LOCUS       NM_007923               4420 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ELK4, member of ETS oncogene family (Elk4), transcript
            variant 1, mRNA.
ACCESSION   NM_007923 XR_106090 XR_107236
VERSION     NM_007923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4420)
  AUTHORS   Yang,H., Yuan,Y., Yang,K., Wang,N. and Li,X.
  TITLE     ELK4 ameliorates cognitive impairment and neuroinflammation induced
            by obstructive sleep apnea
  JOURNAL   Brain Res Bull 216, 111054 (2024)
   PUBMED   39173777
  REMARK    GeneRIF: ELK4 ameliorates cognitive impairment and
            neuroinflammation induced by obstructive sleep apnea.
REFERENCE   2  (bases 1 to 4420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4420)
  AUTHORS   Blair,L., Pattison,M.J., Chakravarty,P., Papoutsopoulou,S.,
            Bakiri,L., Wagner,E.F., Smale,S. and Ley,S.C.
  TITLE     TPL-2 Inhibits IFN-beta Expression via an ERK1/2-TCF-FOS Axis in
            TLR4-Stimulated Macrophages
  JOURNAL   J Immunol 208 (4), 941-954 (2022)
   PUBMED   35082159
REFERENCE   4  (bases 1 to 4420)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4420)
  AUTHORS   AlOgayil,N., Bauermeister,K., Galvez,J.H., Venkatesh,V.S.,
            Zhuang,Q.K., Chang,M.L., Davey,R.A., Zajac,J.D., Ida,K., Kamiya,A.,
            Taketo,T., Bourque,G. and Naumova,A.K.
  TITLE     Distinct roles of androgen receptor, estrogen receptor alpha, and
            BCL6 in the establishment of sex-biased DNA methylation in mouse
            liver
  JOURNAL   Sci Rep 11 (1), 13766 (2021)
   PUBMED   34215813
  REMARK    Erratum:[Sci Rep. 2021 Nov 22;11(1):22975. doi:
            10.1038/s41598-021-02512-8. PMID: 34811454]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4420)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 4420)
  AUTHORS   Li,J., Shiroyanagi,Y., Lin,G., Haqq,C., Lin,C.S., Lue,T.F.,
            Willingham,E. and Baskin,L.S.
  TITLE     Serum response factor, its cofactors, and epithelial-mesenchymal
            signaling in urinary bladder smooth muscle formation
  JOURNAL   Differentiation 74 (1), 30-39 (2006)
   PUBMED   16466398
REFERENCE   8  (bases 1 to 4420)
  AUTHORS   Costello,P.S., Nicolas,R.H., Watanabe,Y., Rosewell,I. and
            Treisman,R.
  TITLE     Ternary complex factor SAP-1 is required for Erk-mediated thymocyte
            positive selection
  JOURNAL   Nat Immunol 5 (3), 289-298 (2004)
   PUBMED   14770179
  REMARK    GeneRIF: SAP-1 is required for Erk-mediated transcriptional events
            in thymocyte development.
REFERENCE   9  (bases 1 to 4420)
  AUTHORS   Giovane,A., Sobieszczuk,P., Mignon,C., Mattei,M.G. and Wasylyk,B.
  TITLE     Locations of the ets subfamily members net, elk1, and sap1 (ELK3,
            ELK1, and ELK4) on three homologous regions of the mouse and human
            genomes
  JOURNAL   Genomics 29 (3), 769-772 (1995)
   PUBMED   8575773
REFERENCE   10 (bases 1 to 4420)
  AUTHORS   Giovane,A., Pintzas,A., Maira,S.M., Sobieszczuk,P. and Wasylyk,B.
  TITLE     Net, a new ets transcription factor that is activated by Ras
  JOURNAL   Genes Dev 8 (13), 1502-1513 (1994)
   PUBMED   7958835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107837.11.
