LOCUS       NM_138953               3660 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus elongation factor for RNA polymerase II 2 (Ell2),
            mRNA.
ACCESSION   NM_138953 XM_484289 XM_898358 XM_898363 XM_898369 XM_911428
            XM_922000 XM_922005 XM_922010 XM_992760 XM_992784 XM_992820
            XM_992847
VERSION     NM_138953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Nelson,A.M., Carew,N.T., Smith,S.M. and Milcarek,C.
  TITLE     RNA Splicing in the Transition from B Cells to Antibody-Secreting
            Cells: The Influences of ELL2, Small Nuclear RNA, and Endoplasmic
            Reticulum Stress
  JOURNAL   J Immunol 201 (10), 3073-3083 (2018)
   PUBMED   30297340
REFERENCE   4  (bases 1 to 3660)
  AUTHORS   Pascal,L.E., Masoodi,K.Z., Liu,J., Qiu,X., Song,Q., Wang,Y.,
            Zang,Y., Yang,T., Wang,Y., Rigatti,L.H., Chandran,U., Colli,L.M.,
            Vencio,R.Z.N., Lu,Y., Zhang,J. and Wang,Z.
  TITLE     Conditional deletion of ELL2 induces murine prostate
            intraepithelial neoplasia
  JOURNAL   J Endocrinol 235 (2), 123-136 (2017)
   PUBMED   28870994
  REMARK    GeneRIF: These results suggest that ELL2 and its pathway genes
            likely play an important role in the development and progression of
            prostate cancer.
REFERENCE   5  (bases 1 to 3660)
  AUTHORS   Sharma,S., Wang,J., Cortes Gomez,E., Taggart,R.T. and Baysal,B.E.
  TITLE     Mitochondrial complex II regulates a distinct oxygen sensing
            mechanism in monocytes
  JOURNAL   Hum Mol Genet 26 (7), 1328-1339 (2017)
   PUBMED   28204537
REFERENCE   6  (bases 1 to 3660)
  AUTHORS   Park,K.S., Bayles,I., Szlachta-McGinn,A., Paul,J., Boiko,J.,
            Santos,P., Liu,J., Wang,Z., Borghesi,L. and Milcarek,C.
  TITLE     Transcription elongation factor ELL2 drives Ig secretory-specific
            mRNA production and the unfolded protein response
  JOURNAL   J Immunol 193 (9), 4663-4674 (2014)
   PUBMED   25238757
  REMARK    GeneRIF: ELL2 is important for many aspects of Ab secretion, XBP1
            expression, and the unfolded protein response.
            GeneRIF: Deletion of the Ell2 gene in mice results in loss of Ig
            secretion from plasma cells and reduced expression of a number of
            other genes involved in secretion and the unfolded protein response
            like XBP1, OcaB (BOB1, Pou2af1), cyclin B2 and Ig light chain
REFERENCE   7  (bases 1 to 3660)
  AUTHORS   Shimizu,H., Kubo,A., Uchibe,K., Hashimoto,M., Yokoyama,S.,
            Takada,S., Mitsuoka,K. and Asahara,H.
  TITLE     The AERO system: a 3D-like approach for recording gene expression
            patterns in the whole mouse embryo
  JOURNAL   PLoS One 8 (10), e75754 (2013)
   PUBMED   24146773
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3660)
  AUTHORS   Benson,M.J., Aijo,T., Chang,X., Gagnon,J., Pape,U.J.,
            Anantharaman,V., Aravind,L., Pursiheimo,J.P., Oberdoerffer,S.,
            Liu,X.S., Lahesmaa,R., Lahdesmaki,H. and Rao,A.
  TITLE     Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and
            elongation factor, RNA polymerase II, 2 (ELL2) are regulators of
            mRNA processing in plasma cells
  JOURNAL   Proc Natl Acad Sci U S A 109 (40), 16252-16257 (2012)
   PUBMED   22991471
  REMARK    GeneRIF: The splicing factor hnRNPLL and the transcription
            elongation factor ELL2 modulate the ratio of secred versus
            membrane-encoding Ighg2b transcripts at the expense of the secreted
            isoform.
REFERENCE   9  (bases 1 to 3660)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (bases 1 to 3660)
  AUTHORS   Martincic,K., Alkan,S.A., Cheatle,A., Borghesi,L. and Milcarek,C.
  TITLE     Transcription elongation factor ELL2 directs immunoglobulin
            secretion in plasma cells by stimulating altered RNA processing
  JOURNAL   Nat Immunol 10 (10), 1102-1109 (2009)
   PUBMED   19749764
  REMARK    GeneRIF: ELL2 enhanced both polyadenylation and exon skipping with
            the gene encoding the immunoglobulin heavy-chain complex (Igh) and
            reporter constructs
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025556.12, AK145868.1 and BE133837.1.
