LOCUS       NM_007924               3065 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus elongation factor RNA polymerase II (Ell), mRNA.
ACCESSION   NM_007924
VERSION     NM_007924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Mourgues,S., Gautier,V., Lagarou,A., Bordier,C., Mourcet,A.,
            Slingerland,J., Kaddoum,L., Coin,F., Vermeulen,W., Gonzales de
            Peredo,A., Monsarrat,B., Mari,P.O. and Giglia-Mari,G.
  TITLE     ELL, a novel TFIIH partner, is involved in transcription restart
            after DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 110 (44), 17927-17932 (2013)
   PUBMED   24127601
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Cho,A., Ko,H.W. and Eggenschwiler,J.T.
  TITLE     FKBP8 cell-autonomously controls neural tube patterning through a
            Gli2- and Kif3a-dependent mechanism
  JOURNAL   Dev Biol 321 (1), 27-39 (2008)
   PUBMED   18590716
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Mitani,K., Yamagata,T., Iida,C., Oda,H., Maki,K., Ichikawa,M.,
            Asai,T., Honda,H., Kurokawa,M. and Hirai,H.
  TITLE     Nonredundant roles of the elongation factor MEN in postimplantation
            development
  JOURNAL   Biochem Biophys Res Commun 279 (2), 563-567 (2000)
   PUBMED   11118326
REFERENCE   7  (bases 1 to 3065)
  AUTHORS   Thirman,M.J., Diskin,E.B., Bin,S.S., Ip,H.S., Miller,J.M. and
            Simon,M.C.
  TITLE     Developmental analysis and subcellular localization of the murine
            homologue of ELL
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1408-1413 (1997)
   PUBMED   9037066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157774.5.
            
            On Sep 1, 2022 this sequence version replaced NM_007924.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014816.1, AK159027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC157774.5         108059-108205       c
            148-195             AC157774.5         74990-75037         c
            196-317             AC157774.5         68942-69063         c
            318-481             AC157774.5         68644-68807         c
            482-747             AC157774.5         66080-66345         c
            748-872             AC157774.5         63904-64028         c
            873-951             AC157774.5         62665-62743         c
            952-1426            AC157774.5         61872-62346         c
            1427-1487           AC157774.5         57320-57380         c
            1488-1659           AC157774.5         57035-57206         c
            1660-1704           AC157774.5         56486-56530         c
            1705-3065           AC157774.5         55042-56402         c
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3065
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /note="elongation factor RNA polymerase II"
                     /db_xref="GeneID:13716"
                     /db_xref="MGI:MGI:109377"
     exon            1..147
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1821
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /note="eleven-nineteen lysine-rich leukemia protein; RNA
                     POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN
                     LYSINE-RICH LEUKEMIA PROTEIN)"
                     /codon_start=1
                     /product="RNA polymerase II elongation factor ELL"
                     /protein_id="NP_031950.2"
                     /db_xref="CCDS:CCDS22372.1"
                     /db_xref="GeneID:13716"
                     /db_xref="MGI:MGI:109377"
                     /translation="MAALKEARSYGLSCGRVSDGSRVSVFHVKLTDSALKAFESYRAH
                     QDSVSLRPSIRFEGSQGHISIPQPDCPEEVRAFSFYLSNIGRDSPQGSFDCIQQYVSS
                     YGDVHLDCLGSIQDKVTVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYMGKKV
                     QFRKPAPGAADAVPSRKRATPINLASAIRKSSGSGASSVVQRPFRDRVLHLLALRPYR
                     KAELLLRLQKDGLTQADKDTLDSLLQQVASVNPKDGTCTLQDCMYKSLQKDWPGYSEG
                     DRQLLKRMLMRKLCQPQNATTDSSPPREHGRSASPSQKRPTDFIDPLASKKPRISHFT
                     QRAQPTLNGKLGAPNGHETLLPAPGPTPSDTLSSSHLPPRLEPPRTHDPLADVSNDLG
                     HSTQDYKHQEATPAPAPHLGLPLLTDFPQAEQPTSSSHTHSRPKKKSKKHKDKERPPE
                     ERPPAPQPDAPTAPALPPDAPGLNGACDNEPTSSSETPDYLLKYPAISSSEQRQSYKN
                     DFNAEYSEYRSLHARIEQITRRFTQLDAQLRQLSQGSDEYETTRGQILQEYRKIKKTN
                     TNYSCEKRRCEYLHRKLAHIKRLIAEYDQRQLQAWP"
     exon            148..195
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            196..317
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            318..481
