LOCUS       NP_525027                727 aa            linear   ROD 27-APR-2025
DEFINITION  engulfment and cell motility protein 1 isoform 3 [Mus musculus].
ACCESSION   NP_525027
VERSION     NP_525027.1
DBSOURCE    REFSEQ: accession NM_080288.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 727)
  AUTHORS   Li,C., Zhang,M., Du,Y., Liu,S., Li,D., Zhang,S., Ji,F., Zhang,J.
            and Jiao,J.
  TITLE     Compromised cell competition exhausts neural stem cells pool
  JOURNAL   Cell Prolif 57 (12), e13710 (2024)
   PUBMED   39010274
REFERENCE   2  (residues 1 to 727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 727)
  AUTHORS   Sharma,A., Achi,S.C., Ibeawuchi,S.R., Anandachar,M.S.,
            Gementera,H., Chaudhury,U., Usmani,F., Vega,K., Sayed,I.M. and
            Das,S.
  TITLE     The crosstalk between microbial sensors ELMO1 and NOD2 shape
            intestinal immune responses
  JOURNAL   Virulence 14 (1), 2171690 (2023)
   PUBMED   36694274
  REMARK    GeneRIF: The crosstalk between microbial sensors ELMO1 and NOD2
            shape intestinal immune responses.
REFERENCE   4  (residues 1 to 727)
  AUTHORS   Yu,S., Geng,X., Liu,H., Zhang,Y., Cao,X., Li,B. and Yan,J.
  TITLE     ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine
            Peritonitis
  JOURNAL   Int J Mol Sci 24 (9), 8103 (2023)
   PUBMED   37175809
  REMARK    GeneRIF: ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine
            Peritonitis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 727)
  AUTHORS   Tran,V., Nahle,S., Robert,A., Desanlis,I., Killoran,R.,
            Ehresmann,S., Thibault,M.P., Barford,D., Ravichandran,K.S.,
            Sauvageau,M., Smith,M.J., Kmita,M. and Cote,J.F.
  TITLE     Biasing the conformation of ELMO2 reveals that myoblast fusion can
            be exploited to improve muscle regeneration
  JOURNAL   Nat Commun 13 (1), 7077 (2022)
   PUBMED   36400788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 727)
  AUTHORS   Grimsley,C.M., Lu,M., Haney,L.B., Kinchen,J.M. and
            Ravichandran,K.S.
  TITLE     Characterization of a novel interaction between ELMO1 and ERM
            proteins
  JOURNAL   J Biol Chem 281 (9), 5928-5937 (2006)
   PUBMED   16377631
REFERENCE   7  (residues 1 to 727)
  AUTHORS   Katoh,H., Fujimoto,S., Ishida,C., Ishikawa,Y. and Negishi,M.
  TITLE     Differential distribution of ELMO1 and ELMO2 mRNAs in the
            developing mouse brain
  JOURNAL   Brain Res 1073-1074, 103-108 (2006)
   PUBMED   16443196
REFERENCE   8  (residues 1 to 727)
  AUTHORS   Kakoki,M., Tsai,Y.S., Kim,H.S., Hatada,S., Ciavatta,D.J.,
            Takahashi,N., Arnold,L.W., Maeda,N. and Smithies,O.
  TITLE     Altering the expression in mice of genes by modifying their 3'
            regions
  JOURNAL   Dev Cell 6 (4), 597-606 (2004)
   PUBMED   15068798
REFERENCE   9  (residues 1 to 727)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (residues 1 to 727)
  AUTHORS   Gumienny,T.L., Brugnera,E., Tosello-Trampont,A.C., Kinchen,J.M.,
            Haney,L.B., Nishiwaki,K., Walk,S.F., Nemergut,M.E., Macara,I.G.,
            Francis,R., Schedl,T., Qin,Y., Van Aelst,L., Hengartner,M.O. and
            Ravichandran,K.S.
  TITLE     CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is
            required for phagocytosis and cell migration
  JOURNAL   Cell 107 (1), 27-41 (2001)
   PUBMED   11595183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126555.3, AC124183.4, AC165346.4, AC132085.3, AC153143.4 and
            AC124751.4.
            
            Transcript Variant: This variant (3) represents the longer
            transcript and encodes the longer isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220253.1, SRR7652917.851623.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.21 cM"
     Protein         1..727
                     /product="engulfment and cell motility protein 1 isoform
                     3"
                     /note="engulfment and cell motility protein 1; engulfment
                     and cell motility 1, ced-12 homolog"
                     /calculated_mol_wt=83805
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by HCK.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Site            100
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Site            105
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Region          115..280
                     /region_name="ELMO_ARM"
                     /note="ELMO, armadillo-like helical domain; pfam11841"
                     /db_xref="CDD:463369"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by HCK.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Region          303..481
                     /region_name="ELMO_CED12"
                     /note="ELMO/CED-12 family; pfam04727"
                     /db_xref="CDD:461411"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by HCK.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Site            511
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by HCK.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Region          546..675
                     /region_name="PH_ELMO1_CED-12"
                     /note="Engulfment and cell motility protein 1 pleckstrin
                     homology (PH) domain; cd13359"
                     /db_xref="CDD:270166"
     Region          707..714
                     /region_name="SH3-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BPU7.2)"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by HCK.
                     /evidence=ECO:0000250|UniProtKB:Q92556; propagated from
                     UniProtKB/Swiss-Prot (Q8BPU7.2)"
     CDS             1..727
                     /gene="Elmo1"
                     /gene_synonym="6330578D22Rik; C230095H21Rik; CED-12"
                     /coded_by="NM_080288.2:339..2522"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS26265.1"
                     /db_xref="GeneID:140580"
                     /db_xref="MGI:MGI:2153044"
ORIGIN      
        1 mpppsdivkv aiewpgaypk lmeidqkkpl saiikevcdg wslanheyfa lqhadssnfy
       61 iteknrneik ngtilrltts paqnaqqlhe riqsssmdak lealkdlasl srdvtfaqef
      121 inldgisllt qmvesgtery qklqkimkpc fgdmlsftlt afvelmdhgi vswdtfsvaf
      181 ikkiasfvnk saidisilqr slailesmvl nshdlyqkva qeitigqlip hlqgtdqeiq
      241 tytiavinal flkapderrq emanilaqkq lryiilthvi raqrainnem ahqlyvlqvl
      301 tfnlledrmm tkmdpqdqaq rdiifelrri afdaesepnn ssgsmekrks mytrdykklg
      361 finhvnpamd ftqtppgmla ldnmlyfakh hqdayirivl enssredkhe cpfgrssiel
      421 tkmlceilkv gelpsetcnd fhpmffthdr sfeeffcici qllnktwkem ratsedfnkv
      481 mqvvkeqvmr alttkpssld qfksklqnls yteilkirqs ermnqedfqs rpilelkeki
      541 qpeilelikq qrlnrlvegt cfrklnarrr qdkfwycrls pnhkvlhygd leespqgevp
      601 hdslqdklpv adikavvtgk dcphmkekga lkqnkevlel afsilydsnc qlnfiapdkh
      661 eyciwtdgln allgkdmmsd ltrndldtll smeiklrlld leniqipdap ppipkepsny
      721 dfvydcn
//
