LOCUS       NM_010125               2216 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus E74-like factor 5 (Elf5), transcript variant 1, mRNA.
ACCESSION   NM_010125
VERSION     NM_010125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2216)
  AUTHORS   Hu,A., Pickup,M.E., Lawal,M.A., Patel,H.J. and Ahmed,M.I.
  TITLE     The involvement of Elf5 in regulating keratinocyte proliferation
            and differentiation processes in skin
  JOURNAL   PLoS One 20 (1), e0316134 (2025)
   PUBMED   39752333
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2216)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   3  (bases 1 to 2216)
  AUTHORS   Kim,U., Debnath,R., Maiz,J.E., Rico,J., Sinha,S., Blanco,M.A. and
            Chakrabarti,R.
  TITLE     DeltaNp63 regulates MDSC survival and metabolism in triple-negative
            breast cancer
  JOURNAL   iScience 27 (4), 109366 (2024)
   PUBMED   38510127
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2216)
  AUTHORS   Li,T., Xu,L., Wei,Z., Zhang,S., Liu,X., Yang,Y., Gu,Y. and Zhang,J.
  TITLE     ELF5 drives angiogenesis suppression though stabilizing WDTC1 in
            renal cell carcinoma
  JOURNAL   Mol Cancer 22 (1), 184 (2023)
   PUBMED   37980532
  REMARK    GeneRIF: ELF5 drives angiogenesis suppression though stabilizing
            WDTC1 in renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2216)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2216)
  AUTHORS   Tummala,R. and Sinha,S.
  TITLE     Differentiation-specific transcriptional regulation of the ESE-2
            gene by a novel keratinocyte-restricted factor
  JOURNAL   J Cell Biochem 97 (4), 766-781 (2006)
   PUBMED   16229011
  REMARK    GeneRIF: KRF is a novel transcription factor that is restricted to
            nuclear extracts isolated from keratinocytes and that binds to
            unique DNA sequences, which do not resemble any known consensus
            binding motif for transcription factors.[KRF]
REFERENCE   7  (bases 1 to 2216)
  AUTHORS   Donnison,M., Beaton,A., Davey,H.W., Broadhurst,R., L'Huillier,P.
            and Pfeffer,P.L.
  TITLE     Loss of the extraembryonic ectoderm in Elf5 mutants leads to
            defects in embryonic patterning
  JOURNAL   Development 132 (10), 2299-2308 (2005)
   PUBMED   15829518
  REMARK    GeneRIF: Loss of the extraembryonic ectoderm in Elf5 mutants leads
            to defects in embryonic patterning.
REFERENCE   8  (bases 1 to 2216)
  AUTHORS   Zhou,J., Chehab,R., Tkalcevic,J., Naylor,M.J., Harris,J.,
            Wilson,T.J., Tsao,S., Tellis,I., Zavarsek,S., Xu,D.,
            Lapinskas,E.J., Visvader,J., Lindeman,G.J., Thomas,R.,
            Ormandy,C.J., Hertzog,P.J., Kola,I. and Pritchard,M.A.
  TITLE     Elf5 is essential for early embryogenesis and mammary gland
            development during pregnancy and lactation
  JOURNAL   EMBO J 24 (3), 635-644 (2005)
   PUBMED   15650748
  REMARK    GeneRIF: Elf5 is essential for developmental processes in the
            embryo and in the mammary gland during pregnancy
REFERENCE   9  (bases 1 to 2216)
  AUTHORS   Lapinskas,E.J., Palmer,J., Ricardo,S., Hertzog,P.J., Hammacher,A.
            and Pritchard,M.A.
  TITLE     A major site of expression of the ets transcription factor Elf5 is
            epithelia of exocrine glands
  JOURNAL   Histochem Cell Biol 122 (6), 521-526 (2004)
   PUBMED   15655699
  REMARK    GeneRIF: demonstrated for the first time that Elf5 protein is
            localised to epithelium of exocrine glands including the kidney,
            mammary gland, stomach and the submandibular salivary gland
REFERENCE   10 (bases 1 to 2216)
  AUTHORS   Zhou,J., Ng,A.Y., Tymms,M.J., Jermiin,L.S., Seth,A.K., Thomas,R.S.
            and Kola,I.
  TITLE     A novel transcription factor, ELF5, belongs to the ELF subfamily of
            ETS genes and maps to human chromosome 11p13-15, a region subject
            to LOH and rearrangement in human carcinoma cell lines
  JOURNAL   Oncogene 17 (21), 2719-2732 (1998)
   PUBMED   9840936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145214.1, AF049702.1, AK132484.1 and AL773505.5.
