LOCUS       NM_001384186            4696 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat and fibronectin type III,
            extracellular 1 (Elfn1), transcript variant 2, mRNA.
ACCESSION   NM_001384186 XM_006504701
VERSION     NM_001384186.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4696)
  AUTHORS   Miller,M.L., Pindwarawala,M. and Agosto,M.A.
  TITLE     Complex N-glycosylation of mGluR6 is required for trans-synaptic
            interaction with ELFN adhesion proteins
  JOURNAL   J Biol Chem 300 (4), 107119 (2024)
   PUBMED   38428819
  REMARK    GeneRIF: Complex N-glycosylation of mGluR6 is required for
            trans-synaptic interaction with ELFN adhesion proteins.
            Erratum:[J Biol Chem. 2024 Oct;300(10):107782. doi:
            10.1016/j.jbc.2024.107782.. PMID: 39332159]
REFERENCE   2  (bases 1 to 4696)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4696)
  AUTHORS   Stachniak,T.J., Argunsah,A.O., Yang,J.W., Cai,L. and Karayannis,T.
  TITLE     Presynaptic Kainate Receptors onto Somatostatin Interneurons Are
            Recruited by Activity throughout Development and Contribute to
            Cortical Sensory Adaptation
  JOURNAL   J Neurosci 43 (43), 7101-7118 (2023)
   PUBMED   37709538
REFERENCE   4  (bases 1 to 4696)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   5  (bases 1 to 4696)
  AUTHORS   Beier,C., Bocchero,U., Levy,L., Zhang,Z., Jin,N., Massey,S.C.,
            Ribelayga,C.P., Martemyanov,K., Hattar,S. and Pahlberg,J.
  TITLE     Divergent outer retinal circuits drive image and non-image visual
            behaviors
  JOURNAL   Cell Rep 39 (13), 111003 (2022)
   PUBMED   35767957
REFERENCE   6  (bases 1 to 4696)
  AUTHORS   Tomioka,N.H., Yasuda,H., Miyamoto,H., Hatayama,M., Morimura,N.,
            Matsumoto,Y., Suzuki,T., Odagawa,M., Odaka,Y.S., Iwayama,Y., Won
            Um,J., Ko,J., Inoue,Y., Kaneko,S., Hirose,S., Yamada,K.,
            Yoshikawa,T., Yamakawa,K. and Aruga,J.
  TITLE     Elfn1 recruits presynaptic mGluR7 in trans and its loss results in
            seizures
  JOURNAL   Nat Commun 5, 4501 (2014)
   PUBMED   25047565
  REMARK    GeneRIF: Elfn1 protein increases during postnatal development and
            localizes to postsynaptic sites of somatostatin-containing
            interneurons in the hippocampal CA1 stratum oriens and dentate
            gyrus hilus.Elfn1 recruits mGluR7 to synaptic sites.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4696)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4696)
  AUTHORS   Dolan,J. and Mitchell,K.J.
  TITLE     Mutation of Elfn1 in mice causes seizures and hyperactivity
  JOURNAL   PLoS One 8 (11), e80491 (2013)
   PUBMED   24312227
  REMARK    GeneRIF: Mutation of Elfn1 in mice causes seizures and
            hyperactivity.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4696)
  AUTHORS   Sylwestrak,E.L. and Ghosh,A.
  TITLE     Elfn1 regulates target-specific release probability at
            CA1-interneuron synapses
  JOURNAL   Science 338 (6106), 536-540 (2012)
   PUBMED   23042292
  REMARK    GeneRIF: postsynaptic expression of Elfn1 in oriens-lacunosum
            moleculare interneurons regulates presynaptic release probability,
            which confers target-specific synaptic properties to pyramidal cell
            axons.
REFERENCE   10 (bases 1 to 4696)
  AUTHORS   Dolan,J., Walshe,K., Alsbury,S., Hokamp,K., O'Keeffe,S.,
            Okafuji,T., Miller,S.F., Tear,G. and Mitchell,K.J.
