LOCUS       NM_013508               4234 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ELK3, member of ETS oncogene family (Elk3), transcript
            variant 1, mRNA.
ACCESSION   NM_013508
VERSION     NM_013508.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Liu,Q., Yang,Y., Wu,M., Wang,M., Yang,P., Zheng,J., Du,Z., Pang,Y.,
            Bao,L., Niu,Y. and Zhang,R.
  TITLE     Hub gene ELK3-mediated reprogramming lipid metabolism regulates
            phenotypic switching of pulmonary artery smooth muscle cells to
            develop pulmonary arterial hypertension induced by PM2.5
  JOURNAL   J Hazard Mater 465, 133190 (2024)
   PUBMED   38071773
  REMARK    GeneRIF: Hub gene ELK3-mediated reprogramming lipid metabolism
            regulates phenotypic switching of pulmonary artery smooth muscle
            cells to develop pulmonary arterial hypertension induced by PM2.5.
REFERENCE   2  (bases 1 to 4234)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4234)
  AUTHORS   Li,T.Z., Bai,C.Y., Wu,B., Zhang,C.Y., Wang,W.T., Shi,T.W. and
            Zhou,J.
  CONSRTM   SIRIGULENG
  TITLE     The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis
            in alcoholic liver disease
  JOURNAL   Commun Biol 6 (1), 682 (2023)
   PUBMED   37400491
  REMARK    GeneRIF: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and
            fibrosis in alcoholic liver disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4234)
  AUTHORS   Liu,N., He,J., Fan,D., Gu,Y., Wang,J., Li,H., Zhu,X., Du,Y.,
            Tian,Y., Liu,B. and Fan,Z.
  TITLE     Circular RNA circTmem241 drives group III innate lymphoid cell
            differentiation via initiation of Elk3 transcription
  JOURNAL   Nat Commun 13 (1), 4711 (2022)
   PUBMED   35953472
  REMARK    GeneRIF: Circular RNA circTmem241 drives group III innate lymphoid
            cell differentiation via initiation of Elk3 transcription.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4234)
  AUTHORS   Kerr,N., Pintzas,A., Holmes,F., Hobson,S.A., Pope,R., Wallace,M.,
            Wasylyk,C., Wasylyk,B. and Wynick,D.
  TITLE     The expression of ELK transcription factors in adult DRG: Novel
            isoforms, antisense transcripts and upregulation by nerve damage
  JOURNAL   Mol Cell Neurosci 44 (2), 165-177 (2010)
   PUBMED   20304071
REFERENCE   6  (bases 1 to 4234)
  AUTHORS   Giovane,A., Sobieszczuk,P., Ayadi,A., Maira,S.M. and Wasylyk,B.
  TITLE     Net-b, a Ras-insensitive factor that forms ternary complexes with
            serum response factor on the serum response element of the fos
            promoter
  JOURNAL   Mol Cell Biol 17 (10), 5667-5678 (1997)
   PUBMED   9315625
REFERENCE   7  (bases 1 to 4234)
  AUTHORS   Nozaki,M., Onishi,Y., Kanno,N., Ono,Y. and Fujimura,Y.
  TITLE     Molecular cloning of Elk-3, a new member of the Ets family
            expressed during mouse embryogenesis and analysis of its
            transcriptional repression activity
  JOURNAL   DNA Cell Biol 15 (10), 855-862 (1996)
   PUBMED   8892757
REFERENCE   8  (bases 1 to 4234)
  AUTHORS   Tamai,Y., Taketo,M., Nozaki,M. and Seldin,M.F.
  TITLE     Mouse Elk oncogene maps to chromosome X and a novel Elk oncogene
            (Elk3) maps to chromosome 10
  JOURNAL   Genomics 26 (2), 414-416 (1995)
   PUBMED   7601474
REFERENCE   9  (bases 1 to 4234)
  AUTHORS   Giovane,A., Pintzas,A., Maira,S.M., Sobieszczuk,P. and Wasylyk,B.
  TITLE     Net, a new ets transcription factor that is activated by Ras
  JOURNAL   Genes Dev 8 (13), 1502-1513 (1994)
   PUBMED   7958835
REFERENCE   10 (bases 1 to 4234)
  AUTHORS   Lopez,M., Oettgen,P., Akbarali,Y., Dendorfer,U. and Libermann,T.A.
  TITLE     ERP, a new member of the ets transcription factor/oncoprotein
            family: cloning, characterization, and differential expression
            during B-lymphocyte development
  JOURNAL   Mol Cell Biol 14 (5), 3292-3309 (1994)
   PUBMED   7909357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161054.3, AK052546.1 and AC140379.3.
