LOCUS       NM_007922               3548 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ELK1, member of ETS oncogene family (Elk1), mRNA.
ACCESSION   NM_007922
VERSION     NM_007922.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Liang,J., Zhang,J., Fan,J., Chen,S. and Wu,W.
  TITLE     ANXA3 interference inactivates ERK/ELK1 pathway to mitigate
            inflammation and apoptosis in sepsis-associated acute lung injury
  JOURNAL   Mol Immunol 167, 25-33 (2024)
   PUBMED   38310670
  REMARK    GeneRIF: ANXA3 interference inactivates ERK/ELK1 pathway to
            mitigate inflammation and apoptosis in sepsis-associated acute lung
            injury.
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Su,C., Liu,M., Yao,X., Hao,W., Ma,J., Ren,Y., Gao,X., Xin,L.,
            Ge,L., Yu,Y., Wei,M. and Yang,J.
  TITLE     Vascular injury activates the ELK1/SND1/SRF pathway to promote
            vascular smooth muscle cell proliferative phenotype and neointimal
            hyperplasia
  JOURNAL   Cell Mol Life Sci 81 (1), 59 (2024)
   PUBMED   38279051
  REMARK    GeneRIF: Vascular injury activates the ELK1/SND1/SRF pathway to
            promote vascular smooth muscle cell proliferative phenotype and
            neointimal hyperplasia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Rahim,G., Araud,T., Jaquier-Gubler,P. and Curran,J.
  TITLE     Alternative splicing within the elk-1 5' untranslated region serves
            to modulate initiation events downstream of the highly conserved
            upstream open reading frame 2
  JOURNAL   Mol Cell Biol 32 (9), 1745-1756 (2012)
   PUBMED   22354998
REFERENCE   5  (bases 1 to 3548)
  AUTHORS   Cesari,F., Brecht,S., Vintersten,K., Vuong,L.G., Hofmann,M.,
            Klingel,K., Schnorr,J.J., Arsenian,S., Schild,H., Herdegen,T.,
            Wiebel,F.F. and Nordheim,A.
  TITLE     Mice deficient for the ets transcription factor elk-1 show normal
            immune responses and mildly impaired neuronal gene activation
  JOURNAL   Mol Cell Biol 24 (1), 294-305 (2004)
   PUBMED   14673163
REFERENCE   6  (bases 1 to 3548)
  AUTHORS   Sharrocks,A.D.
  TITLE     Complexities in ETS-domain transcription factor function and
            regulation: lessons from the TCF (ternary complex factor)
            subfamily. The Colworth Medal Lecture
  JOURNAL   Biochem Soc Trans 30 (2), 1-9 (2002)
   PUBMED   12023815
REFERENCE   7  (bases 1 to 3548)
  AUTHORS   Vanhoutte,P., Nissen,J.L., Brugg,B., Gaspera,B.D., Besson,M.J.,
            Hipskind,R.A. and Caboche,J.
  TITLE     Opposing roles of Elk-1 and its brain-specific isoform, short
            Elk-1, in nerve growth factor-induced PC12 differentiation
  JOURNAL   J Biol Chem 276 (7), 5189-5196 (2001)
   PUBMED   11050086
  REMARK    GeneRIF: Characterizes an orthologous rat short isoform derived
            from an in-frame downstream start codon.
REFERENCE   8  (bases 1 to 3548)
  AUTHORS   Grevin,D., Ung,S., Denhez,F., Dehem,M., Quatannens,B., Begue,A.,
            Stehelin,D. and Martin,P.
  TITLE     Structure and organization of the mouse elk1 gene
  JOURNAL   Gene 174 (1), 185-188 (1996)
   PUBMED   8863747
REFERENCE   9  (bases 1 to 3548)
  AUTHORS   Whitmarsh,A.J., Shore,P., Sharrocks,A.D. and Davis,R.J.
  TITLE     Integration of MAP kinase signal transduction pathways at the serum
            response element
  JOURNAL   Science 269 (5222), 403-407 (1995)
   PUBMED   7618106
REFERENCE   10 (bases 1 to 3548)
  AUTHORS   Tamai,Y., Taketo,M., Nozaki,M. and Seldin,M.F.
  TITLE     Mouse Elk oncogene maps to chromosome X and a novel Elk oncogene
            (Elk3) maps to chromosome 10
  JOURNAL   Genomics 26 (2), 414-416 (1995)
   PUBMED   7601474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY728635.1, AK132354.1 and
            AL671853.7.