  TITLE     The extracellular leucine-rich repeat superfamily; a comparative
            survey and analysis of evolutionary relationships and expression
            patterns
  JOURNAL   BMC Genomics 8, 320 (2007)
   PUBMED   17868438
  REMARK    Erratum:[BMC Genomics. 2009;10:230]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130221.4 and AC145748.4.
            
            On Jun 4, 2020 this sequence version replaced XM_006504701.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1069066.1,
                                           SRR7345562.910135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               AC130221.4         191919-192866
            949-4696            AC145748.4         84408-88155
FEATURES             Location/Qualifiers
     source          1..4696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.81 cM"
     gene            1..4696
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /note="leucine rich repeat and fibronectin type III,
                     extracellular 1"
                     /db_xref="GeneID:243312"
                     /db_xref="MGI:MGI:2442479"
     exon            1..948
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /inference="alignment:Splign:2.1.0"
     exon            949..4696
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /inference="alignment:Splign:2.1.0"
     CDS             1214..3700
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; extracellular leucine-rich repeat and
                     fibronectin type-III domain-containing protein 1; protein
                     phosphatase 1 regulatory subunit 28; protein ELFN1"
                     /codon_start=1
                     /product="protein ELFN1 isoform 1 precursor"
                     /protein_id="NP_001371115.1"
                     /db_xref="GeneID:243312"
                     /db_xref="MGI:MGI:2442479"
                     /translation="MAGHGWGTAWVLVAAATLLHAGGLAQGDCWLIEGDKGFVWLAIC
                     SQNQPPYEAIPQQINNTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDG
                     AFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLIEVVMASAFWECPNIVN
                     IDLSMNRIQQLGSGTFAGLTKLSVCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRV
                     QCESPPVYAGYFLLGQGRHGHQRSILSKLQSVCTEGSYTAEVLGPPRPVPGRSQPGHS
                     PPPPPPEPSDMPCADDECFSGDGTTPLVILTTLVPQTEARPSMKVKQLTQNSATIMVQ
                     LPSPFNRMYTLEQYNNSKSFTVSKLTQPQEEIRLTNLYTLTNYTYCVVSTSSGTHHNH
                     TCLTICLPKPPSPPGPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRKRRRQEEKH
                     KKAVAAAAGSLKKTIIELKYGPEIEAPGLAPLTQGPLLGPEAVTRIPYLPAATSDVEQ
                     YKLVESSETPKATKGNYIEVRTGEPQERRGCELSRPGEPQSSVAEISTIAKEVDRVNQ
                     IINNCIDALKSESTSFQGAKSGAVSAAEPQLVLLSEPLASKHSFLSPVYKDAFGHGGL
                     QRHHSVEAAPGPPRASTSSSGSARSPRTFRAEATGTHKAPATETKYIEKSSPVPETIL
                     TVTPAATVLRAEADKSRQYGEHRHSYPGSHPAEPPAPPPPPPTHEGLGGRKASILEPL
                     TRPRPRDLVYSQLSPQYHNLSYSSSPEYTCRASPSIWERLRLSRRRHKDDAEFMAAGH
