H., Fujimoto,S., Ishida,C., Ishikawa,Y. and Negishi,M.
  TITLE     Differential distribution of ELMO1 and ELMO2 mRNAs in the
            developing mouse brain
  JOURNAL   Brain Res 1073-1074, 103-108 (2006)
   PUBMED   16443196
REFERENCE   9  (bases 1 to 4600)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   10 (bases 1 to 4600)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045428.1, BC033418.1, AK035710.1 and AI666775.1.
            
            On Apr 29, 2004 this sequence version replaced NM_080287.1.
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            coding region compared to variant 2. It encodes isoform 3, which is
            shorter than isoform 2. Variants 3 and 4 encode the same isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129023.1, SRR1660815.167618.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               AK045428.1         2-380
            380-3478            BC033418.1         310-3408
            3479-4584           AK035710.1         1865-2970
            4585-4600           AI666775.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..4600
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.53 cM"
     gene            1..4600
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="engulfment and cell motility 2"
                     /db_xref="GeneID:140579"
                     /db_xref="MGI:MGI:2153045"
     exon            1..62
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            63..175
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2260
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     engulfment and cell motility protein 2; CED-12 homolog A"
                     /codon_start=1
                     /product="engulfment and cell motility protein 2 isoform
                     3"
                     /protein_id="NP_525026.2"
                     /db_xref="CCDS:CCDS17075.1"
                     /db_xref="GeneID:140579"
                     /db_xref="MGI:MGI:2153045"
                     /translation="MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLP
                     NPEYYTLRYADGPQLYVTEQTRNDIKNGTILQLAVSPSRAARQLMERTQSSSMETRLD
                     AMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDH
                     GIVSWDMVSVTFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVG
                     QLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNR
                     PIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNVP
                     GSGTEKRKAMYTKDYKMLGFTNHINPALDFTQTPPGMLALDNMLYLAKVHQDTYIRIV
                     LENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFG
                     ICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEIL
                     RLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRKIGNRRRQER
                     FWHCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSAL
                     KQNKEVLELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTL
                     LSMEMKLRLLDLENIQIPEAPPPVPKEPSSYDFVYHYG"
     exon            176..216
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            217..289
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            290..340
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            341..522
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            523..622
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            623..774
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            775..853
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            854..904
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1027
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1162
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1267
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1376
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1513
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1677
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1790
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1898
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1981
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2059
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..4590
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3447..3452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="hexamer: AATAAA"
     polyA_site      3466
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="major polyA site"
     regulatory      4565..4570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /note="hexamer: AATAAA"
     polyA_site      4590
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
ORIGIN      
        1 agacggggcc agtggagcgg cggcgggacg cgggcgcgga gctgggcctc ggcgggtgcc
       61 gggcagctgt gtcttgaaga agggcccgcc gggaacaatg ccgcctccgt ctgacattgt
      121 caaagtggcc atcgagtggc caggtgctaa cgcccagctc cttgaaattg accagaaacg
      181 gccgctggca tccatcatca aggaggtgtg cgatgggtgg tcactgccga acccggagta
      241 ctacaccctc cgctatgcag atgggcctca gctctacgtc acggagcaga cccgaaatga
      301 cattaagaac gggacaatct tacaactggc cgtctccccg tcccgggctg cacgccagct
      361 gatggaaagg acccagtcat ctagtatgga gacccggctg gatgccatga aggagttggc
      421 taagctctca gctgacgtga ctttcgccac ggagttcatt aacatggacg gcatcattgt