            
            On Mar 16, 2012 this sequence version replaced NM_007922.4.
            
            Summary: This gene is a member of the Ets family of transcription
            factors and of the ternary complex factor (TCF) subfamily. Proteins
            of the TCF subfamily form a ternary complex by binding to the the
            serum response factor and the serum response element in the
            promoter of the c-fos proto-oncogene. The protein encoded by this
            gene is a nuclear target for the ras-raf-MAPK signaling cascade.
            This gene may produce multiple isoforms by the use of alternative
            translational start codons. [provided by RefSeq, Mar 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132354.1, SRR9219381.112977.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 22354998
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY728635.1         1-8
            9-619               AK132354.1         2-612
            620-620             AL671853.7         26142-26142         c
            621-3548            AK132354.1         614-3541
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.45 cM"
     gene            1..3548
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /note="ELK1, member of ETS oncogene family"
                     /db_xref="GeneID:13712"
                     /db_xref="MGI:MGI:101833"
     exon            1..169
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..413
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      181..189
                     /regulatory_class="uORF"
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:22354998]"
                     /note="this uORF is known as uORF2 and is predicted to
                     encode a 2 aa peptide (PMID:22354998)"
     CDS             204..1493
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /codon_start=1
                     /product="ETS domain-containing protein Elk-1"
                     /protein_id="NP_031948.4"
                     /db_xref="CCDS:CCDS30048.1"
                     /db_xref="GeneID:13712"
                     /db_xref="MGI:MGI:101833"
                     /translation="MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVAR
                     LWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQ
                     PEVSVTSAIAMAPATVHAGPGDTATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYST
                     FTIQSLQPQPQPPIPPRPASVLPNTTPAGVPAPASGSRSTSPNPLEACLEAEEAGLPL
                     QVILTPPEAPNQKSEELSLDPSFGHPQPPEVKVEGPKEELEAARAGGFSSEAVKAEPE
                     VSASEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGP
                     ERTPGSGTSSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPA
                     KLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP"
     exon            414..860
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1292
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1394
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..3548
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /note="hexamer: AATATA"
     polyA_site      2787
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
                     /note="major polyA site"
     polyA_site      3231
                     /gene="Elk1"
                     /gene_synonym="Elk-1"
ORIGIN      
        1 gagagcccac gtgagcggtg gggaaacgca ggggcggctt ctggttgctg cttctgctgt
       61 cgccgccacc accgccgccg ccttggaacc ggggcctggg gggcggtggg gcctcgtatg
      121 gagcccccgc cccccggagc tgccactgcc accgccgcgc cactcgcagg tactcctgga
      181 atggcgtgag tgcttcccta gtgatggacc catctgtgac gctgtggcag tttctgctgc
      241 agcttctgag agaacaaggt aatggccaca tcatctcctg gacctcacgg gatggtggtg
      301 agttcaagtt ggtggatgca gaggaggtgg cccggctatg gggactgcgc aagaacaaga
      361 ccaacatgaa ttacgacaag cttagccggg ccttgcggta ctactatgat aagaatatca
      421 tccgcaaggt gagcggccag aagtttgtct acaagtttgt gtcctaccca gaggttgcag