                     ALRKKVQFAKDEDLHDILDYWKGVSAQHKS"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /note="hexamer: ACTAAA"
     polyA_site      4696
                     /gene="Elfn1"
                     /gene_synonym="A930017N06Rik; Ppp1r28"
                     /note="major polyA site"
ORIGIN      
        1 gagagaatgt tgcatctcgg agggcctgac aaccttgtac catctctgat tctcccctcc
       61 ccgccgcccg ccccgtgaaa caatcgtccc tgcgggtgga gctgtgacac gcgcgcttac
      121 atagggtctg acttcggggt caacttctac atggcttcct gcgggtgcgt gtgtgtgcac
      181 aggcgtgact gtacgcgcgt gcacatctct gcctctcgta cccacctccc atcgccacga
      241 agggtcccaa ccccatgaca ctcggggact tgggctccac ggctcttagc tcagtggcct
      301 gggacgcggg caggggacgc aggcaaagcc aggaaaagga ggcgaggctg tgttgcggcg
      361 tcctgagatg tccccccggc tccagccaac ttcccctcag ggagccttga tcccctcccg
      421 gggcaaccta tggacgtgca gcggcccccg cccctgctcc ggtcccctcc ccgcgcggct
      481 cccacgtccg acctgcctcg cgctcacaaa atgaaccacc gcctcgcgtc gccgcggccg
      541 ctgccgccgc gcccgctccc gagctcgaga gccggagccg cccggcccct tcggcgtcgc
      601 cggcgccgcg gccgccccgc ctgcccggcc ggtccggggc tgctccgatc gcgcggtccc
      661 cggctcttga cgcagtgagc gccgcagccc ggctcccgca ggctcctctc cgctcccggc
      721 gagaggccga tcctcaagcc cggcgggctc cgggaggggc gggcaacgcg ggagggggag
      781 gaggtctgtc tggagccagc aagaaccccg aggaggaaga ggaggaggaa gcaggggcag
      841 ccgccgccgc cgccgccacc gccaccgcgg cgctccgggg acttcggcgc gcgtgctctg
      901 ctagccggtg atcgagcctt caaccctggg ggccacaacc ccgttcagca gagagtactt
      961 caggcagagg aaccgggcga agccaccagg atacacaggc ccatgggaaa acaggctgtg
     1021 gccaccttgg gaccggggag gacgacaaag ggcggcgggc agtgagggag ccattctccc
     1081 tcccgacacc tgcgtcatgc agcttgggac aggacatctc tgacagtgca ggcagtgatc
     1141 catcccaccc ctaagtcccc tgggggggcc cactgcccag ccctcccccc atccccacag
     1201 gcagtgtccc gagatggctg ggcacgggtg gggtacagcg tgggtacttg tggcagccgc
     1261 cacgttactg cacgcgggtg ggctggccca aggtgactgc tggctgattg agggtgacaa
     1321 aggcttcgtg tggttggcca tctgcagcca gaaccagcca ccctatgagg ccatccccca
     1381 acagatcaac aacaccatcg tggacctgcg gcttaacgag aaccgtatcc gcagcgtgca
     1441 gtacgcctcc ctgagccgct tcggaaacct cacatacctc aacctcacca agaacgagat
     1501 cggctacatc gaggacgggg ccttctccgg ccagttcaac ctccaggtgc tgcagctggg
     1561 ctacaaccgg ctgcgcaacc tcacggaggg catgctgcgg ggcctgagca agctcgagta
     1621 cctgtaccta caggccaacc tcatcgaggt ggtgatggcc agcgccttct gggagtgtcc
     1681 caacatcgtc aacatagatc tctccatgaa tcgcatccag cagctgggca gcggcacctt
     1741 cgcaggcctg accaagctct cggtgtgtga gatctacagc aaccctttct actgctcctg
     1801 tgagctgctg ggtttcctgc gctggctggc tgccttcacc aacgccacac agacccatga
     1861 ccgggtgcag tgtgagtctc ctcctgtcta cgcaggctac ttcctcctgg gccagggccg
     1921 ccacggccac caacgtagca tccttagcaa gcttcagtct gtgtgcacag agggctccta
     1981 cactgctgag gtgcttggcc caccccgtcc ggtgccaggc cggtcacagc cgggacattc
     2041 gccacctccg cctccaccag agcctagtga catgccctgc gctgatgacg agtgcttctc
     2101 cggagatggc accacgccgc tggtgatcct gactacgctg gtccctcaga cagaggcccg
     2161 tccctccatg aaggtcaagc agctgaccca aaattcggcc accatcatgg tgcagctgcc