            
            On Dec 5, 2019 this sequence version replaced NM_007923.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156537.1, BC144844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC107837.11        95880-96200
            322-537             AC107837.11        102643-102858
            538-1407            AC107837.11        105853-106722
            1408-1524           AC107837.11        107610-107726
            1525-4420           AC107837.11        111813-114708
FEATURES             Location/Qualifiers
     source          1..4420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..4420
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /note="ELK4, member of ETS oncogene family"
                     /db_xref="GeneID:13714"
                     /db_xref="MGI:MGI:102853"
     exon            1..321
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..537
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..1407
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1524
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..4420
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4397..4402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /note="hexamer: ATTAAA"
     polyA_site      4420
                     /gene="Elk4"
                     /gene_synonym="2310011G17Rik; A130026I01Rik; SAP-1; Sap1"
                     /note="major polyA site"
ORIGIN      
        1 gagagtggcg gaggccgcgg aacgacggga gacggcggcc gtagtgaaga acgtcgagcg
       61 cacgcacggc gagtggcagc ttaactatag ccacttcgcc gtcccggccg cgtgtgcgag
      121 ggcggggctc gagacctgcg gcagcgggag atgcgggcgg ctgcgggcac gcggctggct
      181 cggctcggcc gccgctttct cgggccccgg cgcgggggtc gccactgttc gccgcgcggt
      241 ctttgaggtc cgagtgtgag gagcggtggg cgacagagtc tcgcaccgcg ttcaaggccg
      301 aggagtcccg tgccctgcct gcccattgct atggacagtg ccatcactct gtggcagttc
      361 cttctccagc tcctgcagga gcctcagaat gagcacatga tctgctggac atctaacaat
      421 ggggagttca agcttctgca ggcggaggag gtggctcgtc tttgggggat tcgcaagaac
      481 aagcctaata tgaattatga taaactcagc cgagccctgc gatactacta cgtaaagaac
      541 atcattaaaa aagtgaatgg tcagaagttt gtgtacaagt ttgtctccta tccagagatt
      601 ttgaaaatgg acccactgac ggtaggcagg attgagggag actgtgaagc tttaaattcc
      661 attgaaacca gcagttccaa agatgttgag tatggaggaa aggagaggcc acctcagcct
      721 ggagccaaga cctctagtcg caatgactac atacactctg gtttgtattc ttcatttact
      781 cttaactctc tgaacacctc caataagaag cttttcaagt caataaagat agagaatcca
      841 gcggaaaaac tagcagagaa gaaagcccag gagccaacac cgtccgtcat caaatttgtg
      901 acaacgcctg ccaaaaagcc gcccatcgag cctgtcgctg ctgcctttgc aacgagccct
      961 agtctttctc catcttctga agaaactatc caagctttgg agacattagt ctctcccaca
     1021 ctaccttccc tggaaacccc agcctccata tccattctgg ctaccacctt taaccccact
     1081 cctccggttc catccacacc ccttcctcta aaggagcctc ccaggacacc ttctccacca
     1141 ctgagttcta acccagacat tgacacagac attgagtcag tggcttctca gccaatggaa
     1201 cttccagaga acttatcact ggagcctaaa aatgaggatt cagctttgcc agaaaaggac
     1261 aaaacaaata actcatcaag atctaagaag cccaaagggt tagaactgac acccgccctt
     1321 gtggtcacag gcagtgaccc cagccccttg gggatcctaa gcccatctct cccgacagcg
     1381 tctcttacac cagcactctt ttcacagact cccatcttgc tgactccgag ccccttgctc
     1441 tccagcatcc acttttggag cactctcagc ccgtttgctc ccttgagccc agccagactg
     1501 caaggtgcta atacgctttt ccagtttccc tctgtactca acagtcatgg cccgttcact
     1561 ctgtcaggcc tggacggacc ttccactccg ggcccatttt ctccagacct gcagaagaca
     1621 taaccagtgc agttgtggac tgagagacca agggactagg aaacagacac ccgccatgac