      481 gctgacgagg ctcgtggaga gtgggaccaa gctcctgtcc cactacagtg agatgctggc
      541 attcaccctg actgccttct tagagctcat ggatcatggc attgtctcct gggacatggt
      601 ttcagtcacc tttattaagc agattgcagg gtacgtgagc cagcccatgg tcgatgtgtc
      661 catcctccag cggtccctgg ccatcctaga gagcatggta ctaaacagcc agagcctgta
      721 ccagaagata gcggaggaga tcaccgtggg acagctcatc tcccacctgc aggtctccaa
      781 ccaggagatc cagacctacg ccattgctct gattaacgcg ctgttcctga aggcccccga
      841 agacaagaga caggacatgg ccaatgcctt tgcacagaag caccttcggt ccataatcct
      901 gaaccatgtg atcagaggga atcgtccaat caaaacagag atggcccatc agctgtatgt
      961 ccttcaggtc ttgaccttta accttctgga agaaagaatg atgaccaaga tggatcccaa
     1021 tgaccaggct cagagagaca ttatatttga actgaggagg attgccttcg acgcagagtc
     1081 tgaccccagc aacgtccccg ggagtgggac tgaaaagcgc aaggccatgt ataccaagga
     1141 ctataaaatg ctgggcttca ccaaccatat caacccagcc ttggacttca cccagactcc
     1201 tcctggaatg ctggcgctgg acaacatgct gtacctggct aaagtccacc aggacaccta
     1261 catccggatc gtgctggaga acagcagtcg ggaggacaaa cacgagtgtc cgttcggccg
     1321 cagtgccatc gagctcacca agatgctctg tgagatcctg caggtcgggg agctccctaa
     1381 tgaagggcgc aatgactacc accccatgtt cttcacccac gaccgagcct tcgaggaact
     1441 cttcgggatc tgcatccagc tgctgaacaa gacctggaag gagatgaggg cgacagccga
     1501 ggatttcaac aaggttatgc aagttgtccg agagcagatc acccgggctc tgccctctaa
     1561 acccaactct ttggatcagt tcaagagtaa acttcgtagc ctgagctact cagaaattct
     1621 gcggttgcgc cagtctgaga ggatgagcca ggatgatttc cagtccccac caattgtgga
     1681 gcttcgagag aagatacagc ctgagatcct ggagctgatc aagcaacagc gcctcaaccg
     1741 gctatgcgag ggcagcagct tccggaaaat cgggaaccgt cgtcggcaag agaggttctg
     1801 gcactgccgc ttggcactga accacaaggt tttgcattac ggtgacttgg atgacaaccc
     1861 tcaaggggag gtgacattcg aatccctgca ggagaaaatt cctgttgcag atattaaggc
     1921 cattgttact ggaaaagact gtcctcacat gaaagagaag agtgccctga aacagaacaa
     1981 ggaggtgttg gaattggcct tctccatcct gtatgatcct gatgagacac tgaatttcat
     2041 tgctcccaac aagtatgagt actgcatctg gattgatgga ctcagcgctc tcctggggaa
     2101 ggatatgtcc agcgagctaa ccaagagcga cttggacacg ctgctgagca tggagatgaa
     2161 gctgcggctt ctggacttgg agaacattca gatccccgag gcgccacctc cggtccccaa
     2221 ggagcccagc agctatgact tcgtctatca ctatggctga gcgggaaggg actggggccc
     2281 aggagagaca ctggcagccc acgccacttg tacaaactct gtagtgattg tggtaactac
     2341 tcctcagagc cagtgggacc cagagcttct ctctgtccca tccaccagga gtcatgaagt
     2401 cagggcatgc tgccctcctc agcaccacag agcctgggtc gggcttggag gggtgaactc
     2461 atgaggctcc tgcctcccgc tctgcgtcac atctgcatct ggtactggac ctactgacag
     2521 ccatcccctt tcctttcaag tctcctctct ggtttgttgg agagcccatg tgggccaaag
     2581 ctggtccatg aaaggctgac catgggggca agaggcctgg ggagctcggt gagagcctcg
     2641 gagtgactgt cttcaggtgg ctcaggcaag aacaggcctt gagctcctgc ttaataggtc
     2701 tctgagggct catcccagcc tcgtcctgtg cctcatgctg ctgcctctgg ggtttggccc
     2761 taccatgtct agtctctaga gacacccgtc tctcttgtcc ttgcaggtat caggacaggt
     2821 agtaattttg ccccaagccc tcagcctcat cctggccagg cagaggcctc cagcctgagt
     2881 cctgctctct taggctttag gaatgaacac tgcagggaaa ggcaggctga ggcctctggc
     2941 tccccctacc cctccagtcc tctctcttcc ttgctgaggc acaatattcc catgccccct
     3001 cagttacagg cccctccgtt tgcttccctc ctgcctcaga caggggtgtt gccttccctt
     3061 tctccccttc ctggcgctgt ggtttgtgcc attagccatg atttcacagc ggctggggcc
     3121 acagctgtgc cacggccttc attggtgctg cagcactgga agcccacgcg cacagcctct
     3181 ttccttggac gcatgttacc atggtggtat tcagtactgg tagcctggca tggtgggtac
     3241 tacccagtga agagtgtact atatattttc tttactatag gccatactta tacagacatg
     3301 tatatatatt tatataagat cttcctatct taggatagaa tgtttaaggg aaaataaaat
     3361 caagaacaaa actgtagtgc tctcagtcat gagctgtgag tgtaaccaga gagcagccag
     3421 gagcttcctg tcagtgatgt gttttcaata aatactcttt catgtagact gcttcctatc
     3481 cacacctctt cctctgcact tattccctgt cccaagggtg aggagcggcc tgacagcctt
     3541 catttcagtg tgcctgggag catgtggaga gctcccagcc actctgagag catctccctc
     3601 tcccctcatc tctcctgctc ttgtcatgcg caaactactc acacctgctg gctaaggatg
     3661 ctcacagctt gtgctacagg acagagcgtt ttctgctcag tcgtgctggg tacaacgtgg
     3721 aaaggcatac tgtacacccc caagaaccca tcctcccttt ttcccctgcc agggacacag
     3781 ccagggaaca gctcgagtac ttgtgccttt caaagaagac atgttccgca ccccgcatgt
     3841 tgcctgcagt tagtgcccag cttgccagct ggtgctttaa gctggtgctc ccatcagcag
     3901 ccttggtagc tgggaggttt gaatgaaggc agtgatgaaa atagatactt ccccttgcct
     3961 cagtcagaag ggggtgagga caggcgcttt cagaaggcat agaaagtgca tgcaacgcag
     4021 gctttgaggg ctgaacgaag ccaagacctt gggctgcgat gggcaccatt gtaggtctca
     4081 ggaagcattg aatcaacgaa tgctttcgtg atgccagctg gcaacagcct acagcagcag
     4141 tgtgcacaaa gcacagctta cacgctggcc ttgagccttc tgctaggagc caggagccca
     4201 gccaagtcat gtgcaaggat tcctgtttgc agccagtcct agtagagccc ggatgagcag
     4261 acgccgagaa ctgggccagc tcgggtctgc agccctagct tgcatggctt agaggttatc
     4321 ttgcccacat actctgtacc tgaaatgagt caaatccagg tgtgctaaat tggtgttctg
     4381 cggccactgt aacctgcttc cctgggctcc cggtaagact agatccttct tacccccttc
     4441 cttttgggtt ccatttcctc tgcgatgaac ttcacgtact cagcctattg aataattctc
     4501 acaaatttat aggcatacgc aatgtcacaa agtgtccatt atcactttgc caggacgttt
     4561 tactaataaa atttaatggt tgtcatgtca aaaaaaaaaa
//