            
            On Oct 5, 2007 this sequence version replaced NM_013508.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (Elk3, also known as Net). This isoform is predominantly localized
            in the nucleus and has been shown to inhibit transcription
            (PMID:20304071).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052546.1, Z32815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC161054.3         102897-103220       c
            325-3290            AK052546.1         2-2967
            3291-4234           AC140379.3         101096-102039       c
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.04 cM"
     gene            1..4234
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /note="ELK3, member of ETS oncogene family"
                     /db_xref="GeneID:13713"
                     /db_xref="MGI:MGI:101762"
     exon            1..408
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..617
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1640
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /note="isoform Elk3 is encoded by transcript variant 1;
                     ETS domain-containing protein Elk-3; ETS-domain protein
                     ELK-3; ETS-related protein ERP; ETS-related protein NET"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-3 isoform
                     Elk3"
                     /protein_id="NP_038536.2"
                     /db_xref="CCDS:CCDS24124.1"
                     /db_xref="GeneID:13713"
                     /db_xref="MGI:MGI:101762"
                     /translation="MESAITLWQFLLHLLLDQKHEHLICWTSNDGEFKLLKAEEVAKL
                     WGLRKNKTNMNYDKLSRALRYYYDKNIIKKVIGQKFVYKFVSFPDILKMDPHAVEISR
                     ESLLLQDGDCKVSPEGREVHRHGLSSLKSASRNEYLHSGLYSSFTINSLQNAPEAFKA
                     IKTEKLEEPCDDSPPVEEVRTVIRFVTNKTDKHITRPVVSLPSTSETAAAAASAFLAS
                     SVSAKISSLMLPNAASISSASPSSSRSPSLSPDSPLPSEHRSLFLEAACHDSDSLEPL
                     NLSSGSKTKSPSLPPKGKKPKGLEISAPQLLLSGTDIGSIALNSPALPSGSLTPAFFT
                     AQTPSGLFLASSPLLPSIHFWSSLSPVAPLSPARLQGPNTLFQFPTLLNGHMPVPLPS
                     LDRAPSPVLLSPSSQKS"
     exon            618..1418
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1541
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..4234
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /note="hexamer: AATAAA"
     polyA_site      2325
                     /gene="Elk3"
                     /gene_synonym="D430049E23Rik; Erp; Etrp; Net; Sap-2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgcggg gcgtgcgggc gggcgcgggg cccggcgccg ggggtatgcg cgggtctggg
       61 cgggcagccc cggcgcacag ccgcggcccg ggcgcacggc gcggggcgga aaagcctgtt
      121 tacacagact gcacaccgcc tggggaataa tgcagtaaag gaagtgagca ggctcggcct
      181 gactgctcca acttcctgct ctcacacaca ccagaggagg gggggggggg agaaaaaaaa
      241 aaagaggagc gagagaaaga aaaaaaaaag aggggggaaa atcaggatct cattacaaga
      301 gcaacagacc gtctgcagac gcctgtcagc atggaaagtc gggggctttc gcccggttcc
      361 tcctagaaat ctccccaaga agactcccaa acgctccccc acgtctgggt atggagagtg
      421 caatcacgct gtggcagttc ctcttgcact tgctgctgga ccagaaacat gagcacctca
      481 tctgctggac atcgaacgat ggcgagttca agctcctcaa ggcggaagaa gtggccaagc
      541 tgtggggcct ccgcaagaac aagaccaaca tgaactacga caagctgagc agagcgctga
      601 gatactatta cgacaagaac atcatcaaga aagtgatcgg gcagaagttt gtgtacaagt
      661 tcgtctcttt cccggatatc ctgaaaatgg atcctcacgc ggtagagatc agccgggaga
      721 gcctcctgct gcaggacggc gactgtaagg tgtccccgga aggccgagag gtccacaggc
      781 acggcttgtc ctctctcaaa agtgccagcc gcaacgagta cctccactcg ggcctctact
      841 cgtccttcac catcaactcc ctgcagaacg ctccagaggc cttcaaggcc atcaagacgg
      901 agaagctgga ggagccctgt gatgacagtc cccctgtgga agaagtcagg actgtgatca
      961 ggtttgtgac caataaaacc gacaagcaca tcaccaggcc tgtggtgtcc ctgccttcca
     1021 catccgagac cgctgcggca gcggcatccg ctttcctggc ctcgtctgtc tcagccaaga
     1081 tctcctcttt aatgttgcca aatgctgcca gcatttcgtc tgcgtcaccc tcttcatctc
