LOCUS       NP_525026                720 aa            linear   ROD 01-JUN-2024
DEFINITION  engulfment and cell motility protein 2 isoform 3 [Mus musculus].
ACCESSION   NP_525026
VERSION     NP_525026.2
DBSOURCE    REFSEQ: accession NM_080287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 720)
  AUTHORS   Tang,Y.C., Ponsin,K., Graham-Paquin,A.L., Luthold,C., Homsy,K.,
            Schindler,M., Tran,V., Cote,J.F., Bordeleau,F., Khadra,A. and
            Bouchard,M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   2  (residues 1 to 720)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 720)
  AUTHORS   Sato,Y., Sato,A., Mizuno,S., Hirota,J.N., Fujima,S., Ishii,C.,
            Sano,Y. and Furuichi,T.
  TITLE     Comparative gene expression analysis of the engulfment and cell
            motility (ELMO) protein family in the mouse brain
  JOURNAL   Gene Expr Patterns 34, 119070 (2019)
   PUBMED   31521773
REFERENCE   4  (residues 1 to 720)
  AUTHORS   Weng,Z., Situ,C., Lin,L., Wu,Z., Zhu,J. and Zhang,R.
  TITLE     Structure of BAI1/ELMO2 complex reveals an action mechanism of
            adhesion GPCRs via ELMO family scaffolds
  JOURNAL   Nat Commun 10 (1), 51 (2019)
   PUBMED   30604775
  REMARK    GeneRIF: Study demonstrated that an evolutionarily conserved
            fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is
            specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of
            the ELMO family scaffolds. The crystal structures of ELMO2-RAE and
            its complex with BAI1 uncover the molecular basis of BAI/ELMO
            interactions.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 720)
  AUTHORS   Ho,E., Ivanova,I.A. and Dagnino,L.
  TITLE     Integrin-linked kinase and ELMO2 modulate recycling endosomes in
            keratinocytes
  JOURNAL   Biochim Biophys Acta 1863 (12), 2892-2904 (2016)
   PUBMED   27627840
  REMARK    GeneRIF: Ilk and ELMO2 modulate recycling endosomes in
            keratinocytes undergoing intercellular adhesion mediated through
            cell-cell contacts, including E-cadherin-based adherens junctions.
REFERENCE   6  (residues 1 to 720)
  AUTHORS   Sun,Y., Ren,W., Cote,J.F., Hinds,P.W., Hu,X. and Du,K.
  TITLE     ClipR-59 interacts with Elmo2 and modulates myoblast fusion
  JOURNAL   J Biol Chem 290 (10), 6130-6140 (2015)
   PUBMED   25572395
  REMARK    GeneRIF: Collectively, our studies demonstrate that formation of an
            Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
REFERENCE   7  (residues 1 to 720)
  AUTHORS   Ho,E., Irvine,T., Vilk,G.J., Lajoie,G., Ravichandran,K.S.,
            D'Souza,S.J. and Dagnino,L.
  TITLE     Integrin-linked kinase interactions with ELMO2 modulate cell
            polarity
  JOURNAL   Mol Biol Cell 20 (13), 3033-3043 (2009)
   PUBMED   19439446
  REMARK    GeneRIF: Resutls show that the interaction with ELMO2 and RhoG is
            essential for the ability of ILK to induce front-rear cell
            polarity.
REFERENCE   8  (residues 1 to 720)
  AUTHORS   Katoh,H., Fujimoto,S., Ishida,C., Ishikawa,Y. and Negishi,M.
  TITLE     Differential distribution of ELMO1 and ELMO2 mRNAs in the
            developing mouse brain
  JOURNAL   Brain Res 1073-1074, 103-108 (2006)
   PUBMED   16443196
REFERENCE   9  (residues 1 to 720)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   10 (residues 1 to 720)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045428.1, BC033418.1, AK035710.1 and AI666775.1.
            
            On Apr 29, 2004 this sequence version replaced NP_525026.1.
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            coding region compared to variant 2. It encodes isoform 3, which is
            shorter than isoform 2. Variants 3 and 4 encode the same isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129023.1, SRR1660815.167618.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.53 cM"
     Protein         1..720
                     /product="engulfment and cell motility protein 2 isoform
                     3"
                     /note="engulfment and cell motility protein 2; CED-12
                     homolog A"
                     /calculated_mol_wt=82412
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660,
                     ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (Q8BHL5.1)"
     Region          115..272
                     /region_name="ELMO_ARM"
                     /note="ELMO, armadillo-like helical domain; pfam11841"
                     /db_xref="CDD:463369"
     Region          295..474
                     /region_name="ELMO_CED12"
                     /note="ELMO/CED-12 family; pfam04727"
                     /db_xref="CDD:461411"
     Site            503
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JJ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHL5.1)"
     Region          539..668
                     /region_name="PH_ELMO1_CED-12"
                     /note="Engulfment and cell motility protein 1 pleckstrin
                     homology (PH) domain; cd13359"
                     /db_xref="CDD:270166"
     Region          700..707
                     /region_name="SH3-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHL5.1)"
     Site            717
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (Q8BHL5.1)"
     CDS             1..720
                     /gene="Elmo2"
                     /gene_synonym="1190002F24Rik; CED-12"
                     /coded_by="NM_080287.2:98..2260"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS17075.1"
                     /db_xref="GeneID:140579"
                     /db_xref="MGI:MGI:2153045"
ORIGIN      
        1 mpppsdivkv aiewpganaq lleidqkrpl asiikevcdg wslpnpeyyt lryadgpqly
       61 vteqtrndik ngtilqlavs psraarqlme rtqsssmetr ldamkelakl sadvtfatef
      121 inmdgiivlt rlvesgtkll shysemlaft ltaflelmdh givswdmvsv tfikqiagyv
      181 sqpmvdvsil qrslailesm vlnsqslyqk iaeeitvgql ishlqvsnqe iqtyaialin
      241 alflkapedk rqdmanafaq khlrsiilnh virgnrpikt emahqlyvlq vltfnlleer
      301 mmtkmdpndq aqrdiifelr riafdaesdp snvpgsgtek rkamytkdyk mlgftnhinp
      361 aldftqtppg mlaldnmlyl akvhqdtyir ivlenssred khecpfgrsa ieltkmlcei
      421 lqvgelpneg rndyhpmfft hdrafeelfg iciqllnktw kemrataedf nkvmqvvreq
      481 itralpskpn sldqfksklr slsyseilrl rqsermsqdd fqsppivelr ekiqpeilel
      541 ikqqrlnrlc egssfrkign rrrqerfwhc rlalnhkvlh ygdlddnpqg evtfeslqek
      601 ipvadikaiv tgkdcphmke ksalkqnkev lelafsilyd pdetlnfiap nkyeyciwid
      661 glsallgkdm sseltksdld tllsmemklr lldleniqip eapppvpkep ssydfvyhyg
//