            
            On Mar 12, 2009 this sequence version replaced NM_010125.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF049702.1, AK145214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK145214.1         8-16
            10-325              AF049702.1         1-316
            326-982             AK132484.1         646-1302
            983-2216            AL773505.5         3007-4240
FEATURES             Location/Qualifiers
     source          1..2216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..2216
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="E74-like factor 5"
                     /db_xref="GeneID:13711"
                     /db_xref="MGI:MGI:1335079"
     exon            1..121
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     exon            122..246
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     CDS             126..887
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="Epithelium specific Ets-2"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-5"
                     /protein_id="NP_034255.2"
                     /db_xref="CCDS:CCDS16477.1"
                     /db_xref="GeneID:13711"
                     /db_xref="MGI:MGI:1335079"
                     /translation="MLDSVTHSTFLPNASFCDPLMPWTDLFSNEDYYPAFEHQTACDS
                     YWTSVHPEYWTKRHVWEWLQFCCDQYKLDANCISFCHFNISGLQLCSMTQEEFIEAAG
                     ICGEYLYFILQNIRSQGYSFFNDAEETKTGIKDYADSSCLKTSGIKSQDCHSRTSLQS
                     SHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLS
                     RALRYYYKTGILERVDRRLVYKFGKNAHGWQEEKL"
     exon            247..480
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     exon            481..531
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     exon            532..594
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     exon            595..790
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     exon            791..2216
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /inference="alignment:Splign:2.1.0"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="hexamer: GATAAA"
     polyA_site      1069
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="major polyA site"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="hexamer: AATAAA"
     polyA_site      2216
                     /gene="Elf5"
                     /gene_synonym="ESE-2; ESE-5; ESE-5."
                     /note="major polyA site"
ORIGIN      
        1 gtcacttata tcacacggct acaggtgcct ttatttctac agtccgctgg tgctgggagc
       61 gcgcttgcct tctcttgcct tgaaagcctt ctgtctggac ctagccacca cttgtcttca
      121 cggtgatgtt ggactccgta acccatagca ccttcctgcc caacgcatcc ttctgtgacc
      181 ccctgatgcc ttggaccgat ctgttcagca atgaagacta ctaccctgcc tttgagcatc
      241 agacagcctg tgattcctac tggacatcag tgcaccctga atactggacc aagcgccatg
      301 tctgggaatg gctccaattc tgctgcgacc agtacaagct tgatgccaac tgcatctcct
      361 tctgtcactt caacatcagc ggcctgcagc tctgcagcat gacgcaggag gagttcattg
      421 aggcagccgg catctgtggg gagtacctgt acttcattct ccagaacatt cgctcgcaag
      481 gttactcctt tttcaatgat gctgaagaga ccaagactgg catcaaagac tatgctgatt
      541 ccagttgctt gaaaacaagt ggcatcaaga gtcaagactg tcacagccga acaagcctcc
      601 aaagttctca cctgtgggaa tttgtcagag acttgctgct gtcccctgaa gagaactgtg
      661 gcatcctgga atgggaagac agggagcagg gcattttccg agtggttaag tcagaagccc
      721 tggcaaagat gtggggacaa aggaagaaga atgacaggat gacgtacgag aagctgagcc
      781 gagccctgag atactactat aaaacgggaa ttctggagcg ggttgaccgg aggttagtgt
      841 acaaatttgg aaagaacgcg cacgggtggc aggaagagaa actctgatgg acaccggaca
      901 ccaggctcat ttgatggatt tctgttgttg gaaacaatca gatcaaacta gacatttgaa
      961 agtctccctc ctccccctcc tccccctcct ccccctcctc ttcttcctcc ccctcctcct
     1021 cttcaaaacc tacaaacaca ctgataaaat ttctgcatgt ctcagcttac atttgaattc
     1081 agttgttgtc tattggggcg atgccatcag cccttaagca atcgtcttca tcccaagggg
     1141 gaggaaggga tggtcttgtg gcaacttggt gtgacactgt ctccttaatg aagtgtttgg
     1201 agctaaggga gccagtgtta tgggtgctgt ttcacaagag gacccgttgc accattaaga
     1261 cacacgatcc tcccgttcca ggggttctga gcggtcgact gaggcagctt gcctgtggtt
     1321 agtttttagg aaagggtgat gtaagacttc cttgctttag atttgaaatt atcacagtta
     1381 tattccatag aagaattttt aattaaaaaa attttagtgg ctaagccact aaactgggac
     1441 ctaattggat gtagcctaag ttactaataa gtctcttaac cagatcacca tttccaacca
     1501 cttagccaca gtcacttgat ccacggccaa tccttctgaa cttaacatcc ttgtagttag
     1561 tcaccttggg aattgctacc tagattgtta cccccttcac ctcactggtg gctatcatca
     1621 ggtctacagt gacctgatca acagacatgt gcattaattt ctaaatcact gctgtgccta
     1681 tgattcaaac cgtcagcgtg ttcagtttat tgattctctc tgaggtcgga atttattgat
     1741 tctctctgag gctaagacat taaaccttta ccaagcagag aacgtcctaa caagccacga
     1801 tagccgaaca cagcatcgat ctcttctctt ttctgatgaa tactcaaact ttccaacata
     1861 ttctcttcac aaaagtaaag acagtgaatt tacatcaatc aacgttcatg ggttaaagtc
     1921 tgcactgaca tttccttgtc tgccgttgca tgccgttggc atgcaaggtg ttaatgacct
     1981 gcaacatggt ggagtgccct gaaccctaac ttccccagag ttgggactgt ctagtgaccg
     2041 gcactgaata gcaatgcagg ctgaagacct ccaggtttag aatttaacct caaaagtaac
     2101 ttgtttttaa aaagaaatgt gaattactgt aaaataatct atttttggat tcgtgtgttt
     2161 ttcaggtgga tatagtttat aaacaatgtg aataaaaaat atttaacatg ttcaaa
//