            
            On or before Oct 19, 2006 this sequence version replaced
            XM_484289.4, XM_898358.2, XM_898363.2, XM_898369.2, XM_911428.2,
            XM_922000.2, XM_922005.2, XM_922010.2, XM_992847.1, XM_992820.1,
            XM_992784.1, XM_992760.1, NM_138953.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156164.1, AK145868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                CT025556.12        90811-90862
            53-1023             AK145868.1         2-972
            1024-1024           CT025556.12        145320-145320
            1025-3508           AK145868.1         974-3457
            3509-3660           BE133837.1         1-152               c
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.93 cM"
     gene            1..3660
                     /gene="Ell2"
                     /note="elongation factor for RNA polymerase II 2"
                     /db_xref="GeneID:192657"
                     /db_xref="MGI:MGI:2183438"
     exon            1..314
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2087
                     /gene="Ell2"
                     /note="eleven-nineteen lysine-rich leukemia gene 2;
                     elongation factor RNA polymerase II 2; ELL-related RNA
                     polymerase II, elongation factor"
                     /codon_start=1
                     /product="RNA polymerase II elongation factor ELL2"
                     /protein_id="NP_620403.2"
                     /db_xref="CCDS:CCDS36734.1"
                     /db_xref="GeneID:192657"
                     /db_xref="MGI:MGI:2183438"
                     /translation="MAAGGAAGLREEQRYGLACGRLGQDNITVLHVKLTETAIRALET
                     YQSHKNLIPFRPSIQFQGLQGLMKIPKNDPFNEVQNFNFYLSNVGRDNPQGSFDCIQQ
                     TLSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYV
                     GKRVQIRKAPQAISDTVPERKRSTPMNPANTIRKMHSGNSVSQRPYRDRVIHLLALKA
                     YKKPELLARLQKDGVNQKDKNSLGAILQQVANLNPKDLSYTLKDYVFKELQRDWPGYS
                     ETDRQTLDLVLSRKLNPSQNASTSRSESPLCSSKDAASSPQKRPLDSDFIDPLMNKKA
                     RISHLTNRVPPTLNGYLNPTSEKSCAGLLPPPAAAAIPTLSPLPSTHLPVSNPPQTVN
                     SNSNSPSTPEGLGTQDLPVDSFSQNGSIFEDQQEKYTSRTCLETLPPSSALLKCPKPM
                     EEEHPVSHKKSKKKSKKHKEKDQIKKLDIETMEEKEEDLQREETAKLSNASPNPNEGV
                     KEGCTASMEPSSALELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVAR
                     RFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIK
                     RLIGEFDQQQAESWH"
     exon            315..362
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..484
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..648
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..908
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1033
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1118
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1686
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1753
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1925
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..1970
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..3652
                     /gene="Ell2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ell2"
                     /note="hexamer: TATAAA"
     polyA_site      3512
                     /gene="Ell2"
                     /note="major polyA site"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ell2"
                     /note="hexamer: AATAAA"
     polyA_site      3652
                     /gene="Ell2"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcagct gtggaagccc gaggtctagc tgcgcgcagt atatgacagt acgtcagcag
       61 cgggatggcc gtagctgtgg cggcggctgc aggagcccga gcagccgcgg ccgcagtgga
      121 ggctggagcc cgagcggcgt ccgcggtggc accccgggga gtttaagatg gcggcggggg
      181 gggctgcggg actgcgggag gagcagcggt acgggctggc gtgcgggcgg ctggggcagg
      241 acaacatcac cgtgctgcat gtgaagctca ccgagacggc gatccgggcg ctggagactt
      301 accagagcca caagaattta attcctttta gaccttcaat tcagttccaa ggactccaag
      361 ggcttatgaa aattcccaaa aatgatccct tcaatgaagt ccagaacttt aacttctact