     1681 tcggttcgaa atgagggctc gtctgcagtg ctcgtgattt tcccactgcc tgtcgccagg
     1741 ccttgaggac tctgtacaga aaatgcctta attggagtcc aagctccacc tcacttcttt
     1801 ttttaaaaag gtgttttttt gttgttgttt ttgctttttt tttttttttt ttttagcttt
     1861 gtgcaaaaaa cattggtcta ttggggttca gcagctgtgt ttctcaagag agtcacagaa
     1921 caaagtcact ggccttggat gttaggaccc tttggccagg gggagaaagt atgcttagaa
     1981 tctgttactt aaatacttgt tagctatgta tgatggccca cttctgtgat ctcagcactt
     2041 gggaagctga ggtgggagga gaacgccaag gatggagggc cagcctgggc tatatatata
     2101 tagtgagact gtctcagaaa gacacaaata ctacttaaat gaagctagga gtatatttag
     2161 tagcgagtac tctctgttga gtgtctgaag agagtggctc atcaggagtg ggagaaacct
     2221 taggcggatt gaccatgctg gggctctggt gtgccctgag ctctgacatg acagttccac
     2281 agaaaggcat cttgtttgca cttacccgag cacatctctg tgccatccat acctatgatc
     2341 atgtctaaac ctgtcactag gccctgagct attttaacac aagattttga aagctcagtt
     2401 ttaatgtggg ttttggaaca ttctgtgagg ataggagatc ccactgtgag cacagatctc
     2461 tggtgtgtgc tttgagtggt gtggttctgt aaccatgcaa cacaacatgc aaatggtgat
     2521 ttgtcggaga gtagagttgt agtttgaaag ttaaaaacag gcaaccaaaa aggttcagtt
     2581 aaatacccag agataggagg tgggatattt cccagctaga aggcccccag agtgacaggc
     2641 cccctttctt gtcaatttta tccacttctg ctatgcactt aacatgatga tcccttttaa
     2701 atctaaggtc agaggatgaa gcagcgttta ggtgtaatca ggaaggcgaa ctccaaagtg
     2761 aaacttgcag ttagctggag atgcaggcat gcttatttct tttcacaagt gttttacctt
     2821 atggaagatc agattgcatc tgaccattct catacatagg aatttgatta ctaagttagt
     2881 aatgagaagt aggggccttt cacctgcata ttataaaata ctgtgtggta agacagagcc
     2941 agatgtgtac attgatcttg aattgatgct aatttcacag tggaatcttg aaaattttga
     3001 ctctaaagtc cagaattaaa ttacatgttc ttccccctgc ccactaaacc ctagccgtga
     3061 cctgagtggc acgaaggagg ggcttgtggg ctcagaatga cactgatatc cggtggcatc
     3121 ttttcagctg catagcgttg gctgtccagt gcagagacta gaagtatgct ggctggggag
     3181 gggagggcca cggtgccttt tagaggggtg gctggagacc tgttactggt tcatttatgg
     3241 ctatcttaag agctctgttc ccaggatgtg caatagtagt gtgagaagta gtgttcagag
     3301 tggtgggaac aggtactgta atgggcttgc ttctcatggt gcagtattta gtttgcatgc
     3361 atatttggaa tttccctcag cagcactttg tagtaattta gtgggttaat attgtgtaaa
     3421 ctaagtaagt attgatagac gacctaacta gatatttgaa attctgaaaa cataaaacta
     3481 tttttatctt cttgagttaa aggagaaaag ccattggtgt gtttttacag atgaactatt
     3541 tggtaattta ctgtcttagc acagagctgc cttgggtccg agggtaccat ttaaactcag
     3601 gctgggtgtg gtagcacagg cctgtaatcc caccacgtgg gaaatggaag ctggaggatc
     3661 aagagtctga actagcctca gctacatagt aagttcgaga ctagcttaga ctacaagaga
     3721 ccctgtctca aaaaaacaag caaaaacctc acaactttgt aagaaaccat gaggccttgt
     3781 ggggttggat agaccttcct tggaatgaat ttgtggaagc acgtgcttgg tctgtggacg
     3841 cgcatgcgtg tggcctttat tttttttaag ttggtatata accttgctgt gtgtgtgagg
     3901 cagacatttc tatctataga ctacctcctt cctagaaaag tctgagcttt gtgttggttt
     3961 gaatagccat agagttctta gcatcaacag atactcaggg agagacgctg tcccttcagc
     4021 tcatccctgg tgtgcatcac cagtcacctt gctaggacaa gcagtgttgg gcatcagtag
     4081 cctgaggcaa gggaggagca gcctgtcaga gtttgagacc ccttctgagg cattgtagtt
     4141 ctaattctgc tccggaccat ctccgcttag ctcagtgact gaaggtttag agttgggggt
     4201 ctcagggtgg tcctgtgaag gcctgggttg gagggtctgc cagttccctt gggtgcccat
     4261 tggtcccctg tggtgggtct ggaggctgtg caccgtggct cagagcagtg ccacacaccc
     4321 ctgtatctgc atccctaggg ggaagggggt cacttaaact gtacttttac tcgtgacgat
     4381 gtttttaaaa tacaaaatta aaatgtcaag tttaacttaa
//