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            482..747
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            748..872
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            873..951
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1426
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1487
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1659
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1704
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..3065
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /note="hexamer: AATAAA"
     polyA_site      3065
                     /gene="Ell"
                     /gene_synonym="Ell1; Men"
                     /note="major polyA site"
ORIGIN      
        1 gatggttgca agatggcggc gctgaaggag gctaggagtt acgggttgtc gtgtgggcgc
       61 gtgagcgacg gcagcagggt gtcggtgttc cacgtgaagc tcaccgacag tgctttgaag
      121 gcttttgaaa gctaccgggc ccaccaggat tctgtgtcac tgagaccttc catccgattt
      181 gaaggaagcc aagggcacat ctctataccc cagcctgact gcccagagga ggtgcgggcc
      241 ttctccttct acctctccaa tattggccgc gacagccctc agggcagctt tgattgcatc
      301 caacaatatg tatccagcta tggggatgta cacctggact gcctgggcag catccaggac
      361 aaggtcacgg tgtgtgctac tgatgactcc taccagaaag cacgacagag catggcacag
      421 gcagaggagg agactcggag ccgaagtgcc atcgtcatta aggctggagg ccgatacatg
      481 gggaaaaagg ttcagtttcg gaagccagcg ccaggggcag ctgatgcagt accctcccgg
      541 aagcgtgcta cccccattaa cctggcaagt gccatcagaa agagcagtgg gagtggagcc
      601 agcagtgtgg tacagaggcc cttccgagat cgggtgctac acctcctggc cctgaggccc
      661 tacaggaagg ctgagctgct gctgcggttg cagaaggatg ggttgacaca ggcagacaag
      721 gacaccctgg acagcctgct gcagcaggtg gccagtgtga accccaagga tggcacgtgc
      781 acgctgcagg actgcatgta caaaagcctg cagaaggact ggcccggcta ctctgagggg
      841 gaccggcagc tgctgaagcg catgctcatg cggaagctgt gtcagccaca gaatgccact
      901 acagactcca gcccgccccg agagcatgga cgctctgcct caccctctca gaaacggcct
      961 acagacttca ttgaccccct ggccagcaag aagccccgga tctcacattt cacacagcga
     1021 gcacaaccca ccctcaatgg caaactgggt gcccccaatg gccatgagac actgctgcct
     1081 gctccaggac ccaccccatc agacaccctc agctctagcc atctgccccc acggctggag
     1141 cccccaagga cccacgaccc cctagctgat gtcagtaatg acctaggtca cagtacccag
     1201 gactacaagc accaggaagc caccccagct ccagcacccc atcttggtct tcccctgctg
     1261 acggactttc ctcaggctga gcaacctact agctcctcac acacccacag ccgacccaag
     1321 aagaagtcca agaagcacaa agacaaggag cggccccctg aagaaaggcc ccccgcccca
     1381 cagcctgatg cacctactgc ccctgcacta ccgccagatg ccccaggtct gaatggagcc
     1441 tgtgacaatg aacccacatc ctcgtcagag accccggact atttgctgaa atacccagcc
     1501 atctcgtcgt cagagcagcg tcagagctac aagaatgact tcaatgctga gtacagcgag
     1561 taccgcagtc tgcacgcgcg gatcgagcag atcacccgca ggttcaccca gcttgacgca
     1621 cagctcagac agctgagcca gggctctgat gagtacgaga caacccgtgg gcaaattctt
     1681 caggaataca ggaaaatcaa aaagaccaac accaactaca gctgtgagaa gcgacgctgc
     1741 gaatacctgc accgcaagct ggcgcacatt aagaggctca tcgcagagta tgaccagcgg
     1801 cagcttcagg cctggcccta gcacagacag gcagacctga cggctccgcc tgcctttcct
     1861 agttttatat gaactcggcc ctttagctgc cgcagagaca tctatttttg taccttttct
     1921 actccgtgcc tcctccaagg cccacgcctc caagtgttag aagccccagg gagagtgagc
     1981 agcgagtgcc aggccctgct gccttcagat ccccagcgga caaggttgct gcagtttgct
     2041 ggctgtgccc aaagctctta gcagcggcct ccgcagcatg tgctcctcag tccccaacac
     2101 actgcccttc atgtcacact gtggctgtgt ggttctgtct gtccctccat ccatttgtgg
     2161 gtcctgggat cacctccctg ctgggtccca cttggggggt gctgagggtg gcaccttgct
     2221 tgccttctcc agggcgcagg cctgaggccc ccaattgctg ctttctcact gtgcctcgtc
     2281 tcatacccca aatccaaatc caaggggcca tcagtgtgca tgtgtctgtg tgcgtgtaca
     2341 tgtagtatga gtgggtctcc acacattcag agggaagcca ttggggaggt ggtgggggcc
     2401 actgctgtag ggcagggaaa gaatgtcaaa gacagatgtc tattttttta aatggtgaag
     2461 atgtctttgg gtggcttcca aagagcctgg ctgcctggag gcacctgcct ggcacagtcc
     2521 cccaccccca gtcagctctt agctttcttt tgggattcct agagtcccca gaccctagag
     2581 gaaccaagct ttcaatagat gttggtttct tctccggggc aggaccaggc tctgcatggt
     2641 gcacttctct cacagctaca ctgcgcaggc tcagggtaga tcccaggtta cccctctcct
     2701 gccctgagaa ctccatccag ggctattgat tgaactgatg gtatgtttga gttgtttcat
     2761 tgtctgagat tttgttgtct gtctgagatt tgggaaaggc agggccacac tctggggctg
     2821 caggtggtgg ctggcagctt aagcatggtc taacttattg gtgttctccc cgcctttgaa
     2881 ctgtgctgtg gagaaagtct actttgagcc atggagttgg tgtttacaaa gtcttcactt
     2941 ttgccaaaac gttacaattg acagagaggc ggtgcctcca ggtcctttct tagagtttgt
     3001 cttctgtaca caaagcaggt gaaccgccaa ctttcaaagt ctataataaa tttgatggaa
     3061 tttaa
//