      421 tgtcaaacgt gggaagagat aatcctcagg gcagctttga ctgcatccag caaacactct
      481 ctagctctgg agcctcccag ctcaattgcc tgggatttat acaagataaa attacagtgt
      541 gtgcaacaaa tgattcctat cagatgacgc gagaaagaat gacccaggca gaggaggaat
      601 cccgtaatcg aagcacaaaa gttatcaaac ccggtggacc atatgtaggg aaaagagtgc
      661 aaattcgtaa agctcctcaa gccatctcgg acacagtgcc tgagaggaaa aggtcaacgc
      721 ccatgaaccc tgcaaataca attcgaaaga tgcatagtgg caacagtgtc tctcagaggc
      781 catacaggga cagggtcatc catttactgg cactaaaagc ctacaagaaa cctgagctgc
      841 ttgctcgact gcagaaagat ggtgtcaatc aaaaagacaa gaactccttg ggagcaattc
      901 tgcaacaggt ggccaatctg aatcctaagg acctctccta tactttaaag gattatgtat
      961 ttaaggagct ccagcgagac tggccaggtt acagtgagac agacagacag acattggatt
     1021 tggtgctctc tagaaaacta aatccatctc agaatgctag caccagccgg tcagagtctc
     1081 ccctgtgttc cagcaaagac gctgcctcat ctcctcagaa acgacctttg gattcagatt
     1141 tcattgatcc tttaatgaac aaaaaagctc gaatatctca cctaacaaac agagtcccac
     1201 cgacattaaa tggttatttg aatcccacca gtgaaaaatc ttgtgcaggc ctcctaccac
     1261 cccctgcagc tgctgccatc cccaccctct cgccgctgcc ttcaacccac ctgcctgtct
     1321 ccaatcctcc tcagactgta aattccaact ccaattcccc tagcactcca gaaggcctgg
     1381 ggactcaaga cctgcctgtt gacagtttta gtcaaaatgg tagcatcttt gaggaccagc
     1441 aagaaaaata tacctcaagg acttgtctgg aaacattacc ccccagctca gctctgctaa
     1501 agtgtccaaa gcccatggaa gaagagcatc cagtgtctca caaaaagtcc aaaaagaagt
     1561 ctaaaaaaca caaggaaaag gaccaaataa agaaacttga cattgagacc atggaggaga
     1621 aggaggaaga ccttcagaga gaagaaactg ccaagctgag taatgccagt ccaaatccca
     1681 atgaaggagt taaagaaggg tgcacagcct ccatggagcc ttcttcagca cttgaactcc
     1741 cagattattt gataaaatat attgctattg tctcttatga gcaacgccag aattacaagg
     1801 atgacttcaa tgctgagtat gatgaataca gagctttgca tgcaaggatg gagactgtag
     1861 ccaggagatt tattaaactg gatgcacaac gaaaacgcct ttctccgggt tcaaaagagt
     1921 accagaatgt tcatgaagaa gtcttacagg aatatcagaa gatcaagcag tccagtccca
     1981 attaccatga agaaaaatac agatgtgaat atcttcataa caagctggct cacatcaaaa
     2041 gactaatagg tgaatttgac caacagcaag cagagtcatg gcactaaagc tctgcttgga
     2101 ccagaagatg tgaataaact aaagcttatt tatttaaaat tccagatgag ttgctctaga
     2161 ttctaaaaga tgaaactttg cttgttggaa gtttcagtat tagtaaactt gagttacttt
     2221 ttttcctctc tattttactt tgctgccctg aattttgaag ctgctttttt tctggtcctc
     2281 tccccaacca cccaccccca acccccaact tgtttgttaa tagaagcaat ttttaagaga
     2341 ttggggatcc agtgtctata cttcaaatca attttccttg ataacttgtc tttgtcatta
     2401 gcgatgattt tttttttttt tagatatcgg ggatgcaaag tccatacaga tgcaaagaat
     2461 tgcgtgtgtt taaaacaaga caaaacagta atgtgcaagg tgaaaagctt ttggataaac
     2521 aaaagcctat tttctgacct ttcttaatgt aaactctttg ccttaaatgg tagaatattt
     2581 agacatttgc acaaagtaca aaaaatcaaa acattgtttt tggagggttg aaaaatagaa
     2641 agtgaatgtg tatagttttc tatacacata catacataca tacatacata catacataca
     2701 tacatacata catgcataca tacatacata catacataca tacatacata catacgggct
     2761 gtctggctct agagtgttaa atctgcccta aaagttaaac ccccattgca atggctgcct
     2821 taaggtgttt gctagttgtg tacatcatgt ggttaaccag tagctacact gcttcccagt
     2881 gataacagcc ccagcccggg aagcacactg tggcctacca gcatcagaac ctgtgtgttc
     2941 tgcttgtctg tctgcagagc tgctgtggat gtgagctgtg tgaaggttaa aaagctgcta
     3001 ctctcagtag gccggacact caggttaaag agctgacgag tgttgcagta gcttgttggt
     3061 gtgtgtttgc ttggtttttg tttgtttctg tcaaattgct acttctattg tggaagacaa
     3121 aagcatttcc atttcaacag tttgtcagct ttattaatgt tgggcaaaaa atgatatgtt
     3181 atgaaaatga aacagatctt atagttttgg ggcaaaatga caaaaataaa tgtgtaggta
     3241 acctatttat atactgctat aaagtatttt ttgaagaaag atatgcaaag aagctattac
     3301 ctacatcaga tgtatattta aatttttttt catcctggat cccaggaata taaaaagagt
     3361 agatatattt aaccataaca tactgtgact catcaaatag cacaaacttt catttcatgg
     3421 agtttatctg ttaacgttga tttaaactat cacttgtctt atcatgtggg aacataagtt
     3481 atgtggtcaa aatataaaga ttttgaacta aagttgattc aggttgtctt gtattgtctc
     3541 aaagtgctgc cagttgaaaa gggaagcatt atgtttacaa atctgttttg aaatgtttgc
     3601 caaaattttg gtagtatctt taataaagat gtttgtcttc agcatccaaa aaaaaaaaaa
//