     1141 ggtccccatc cctgtccccc gactctcccc tcccttctga acacagaagc ctcttcctgg
     1201 aggcagcctg ccatgactcg gattctctgg agcccctgaa tctgtcatcg ggctccaaaa
     1261 ccaagtctcc atctcttccc ccaaaaggca aaaaacccaa aggcttggaa atctctgcac
     1321 cccaactgtt gctctccggc accgacatcg gctccatcgc cctcaacagc ccagccctcc
     1381 cctcaggatc cctcactcca gccttcttca ccgcacagac accaagtgga ctgtttctgg
     1441 cctcgagtcc gctgctgccc agcatacact tctggagcag ccttagtcct gtcgccccac
     1501 tgagtcctgc caggctgcaa gggccgaaca cacttttcca gttccccaca ctgctcaacg
     1561 gtcacatgcc ggtgccgctc cccagtctgg acagagctcc atccccagtt ctgctgtccc
     1621 ccagctctca gaaatcctga tgatgggcca ccaacgtcac tgtcatcaac taaggactca
     1681 gaacagatga cggatgatgc cagtttgtcc ccatgggcta gtttacctgt gtcatgagaa
     1741 ggacattgtg aaacctggtt catttggttt gcacttttcg taacatggat aatctagatg
     1801 tatgttagca ttttaaaaca aaagttttgt ctttttatat atatatatat atatatattc
     1861 agctctctat aaaagtctgt ttcgcattca gtgaatttta atgtttgtgg tttttttttt
     1921 aatcttgtta gctctggagt gttgaacact gccagggagg agcctttctt aatgttttca
     1981 atgtaactaa tgaggatgtg aagcctttta ttgctttaac tctacatatg ctgaactccg
     2041 cttgcataca cgatgtaacc agctgtgcct tcctttgcat ttagtgttat gtacatgaat
     2101 ttatgtattt ctagtattga gaggaactgt ttgaaggaca ccttggcatc caacagctct
     2161 ccgtagaggg ttattttctc acgtagacac gttcaagtga acctccatcg cggtaagaac
     2221 tgccttagga cctcttcgga actgaaatcc agtaatgtcc aagtgatggg tttttatata
     2281 agaatgaacg aagccatatt tagacaataa acattgttta aagaacatgt tccaaagtgc
     2341 acttttttaa aagaagaact ttgagagacc aagccgctca gccgtttgta gaagcctttc
     2401 tacttcctgc agaagtctgg aatgctaagg ctccgttaag ttcacaccag ccaaactctc
     2461 aaggggactt tccaggtttg tatttaattt tgagactagc cctgctctct tcatttccta
     2521 caaccacaac catctggtat ctttgtcact actgggagtt aaggtttctt tagattcctg
     2581 gcatgacaat taatatttaa aacctaatgt tttagggctg aggatatagc tccatagaat
     2641 gtgtaacctg catgtgttga ggctgtgggt ataaacccca gtaacctgtc tccctgtctc
     2701 tccccaaaaa gggcgtggtg ggaaacaaac taagaatgtt ttggaagatg cttacagatg
     2761 gtgaattcaa acaaagaaat gtttatatac taccagccat gtatagagat atttcctgtg
     2821 tgtagatata atttttgatg gattaaatcc aatgcattac taagagctgg aggaactgaa
     2881 ggccttgctt ctgaggatga gcactcaaga gccaccgctt tcggtagtaa tgatgatgag
     2941 aataaaggga ctctgagaag gggagacttg tcaggatctc cctctgaaac ggatgcagca
     3001 gctcctcaga tgctccgcag ggaaggcttc acgtgctgag tatggcttcc ggctgtgacg
     3061 cgagcagcct ctcatctggt gagaccctga aggcagcaca cctgtgctta aggggaagtt
     3121 ctactgtaac actctgaagg caaggcactt taaattcaag atcaggtgag ctgaaacacc
     3181 actcatctat aagtattaaa caaacaaaca aacaaacaac tgcaatgtgc ctctacagac
     3241 tagatactaa atagaggatt ataagggggt taaaaaaaca aagctcgtgc aaaaaatttg
     3301 aattttaaac aatctaaaat tatgtttaga tacttacaca ttgagactta ctaccgaagt
     3361 tgactttctt tctaaggggc atgtgtcttt actaagggga gaaaaaaacc tctgactgta
     3421 aagccatgga gacagctcca agcccataaa tagatgccct gccactccct cacggcgaag
     3481 aataaatgtg tactaaaata aaaaggagct ggttcaggag gctgtaatta ccgaacacag
     3541 tgtcagagct gggaggggct ttgagagtgc tggcttccag ctgttctctg gtcaagacag
     3601 gcacacagga caggggtggt gggggtggag aagctggcct ggagctgcct ggggccatag
     3661 catccactga gggaagagta agagagcctc agaacgtaag gaaacgtaag gttggaatgt
     3721 ttaaaatggc tagatgagga tgcatttgat gtgcaagagt cttaagaaga aactaaaggg
     3781 actgatgtgc agggatctca acaagatgac cttctgtcga cctttaaact ataaacgctg
     3841 gttggaaatg ttcccatgac tgtaagtctg cctgttgatt ccttttcttc caactaccat
     3901 gattctcctg tggacccaga tgctggcatg aggactgtag aatggagaac gacagcctct
     3961 ctgccttctg tgtttttaac aggagaaatt cagccggaac gtaggctccc aagagcatcc
     4021 ccggctctct tttctatgct tgcgtcatca gtgtttgact gctgaggctg agtgaggttg
     4081 gagctctaga acctcactgt gggagctgaa ctccgtccct gcgcacagct ttcctacagc
     4141 tgcagggctt cctccgcggc cacacgggtg tcgtttttac tgtaatactg ttttgctgaa
     4201 taaatacttt gtaataaaag agtgtttgga ttcg
//