      481 ggtgctccac tgaagactgc ccaccccagc ctgaggtgtc tgtaacctcg gccatagcca
      541 tggcccctgc tactgtccat gcaggcccag gggacactgc cactggaaag ccaggaacac
      601 caaagggtgc aggaatgaca ggccaaggtg gcttagcacg aagcagccgg aatgaataca
      661 tgcgctcggg cctctattct accttcacaa tacaatccct gcagccacag ccacagccac
      721 ccattcctcc tcggcctgcc tcagtgcttc ccaacactac ccctgcagga gtaccagcac
      781 ccgcctcagg gagcaggagc accagtccaa accccttaga agcctgtttg gaagcagaag
      841 aggctggtct gcccctgcag gttatcctaa ccccaccaga ggccccaaac cagaaatccg
      901 aagagttgag tctggaccca agttttggcc atccacagcc cccagaagtc aaagtggagg
      961 ggcctaagga agaattggaa gctgcaaggg ctggaggctt cagttcagaa gctgtcaaag
     1021 ctgaaccaga agtctcagcc tcagaaggcc tgctggctcg gctcccagcc atcctaacag
     1081 agaacacagc ccaggtgtgt ggcctctcca cttccaccac tgagatcacc caaccgcaga
     1141 agggccgaaa gcctcgggac ctggaacttc cacttagccc aagcctgctg ggtggccagg
     1201 gacctgaacg gactccagga tcaggaacaa gctctggtct tcaggcaccg gggccagcgc
     1261 taacgccatc cctgctcccc acacatacct tgaccccggt gctgctgaca cccagctcgc
     1321 tgccccctag catccatttc tggagcactc tgagtccaat tgcaccccgt agtccagcca
     1381 agctctcctt ccagtttccg tccagtggca gcgcacaggt gcacatccct tccatcagtg
     1441 tggatggcct ctcgaccccc gtggtgctct ccccagggcc ccagaagcca tgactaccac
     1501 caccacccct tttttggagt ccatccatct atgctcctga actctccagt tagccatctc
     1561 aaggagaaac atagttaaac tgacagactt aagctctgat tgtggtgggg tggatattcc
     1621 tggaaaagtg aatatttcac taactcctcc acccaaaaca gacaacttct ttcttctttg
     1681 ccagcctccc agtggctgcc cttacacgtc tcctacttca atggtggggc ggtttattta
     1741 tttatttttt gaaggccact gggaagaatc tggcccaacc tttttagggg agtgggtaag
     1801 acatctcacc catttcctcc ccattttttc ctaaaacaag acaatcaggg catggcttga
     1861 gaggaacctt tatttattta tttctcagcc tgcccttggg gagttgaggg tgccctgtct
     1921 tcattttgcg acatgggttg aagaactagc ttgttttgtt ttattattcc tggctgtatc
     1981 tgagtccagg gagcccttgt acgatttaat ggtttgggag tggtagccag ggaatcaaca
     2041 ctgttaaaat aggaattgct acctccctaa ccttcttctc agtcagcttg ttcttttctc
     2101 aagtaacctt ttggccaggg aggactattc cttttgttgt tcttcccccc tgagaagcca
     2161 ttcctttgtc tgccaaattt cctggggccc tgcctattac ctcccaatgg agggtttttt
     2221 tgggtggtgg tccccgtctg gggggcccct ccagctagta ctccaggtct ctgtctccca
     2281 cccccttcca ttttgatagt ataatctatt tttaaatggg gcttttcaat aggggagagg
     2341 gaaacatctc ttcctatatc agatgggtgg gtaggcgggt gggtgggaag taagggattt
     2401 ggaggcggtc ttcctgccac ccccaagtgt ttatttttta taccaaacat gtatttttgg
     2461 ctccctccca gccccccaat ttcctgcagg cgggtacaaa ggaccctttt aagtgtccct
     2521 ggagttggga gggaggaatg ggggacatgg agcctgtctt atatcaatct aggctggagg
     2581 aggtggatca aaagactccc aggctcacct cctgtcagca ctggcccaga ccaggcctga
     2641 agacctgggg gttggtgatt tgggggacgg tgctatactc gtctccacta cttgttttgc
     2701 ttccccaaaa tggacctttt tttctaagag tcccagagaa tggggaattg ttcctgtaaa
     2761 tatatatttt taaaggtgtt gctgaaagct gttggtattt ttttttctcc tgtgtcacca
     2821 aaataagcca tgacagccac gaatatgaag aacaataagg gcgaggcaaa gattgactgt
     2881 gagagaggca aaatgatggc atatgtcaga gactgataca gactgctgat tggtaaccag
     2941 tgtgatgaga gaaaccgaaa gattttaaat atgtgtgtcg caggtcagaa gtgtgaccgc
     3001 aaacattttt gtacatgtgt atgcatggtc ttatgtgtgg tgtgttgtct actggaacac
     3061 tgtcccctcc tttgagacag ggtctcatct ttgcctaaac ttaccagttg ggatacactt
     3121 gctggccatc aagtctcaag gatctacctg gttctacctt gggattacaa gcatgtactt
     3181 ctatgcctgg aatttttacc tgtattgtag ggatcaaacg gtcacctttt accacgttga
     3241 ctcctttatt cacagggttg tgcaaagcaa gtgttttatt gactgggcca tttctccagt
     3301 cccaaccatt tgtagatgaa aagtcacact gttagtagag aaatggtttt gagaaatggt
     3361 ttgtgtgtga aattaagtca tggaggtata tgtttaagaa gctgattgtg tgagccaggt
     3421 ggtagaggca cacgtcttta atcccagcac tggggaagga gaagcaagta ggtctcagag
     3481 ttcaaggtca gcctggtcta cagagcaagt tccaggacag ccagggctac acagagaaac
     3541 cctgtctc
//
