LOCUS       NM_145973               1745 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus elongation factor RNA polymerase II-like 3 (Ell3),
            mRNA.
ACCESSION   NM_145973 XM_983066
VERSION     NM_145973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Meng,S., Liu,X., Zhu,S., Xie,P., Fang,H., Pan,Q., Fang,K., Li,F.,
            Zhang,J., Che,Z., Zhang,Q., Mao,G., Wang,Y., Hu,P., Chen,K.,
            Sun,F., Xie,W., Luo,Z. and Lin,C.
  TITLE     Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3
            function as enhancers to regulate naive pluripotency in embryonic
            stem cells
  JOURNAL   Nat Cell Biol 25 (9), 1319-1331 (2023)
   PUBMED   37591949
  REMARK    GeneRIF: Young LINE-1 transposon 5' UTRs marked by elongation
            factor ELL3 function as enhancers to regulate naive pluripotency in
            embryonic stem cells.
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Lin,C., Garruss,A.S., Luo,Z., Guo,F. and Shilatifard,A.
  TITLE     The RNA Pol II elongation factor Ell3 marks enhancers in ES cells
            and primes future gene activation
  JOURNAL   Cell 152 (1-2), 144-156 (2013)
   PUBMED   23273992
  REMARK    GeneRIF: Study found that Ell3, a member of the Ell
            (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II
            elongation factors, occupies enhancers in embryonic stem cells.
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Ahn,H.J., Cha,Y., Moon,S.H., Jung,J.E. and Park,K.S.
  TITLE     Ell3 enhances differentiation of mouse embryonic stem cells by
            regulating epithelial-mesenchymal transition and apoptosis
  JOURNAL   PLoS One 7 (6), e40293 (2012)
   PUBMED   22768269
  REMARK    GeneRIF: The present results suggest that Ell3 promotes the
            differentiation of mouse embryonic stem cells by activating the
            expression of epithelial-mesenchymal transition-related genes and
            by suppressing p53 expression.
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC045151.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_983066.1, NM_145973.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045151.1, SRR15390195.552776.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.39 cM"
     gene            1..1745
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /note="elongation factor RNA polymerase II-like 3"
                     /db_xref="GeneID:269344"
                     /db_xref="MGI:MGI:2673679"
     exon            1..206
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1262
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /codon_start=1
                     /product="RNA polymerase II elongation factor ELL3"
                     /protein_id="NP_666085.2"
                     /db_xref="CCDS:CCDS16644.1"
                     /db_xref="GeneID:269344"
                     /db_xref="MGI:MGI:2673679"
                     /translation="MEGTQEALSGKMRLLFTPAARTSLLMLRLNEAALRALQECQQQQ
                     VRPVIAFQGHRGYLRFPGPGWSCLFSFIVSQCGQEGTNGGLDLVYQRLGRSGPNCLHC
                     LGSLRERLTIWAAMDTIPAPLLAQEHLTEGTRESESWQDTGDEPEGHPQLAPDEVSDP
                     LASHHEQSLPGSSSEPMAQWEMRNHTYLPSREPDQSLLSPASQKRLDKKRSAPITTEE
                     PEEKRLRALPLASSPLQGLANQDSQEGEDWGQDEDEEGDEDGDSRLEQSLSAPSASES
                     PSPEEVPDYLLQYRAIHSTEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIK
                     RLQRGTPEHKVLEDKIVQEYKKFRKRYPSYREEKHRCEYLHQKLSHIKGLILEFEEKN
                     RGS"
     exon            207..242
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            243..355
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..542
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..622
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            623..698
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..891
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            892..934
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1106
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1151
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1674
                     /gene="Ell3"
                     /gene_synonym="A930015D22Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagcctag gcttgcacag cagaggtggc cctcacctgt ggtcccggtt ctgcatgtgc
       61 gcgactttgg caccatggag gggacccagg aagctctgag tgggaaaatg cggctcctct
      121 tcacccccgc tgctcggacc agcctcctga tgctaaggct caacgaggcg gcgctgcggg
      181 cattgcaaga gtgtcagcag caacaggtac ggccagtgat cgctttccaa ggccaccgag
      241 ggtacctaag gtttccaggc ccgggatggt cctgcctttt ctccttcata gtatcccagt
      301 gtggccaaga gggcactaat ggtggcttgg accttgtgta ccaacgctta ggcagatctg
      361 ggccgaactg tctccactgc ctgggctccc ttagagagcg actcactatt tgggcagcca
      421 tggatactat cccagctcca ctgttagctc aggaacacct gactgaaggt accagagagt
      481 ctgagagctg gcaggacact ggagacgaac ctgaaggcca tccccagctg gcaccagatg
      541 aggtgtctga cccactggca agccaccatg aacagtcact cccaggatcc tccagtgagc
      601 ccatggcaca atgggaaatg aggaaccaca cttatcttcc aagcagagag cctgatcagt
      661 ccctgctttc ccctgctagc cagaaacgcc tggacaagaa acgttcagca cctataacca
      721 ctgaagaacc agaggaaaag aggctcagag ctctgcctct agcctcaagt ccactacaag
      781 ggctagcaaa tcaggactca caagagggag aagactgggg ccaagatgaa gatgaagagg
      841 gagatgaaga tggagattcc aggcttgagc agagcctctc agctccatca gcctctgaat
      901 ccccaagccc tgaggaggta ccagattatc tcctgcaata cagagccatc cacagcacag
      961 agcagcaaca ggcctatgag caggactttg agaccgacta tgctgagtac cgcattctgc
     1021 atgctcgagt tggggctgca agccagaggt tcacagagct gggggcagag atcaagagac
     1081 ttcagcgagg aactccagaa cacaaggtgc tggaagacaa gatagtccag gagtataaaa
     1141 agttcagaaa gcggtatcca agttacaggg aggagaagca tcgctgtgag tacctgcatc
     1201 agaaactgtc ccacattaaa ggtctcatcc tggaatttga ggagaagaac aggggcagct
     1261 gagactgtcc agagggctcg gatcttcccc ggtgatgaac acaacagctg cttttctgat
     1321 tttgtccctt acatccacag tgaccaagta gagagccatc ctaggttctt gcagtttgat
     1381 ttttgatgtt gccataattt tttttagggt gtgggcatgg tatcatctcc tcagctgtgc
     1441 caggagacta ggaaagtagg aggtgcttgg cttcttcaac tttactttag ctaagtcatt
     1501 tctagatcct gaaaagtgac atttccaggt taaccttgag aatattagac aaataagcaa
     1561 cttgagggga gttgccttgc agggataaaa tgagaacttc tgatgacaga actcattgaa
     1621 cttatagtgt acctttatgt aacatggctg aaaaattaaa actgattgct tctgaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaa
//