     2221 gagcccgttc aaccgcatgt acacgctgga gcagtacaat aacagcaaat cgttcaccgt
     2281 gtccaagctg acccagcctc aggaggagat ccgcctcacc aatctttaca cactcaccaa
     2341 ctacacatac tgcgtggtct ctaccagctc cggcacccat cataaccaca cctgccttac
     2401 catctgcctg cccaagccgc ccagcccacc gggccccgtg cccagcccct ccacagccac
     2461 ccactacatc atgaccatcc tgggctgcct ctttggtatg gtactggttc tgggcgctgt
     2521 ctattactgc ctgcgcaagc ggaggcgaca agaggagaaa cacaagaagg ctgtggcagc
     2581 ggcagctggc agcttgaaaa aaaccatcat cgagcttaag tatggtcctg agattgaggc
     2641 gcctggcctg gctcccctga cccagggtcc gctgcttggc cctgaggctg tgactcgaat
     2701 accctacctg ccagccgcca ccagtgacgt ggagcagtat aagctggtgg agagcagcga
     2761 gacccccaag gccaccaagg ggaactacat tgaagtgcgc acgggggagc cgcaggagcg
     2821 cagaggctgt gagctgagcc ggccaggtga accccagagc tcagtagcgg agatctccac
     2881 cattgccaag gaagtggaca gagtcaacca gatcattaac aactgcatcg acgccctcaa
     2941 gtccgagtcc acctccttcc agggcgccaa atcaggggcc gtgtctgcgg ctgagccgca
     3001 gctggtgctg ctgtccgagc ctctggccag caagcacagc ttcctgtccc ctgtatacaa
     3061 agatgccttt ggccatggtg gcctgcagcg gcaccacagt gtggaggctg cgcccgggcc
     3121 cccgagggcc agcacttcat ccagcggttc tgcacgcagc cctcgcacct tccgggctga
     3181 ggccaccggc acacataagg ccccagccac cgagaccaag tacattgaaa aaagctcacc
     3241 tgtgcccgag accatcctca ctgtgacacc cgcggccact gtgctgcggg cggaggccga
     3301 caagagtcgc cagtacggcg agcatcggca ctcatacccc ggctctcacc ctgccgagcc
     3361 acctgcccct ccaccacctc cacccactca cgagggcttg ggtggccgca aggcatccat
     3421 cctggagcct ctgacccggc cacgaccccg agacctcgtc tactcgcagc tgtccccaca
     3481 gtaccacaac ctgagctatt catccagccc cgagtacacc tgcagggcat ccccaagcat
     3541 ctgggagcgt ctcagactga gccgacggag acacaaggat gatgcggagt tcatggcggc
     3601 tggccacgcc ctgcgcaaga aggttcagtt tgccaaagac gaggacctgc atgacatcct
     3661 agactactgg aaaggcgtgt ctgcccagca caagtcctga acctccctcc accctttggc
     3721 agggcccaag gaagcctggc cctgtcctct ccgaaactcg tgatgcccat tggaccaaaa
     3781 aggatagacc acccacagca gctatccctg actgagactt aacactaaat ccaacatatg
     3841 tgcacaacca ggggccgctg catacagcac ctggcccaca gggacagctt ggggaggccg
     3901 caggtggccg agacagtaga tatactaact tccatgtaaa ctgtaatgtg cctgctgcct
     3961 ggtgcaagca agcaagacac acacacacac acacacacac acacacacac actcacacac
     4021 tcacatactc acatacactc acacattcac acacttacac tcacacatac attcacacac
     4081 acaaatgcac acacatgcat gtgcgcgtgc acacacaaac atttgcacac actcacacat
     4141 gcacatgcac acacatgcac acatgggact tcggaaaact gtgtcttacg ggtgggggtg
     4201 ggggagggga agtttttcca ttatctttcc tgttttgagt cttctcttcc ttttccttct
     4261 tctctctctt tattttcttc ctttttaaaa aatatatata taaaagtgaa aatctttaaa
     4321 aaaaataaaa gagagagaaa gaagaaagaa ctaaatcacc tagcgtgggg catgtgacca
     4381 agtctagcca gcttcatggc accccctaaa tatgatctcc caggctgtgg agtgcagagg
     4441 ggtggagcat ctggagcctg tgagactcta gtggggaggt gaagactgtg cctggggacc
     4501 agtcagggtg gcaagagggg tgcaggctgg gaaacattgt gtggtccctc cacctcgacc
     4561 ccatctttat tgtacactgt agctgttcta ttgtacagaa aaaaaaatct atatttgcaa
     4621 agtttgctgt aaaatgagag agagaaaaaa agactatgtc tactaaaaaa aatctgcaaa
     4681 ggaaaaaaaa tccaaa
//
